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We reviewed the literature in multiple databases which investigate ANS function in migraine patients and healthy subjects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This systematic review and meta-analysis examined the respective deep breathing, Valsalva manoeuvre, orthostatic and isometric challenge results, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-analyses of Observational Studies in Epidemiology (MOOSE) statements.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Seven articles met all inclusion criteria. Fixed-effects meta-analysis showed migraine patients (<jats:italic>n<\/jats:italic>\u2009=\u2009424), collectively, had lower interictal autonomic test results compared with healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u2009268). In detail, this was true for the standardized mean difference (g) of deep breathing (g= -0.32; 95% confidence interval (CI) -0.48, -0.16), orthostatic challenge (g= -0.28; 95% CI -0.44, -0.13) and isometric challenge (g= -0.55; 95% CI -0.71, -0.39) and for the difference of means (MD) of the Valsalva ratio (MD = -0.17; 95% CI -0.23, -0.10).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Interictal ANS dysfunction can be identified in migraine patients when compared to healthy controls. These findings indicate the importance to evaluate ANS function in migraine patients - especially, as migraine-specific prophylactic therapies (such as anti-calcitonin gene-related peptide (CGRP) antibodies) may affect the function of the ANS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s10194-024-01758-7","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T10:01:49Z","timestamp":1712743309000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Reconceptualizing autonomic function testing in migraine: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"25","author":[{"given":"Antun R.","family":"Paveli\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Zebenholzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"W\u00f6ber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"1758_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/j.1526-4610.1985.hed2501040.x","volume":"25","author":"LS Rubin","year":"1985","unstructured":"Rubin LS, Graham D, Pasker R, Calhoun W (1985) Autonomic nervous system dysfunction in common migraine. 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