{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:54:28Z","timestamp":1790884468130,"version":"4.1.0"},"reference-count":107,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF2023R1A2C1008079"],"award-info":[{"award-number":["NRF2023R1A2C1008079"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trigeminal neuropathic pain (TNP) is a major concern in both dentistry and medicine. The progression from normal to chronic TNP through activation of the insular cortex (IC) is thought to involve several neuroplastic changes in multiple brain regions, resulting in distorted pain perception and associated comorbidities. While the functional changes in the insula are recognized contributors to TNP, the intricate mechanisms underlying the involvement of the insula in TNP processing remain subjects of ongoing investigation. Here, we have overviewed the most recent advancements regarding the functional role of IC in regulating TNP alongside insights into the IC\u2019s connectivity with other brain regions implicated in trigeminal pain pathways. In addition, the review examines diverse modulation strategies that target the different parts of the IC, thereby suggesting novel diagnostic and therapeutic management of chronic TNP in the future.<\/jats:p>","DOI":"10.1186\/s10194-024-01784-5","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T09:03:08Z","timestamp":1715331788000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain"],"prefix":"10.1186","volume":"25","author":[{"given":"Jaisan","family":"Islam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Taufiqur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"KC","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Seok","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"issue":"6","key":"1784_CR1","doi-asserted-by":"publisher","first-page":"611","DOI":"10.35975\/apic.v24i6.1398","volume":"24","author":"M Abdallah","year":"2020","unstructured":"Abdallah M, Khalil S, Hamed A, Soliman RK, Mohamed A (2020) Brain activity assessment by functional MRI before and after radiofrequency of gasserian ganglia in patients with trigeminal neuralgia. Anaesth Pain Intensive Care 24(6):611\u2013621","journal-title":"Anaesth Pain Intensive Care"},{"key":"1784_CR2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neuroscience.2014.01.046","volume":"266","author":"F Akhter","year":"2014","unstructured":"Akhter F, Haque T, Sato F, Kato T, Ohara H, Fujio T, Tsutsumi K, Uchino K, Sessle B, Yoshida A (2014) Projections from the dorsal peduncular cortex to the trigeminal subnucleus caudalis (medullary dorsal horn) and other lower brainstem areas in rats. Neuroscience 266:23\u201337","journal-title":"Neuroscience"},{"issue":"1","key":"1784_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.nbd.2008.09.003","volume":"33","author":"P Alvarez","year":"2009","unstructured":"Alvarez P, Dieb W, Hafidi A, Voisin DL, Dallel R (2009) Insular cortex representation of dynamic mechanical allodynia in trigeminal neuropathic rats. Neurobiol Dis 33(1):89\u201395","journal-title":"Neurobiol Dis"},{"key":"1784_CR4","doi-asserted-by":"publisher","first-page":"174480692110577","DOI":"10.1177\/17448069211057750","volume":"18","author":"EI Araya","year":"2022","unstructured":"Araya EI, Carvalho EC, Andreatini R, Zamponi GW, Chichorro JG (2022) Trigeminal neuropathic pain causes changes in affective processing of pain in rats. Mol Pain 18:17448069211057750","journal-title":"Mol Pain"},{"issue":"3","key":"1784_CR5","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.biopsych.2013.11.027","volume":"76","author":"JA Avery","year":"2014","unstructured":"Avery JA, Drevets WC, Moseman SE, Bodurka J, Barcalow JC, Simmons WK (2014) Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula. Biol Psychiatry 76(3):258\u2013266","journal-title":"Biol Psychiatry"},{"issue":"7","key":"1784_CR6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/nrn3950","volume":"16","author":"LF Barrett","year":"2015","unstructured":"Barrett LF, Simmons WK (2015) Interoceptive predictions in the brain. Nat Rev Neurosci 16(7):419\u2013429","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"1784_CR7","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1152\/jn.00253.2010","volume":"104","author":"U Baumg\u00e4rtner","year":"2010","unstructured":"Baumg\u00e4rtner U, Iannetti GD, Zambreanu L, Stoeter P, Treede R-D, Tracey I (2010) Multiple somatotopic representations of heat and mechanical pain in the operculo-insular cortex: a high-resolution fMRI study. J Neurophysiol 104(5):2863\u20132872","journal-title":"J Neurophysiol"},{"issue":"42","key":"1784_CR8","doi-asserted-by":"publisher","first-page":"10646","DOI":"10.1523\/JNEUROSCI.2305-06.2006","volume":"26","author":"L Becerra","year":"2006","unstructured":"Becerra L, Morris S, Bazes S, Gostic R, Sherman S, Gostic J, Pendse G, Moulton E, Scrivani S, Keith D (2006) Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli. J Neurosci 26(42):10646\u201310657","journal-title":"J Neurosci"},{"issue":"9","key":"1784_CR9","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/S1474-4422(20)30233-7","volume":"19","author":"L Bendtsen","year":"2020","unstructured":"Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T, Obermann M, Cruccu G, Maarbjerg S (2020) Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia. Lancet Neurol 19(9):784\u2013796","journal-title":"Lancet Neurol"},{"key":"1784_CR10","unstructured":"Benison AM (2012) Insular cortex: functional mapping and allodynic behavior in the rat. University of Colorado at Boulder"},{"issue":"17","key":"1784_CR11","doi-asserted-by":"publisher","first-page":"6317","DOI":"10.1523\/JNEUROSCI.0076-11.2011","volume":"31","author":"AM Benison","year":"2011","unstructured":"Benison AM, Chumachenko S, Harrison JA, Maier SF, Falci SP, Watkins LR, Barth DS (2011) Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy. J Neurosci 31(17):6317\u20136328","journal-title":"J Neurosci"},{"issue":"5","key":"1784_CR12","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3390\/brainsci11050639","volume":"11","author":"D Bergeron","year":"2021","unstructured":"Bergeron D, Obaid S, Fournier-Gosselin M-P, Bouthillier A, Nguyen DK (2021) Deep brain stimulation of the posterior insula in chronic pain: a theoretical framework. Brain Sci 11(5):639","journal-title":"Brain Sci"},{"issue":"2","key":"1784_CR13","doi-asserted-by":"publisher","first-page":"384","DOI":"10.2174\/1570159X19666210609161447","volume":"20","author":"H Bonilla-Jaime","year":"2022","unstructured":"Bonilla-Jaime H, S\u00e1nchez-Salcedo JA, Estevez-Cabrera MM, Molina-Jim\u00e9nez T, Cortes-Altamirano JL, Alfaro-Rodr\u00edguez A (2022) Depression and pain: use of antidepressants. Curr Neuropharmacol 20(2):384","journal-title":"Curr Neuropharmacol"},{"issue":"6047","key":"1784_CR14","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1126\/science.1204076","volume":"333","author":"X Chen","year":"2011","unstructured":"Chen X, Gabitto M, Peng Y, Ryba NJ, Zuker CS (2011) A gustotopic map of taste qualities in the mammalian brain. Science 333(6047):1262\u20131266","journal-title":"Science"},{"issue":"5","key":"1784_CR15","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.ejpain.2007.08.008","volume":"12","author":"U Coffeen","year":"2008","unstructured":"Coffeen U, L\u00f3pez-Avila A, Ortega-Legaspi JM, Del \u00c1ngel R, L\u00f3pez-Mu\u00f1oz FJ, Pellicer F (2008) Dopamine receptors in the anterior insular cortex modulate long-term nociception in the rat. Eur J Pain 12(5):535\u2013543","journal-title":"Eur J Pain"},{"issue":"2","key":"1784_CR16","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ejpain.2010.06.007","volume":"15","author":"U Coffeen","year":"2011","unstructured":"Coffeen U, Ortega-Legaspi JM, L\u00f3pez-Mu\u00f1oz FJ, Sim\u00f3n-Arceo K, Jaimes O, Pellicer F (2011) Insular cortex lesion diminishes neuropathic and inflammatory pain-like behaviours. Eur J Pain 15(2):132\u2013138","journal-title":"Eur J Pain"},{"issue":"01","key":"1784_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.4236\/wjns.2016.61003","volume":"6","author":"U Coffeen","year":"2016","unstructured":"Coffeen U, Canseco-Alba A, Sim\u00f3n-Arceo K, Mercado F, Almanza A, Jaimes O, Pellicer F (2016) Extracellular levels of 5HT and 5HIAA increase after an inflammatory process in the rat\u2019s insular cortex. World J Neurosci 6(01):23","journal-title":"World J Neurosci"},{"issue":"2","key":"1784_CR18","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/cne.20240","volume":"477","author":"A Craig","year":"2004","unstructured":"Craig A (2004) Distribution of trigeminothalamic and spinothalamic lamina I terminations in the macaque monkey. J Comp Neurol 477(2):119\u2013148","journal-title":"J Comp Neurol"},{"issue":"1","key":"1784_CR19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nrn2555","volume":"10","author":"AD Craig","year":"2009","unstructured":"Craig AD (2009) How do you feel\u2014now? The anterior insula and human awareness. Nat Rev Neurosci 10(1):59\u201370","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"1784_CR20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/72131","volume":"3","author":"AD Craig","year":"2000","unstructured":"Craig AD, Chen K, Bandy D, Reiman EM (2000) Thermosensory activation of insular cortex. Nat Neurosci 3(2):184\u2013190","journal-title":"Nat Neurosci"},{"issue":"4","key":"1784_CR21","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.neuron.2013.02.008","volume":"77","author":"HD Critchley","year":"2013","unstructured":"Critchley HD, Harrison NA (2013) Visceral influences on brain and behavior. Neuron 77(4):624\u2013638","journal-title":"Neuron"},{"issue":"8","key":"1784_CR22","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1056\/NEJMra1914484","volume":"383","author":"G Cruccu","year":"2020","unstructured":"Cruccu G, Di Stefano G, Truini A (2020) Trigeminal neuralgia. N Engl J Med 383(8):754\u2013762","journal-title":"N Engl J Med"},{"issue":"10","key":"1784_CR23","doi-asserted-by":"publisher","first-page":"e3396","DOI":"10.1371\/journal.pone.0003396","volume":"3","author":"AF DaSilva","year":"2008","unstructured":"DaSilva AF, Becerra L, Pendse G, Chizh B, Tully S, Borsook D (2008) Colocalized structural and functional changes in the cortex of patients with trigeminal neuropathic pain. PLoS ONE 3(10):e3396","journal-title":"PLoS ONE"},{"issue":"4","key":"1784_CR24","doi-asserted-by":"publisher","first-page":"e769","DOI":"10.1097\/PR9.0000000000000769","volume":"4","author":"AF DaSilva","year":"2019","unstructured":"DaSilva AF, Zubieta J-K, DosSantos MF (2019) Positron emission tomography imaging of endogenous mu-opioid mechanisms during pain and migraine. Pain Rep 4(4):e769","journal-title":"Pain Rep"},{"issue":"2","key":"1784_CR25","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/(SICI)1096-9861(19990726)410:2<178::AID-CNE2>3.0.CO;2-F","volume":"410","author":"C Desbois","year":"1999","unstructured":"Desbois C, Le Bars D, Villanueva L (1999) Organization of cortical projections to the medullary subnucleus reticularis dorsalis: a retrograde and anterograde tracing study in the rat. J Comp Neurol 410(2):178\u2013196","journal-title":"J Comp Neurol"},{"issue":"6","key":"1784_CR26","doi-asserted-by":"publisher","first-page":"e66340","DOI":"10.1371\/journal.pone.0066340","volume":"8","author":"DD DeSouza","year":"2013","unstructured":"DeSouza DD, Moayedi M, Chen DQ, Davis KD, Hodaie M (2013) Sensorimotor and pain modulation brain abnormalities in trigeminal neuralgia: a paroxysmal, sensory-triggered neuropathic pain. PLoS ONE 8(6):e66340","journal-title":"PLoS ONE"},{"issue":"6","key":"1784_CR27","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1097\/j.pain.0000000000000156","volume":"156","author":"DD DeSouza","year":"2015","unstructured":"DeSouza DD, Davis KD, Hodaie M (2015) Reversal of insular and microstructural nerve abnormalities following effective surgical treatment for trigeminal neuralgia. Pain 156(6):1112\u20131123","journal-title":"Pain"},{"key":"1784_CR28","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.brainres.2007.01.055","volume":"1143","author":"C Devue","year":"2007","unstructured":"Devue C, Collette F, Balteau E, Degueldre C, Luxen A, Maquet P, Br\u00e9dart S (2007) Here I am: the cortical correlates of visual self-recognition. Brain Res 1143:169\u2013182","journal-title":"Brain Res"},{"key":"1784_CR29","doi-asserted-by":"publisher","first-page":"100124","DOI":"10.1016\/j.ynpai.2023.100124","volume":"13","author":"B Donertas-Ayaz","year":"2023","unstructured":"Donertas-Ayaz B, Caudle RM (2023) Locus coeruleus-noradrenergic modulation of trigeminal pain: implications for trigeminal neuralgia and psychiatric comorbidities. Neurobiol Pain 13:100124","journal-title":"Neurobiol Pain"},{"issue":"7","key":"1784_CR30","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.tics.2015.05.005","volume":"19","author":"V Droutman","year":"2015","unstructured":"Droutman V, Read SJ, Bechara A (2015) Revisiting the role of the insula in addiction. Trends Cogn Sci 19(7):414\u2013420","journal-title":"Trends Cogn Sci"},{"key":"1784_CR31","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3389\/fnbeh.2014.00350","volume":"8","author":"K Emmert","year":"2014","unstructured":"Emmert K, Breimhorst M, Bauermann T, Birklein F, Van De Ville D, Haller S (2014) Comparison of anterior cingulate vs. insular cortex as targets for real-time fMRI regulation during pain stimulation. Front Behav Neurosci 8:350","journal-title":"Front Behav Neurosci"},{"issue":"10","key":"1784_CR32","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1176\/appi.ajp.2007.07030504","volume":"164","author":"A Etkin","year":"2007","unstructured":"Etkin A, Wager TD (2007) Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 164(10):1476\u20131488","journal-title":"Am J Psychiatry"},{"key":"1784_CR33","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fnana.2019.00043","volume":"13","author":"HC Evrard","year":"2019","unstructured":"Evrard HC (2019) The organization of the primate insular cortex. Front Neuroanat 13:43","journal-title":"Front Neuroanat"},{"key":"1784_CR34","unstructured":"Fermin AS, Friston K, Yamawaki S (2021) Insula interoception, active inference and feeling representation. arXiv Preprint. arXiv:211212290"},{"key":"1784_CR35","doi-asserted-by":"crossref","unstructured":"Fujita S, Yamamoto K, Kobayashi M (2019) Trigeminal nerve transection-induced neuroplastic changes in the somatosensory and insular cortices in a rat ectopic pain model. Eneuro 6 (1)","DOI":"10.1523\/ENEURO.0462-18.2019"},{"issue":"1","key":"1784_CR36","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1093\/cercor\/bhr104","volume":"22","author":"DS Gallay","year":"2012","unstructured":"Gallay DS, Gallay M, Jeanmonod D, Rouiller EM, Morel A (2012) The insula of Reil revisited: multiarchitectonic organization in macaque monkeys. Cereb Cortex 22(1):175\u2013190","journal-title":"Cereb Cortex"},{"key":"1784_CR37","doi-asserted-by":"publisher","first-page":"174480692090189","DOI":"10.1177\/1744806920901890","volume":"16","author":"E Gambeta","year":"2020","unstructured":"Gambeta E, Chichorro JG, Zamponi GW (2020) Trigeminal neuralgia: an overview from pathophysiology to pharmacological treatments. Mol Pain 16:1744806920901890","journal-title":"Mol Pain"},{"issue":"9","key":"1784_CR38","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1038\/s41593-019-0469-1","volume":"22","author":"DA Gehrlach","year":"2019","unstructured":"Gehrlach DA, Dolensek N, Klein AS, Roy Chowdhury R, Matthys A, Jungh\u00e4nel M, Gaitanos TN, Podgornik A, Black TD, Reddy Vaka N (2019) Aversive state processing in the posterior insular cortex. Nat Neurosci 22(9):1424\u20131437","journal-title":"Nat Neurosci"},{"key":"1784_CR39","doi-asserted-by":"publisher","first-page":"e55585","DOI":"10.7554\/eLife.55585","volume":"9","author":"DA Gehrlach","year":"2020","unstructured":"Gehrlach DA, Weiand C, Gaitanos TN, Cho E, Klein AS, Hennrich AA, Conzelmann K-K, Gogolla N (2020) A whole-brain connectivity map of mouse insular cortex. Elife 9:e55585","journal-title":"Elife"},{"issue":"12","key":"1784_CR40","doi-asserted-by":"publisher","first-page":"R580","DOI":"10.1016\/j.cub.2017.05.010","volume":"27","author":"N Gogolla","year":"2017","unstructured":"Gogolla N (2017) The insular cortex. Curr Biol 27(12):R580\u2013R586","journal-title":"Curr Biol"},{"key":"1784_CR41","doi-asserted-by":"crossref","unstructured":"Gorrino I, Canessa N, Mattavelli G (2023) Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control. Front Behav Neurosci 17","DOI":"10.3389\/fnbeh.2023.1234837"},{"issue":"16","key":"1784_CR42","doi-asserted-by":"publisher","first-page":"5956","DOI":"10.1523\/JNEUROSCI.5980-10.2011","volume":"31","author":"SM Gustin","year":"2011","unstructured":"Gustin SM, Peck CC, Wilcox SL, Nash PG, Murray GM, Henderson LA (2011) Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes. J Neurosci 31(16):5956\u20135964","journal-title":"J Neurosci"},{"key":"1784_CR43","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s00330-010-1971-8","volume":"21","author":"A Gutzeit","year":"2011","unstructured":"Gutzeit A, Meier D, Meier M, von Weymarn C, Ettlin DA, Graf N, Froehlich J, Binkert C, Br\u00fcgger M (2011) Insula-specific responses induced by dental pain. A proton magnetic resonance spectroscopy study. Eur Radiol 21:807\u2013815","journal-title":"Eur Radiol"},{"key":"1784_CR44","doi-asserted-by":"crossref","unstructured":"Han J, Kwon M, Cha M, Tanioka M, Hong S-K, Bai SJ, Lee BH (2015) Plasticity-related PKM\u03b6 signaling in the insular cortex is involved in the modulation of neuropathic pain after nerve injury. Neural plasticity 2015","DOI":"10.1155\/2015\/601767"},{"key":"1784_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11916-013-0392-1","volume":"18","author":"R Hassanzadeh","year":"2014","unstructured":"Hassanzadeh R, Jones JC, Ross EL (2014) Neuromodulation for intractable headaches. Curr Pain Headache Rep 18:1\u20138","journal-title":"Curr Pain Headache Rep"},{"key":"1784_CR46","doi-asserted-by":"crossref","unstructured":"Hayes DJ, Chen DQ, Zhong J, Lin A, Behan B, Walker M, Hodaie M (2017) Affective circuitry alterations in patients with trigeminal neuralgia. Front Neuroanat:73","DOI":"10.3389\/fnana.2017.00073"},{"key":"1784_CR47","doi-asserted-by":"publisher","first-page":"102039","DOI":"10.1016\/j.nicl.2019.102039","volume":"24","author":"D Henssen","year":"2019","unstructured":"Henssen D, Dijk J, Knepfl\u00e9 R, Sieffers M, Winter A, Vissers K (2019) Alterations in grey matter density and functional connectivity in trigeminal neuropathic pain and trigeminal neuralgia: a systematic review and meta-analysis. NeuroImage: Clin 24:102039","journal-title":"NeuroImage: Clin"},{"issue":"1","key":"1784_CR48","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13293-024-00593-4","volume":"15","author":"D Iezzi","year":"2024","unstructured":"Iezzi D, C\u00e1ceres-Rodr\u00edguez A, Strauss B, Chavis P, Manzoni OJ (2024) Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex. Biology sex Differences 15(1):29","journal-title":"Biology sex Differences"},{"issue":"16","key":"1784_CR49","doi-asserted-by":"publisher","first-page":"8421","DOI":"10.3390\/ijms22168421","volume":"22","author":"J Islam","year":"2021","unstructured":"Islam J, Kc E, Kim S, Kim HK, Park YS (2021) Stimulating gabaergic neurons in the nucleus accumbens core alters the trigeminal neuropathic pain responses in a rat model of infraorbital nerve injury. Int J Mol Sci 22(16):8421","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1784_CR50","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1007\/s12017-023-08752-3","volume":"25","author":"J Islam","year":"2023","unstructured":"Islam J, Kc E, Kim S, Chung MY, Park KS, Kim HK, Park YS (2023) Optogenetic Inhibition of Glutamatergic Neurons in the dysgranular posterior insular cortex modulates Trigeminal Neuropathic Pain in CCI-ION rat. Neuromol Med 25(4):516\u2013532","journal-title":"Neuromol Med"},{"issue":"6946","key":"1784_CR51","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/nature01808","volume":"424","author":"L Jasmin","year":"2003","unstructured":"Jasmin L, Rabkin SD, Granato A, Boudah A, Ohara PT (2003) Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex. Nature 424(6946):316\u2013320","journal-title":"Nature"},{"issue":"1","key":"1784_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13041-020-00605-5","volume":"13","author":"A Ju","year":"2020","unstructured":"Ju A, Fernandez-Arroyo B, Wu Y, Jacky D, Beyeler A (2020) Expression of serotonin 1A and 2A receptors in molecular-and projection-defined neurons of the mouse insular cortex. Mol Brain 13(1):1\u201313","journal-title":"Mol Brain"},{"key":"1784_CR53","doi-asserted-by":"publisher","first-page":"e60336","DOI":"10.7554\/eLife.60336","volume":"9","author":"D Kargl","year":"2020","unstructured":"Kargl D, Kaczanowska J, Ulonska S, Groessl F, Piszczek L, Lazovic J, Buehler K, Haubensak W (2020) The amygdala instructs insular feedback for affective learning. Elife 9:e60336","journal-title":"Elife"},{"key":"1784_CR54","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neuroscience.2016.08.005","volume":"334","author":"R Kaushal","year":"2016","unstructured":"Kaushal R, Taylor BK, Jamal A, Zhang L, Ma F, Donahue R, Westlund K (2016) GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NA\u03b11 receptors in the medial prefrontal cortex. Neuroscience 334:148\u2013159","journal-title":"Neuroscience"},{"key":"1784_CR55","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3389\/fnhum.2013.00628","volume":"7","author":"H Knotkova","year":"2013","unstructured":"Knotkova H, Nitsche MA, Cruciani RA (2013) Putative physiological mechanisms underlying tDCS analgesic effects. Front Hum Neurosci 7:628","journal-title":"Front Hum Neurosci"},{"key":"1784_CR56","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/B978-0-12-385198-7.00011-4","volume":"97","author":"M Kobayashi","year":"2011","unstructured":"Kobayashi M (2011) Macroscopic connection of rat insular cortex: anatomical bases underlying its physiological functions. Int Rev Neurobiol 97:285\u2013303","journal-title":"Int Rev Neurobiol"},{"issue":"3","key":"1784_CR57","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.job.2018.04.002","volume":"60","author":"M Kobayashi","year":"2018","unstructured":"Kobayashi M (2018) Mechanisms of orofacial sensory processing in the rat insular cortex. J Oral Biosci 60(3):59\u201364","journal-title":"J Oral Biosci"},{"issue":"2","key":"1784_CR58","doi-asserted-by":"publisher","first-page":"144","DOI":"10.2334\/josnusd.19-0386","volume":"62","author":"M Kobayashi","year":"2020","unstructured":"Kobayashi M, Nakaya Y (2020) Anatomical aspects of corticotrigeminal projections to the medullary dorsal horn. J Oral Sci 62(2):144\u2013146","journal-title":"J Oral Sci"},{"issue":"5","key":"1784_CR59","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2174\/1570159X13666150425002304","volume":"14","author":"K Koga","year":"2016","unstructured":"Koga K, Li S, Zhuo M (2016) Metabotropic glutamate receptor dependent cortical plasticity in chronic pain. Curr Neuropharmacol 14(5):427\u2013434","journal-title":"Curr Neuropharmacol"},{"issue":"1","key":"1784_CR60","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/cne.902700105","volume":"270","author":"LA Krushel","year":"1988","unstructured":"Krushel LA, van Der Kooy D (1988) Visceral cortex: integration of the mucosal senses with limbic information in the rat agranular insular cortex. J Comp Neurol 270(1):39\u201354","journal-title":"J Comp Neurol"},{"issue":"6","key":"1784_CR61","doi-asserted-by":"publisher","first-page":"5736","DOI":"10.3390\/ijms24065736","volume":"24","author":"C Labrakakis","year":"2023","unstructured":"Labrakakis C (2023) The role of the insular cortex in Pain. Int J Mol Sci 24(6):5736","journal-title":"Int J Mol Sci"},{"issue":"2\u20133","key":"1784_CR62","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ejphar.2007.09.022","volume":"578","author":"T Lau","year":"2008","unstructured":"Lau T, Schloss P (2008) The cannabinoid CB1 receptor is expressed on serotonergic and dopaminergic neurons. Eur J Pharmacol 578(2\u20133):137\u2013141","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"1784_CR63","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3344\/kjp.2021.34.3.332","volume":"34","author":"C-H Lee","year":"2021","unstructured":"Lee C-H, Jang H-Y, Won H-S, Kim J-S, Kim Y-D (2021) Epidemiology of trigeminal neuralgia: an electronic population health data study in Korea. Korean J pain 34(3):332\u2013338","journal-title":"Korean J pain"},{"issue":"4","key":"1784_CR64","doi-asserted-by":"publisher","first-page":"e94300","DOI":"10.1371\/journal.pone.0094300","volume":"9","author":"C-s Lin","year":"2014","unstructured":"Lin C-s (2014) Brain signature of chronic orofacial pain: a systematic review and meta-analysis on neuroimaging research of trigeminal neuropathic pain and temporomandibular joint disorders. PLoS ONE 9(4):e94300","journal-title":"PLoS ONE"},{"key":"1784_CR65","unstructured":"Lindholm P (2017) Neural mechanisms of orofacial pain-effects of transcranial magnetic stimulation"},{"key":"1784_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13041-019-0541-5","volume":"13","author":"Y Liu","year":"2020","unstructured":"Liu Y, Chen Q-Y, Lee JH, Li X-H, Yu S, Zhuo M (2020) Cortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice. Mol Brain 13:1\u201310","journal-title":"Mol Brain"},{"issue":"6","key":"1784_CR67","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.neuron.2019.12.027","volume":"105","author":"Y Livneh","year":"2020","unstructured":"Livneh Y, Sugden AU, Madara JC, Essner RA, Flores VI, Sugden LA, Resch JM, Lowell BB, Andermann ML (2020) Estimation of current and future physiological states in insular cortex. Neuron 105(6):1094\u20131111 e1010","journal-title":"Neuron"},{"issue":"4","key":"1784_CR68","doi-asserted-by":"publisher","first-page":"e34798","DOI":"10.1371\/journal.pone.0034798","volume":"7","author":"J L\u00f6tsch","year":"2012","unstructured":"L\u00f6tsch J, Walter C, Felden L, N\u00f6th U, Deichmann R, Oertel BG (2012) The human operculo-insular cortex is pain-preferentially but not pain-exclusively activated by trigeminal and olfactory stimuli. PLoS ONE 7(4):e34798","journal-title":"PLoS ONE"},{"key":"1784_CR69","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s12264-016-0016-y","volume":"32","author":"C Lu","year":"2016","unstructured":"Lu C, Yang T, Zhao H, Zhang M, Meng F, Fu H, Xie Y, Xu H (2016) Insular cortex is critical for the perception, modulation, and chronification of pain. Neurosci Bull 32:191\u2013201","journal-title":"Neurosci Bull"},{"key":"1784_CR70","doi-asserted-by":"publisher","first-page":"1131167","DOI":"10.3389\/fnana.2023.1131167","volume":"17","author":"ML Mathiasen","year":"2023","unstructured":"Mathiasen ML, Aggleton JP, Witter MP (2023) Projections of the insular cortex to orbitofrontal and medial prefrontal cortex: a tracing study in the rat. Front Neuroanat 17:1131167","journal-title":"Front Neuroanat"},{"issue":"1\u20132","key":"1784_CR71","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.pain.2009.07.014","volume":"146","author":"L Mazzola","year":"2009","unstructured":"Mazzola L, Isnard J, Peyron R, Gu\u00e9not M, Mauguiere F (2009) Somatotopic organization of pain responses to direct electrical stimulation of the human insular cortex. Pain 146(1\u20132):99\u2013104","journal-title":"Pain"},{"issue":"2","key":"1784_CR72","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ejpain.2010.06.006","volume":"15","author":"X Moisset","year":"2011","unstructured":"Moisset X, Villain N, Ducreux D, Serrie A, Cunin G, Valade D, Calvino B, Bouhassira D (2011) Functional brain imaging of trigeminal neuralgia. Eur J Pain 15(2):124\u2013131","journal-title":"Eur J Pain"},{"key":"1784_CR73","doi-asserted-by":"crossref","unstructured":"Montano N, Conforti G, Di Bonaventura R, Meglio M, Fernandez E, Papacci F (2015) Advances in diagnosis and treatment of trigeminal neuralgia. Therapeutics and clinical risk management:289\u2013299","DOI":"10.2147\/TCRM.S37592"},{"issue":"5","key":"1784_CR74","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.jpain.2009.08.011","volume":"11","author":"F Mori","year":"2010","unstructured":"Mori F, Codec\u00e0 C, Kusayanagi H, Monteleone F, Buttari F, Fiore S, Bernardi G, Koch G, Centonze D (2010) Effects of anodal transcranial direct current stimulation on chronic neuropathic pain in patients with multiple sclerosis. J pain 11(5):436\u2013442","journal-title":"J pain"},{"issue":"7879","key":"1784_CR75","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41586-021-03970-w","volume":"598","author":"R Mu\u00f1oz-Casta\u00f1eda","year":"2021","unstructured":"Mu\u00f1oz-Casta\u00f1eda R, Zingg B, Matho KS, Chen X, Wang Q, Foster NN, Li A, Narasimhan A, Hirokawa KE, Huo B (2021) Cellular anatomy of the mouse primary motor cortex. Nature 598(7879):159\u2013166","journal-title":"Nature"},{"key":"1784_CR76","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.npbr.2019.06.002","volume":"33","author":"I Mutschler","year":"2019","unstructured":"Mutschler I, H\u00e4nggi J, Frei M, Lieb R, Grosse Holforth M, Seifritz E, Spinelli S (2019) Insular volume reductions in patients with major depressive disorder. Neurol Psychiatry Brain Res 33:39\u201347","journal-title":"Neurol Psychiatry Brain Res"},{"key":"1784_CR77","doi-asserted-by":"crossref","unstructured":"Nakaya N, Yamamoto Y, Kobayashi K (2022) Descending projections from the insular cortex to the trigeminal spinal subnucleus caudalis facilitate excitatory outputs to the parabrachial nucleus in rats. Pain. 10.1097","DOI":"10.1097\/j.pain.0000000000002755"},{"key":"1784_CR78","doi-asserted-by":"publisher","first-page":"148248","DOI":"10.1016\/j.brainres.2023.148248","volume":"1804","author":"Y Nakaya","year":"2023","unstructured":"Nakaya Y, Iwata K, Kobayashi M (2023) Insular cortical descending projections facilitate neuronal responses to noxious but not innoxious stimulation in rat trigeminal spinal subnucleus caudalis. Brain Res 1804:148248","journal-title":"Brain Res"},{"issue":"4","key":"1784_CR79","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.tins.2017.02.002","volume":"40","author":"H Namkung","year":"2017","unstructured":"Namkung H, Kim S-H, Sawa A (2017) The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology. Trends Neurosci 40(4):200\u2013207","journal-title":"Trends Neurosci"},{"key":"1784_CR80","doi-asserted-by":"publisher","first-page":"146588","DOI":"10.1016\/j.brainres.2019.146588","volume":"1728","author":"D Noma","year":"2020","unstructured":"Noma D, Fujita S, Zama M, Mayahara K, Motoyoshi M, Kobayashi M (2020) Application of oxytocin with low-level laser irradiation suppresses the facilitation of cortical excitability by partial ligation of the infraorbital nerve in rats: an optical imaging study. Brain Res 1728:146588","journal-title":"Brain Res"},{"issue":"43","key":"1784_CR81","doi-asserted-by":"publisher","first-page":"14420","DOI":"10.1523\/JNEUROSCI.3025-10.2010","volume":"30","author":"R Noseda","year":"2010","unstructured":"Noseda R, Constandil L, Bourgeais L, Chalus M, Villanueva L (2010) Changes of meningeal excitability mediated by corticotrigeminal networks: a link for the endogenous modulation of migraine pain. J Neurosci 30(43):14420\u201314429","journal-title":"J Neurosci"},{"issue":"4","key":"1784_CR82","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.biopsych.2006.03.042","volume":"60","author":"MP Paulus","year":"2006","unstructured":"Paulus MP, Stein MB (2006) An insular view of anxiety. Biol Psychiatry 60(4):383\u2013387","journal-title":"Biol Psychiatry"},{"issue":"2","key":"1784_CR83","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.neuroimage.2010.09.012","volume":"54","author":"E Peltz","year":"2011","unstructured":"Peltz E, Seifert F, DeCol R, D\u00f6rfler A, Schwab S, Maih\u00f6fner C (2011) Functional connectivity of the human insular cortex during noxious and innocuous thermal stimulation. NeuroImage 54(2):1324\u20131335","journal-title":"NeuroImage"},{"issue":"8","key":"1784_CR84","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/j.neurom.2022.05.009","volume":"26","author":"RCM Pereira","year":"2023","unstructured":"Pereira RCM, Medeiros P, Coimbra NC, Machado HR, de Freitas RL (2023) Cortical neurostimulation and N-methyl-D-aspartate glutamatergic receptor activation in the dysgranular layer of the posterior insular cortex modulate chronic neuropathic pain. Neuromodulation: Technol Neural Interface 26(8):1622\u20131636","journal-title":"Neuromodulation: Technol Neural Interface"},{"key":"1784_CR85","doi-asserted-by":"crossref","unstructured":"Ramos-Prats A, Paradiso E, Castaldi F, Sadeghi M, Mir MY, H\u00f6rtnagl H, G\u00f6bel G, Ferraguti F (2022) VIP-expressing interneurons in the anterior insular cortex contribute to sensory processing to regulate adaptive behavior. Cell Rep 39 (9)","DOI":"10.1016\/j.celrep.2022.110893"},{"issue":"12","key":"1784_CR86","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1093\/cercor\/bhn054","volume":"18","author":"KM Rodgers","year":"2008","unstructured":"Rodgers KM, Benison AM, Klein A, Barth DS (2008) Auditory, somatosensory, and multisensory insular cortex in the rat. Cereb Cortex 18(12):2941\u20132951","journal-title":"Cereb Cortex"},{"issue":"5","key":"1784_CR87","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1093\/cercor\/bhaa376","volume":"31","author":"C Rousseau","year":"2021","unstructured":"Rousseau C, Barbiero M, Pozzo T, Papaxanthis C, White O (2021) Actual and imagined movements reveal a dual role of the insular cortex for motor control. Cereb Cortex 31(5):2586\u20132594","journal-title":"Cereb Cortex"},{"key":"1784_CR88","doi-asserted-by":"crossref","unstructured":"Saper CB (2007) Visceral sensation and visceral sensory disorders. CONTINUUM: Lifelong Learn Neurol 13(6):204\u2013214","DOI":"10.1212\/01.CON.0000299972.43513.28"},{"key":"1784_CR89","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neuroscience.2012.12.024","volume":"233","author":"F Sato","year":"2013","unstructured":"Sato F, Akhter F, Haque T, Kato T, Takeda R, Nagase Y, Sessle B, Yoshida A (2013) Projections from the insular cortex to pain-receptive trigeminal caudal subnucleus (medullary dorsal horn) and other lower brainstem areas in rats. Neuroscience 233:9\u201327","journal-title":"Neuroscience"},{"issue":"4","key":"1784_CR90","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1002\/(SICI)1096-9861(19981005)399:4<440::AID-CNE2>3.0.CO;2-1","volume":"399","author":"CJ Shi","year":"1998","unstructured":"Shi CJ, Cassell M (1998) Cortical, thalamic, and amygdaloid connections of the anterior and posterior insular cortices. J Comp Neurol 399(4):440\u2013468","journal-title":"J Comp Neurol"},{"key":"1784_CR91","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1007\/s42399-020-00415-9","volume":"2","author":"M Silva","year":"2020","unstructured":"Silva M, Ouanounou A (2020) Trigeminal neuralgia: etiology, diagnosis, and treatment. SN Compr Clin Med 2:1585\u20131592","journal-title":"SN Compr Clin Med"},{"issue":"9","key":"1784_CR92","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1002\/hbm.20705","volume":"30","author":"KS Taylor","year":"2009","unstructured":"Taylor KS, Seminowicz DA, Davis KD (2009) Two systems of resting state connectivity between the insula and cingulate cortex. Hum Brain Mapp 30(9):2731\u20132745","journal-title":"Hum Brain Mapp"},{"key":"1784_CR93","doi-asserted-by":"publisher","first-page":"110722","DOI":"10.1016\/j.biopha.2020.110722","volume":"131","author":"N Tsagareli","year":"2020","unstructured":"Tsagareli N, Tsiklauri N, Kvachadze I, Tsagareli MG (2020) Endogenous opioid and cannabinoid systems contribute to antinociception produced by administration of NSAIDs into the insular cortex of rats. Biomed Pharmacother 131:110722","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"1784_CR94","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrn3857","volume":"16","author":"LQ Uddin","year":"2015","unstructured":"Uddin LQ (2015) Salience processing and insular cortical function and dysfunction. Nat Rev Neurosci 16(1):55\u201361","journal-title":"Nat Rev Neurosci"},{"issue":"8","key":"1784_CR95","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.neubiorev.2009.06.002","volume":"33","author":"LQ Uddin","year":"2009","unstructured":"Uddin LQ, Menon V (2009) The anterior insula in autism: under-connected and under-examined. Neurosci Biobehavioral Reviews 33(8):1198\u20131203","journal-title":"Neurosci Biobehavioral Reviews"},{"key":"1784_CR96","doi-asserted-by":"crossref","unstructured":"Unger N, Haeck M, Eickhoff SB, Camilleri JA, Dickscheid T, Mohlberg H, Bludau S, Caspers S, Amunts K (2023) Cytoarchitectonic mapping of the human frontal operculum\u2014new correlates for a variety of brain functions. Front Hum Neurosci 17","DOI":"10.3389\/fnhum.2023.1087026"},{"key":"1784_CR97","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2049-9256-1-9","volume":"1","author":"P Veinante","year":"2013","unstructured":"Veinante P, Yalcin I, Barrot M (2013) The amygdala between sensation and affect: a role in pain. J Mol Psychiatry 1:1\u201314","journal-title":"J Mol Psychiatry"},{"key":"1784_CR98","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3389\/fncel.2015.00493","volume":"9","author":"J Wang","year":"2015","unstructured":"Wang J, Li Z-H, Feng B, Zhang T, Zhang H, Li H, Chen T, Cui J, Zang W-D, Li Y-Q (2015) Corticotrigeminal projections from the insular cortex to the trigeminal caudal subnucleus regulate orofacial pain after nerve injury via extracellular signal-regulated kinase activation in insular cortex neurons. Front Cell Neurosci 9:493","journal-title":"Front Cell Neurosci"},{"issue":"8","key":"1784_CR99","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1097\/j.pain.0000000000000951","volume":"158","author":"Y Wang","year":"2017","unstructured":"Wang Y, Cao D-y, Remeniuk B, Krimmel S, Seminowicz DA, Zhang M (2017) Altered brain structure and function associated with sensory and affective components of classic trigeminal neuralgia. Pain 158(8):1561\u20131570","journal-title":"Pain"},{"issue":"3","key":"1784_CR100","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1097\/j.pain.0000000000001120","volume":"159","author":"Y Wang","year":"2018","unstructured":"Wang Y, Zhang Y, Zhang J, Wang J, Xu J, Li J, Cui G, Zhang J (2018) Structural and functional abnormalities of the insular cortex in trigeminal neuralgia: a multimodal magnetic resonance imaging analysis. Pain 159(3):507\u2013514","journal-title":"Pain"},{"issue":"5","key":"1784_CR101","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.3390\/ijms22052648","volume":"22","author":"N Wang","year":"2021","unstructured":"Wang N, Zhang Y-H, Wang J-Y, Luo F (2021) Current understanding of the involvement of the insular cortex in neuropathic pain: a narrative review. Int J Mol Sci 22(5):2648","journal-title":"Int J Mol Sci"},{"issue":"10","key":"1784_CR102","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1097\/j.pain.0000000000000615","volume":"157","author":"CJ Watson","year":"2016","unstructured":"Watson CJ (2016) Insular balance of glutamatergic and GABAergic signaling modulates pain processing. Pain 157(10):2194\u20132207","journal-title":"Pain"},{"key":"1784_CR103","doi-asserted-by":"crossref","unstructured":"Xu R, Zhang YW, Gu Q, Yuan TJ, Fan BQ, Xia JM, Wu JH, Xia Y, Li WX, Han Y (2023) Brain function activity changes and contribution of neuroinflammatory factors in Insular Cortex of mice. with Dry Eye-Related Chronic Corneal Pain","DOI":"10.22541\/au.167285905.53186769\/v1"},{"issue":"3","key":"1784_CR104","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/cne.903030303","volume":"303","author":"Y Yasui","year":"1991","unstructured":"Yasui Y, Breder CD, Safer CB, Cechetto DF (1991) Autonomic responses and efferent pathways from the insular cortex in the rat. J Comp Neurol 303(3):355\u2013374","journal-title":"J Comp Neurol"},{"key":"1784_CR105","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fnhum.2018.00107","volume":"12","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Mao Z, Pan L, Ling Z, Liu X, Zhang J, Yu X (2018) Dysregulation of pain-and emotion-related networks in trigeminal neuralgia. Front Hum Neurosci 12:107","journal-title":"Front Hum Neurosci"},{"key":"1784_CR106","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s40122-021-00252-1","volume":"10","author":"K-L Zhang","year":"2021","unstructured":"Zhang K-L, Yuan H, Wu F-F, Pu X-Y, Liu B-Z, Li Z, Li K-F, Liu H, Yang Y, Wang Y-Y (2021) Analgesic effect of noninvasive brain stimulation for neuropathic pain patients: a systematic review. Pain Therapy 10:315\u2013332","journal-title":"Pain Therapy"},{"issue":"10","key":"1784_CR107","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1097\/j.pain.0000000000001312","volume":"159","author":"J Zhong","year":"2018","unstructured":"Zhong J, Chen DQ, Hung PS-P, Hayes DJ, Liang KE, Davis KD, Hodaie M (2018) Multivariate pattern classification of brain white matter connectivity predicts classic trigeminal neuralgia. Pain 159(10):2076\u20132087","journal-title":"Pain"}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-024-01784-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10194-024-01784-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-024-01784-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T10:01:53Z","timestamp":1715335313000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejournalofheadacheandpain.biomedcentral.com\/articles\/10.1186\/s10194-024-01784-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,10]]},"references-count":107,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1784"],"URL":"https:\/\/doi.org\/10.1186\/s10194-024-01784-5","relation":{},"ISSN":["1129-2377"],"issn-type":[{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,10]]},"assertion":[{"value":"12 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"76"}}