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Multiple evidence show importance of inflammatory processes in the dura mater for pain generation but contribution of the leptomeninges is less clear. We assessed effects of cortical spreading depolarization (CSD), the pathophysiological mechanism of migraine aura, on expression of inflammatory mediators in the leptomeninges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single CSD event was produced by a focal unilateral microdamage of the cortex in freely behaving rats. Three hours later intact cortical leptomeninges and parenchyma of ipsi-lesional (invaded by CSD) and sham-treated contra-lesional (unaffected by CSD) hemispheres were collected and mRNA levels of genes associated with inflammation (\n                      <jats:italic>Il1b<\/jats:italic>\n                      ,\n                      <jats:italic>Tnf<\/jats:italic>\n                      ,\n                      <jats:italic>Ccl2; Cx3cl1<\/jats:italic>\n                      ,\n                      <jats:italic>Zc3h12a<\/jats:italic>\n                      ) and endocannabinoid CB2 receptors (\n                      <jats:italic>Cnr2<\/jats:italic>\n                      ) were measured using qPCR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three hours after a single unilateral CSD, most inflammatory factors changed their expression levels in the leptomeninges, mainly on the side of CSD. The meninges overlying affected cortex increased mRNA expression of all proinflammatory cytokines (\n                      <jats:italic>Il1b<\/jats:italic>\n                      ,\n                      <jats:italic>Tnf<\/jats:italic>\n                      ,\n                      <jats:italic>Ccl2)<\/jats:italic>\n                      and anti-inflammatory factors\n                      <jats:italic>Zc3h12a<\/jats:italic>\n                      and\n                      <jats:italic>Cx3cl1<\/jats:italic>\n                      . Upregulation of proinflammatory cytokines was found in both meninges and parenchyma while anti-inflammatory markers increased only meningeal expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A single CSD is sufficient to produce pronounced leptomeningeal inflammation that lasts for at least three hours and involves mostly meninges overlying the cortex affected by CSD. The prolonged post-CSD inflammation of the leptomeninges can contribute to mechanisms of headache generation following aura phase of migraine attack.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s10194-024-01823-1","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T19:02:16Z","timestamp":1721070136000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inflammatory response of leptomeninges to a single cortical spreading depolarization"],"prefix":"10.1186","volume":"25","author":[{"given":"Anna A.","family":"Karan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin A.","family":"Gerasimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia S.","family":"Spivak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena M.","family":"Suleymanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila V.","family":"Vinogradova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"issue":"46","key":"1823_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1146\/annurev-neuro-080422-105509","volume":"10","author":"D Levy","year":"2023","unstructured":"Levy D, Moskowitz MA (2023) Meningeal mechanisms and the migraine connection. 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