{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:51:26Z","timestamp":1793029886229,"version":"4.5.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Gazi University ADEP project grant","award":["TGA-2022-7857"],"award-info":[{"award-number":["TGA-2022-7857"]}],"id":[{"id":"https:\/\/ror.org\/054xkpr46","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"DOI":"10.1186\/s10194-024-01891-3","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T02:51:11Z","timestamp":1731034271000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Microbiota alterations are related to migraine food triggers and inflammatory markers in chronic migraine patients with medication overuse headache"],"prefix":"10.1186","volume":"25","author":[{"given":"Doga","family":"Vuralli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Ceren Akgor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hale Gok","family":"Dagidir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u0131nar","family":"Onat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Yalinay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur","family":"Sezerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrunnisa","family":"Bolay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"issue":"24","key":"1891_CR1","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1056\/NEJMra1600266","volume":"375","author":"SV Lynch","year":"2016","unstructured":"Lynch SV, Pedersen O (2016) The human intestinal microbiome in Health and Disease. N Engl J Med 375(24):2369\u20132379","journal-title":"N Engl J Med"},{"key":"1891_CR2","doi-asserted-by":"publisher","first-page":"100090","DOI":"10.1016\/j.ynpai.2022.100090","volume":"11","author":"J Crawford","year":"2022","unstructured":"Crawford J, Liu S, Tao F (2022) Gut microbiota and migraine. Neurobiol Pain 11:100090","journal-title":"Neurobiol Pain"},{"issue":"1","key":"1891_CR3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s10194-024-01730-5","volume":"25","author":"D Vuralli","year":"2024","unstructured":"Vuralli D, Ceren Akgor M, Gok Dagidir H, Gulbahar O, Yalinay M, Bolay H, Lipopolysaccharide VE-cadherin (2024) HMGB1, and HIF-1\u03b1 levels are elevated in the systemic circulation in chronic migraine patients with medication overuse headache: evidence of leaky gut and inflammation. J Headache Pain 25(1):23","journal-title":"J Headache Pain"},{"issue":"1","key":"1891_CR4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s10194-018-0875-x","volume":"19","author":"N Vandenbussche","year":"2018","unstructured":"Vandenbussche N, Laterza D, Lisicki M, Lloyd J, Lupi C, Tischler H et al (2018) Medication-overuse headache: a widely recognized entity amidst ongoing debate. J Headache Pain 19(1):50","journal-title":"J Headache Pain"},{"key":"1891_CR5","doi-asserted-by":"crossref","unstructured":"Ceren Akgor M, Vuralli D, Sucu DH, Gokce S, Tasdelen B, Gultekin F et al (2023) Distinct Food Triggers for Migraine, Medication Overuse Headache and irritable bowel syndrome. J Clin Med. ;12(20)","DOI":"10.3390\/jcm12206488"},{"issue":"7","key":"1891_CR6","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/apt.13746","volume":"44","author":"MR Blake","year":"2016","unstructured":"Blake MR, Raker JM, Whelan K (2016) Validity and reliability of the Bristol Stool Form Scale in healthy adults and patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 44(7):693\u2013703","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"1891_CR7","doi-asserted-by":"publisher","first-page":"151","DOI":"10.5056\/jnm16214","volume":"23","author":"MJ Schmulson","year":"2017","unstructured":"Schmulson MJ, Drossman DA (2017) What is New in Rome IV. J Neurogastroenterol Motil 23(2):151\u2013163","journal-title":"J Neurogastroenterol Motil"},{"issue":"1","key":"1891_CR8","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/s41467-019-14177-z","volume":"11","author":"A Vich Vila","year":"2020","unstructured":"Vich Vila A, Collij V, Sanna S, Sinha T, Imhann F, Bourgonje AR et al (2020) Impact of commonly used drugs on the composition and metabolic function of the gut microbiota. Nat Commun 11(1):362","journal-title":"Nat Commun"},{"issue":"12","key":"1891_CR9","doi-asserted-by":"publisher","first-page":"fj201800560R","DOI":"10.1096\/fj.201800560R","volume":"32","author":"S Edogawa","year":"2018","unstructured":"Edogawa S, Peters SA, Jenkins GD, Gurunathan SV, Sundt WJ, Johnson S et al (2018) Sex differences in NSAID-induced perturbation of human intestinal barrier function and microbiota. Faseb j 32(12):fj201800560R","journal-title":"Faseb j"},{"issue":"6","key":"1891_CR10","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1111\/apt.16013","volume":"52","author":"AE Prizment","year":"2020","unstructured":"Prizment AE, Staley C, Onyeaghala GC, Vivek S, Thyagarajan B, Straka RJ et al (2020) Randomised clinical study: oral aspirin 325\u00a0mg daily vs placebo alters the gut microbial composition and bacterial taxa associated with colorectal cancer risk. Aliment Pharmacol Ther 52(6):976\u2013987","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"1891_CR11","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.cmi.2015.10.003","volume":"22","author":"MAM Rogers","year":"2016","unstructured":"Rogers MAM, Aronoff DM (2016) The influence of non-steroidal anti-inflammatory drugs on the gut microbiome. Clin Microbiol Infect 22(2):178.e1-.e9.","journal-title":"Clin Microbiol Infect"},{"key":"1891_CR12","doi-asserted-by":"publisher","first-page":"114590","DOI":"10.1016\/j.bcp.2021.114590","volume":"190","author":"B L\u00e1z\u00e1r","year":"2021","unstructured":"L\u00e1z\u00e1r B, L\u00e1szl\u00f3 SB, Hutka B, T\u00f3th AS, Mohammadzadeh A, Berekm\u00e9ri E et al (2021) A comprehensive time course and correlation analysis of indomethacin-induced inflammation, bile acid alterations and dysbiosis in the rat small intestine. Biochem Pharmacol 190:114590","journal-title":"Biochem Pharmacol"},{"key":"1891_CR13","doi-asserted-by":"publisher","first-page":"e08973","DOI":"10.7554\/eLife.08973","volume":"4","author":"X Liang","year":"2015","unstructured":"Liang X, Bittinger K, Li X, Abernethy DR, Bushman FD, FitzGerald GA (2015) Bidirectional interactions between indomethacin and the murine intestinal microbiota. Elife 4:e08973","journal-title":"Elife"},{"key":"1891_CR14","doi-asserted-by":"crossref","unstructured":"Maseda D, Zackular JP, Trindade B, Kirk L, Roxas JL, Rogers LM et al (2019) Nonsteroidal anti-inflammatory drugs alter the Microbiota and exacerbate Clostridium difficile Colitis while dysregulating the inflammatory response. mBio. ;10(1)","DOI":"10.1128\/mBio.02282-18"},{"issue":"1","key":"1891_CR15","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s10194-024-01871-7","volume":"25","author":"L Papetti","year":"2024","unstructured":"Papetti L, Del Chierico F, Frattale I, Toto F, Scanu M, Mortera SL et al (2024) Pediatric migraine is characterized by traits of ecological and metabolic dysbiosis and inflammation. J Headache Pain 25(1):171","journal-title":"J Headache Pain"},{"issue":"35","key":"1891_CR16","doi-asserted-by":"publisher","first-page":"e2203707","DOI":"10.1002\/advs.202203707","volume":"9","author":"L Liu","year":"2022","unstructured":"Liu L, Wang H, Zhang H, Chen X, Zhang Y, Wu J et al (2022) Toward a deeper understanding of gut microbiome in Depression: the Promise of Clinical Applicability. Adv Sci (Weinh) 9(35):e2203707","journal-title":"Adv Sci (Weinh)"},{"key":"1891_CR17","doi-asserted-by":"crossref","unstructured":"Maes M, Vasupanrajit A, Jirakran K, Klomkliew P, Chanchaem P, Tunvirachaisakul C et al (2022) Exploration of the gut microbiome in Thai patients with major depressive disorder uncovered a specific bacterial profile with depletion of the <\u2009em\u2009>\u2009Ruminococcus genus as a putative biomarker. medRxiv. :2022.11.06.22282014","DOI":"10.1101\/2022.11.06.22282014"},{"issue":"1","key":"1891_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12967-023-03953-7","volume":"21","author":"H Chen","year":"2023","unstructured":"Chen H, Ou R, Tang N, Su W, Yang R, Yu X et al (2023) Alternation of the gut microbiota in irritable bowel syndrome: an integrated analysis based on multicenter amplicon sequencing data. J Translational Med 21(1):117","journal-title":"J Translational Med"},{"issue":"3","key":"1891_CR19","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s12275-018-8024-4","volume":"56","author":"AJ La Reau","year":"2018","unstructured":"La Reau AJ, Suen G (2018) The Ruminococci: key symbionts of the gut ecosystem. J Microbiol 56(3):199\u2013208","journal-title":"J Microbiol"},{"key":"1891_CR20","doi-asserted-by":"publisher","first-page":"1010853","DOI":"10.3389\/fcimb.2022.1010853","volume":"12","author":"MMH Abdelbary","year":"2022","unstructured":"Abdelbary MMH, Hatting M, Bott A, Dahlhausen A, Keller D, Trautwein C et al (2022) The oral-gut axis: salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease. Front Cell Infect Microbiol 12:1010853","journal-title":"Front Cell Infect Microbiol"},{"key":"1891_CR21","doi-asserted-by":"crossref","unstructured":"Park S, Li C, Wu X, Zhang T (2023) Gut microbiota alterations and their functional differences in Depression according to Enterotypes in Asian individuals. Int J Mol Sci. ;24(17)","DOI":"10.3390\/ijms241713329"},{"key":"1891_CR22","doi-asserted-by":"crossref","unstructured":"Ben\u00edtez-P\u00e1ez A, Del G\u00f3mez EM, L\u00f3pez-Almela I, Moya-P\u00e9rez \u00c1, Codo\u00f1er-Franch P, Sanz Y (2020) Depletion of Blautia Species in the microbiota of obese children relates to intestinal inflammation and metabolic phenotype worsening. mSystems. ;5(2)","DOI":"10.1128\/mSystems.00857-19"},{"issue":"6","key":"1891_CR23","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.3390\/nu13062032","volume":"13","author":"J Companys","year":"2021","unstructured":"Companys J, Gosalbes MJ, Pla-Pag\u00e0 L, Calder\u00f3n-P\u00e9rez L, Llaurad\u00f3 E, Pedret A et al (2021) Gut microbiota Profile and its association with clinical variables and dietary intake in Overweight\/Obese and lean subjects: a cross-sectional study. Nutrients 13(6):2032","journal-title":"Nutrients"},{"key":"1891_CR24","doi-asserted-by":"crossref","unstructured":"Prud\u00eancio APA, Fonseca DC, Machado NM, Alves JTM, Sala P, Fernandes GR et al (2023) Red Meat Intake, Indole-3-Acetate, and Dorea longicatena together affect insulin resistance after gastric bypass. Nutrients. ;15(5)","DOI":"10.3390\/nu15051185"},{"issue":"10","key":"1891_CR25","doi-asserted-by":"publisher","first-page":"e76341","DOI":"10.1371\/journal.pone.0076341","volume":"8","author":"EH Crost","year":"2013","unstructured":"Crost EH, Tailford LE, Le Gall G, Fons M, Henrissat B, Juge N (2013) Utilisation of Mucin glycans by the human gut Symbiont Ruminococcus gnavus is strain-dependent. PLoS ONE 8(10):e76341","journal-title":"PLoS ONE"},{"issue":"1","key":"1891_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1849998","volume":"12","author":"M Van Hul","year":"2020","unstructured":"Van Hul M, Le Roy T, Prifti E, Dao MC, Paquot A, Zucker JD et al (2020) From correlation to causality: the case of Subdoligranulum. Gut Microbes 12(1):1\u201313","journal-title":"Gut Microbes"},{"key":"1891_CR27","doi-asserted-by":"crossref","unstructured":"Singh SB, Carroll-Portillo A, Lin HC (2023) Desulfovibrio Gut: Enemy within? Microorganisms. ;11(7)","DOI":"10.3390\/microorganisms11071772"},{"issue":"4","key":"1891_CR28","first-page":"991","volume":"8","author":"L Weglarz","year":"2003","unstructured":"Weglarz L, Dzierzewicz Z, Skop B, Orchel A, Parfiniewicz B, Wi\u015bniowska B et al (2003) Desulfovibrio desulfuricans lipopolysaccharides induce endothelial cell IL-6 and IL-8 secretion and E-selectin and VCAM-1 expression. Cell Mol Biol Lett 8(4):991\u20131003","journal-title":"Cell Mol Biol Lett"},{"issue":"6","key":"1891_CR29","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s12223-010-0106-6","volume":"55","author":"M Kapral","year":"2010","unstructured":"Kapral M, W\u0119glarz L, Parfiniewicz B, Lodowska J, Jaworska-Kik M (2010) Quantitative evaluation of transcriptional activation of NF-\u03baB p65 and p50 subunits and I\u03baB\u03b1 encoding genes in colon cancer cells by Desulfovibrio desulfuricans endotoxin. Folia Microbiol (Praha) 55(6):657\u2013661","journal-title":"Folia Microbiol (Praha)"},{"issue":"7","key":"1891_CR30","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.archoralbio.2010.05.001","volume":"55","author":"Z Dzier\u017cewicz","year":"2010","unstructured":"Dzier\u017cewicz Z, Szczerba J, Lodowska J, Wolny D, Gruchlik A, Orchel A et al (2010) The role of Desulfovibrio desulfuricans lipopolysaccharides in modulation of periodontal inflammation through stimulation of human gingival fibroblasts. Arch Oral Biol 55(7):515\u2013522","journal-title":"Arch Oral Biol"},{"key":"1891_CR31","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/cells12010089","volume":"12","author":"Y Nie","year":"2022","unstructured":"Nie Y, Xie X-Q, Zhou L, Guan Q, Ren Y, Mao Y et al (2022) Desulfovibrio fairfieldensis-derived outer membrane vesicles damage epithelial barrier and induce inflammation and Pyroptosis in macrophages. Cells 12:89","journal-title":"Cells"},{"key":"1891_CR32","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.physbeh.2016.01.023","volume":"157","author":"NL Ritz","year":"2016","unstructured":"Ritz NL, Burnett BJ, Setty P, Reinhart KM, Wilson MR, Alcock J et al (2016) Sulfate-reducing bacteria impairs working memory in mice. Physiol Behav 157:281\u2013287","journal-title":"Physiol Behav"},{"issue":"9","key":"1891_CR33","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/j.cgh.2019.09.022","volume":"18","author":"F Humbel","year":"2020","unstructured":"Humbel F, Rieder JH, Franc Y, Juillerat P, Scharl M, Misselwitz B et al (2020) Association of alterations in intestinal microbiota with impaired psychological function in patients with inflammatory bowel diseases in Remission. Clin Gastroenterol Hepatol 18(9):2019\u201329e11","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"1891_CR34","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s10194-023-01708-9","volume":"25","author":"J Liu","year":"2024","unstructured":"Liu J, Xi K, Zhang L, Han M, Wang Q, Liu X (2024) Tryptophan metabolites and gut microbiota play an important role in pediatric migraine diagnosis. J Headache Pain 25(1):2","journal-title":"J Headache Pain"},{"issue":"1","key":"1891_CR35","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/art.39802","volume":"69","author":"RY Tito","year":"2017","unstructured":"Tito RY, Cypers H, Joossens M, Varkas G, Van Praet L, Glorieus E et al (2017) Brief report: Dialister as a microbial marker of Disease Activity in Spondyloarthritis. Arthritis Rheumatol 69(1):114\u2013121","journal-title":"Arthritis Rheumatol"},{"key":"1891_CR36","doi-asserted-by":"crossref","unstructured":"G\u00f3rska-Warsewicz H, Laskowski W, Kulykovets O, Kudli\u0144ska-Chylak A, Czeczotko M, Rejman K (2018) Food Products as sources of protein and amino acids-the case of Poland. Nutrients. ;10(12)","DOI":"10.3390\/nu10121977"},{"key":"1891_CR37","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1601-5215.2010.00508.x","volume":"23","author":"N Soh","year":"2011","unstructured":"Soh N, Walter G (2011) Tryptophan and depression: can diet alone be the answer? Acta Neuropsychiatrica 23:3\u201311","journal-title":"Acta Neuropsychiatrica"},{"key":"1891_CR38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fcimb.2018.00013","volume":"8","author":"J Gao","year":"2018","unstructured":"Gao J, Xu K, Liu H, Liu G, Bai M, Peng C et al (2018) Impact of the gut microbiota on intestinal immunity mediated by Tryptophan Metabolism. Front Cell Infect Microbiol 8:13","journal-title":"Front Cell Infect Microbiol"},{"key":"1891_CR39","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.nicl.2018.01.016","volume":"18","author":"M Deen","year":"2018","unstructured":"Deen M, Hansen HD, Hougaard A, N\u00f8rgaard M, Eiberg H, Lehel S et al (2018) High brain serotonin levels in migraine between attacks: a 5-HT4 receptor binding PET study. NeuroImage: Clin 18:97\u2013102","journal-title":"NeuroImage: Clin"},{"issue":"3","key":"1891_CR40","doi-asserted-by":"publisher","first-page":"817","DOI":"10.3390\/ani11030817","volume":"11","author":"Z Rao","year":"2021","unstructured":"Rao Z, Li J, Shi B, Zeng Y, Liu Y, Sun Z et al (2021) Dietary tryptophan levels Impact Growth Performance and Intestinal Microbial Ecology in Weaned piglets via Tryptophan metabolites and intestinal antimicrobial peptides. Animals 11(3):817","journal-title":"Animals"},{"key":"1891_CR41","doi-asserted-by":"crossref","unstructured":"Kohnert E, Kreutz C, Binder N, Hannibal L, Gorkiewicz G, M\u00fcller A et al (2021) Changes in gut microbiota after a four-week intervention with Vegan vs. Meat-Rich diets in healthy participants: a Randomized Controlled Trial. Microorganisms. ;9(4)","DOI":"10.3390\/microorganisms9040727"},{"issue":"2","key":"1891_CR42","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/ismej.2012.104","volume":"7","author":"I Mart\u00ednez","year":"2013","unstructured":"Mart\u00ednez I, Lattimer JM, Hubach KL, Case JA, Yang J, Weber CG et al (2013) Gut microbiome composition is linked to whole grain-induced immunological improvements. Isme j 7(2):269\u2013280","journal-title":"Isme j"},{"issue":"9","key":"1891_CR43","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1038\/s41430-019-0420-2","volume":"73","author":"M Silva","year":"2019","unstructured":"Silva M, Gama J, Pinto N, Pivi G, Brancal H, Carvalho L et al (2019) Sulfite concentration and the occurrence of headache in young adults: a prospective study. Eur J Clin Nutr 73(9):1316\u20131322","journal-title":"Eur J Clin Nutr"},{"issue":"6","key":"1891_CR44","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/0091-6749(86)90261-7","volume":"78","author":"R Dahl","year":"1986","unstructured":"Dahl R, Henriksen JM, Harving H (1986) Red wine asthma: a controlled challenge study. J Allergy Clin Immunol 78(6):1126\u20131129","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"1891_CR45","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1096\/fj.14-259598","volume":"29","author":"CS Reigstad","year":"2015","unstructured":"Reigstad CS, Salmonson CE, Rainey JF III, Szurszewski JH, Linden DR, Sonnenburg JL et al (2015) Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J 29(4):1395","journal-title":"FASEB J"},{"key":"1891_CR46","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/nu13082710","volume":"13","author":"A Cuevas-Sierra","year":"2021","unstructured":"Cuevas-Sierra A, Milagro FI, Aranaz P, Mart\u00ednez JA, Riezu-Boj JI (2021) Gut microbiota differences according to Ultra-processed Food Consumption in a Spanish Population. Nutrients 13:8","journal-title":"Nutrients"},{"issue":"10","key":"1891_CR47","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.biombioe.2010.04.011","volume":"34","author":"J Ruane","year":"2010","unstructured":"Ruane J, Sonnino A, Agostini A (2010) Bioenergy and the potential contribution of agricultural biotechnologies in developing countries. Biomass Bioenergy 34(10):1427\u20131439","journal-title":"Biomass Bioenergy"},{"issue":"2","key":"1891_CR48","doi-asserted-by":"publisher","first-page":"e0007313","DOI":"10.1128\/genomeA.00073-13","volume":"1","author":"A Poehlein","year":"2013","unstructured":"Poehlein A, Zverlov VV, Daniel R, Schwarz WH, Liebl W (2013) Complete genome sequence of Clostridium stercorarium subsp. stercorarium strain DSM 8532, a thermophilic degrader of Plant Cell Wall fibers. Genome Announc 1(2):e0007313","journal-title":"Genome Announc"},{"issue":"2","key":"1891_CR49","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","volume":"19","author":"F Di Vincenzo","year":"2024","unstructured":"Di Vincenzo F, Del Gaudio A, Petito V, Lopetuso LR, Scaldaferri F (2024) Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review. Intern Emerg Med 19(2):275\u2013293","journal-title":"Intern Emerg Med"},{"issue":"Pt 2","key":"1891_CR50","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1099\/00207713-52-2-423","volume":"52","author":"D Taras","year":"2002","unstructured":"Taras D, Simmering R, Collins MD, Lawson PA, Blaut M (2002) Reclassification of Eubacterium formicigenerans Holdeman and Moore 1974 as Dorea formicigenerans gen. nov., comb. nov., and description of Dorea longicatena sp. nov., isolated from human faeces. Int J Syst Evol Microbiol 52(Pt 2):423\u2013428","journal-title":"Int J Syst Evol Microbiol"},{"issue":"9","key":"1891_CR51","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.3390\/microorganisms9091881","volume":"9","author":"C Juste","year":"2021","unstructured":"Juste C, G\u00e9rard P (2021) Cholesterol-to-Coprostanol Conversion by the gut microbiota: what we know, suspect, and ignore. Microorganisms 9(9):1881","journal-title":"Microorganisms"},{"key":"1891_CR52","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1099\/00207713-44-1-137","volume":"44","author":"TA Freier","year":"1994","unstructured":"Freier TA, Beitz D, Li L, Hartman PA (1994) Characterization of Eubacterium coprostanoligenes sp. nov., a cholesterol-reducing anaerobe. Int J Syst Bacteriol 44:137\u2013142","journal-title":"Int J Syst Bacteriol"},{"key":"1891_CR53","doi-asserted-by":"crossref","unstructured":"Connors J, Dawe N, Van Limbergen J (2018) The role of Succinate in the regulation of intestinal inflammation. Nutrients. ;11(1)","DOI":"10.3390\/nu11010025"},{"issue":"3","key":"1891_CR54","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.3390\/neurolint15030073","volume":"15","author":"E Spekker","year":"2023","unstructured":"Spekker E, Nagy-Gr\u00f3cz G (2023) All roads lead to the gut: the importance of the Microbiota and Diet in Migraine. Neurol Int 15(3):1174\u20131190","journal-title":"Neurol Int"},{"issue":"8","key":"1891_CR55","doi-asserted-by":"publisher","first-page":"5285","DOI":"10.1002\/fsn3.4198","volume":"12","author":"H Ahangari","year":"2024","unstructured":"Ahangari H, Bahramian B, Khezerlou A, Tavassoli M, Kiani-Salmi N, Tarhriz V et al (2024) Association between Monosodium glutamate consumption with changes in gut microbiota and related metabolic dysbiosis\u2014A systematic review. Food Sci Nutr 12(8):5285\u20135295","journal-title":"Food Sci Nutr"},{"issue":"2","key":"1891_CR56","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1001\/archneurpsyc.1940.02280080076003","volume":"44","author":"VON STORCH TJC. RELATION OF EXPERIMENTAL HISTAMINE HEADACHE TO MIGRAINE AND NONMIGRAINE HEADACHE","year":"1940","unstructured":"VON STORCH TJC. RELATION OF EXPERIMENTAL HISTAMINE HEADACHE TO MIGRAINE AND NONMIGRAINE HEADACHE (1940) Archives Neurol Psychiatry 44(2):316\u2013322","journal-title":"Archives Neurol Psychiatry"},{"issue":"11","key":"1891_CR57","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1097\/00001756-199507310-00003","volume":"6","author":"LH Lassen","year":"1995","unstructured":"Lassen LH, Thomsen LL, Olesen J (1995) Histamine induces migraine via the H1-receptor. Support for the NO hypothesis of migraine. NeuroReport 6(11):1475\u20131479","journal-title":"NeuroReport"},{"key":"1891_CR58","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.foodchem.2016.09.046","volume":"218","author":"B Del Rio","year":"2017","unstructured":"Del Rio B, Redruello B, Linares DM, Ladero V, Fernandez M, Martin MC et al (2017) The dietary biogenic amines tyramine and histamine show synergistic toxicity towards intestinal cells in culture. Food Chem 218:249\u2013255","journal-title":"Food Chem"},{"issue":"5291","key":"1891_CR59","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/230246a0","volume":"230","author":"I Smith","year":"1971","unstructured":"Smith I, Kellow AH, Mullen PE, Hanington E (1971) Dietary migraine and tyramine metabolism. Nature 230(5291):246\u2013248","journal-title":"Nature"},{"issue":"1","key":"1891_CR60","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.1526-4610.1982.hed2201030.x","volume":"22","author":"RJ Kohlenberg","year":"1982","unstructured":"Kohlenberg RJ (1982) Tyramine sensitivity in dietary migraine: a critical review. Headache 22(1):30\u201334","journal-title":"Headache"},{"issue":"1","key":"1891_CR61","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s10194-020-1078-9","volume":"21","author":"M Arzani","year":"2020","unstructured":"Arzani M, Jahromi SR, Ghorbani Z, Vahabizad F, Martelletti P, Ghaemi A et al (2020) Gut-brain Axis and migraine headache: a comprehensive review. J Headache Pain 21(1):15","journal-title":"J Headache Pain"},{"issue":"11","key":"1891_CR62","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1007\/s11064-016-2039-1","volume":"41","author":"R Maqsood","year":"2016","unstructured":"Maqsood R, Stone TW (2016) The gut-brain Axis, BDNF, NMDA and CNS disorders. Neurochem Res 41(11):2819\u20132835","journal-title":"Neurochem Res"},{"issue":"6","key":"1891_CR63","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/mp.2012.77","volume":"18","author":"G Clarke","year":"2013","unstructured":"Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F et al (2013) The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry 18(6):666\u2013673","journal-title":"Mol Psychiatry"},{"issue":"2","key":"1891_CR64","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","volume":"161","author":"M Yano Jessica","year":"2015","unstructured":"Yano Jessica M, Yu K, Donaldson Gregory P, Shastri Gauri G, Ann P, Ma L et al (2015) Indigenous Bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell 161(2):264\u2013276","journal-title":"Cell"},{"key":"1891_CR65","doi-asserted-by":"crossref","unstructured":"Luki\u0107 I, Getselter D, Koren O, Elliott E (2019) Role of Tryptophan in Microbiota-Induced Depressive-Like Behavior: evidence from Tryptophan Depletion Study. Front Behav Neurosci. ;13","DOI":"10.3389\/fnbeh.2019.00123"},{"issue":"1","key":"1891_CR66","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4161\/gmic.22973","volume":"4","author":"DM Saulnier","year":"2013","unstructured":"Saulnier DM, Ringel Y, Heyman MB, Foster JA, Bercik P, Shulman RJ et al (2013) The intestinal microbiome, probiotics and prebiotics in neurogastroenterology. Gut Microbes 4(1):17\u201327","journal-title":"Gut Microbes"},{"key":"1891_CR67","doi-asserted-by":"crossref","unstructured":"Tanaka M, T\u00f3th F, Poly\u00e1k H, Szab\u00f3 \u00c1, M\u00e1ndi Y, V\u00e9csei L (2021) Immune influencers in Action: metabolites and enzymes of the Tryptophan-Kynurenine metabolic pathway. Biomedicines. ;9(7)","DOI":"10.3390\/biomedicines9070734"},{"issue":"7402","key":"1891_CR68","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature11053","volume":"486","author":"T Yatsunenko","year":"2012","unstructured":"Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M et al (2012) Human gut microbiome viewed across age and geography. Nature 486(7402):222\u2013227","journal-title":"Nature"},{"key":"1891_CR69","doi-asserted-by":"crossref","unstructured":"Yang J, Wu Je, Li Y, Zhang Ye, Cho WC, Ju X et al (2021) Gut bacteria formation and influencing factors. FEMS Microbiol Ecol. ;97(4)","DOI":"10.1093\/femsec\/fiab043"},{"issue":"1","key":"1891_CR70","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s10194-023-01672-4","volume":"24","author":"HG Da\u011f\u0131d\u0131r","year":"2023","unstructured":"Da\u011f\u0131d\u0131r HG, Topa E, Vuralli D, Bolay H (2023) Medication overuse headache is associated with elevated lipopolysaccharide binding protein and pro-inflammatory molecules in the bloodstream. J Headache Pain 24(1):150","journal-title":"J Headache Pain"},{"issue":"1","key":"1891_CR71","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s10194-021-01306-7","volume":"22","author":"H Bolay","year":"2021","unstructured":"Bolay H, Karadas \u00d6, Ozt\u00fcrk B, Sonkaya R, Tasdelen B, Bulut TDS et al (2021) HMGB1, NLRP3, IL-6 and ACE2 levels are elevated in COVID-19 with headache: a window to the infection-related headache mechanism. J Headache Pain 22(1):94","journal-title":"J Headache Pain"},{"key":"1891_CR72","doi-asserted-by":"crossref","unstructured":"Vuralli D, Da\u011fidir HG, Topa EA, Belen HB. (2023) Leaky gut and inflammatory biomarkers in a medication overuse headache model in male rats. Turk J Med Sci 54(1):33\u201341.","DOI":"10.55730\/1300-0144.5763"},{"key":"1891_CR73","doi-asserted-by":"crossref","unstructured":"Yang H, Wang H, Andersson U (2020) Targeting inflammation driven by HMGB1. Front Immunol 11:484","DOI":"10.3389\/fimmu.2020.00484"},{"issue":"5","key":"1891_CR74","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41590-019-0368-3","volume":"20","author":"VAK Rathinam","year":"2019","unstructured":"Rathinam VAK, Zhao Y, Shao F (2019) Innate immunity to intracellular LPS. Nat Immunol 20(5):527\u2013533","journal-title":"Nat Immunol"},{"key":"1891_CR75","doi-asserted-by":"publisher","first-page":"105840","DOI":"10.1016\/j.phrs.2021.105840","volume":"172","author":"K Soca\u0142a","year":"2021","unstructured":"Soca\u0142a K, Doboszewska U, Szopa A, Serefko A, W\u0142odarczyk M, Zieli\u0144ska A et al (2021) The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders. Pharmacol Res 172:105840","journal-title":"Pharmacol Res"},{"issue":"14","key":"1891_CR76","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1177\/03331024221118924","volume":"42","author":"J Thuraiaiyah","year":"2022","unstructured":"Thuraiaiyah J, Erritz\u00f8e-Jervild M, Al-Khazali HM, Schytz HW, Younis S (2022) The role of cytokines in migraine: a systematic review. Cephalalgia 42(14):1565\u20131588","journal-title":"Cephalalgia"},{"issue":"9","key":"1891_CR77","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.5455\/annalsmedres.2023.08.226","volume":"30","author":"D Vuralli","year":"2023","unstructured":"Vuralli D, Bolay H (2023) Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. Annals Med Res 30(9):1149\u20131152","journal-title":"Annals Med Res"},{"issue":"10","key":"1891_CR78","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1111\/j.1526-4610.1993.hed3310524.x","volume":"33","author":"P Martelletti","year":"1993","unstructured":"Martelletti P, Stirparo G, Rinaldi C, Frati L, Giacovazzo M (1993) Disruption of the Immunopeptidergic Network in Dietary Migraine. Headache: J Head Face Pain 33(10):524\u2013527","journal-title":"Headache: J Head Face Pain"},{"issue":"1","key":"1891_CR79","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/s41598-023-27586-4","volume":"13","author":"D Yong","year":"2023","unstructured":"Yong D, Lee H, Min HG, Kim K, Oh HS, Chu MK (2023) Altered gut microbiota in individuals with episodic and chronic migraine. Sci Rep 13(1):626","journal-title":"Sci Rep"},{"issue":"14","key":"1891_CR80","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.3390\/nu16142222","volume":"16","author":"P Gazerani","year":"2024","unstructured":"Gazerani P, Papetti L, Dalkara T, Cook CL, Webster C, Bai J (2024) The brain, the eating plate, and the gut microbiome: partners in Migraine Pathogenesis. Nutrients 16(14):2222","journal-title":"Nutrients"},{"key":"1891_CR81","doi-asserted-by":"crossref","unstructured":"Yoo JY, Groer M, Dutra SVO, Sarkar A, McSkimming DI (2020) Gut microbiota and Immune System interactions. Microorganisms. ;8(10)","DOI":"10.3390\/microorganisms8101587"},{"issue":"8","key":"1891_CR82","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1007\/s10620-012-2167-7","volume":"57","author":"L Wang","year":"2012","unstructured":"Wang L, Christophersen CT, Sorich MJ, Gerber JP, Angley MT, Conlon MA (2012) Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder. Dig Dis Sci 57(8):2096\u20132102","journal-title":"Dig Dis Sci"},{"key":"1891_CR83","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3389\/fnbeh.2017.00009","volume":"11","author":"EE Noble","year":"2017","unstructured":"Noble EE, Hsu TM, Kanoski SE (2017) Gut to Brain Dysbiosis: mechanisms linking western Diet Consumption, the Microbiome, and cognitive impairment. Front Behav Neurosci 11:9","journal-title":"Front Behav Neurosci"},{"issue":"10","key":"1891_CR84","doi-asserted-by":"publisher","first-page":"858","DOI":"10.3390\/nu3100858","volume":"3","author":"MAR Vinolo","year":"2011","unstructured":"Vinolo MAR, Rodrigues HG, Nachbar RT, Curi R (2011) Regulation of inflammation by short chain fatty acids. Nutrients 3(10):858\u2013876","journal-title":"Nutrients"},{"key":"1891_CR85","doi-asserted-by":"publisher","first-page":"108273","DOI":"10.1016\/j.pharmthera.2022.108273","volume":"239","author":"T Ikeda","year":"2022","unstructured":"Ikeda T, Nishida A, Yamano M, Kimura I (2022) Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases. Pharmacol Ther 239:108273","journal-title":"Pharmacol Ther"},{"issue":"1","key":"1891_CR86","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s12035-019-01721-7","volume":"57","author":"Y Tang","year":"2020","unstructured":"Tang Y, Liu S, Shu H, Yanagisawa L, Tao F (2020) Gut microbiota dysbiosis enhances Migraine-Like Pain Via TNF\u03b1 Upregulation. Mol Neurobiol 57(1):461\u2013468","journal-title":"Mol Neurobiol"},{"issue":"7","key":"1891_CR87","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.3390\/nu13072307","volume":"13","author":"C Di Lorenzo","year":"2021","unstructured":"Di Lorenzo C, Ballerini G, Barbanti P, Bernardini A, D\u2019Arrigo G, Egeo G et al (2021) Applications of ketogenic diets in patients with headache: clinical recommendations. Nutrients 13(7):2307","journal-title":"Nutrients"},{"issue":"3","key":"1891_CR88","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00281-018-0676-y","volume":"40","author":"R Ramachandran","year":"2018","unstructured":"Ramachandran R (2018) Neurogenic inflammation and its role in migraine. Semin Immunopathol 40(3):301\u2013314","journal-title":"Semin Immunopathol"},{"key":"1891_CR89","doi-asserted-by":"publisher","first-page":"106422","DOI":"10.1016\/j.jff.2024.106422","volume":"121","author":"M Vajdi","year":"2024","unstructured":"Vajdi M, Khorvash F, Askari G (2024) The effects of inulin supplementation on clinical indices, oxidative stress and inflammatory biomarkers in women with migraine: a double-blind, placebo-controlled, randomized trial. J Funct Foods 121:106422","journal-title":"J Funct Foods"},{"issue":"1","key":"1891_CR90","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s10194-019-1057-1","volume":"20","author":"S Razeghi Jahromi","year":"2019","unstructured":"Razeghi Jahromi S, Ghorbani Z, Martelletti P, Lampl C, Togha M (2019) On behalf of the School of Advanced Studies of the European Headache F. Association of diet and headache. J Headache Pain 20(1):106","journal-title":"J Headache Pain"},{"issue":"1","key":"1891_CR91","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3945\/jn.109.114249","volume":"140","author":"TJ Hartman","year":"2010","unstructured":"Hartman TJ, Albert PS, Zhang Z, Bagshaw D, Kris-Etherton PM, Ulbrecht J et al (2010) Consumption of a legume-enriched, low-glycemic index diet is associated with biomarkers of insulin resistance and inflammation among men at risk for colorectal cancer. J Nutr 140(1):60\u201367","journal-title":"J Nutr"},{"issue":"8","key":"1891_CR92","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.jpain.2015.04.007","volume":"16","author":"CE Ramsden","year":"2015","unstructured":"Ramsden CE, Zamora D, Makriyannis A, Wood JT, Mann JD, Faurot KR et al (2015) Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress. J Pain 16(8):707\u2013716","journal-title":"J Pain"},{"issue":"6","key":"1891_CR93","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00251-017-0992-8","volume":"69","author":"M Abdolahi","year":"2017","unstructured":"Abdolahi M, Tafakhori A, Togha M, Okhovat AA, Siassi F, Eshraghian MR et al (2017) The synergistic effects of \u03c9-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-\u03b1 gene expression and serum level in migraine patients. Immunogenetics 69(6):371\u2013378","journal-title":"Immunogenetics"},{"issue":"3","key":"1891_CR94","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/j.1526-4610.2012.02296.x","volume":"53","author":"EI Aydinlar","year":"2013","unstructured":"Aydinlar EI, Dikmen PY, Tiftikci A, Saruc M, Aksu M, Gunsoy HG et al (2013) IgG-based elimination diet in migraine plus irritable bowel syndrome. Headache 53(3):514\u2013525","journal-title":"Headache"},{"key":"1891_CR95","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1475-2891-10-85","volume":"10","author":"N Mitchell","year":"2011","unstructured":"Mitchell N, Hewitt CE, Jayakody S, Islam M, Adamson J, Watt I et al (2011) Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches. Nutr J 10:85","journal-title":"Nutr J"},{"issue":"12","key":"1891_CR96","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1111\/j.1365-2222.1993.tb00287.x","volume":"23","author":"F Wantke","year":"1993","unstructured":"Wantke F, G\u00f6tz M, Jarisch R (1993) Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches. Clin Exp Allergy 23(12):982\u2013985","journal-title":"Clin Exp Allergy"}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-024-01891-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10194-024-01891-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-024-01891-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T04:03:06Z","timestamp":1731038586000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejournalofheadacheandpain.biomedcentral.com\/articles\/10.1186\/s10194-024-01891-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":96,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1891"],"URL":"https:\/\/doi.org\/10.1186\/s10194-024-01891-3","relation":{},"ISSN":["1129-2377"],"issn-type":[{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"assertion":[{"value":"16 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Clinical Research Ethics Committee of Gazi University Faculty of Medicine. Written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"HB is an Associate Editor of the Journal of Headache and Pain. The rest of the authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"192"}}