{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:18:23Z","timestamp":1790057903468,"version":"4.0.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semmelweis University"},{"name":"Postdoctoral Fellowships for Research in Japan, standard program","award":["P20809"],"award-info":[{"award-number":["P20809"]}]},{"name":"New National Excellence Program","award":["\u00daNKP-23-4-II-SE-2"],"award-info":[{"award-number":["\u00daNKP-23-4-II-SE-2"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Recent meta-analyses estimated 14.6% and 11.2% SNP-based heritability of migraine, compared to twin-heritability estimates of 30\u201360%. This study aimed to investigate heritability estimates in \u201cmigraine-first\u201d individuals, patients for whom G43 (migraine with or without aura) was their first medical diagnosis in their lifetime.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Findings<\/jats:title>\n                <jats:p>Using data from the UK Biobank (<jats:italic>N<\/jats:italic>\u2009=\u2009199,929), genome-wide association studies (GWAS) were conducted on 6,139 migraine-first patients and 193,790 healthy controls. SNP-based heritability was estimated using SumHer, yielding 19.37% (\u00b1\u20090.019) for all SNPs and 21.31% (\u00b1\u20090.019) for HapMap3 variants, substantially surpassing previous estimates. Key risk loci included <jats:italic>PRDM16<\/jats:italic>, <jats:italic>FHL5<\/jats:italic>, <jats:italic>ASTN2<\/jats:italic>, <jats:italic>STAT6<\/jats:italic>\/<jats:italic>LRP1<\/jats:italic>, and <jats:italic>SLC24A3<\/jats:italic>, and pathway analyses highlighted retinol metabolism and steroid hormone biosynthesis as important pathways in these patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The findings underscore that excluding comorbidities at onset time can enhance heritability estimates and genetic signal detection, significantly reducing the extent of \u201cmissing heritability\u201d in migraine.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s10194-024-01870-8","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T15:02:43Z","timestamp":1727449363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Improved polygenic risk prediction in migraine-first patients"],"prefix":"10.1186","volume":"25","author":[{"given":"Dora","family":"Torok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Petschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Baksa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Juhasz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"1870_CR1","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/ng.3598","volume":"48","author":"P Gormley","year":"2016","unstructured":"Gormley P, Anttila V, Winsvold BS et al (2016) Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. 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