{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:25:59Z","timestamp":1788193559095,"version":"build-2803163510"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"DOI":"10.1186\/s10194-024-01929-6","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T06:53:17Z","timestamp":1736491997000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status?"],"prefix":"10.1186","volume":"26","author":[{"given":"Tissa","family":"Wijeratne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanith","family":"Wijeratne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Martelletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasso","family":"Apostolopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Sales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Riddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila G.","family":"Crewther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"1929_CR1","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/s1474-4422(19)30281-9","volume":"18","author":"T Wijeratne","year":"2019","unstructured":"Wijeratne T, Grisold W, Dodick D, Carroll W, World Brain (2019) Day 2019: migraine, the painful truth. Lancet Neurol 18:914. https:\/\/doi.org\/10.1016\/s1474-4422(19)30281-9","journal-title":"Lancet Neurol"},{"key":"1929_CR2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1159\/000494758","volume":"52","author":"T Wijeratne","year":"2019","unstructured":"Wijeratne T, Tang HM, Crewther D, Crewther S (2019) Prevalence of Migraine in the Elderly: a narrated review. Neuroepidemiology 52:104\u2013110. https:\/\/doi.org\/10.1159\/000494758","journal-title":"Neuroepidemiology"},{"key":"1929_CR3","doi-asserted-by":"publisher","first-page":"100473","DOI":"10.1016\/j.ensci.2023.100473","volume":"32","author":"T Wijeratne","year":"2023","unstructured":"Wijeratne T, Wijeratne C, Korajkic N, Bird S, Sales C, Riederer F (2023) Secondary headaches - red and green flags and their significance for diagnostics. eNeurologicalSci 32:100473. https:\/\/doi.org\/10.1016\/j.ensci.2023.100473","journal-title":"eNeurologicalSci"},{"key":"1929_CR4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s10194-020-01208-0","volume":"21","author":"TJ Steiner","year":"2020","unstructured":"Steiner TJ, Stovner LJ, Jensen R, Uluduz D, Katsarava Z (2020) On behalf of lifting the Burden: the global campaign against, H. Migraine remains second among the world\u2019s causes of disability, and first among young women: findings from GBD2019. J Headache Pain 21:137. https:\/\/doi.org\/10.1186\/s10194-020-01208-0","journal-title":"J Headache Pain"},{"key":"1929_CR5","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1212\/wnl.53.3.537","volume":"53","author":"LJ Launer","year":"1999","unstructured":"Launer LJ, Terwindt GM, Ferrari MD (1999) The prevalence and characteristics of migraine in a population-based cohort: the GEM study. Neurology 53:537\u2013542. https:\/\/doi.org\/10.1212\/wnl.53.3.537","journal-title":"Neurology"},{"key":"1929_CR6","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/S0140-6736(97)11370-8","volume":"351","author":"MD Ferrari","year":"1998","unstructured":"Ferrari MD, Migraine (1998) Lancet 351:1043\u20131051. https:\/\/doi.org\/10.1016\/S0140-6736(97)11370-8","journal-title":"Lancet"},{"key":"1929_CR7","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/s41582-019-0216-y","volume":"15","author":"L Edvinsson","year":"2019","unstructured":"Edvinsson L, Haanes KA, Warfvinge K (2019) Does inflammation have a role in migraine? Nat Rev Neurol 15:483\u2013490. https:\/\/doi.org\/10.1038\/s41582-019-0216-y","journal-title":"Nat Rev Neurol"},{"key":"1929_CR8","doi-asserted-by":"publisher","first-page":"1219574","DOI":"10.3389\/fnmol.2023.1219574","volume":"16","author":"S Zhang","year":"2023","unstructured":"Zhang S, Azubuine J, Schmeer C (2023) A systematic literature review on the role of glial cells in the pathomechanisms of migraine. Front Mol Neurosci 16:1219574. https:\/\/doi.org\/10.3389\/fnmol.2023.1219574","journal-title":"Front Mol Neurosci"},{"issue":"3","key":"1929_CR9","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1080\/00207454.2021.1909011","volume":"133","author":"M Al-Hayani","year":"2023","unstructured":"Al-Hayani M, AboTaleb H, Bazi A, Alghamdi B (2023) Depression, anxiety and stress in Saudi migraine patients using DASS-21: local population-based cross-sectional survey. Int J Neurosci 133(3):248\u2013256 Epub 2021 Apr 14. PMID: 33843418","journal-title":"Int J Neurosci"},{"key":"1929_CR10","doi-asserted-by":"publisher","unstructured":"Minen MT, Begasse De Dhaem O, Van Kroon A, Powers S, Schwedt TJ, Lipton R, Silbersweig D (2016) Migraine and its psychiatric comorbidities. J Neurol Neurosurg Psychiatry. 87(7):741-9. https:\/\/doi.org\/10.1136\/jnnp-2015-312233. Epub 2016 Jan 5. PMID: 26733600","DOI":"10.1136\/jnnp-2015-312233"},{"issue":"Suppl 1","key":"1929_CR11","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/head.13300","volume":"58","author":"DW Dodick","year":"2018","unstructured":"Dodick DW (2018) A phase-by-phase review of Migraine Pathophysiology. Headache 58(Suppl 1):4\u201316. https:\/\/doi.org\/10.1111\/head.13300","journal-title":"Headache"},{"key":"1929_CR12","doi-asserted-by":"publisher","unstructured":"Headache Classification Committee of the International Headache Society (IHS) (2018) The International classification of Headache disorders, 3rd edition. Cephalalgia 38(1\u2013211). https:\/\/doi.org\/10.1177\/0333102417738202","DOI":"10.1177\/0333102417738202"},{"key":"1929_CR13","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1111\/head.13613","volume":"59","author":"DC Buse","year":"2019","unstructured":"Buse DC, Fanning KM, Reed ML, Murray S, Dumas PK, Adams AM, Lipton RB (2019) Life with Migraine: effects on relationships, Career, and Finances from the chronic migraine epidemiology and outcomes (CaMEO) study. Headache: J Head Face Pain 59:1286\u20131299. https:\/\/doi.org\/10.1111\/head.13613","journal-title":"Headache: J Head Face Pain"},{"key":"1929_CR14","doi-asserted-by":"crossref","unstructured":"Aylin Yucel P, Andrew Thach P, Sharanya Kumar P, Catherine Loden BS, Mark Bensink P, Neil Goldfarb BA, Robert Cowan MD (2020) Estimating the Economic Burden of Migraine on US Employers. The American Journal of Managed Care 26","DOI":"10.37765\/ajmc.2020.88547"},{"key":"1929_CR15","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1080\/00207454.2019.1681994","volume":"130","author":"Z Karaaslan","year":"2020","unstructured":"Karaaslan Z, \u00d6z\u00e7elik P, Ulukan \u00c7, Ulusoy C, Orhan KS, Orhan EK, K\u00fc\u00e7\u00fckali C, T\u00fcz\u00fcn E, Baykan B, Akdal G (2020) Plasma levels of inflammatory mediators in vestibular migraine. Int J Neurosci 130:330\u2013335. https:\/\/doi.org\/10.1080\/00207454.2019.1681994","journal-title":"Int J Neurosci"},{"key":"1929_CR16","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s11845-019-02136-y","volume":"189","author":"HO Yazar","year":"2020","unstructured":"Yazar HO, Yazar T, Ayg\u00fcn A, Kaygisiz \u015e, Kirba\u015f D (2020) Evaluation of simple inflammatory blood parameters in patients with migraine. Ir J Med Sci 189:677\u2013683. https:\/\/doi.org\/10.1007\/s11845-019-02136-y","journal-title":"Ir J Med Sci"},{"key":"1929_CR17","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s10194-021-01271-1","volume":"22","author":"O Kursun","year":"2021","unstructured":"Kursun O, Yemisci M, van den Maagdenberg AMJM, Karatas H (2021) Migraine and neuroinflammation: the inflammasome perspective. J Headache Pain 22:55. https:\/\/doi.org\/10.1186\/s10194-021-01271-1","journal-title":"J Headache Pain"},{"key":"1929_CR18","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.neurol.2021.07.005","volume":"177","author":"X Moisset","year":"2021","unstructured":"Moisset X, Giraud P, Dallel R (2021) Migraine in multiple sclerosis and other chronic inflammatory diseases. Rev Neurol (Paris) 177:816\u2013820. https:\/\/doi.org\/10.1016\/j.neurol.2021.07.005","journal-title":"Rev Neurol (Paris)"},{"key":"1929_CR19","doi-asserted-by":"publisher","first-page":"6212","DOI":"10.1158\/1078-0432.Ccr-14-0442","volume":"20","author":"B Hu","year":"2014","unstructured":"Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W, Zhang X, Wang WM, Qiu SJ, Zhou J et al (2014) Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res 20:6212\u20136222. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-14-0442","journal-title":"Clin Cancer Res"},{"key":"1929_CR20","doi-asserted-by":"publisher","first-page":"117179","DOI":"10.1016\/j.jns.2020.117179","volume":"419","author":"T Wijeratne","year":"2020","unstructured":"Wijeratne T, Crewther S, Post (2020) -COVID 19 neurological syndrome (PCNS); a novel syndrome with challenges for the global neurology community. J Neurol Sci 419:117179. https:\/\/doi.org\/10.1016\/j.jns.2020.117179","journal-title":"J Neurol Sci"},{"key":"1929_CR21","doi-asserted-by":"publisher","first-page":"117356","DOI":"10.1016\/j.jns.2021.117356","volume":"423","author":"T Wijeratne","year":"2021","unstructured":"Wijeratne T, Wijeratne C (2021) Clinical utility of serial systemic immune inflammation indices (SSIIi) in the context of post covid-19 neurological syndrome (PCNS). J Neurol Sci 423:117356. https:\/\/doi.org\/10.1016\/j.jns.2021.117356","journal-title":"J Neurol Sci"},{"key":"1929_CR22","doi-asserted-by":"publisher","first-page":"1450039","DOI":"10.3389\/fneur.2024.1450039","volume":"15","author":"A Bonura","year":"2024","unstructured":"Bonura A, Alesina A, Sapio E, Brunelli N, Marcosano M, Altamura C, Vernieri F (2024) Acute medications\u2019 intake for migraine: a one-year report in patients undergoing first evaluation at a third level Italian headache center. Front Neurol 15:1450039. https:\/\/doi.org\/10.3389\/fneur.2024.1450039","journal-title":"Front Neurol"},{"key":"1929_CR23","doi-asserted-by":"publisher","first-page":"e58859","DOI":"10.7759\/cureus.58859","volume":"16","author":"S Patil","year":"2024","unstructured":"Patil S, Nadaf N, Gupta S, Barai P, Makhija S, Lodha P, Patel C, Gondane AA, Pawar D, Sharma A (2024) A comparative analysis of the efficacy and safety of Nimesulide\/Paracetamol fixed-dose combination with other NSAIDs in Acute Pain Management: a randomized, prospective, Multicenter, active-controlled study (the SAFE-2 study). Cureus 16:e58859. https:\/\/doi.org\/10.7759\/cureus.58859","journal-title":"Cureus"},{"key":"1929_CR24","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s10194-024-01812-4","volume":"25","author":"HL Wei","year":"2024","unstructured":"Wei HL, Yu YS, Wang MY, Zhou GP, Li J, Zhang H, Zhou Z (2024) Exploring potential neuroimaging biomarkers for the response to non-steroidal anti-inflammatory drugs in episodic migraine. J Headache Pain 25:104. https:\/\/doi.org\/10.1186\/s10194-024-01812-4","journal-title":"J Headache Pain"},{"key":"1929_CR25","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s11910-024-01361-y","volume":"24","author":"MA Hird","year":"2024","unstructured":"Hird MA, Sandoe CH (2024) Migraine Management in medically complex patients: a Narrative Review. Curr Neurol Neurosci Rep 24:423\u2013438. https:\/\/doi.org\/10.1007\/s11910-024-01361-y","journal-title":"Curr Neurol Neurosci Rep"},{"key":"1929_CR26","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3988\/jcn.2023.0485","volume":"20","author":"KY Kim","year":"2024","unstructured":"Kim KY, Ko HY, Bea S, Lee HJ, Shin JY, Chu MK (2024) Treatment patterns and persistence among patients newly diagnosed with migraine in South Korea: a Retrospective Analysis of Health Claims Data. J Clin Neurol 20:529\u2013536. https:\/\/doi.org\/10.3988\/jcn.2023.0485","journal-title":"J Clin Neurol"},{"key":"1929_CR27","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1111\/head.13903","volume":"60","author":"KN Arca","year":"2020","unstructured":"Arca KN, Smith JH, Chiang CC, Starling AJ, Robertson CE, Halker Singh RB, Schwedt TJ, Kissoon NR, Garza I, Rozen TD et al (2020) COVID-19 and Headache Medicine: a narrative review of non-steroidal anti-inflammatory drug (NSAID) and corticosteroid use. Headache 60:1558\u20131568. https:\/\/doi.org\/10.1111\/head.13903","journal-title":"Headache"},{"key":"1929_CR28","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1590\/0004-282x-anp-2020-0188","volume":"79","author":"AVD Silva","year":"2021","unstructured":"Silva AVD, Kiy LMC, Alves CA, Kirylko GC, Bello VA, Poli-Frederico RC (2021) Impact of headache on a supplemental healthcare emergency unit and on use of opioids. Arq Neuropsiquiatr 79:579\u2013583. https:\/\/doi.org\/10.1590\/0004-282x-anp-2020-0188","journal-title":"Arq Neuropsiquiatr"},{"key":"1929_CR29","doi-asserted-by":"publisher","unstructured":"Yang S, Orlova Y, Lipe A, Boren M, Hincapie-Castillo JM, Park H, Chang CY, Wilson DL, Adkins L, Lo-Ciganic WH (2022) Trends in the management of Headache disorders in US Emergency departments: analysis of 2007\u20132018 National Hospital Ambulatory Medical Care Survey Data. J Clin Med 11. https:\/\/doi.org\/10.3390\/jcm11051401","DOI":"10.3390\/jcm11051401"},{"key":"1929_CR30","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s10194-021-01285-9","volume":"22","author":"T Acz\u00e9l","year":"2021","unstructured":"Acz\u00e9l T, K\u00f6rt\u00e9si T, Kun J, Urb\u00e1n P, Bauer W, Herczeg R, Farkas R, Kov\u00e1cs K, V\u00e1s\u00e1rhelyi B, Karvaly GB et al (2021) Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis. J Headache Pain 22:117. https:\/\/doi.org\/10.1186\/s10194-021-01285-9","journal-title":"J Headache Pain"},{"key":"1929_CR31","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1111\/j.1526-4610.2011.01902.x","volume":"51","author":"CM Forcelini","year":"2011","unstructured":"Forcelini CM, Dantas DC, Luz C, Santin R, Stein AT, Barros HM, Barea LM (2011) Analysis of leukocytes in medication-overuse headache, chronic migraine, and episodic migraine. Headache 51:1228\u20131238. https:\/\/doi.org\/10.1111\/j.1526-4610.2011.01902.x","journal-title":"Headache"},{"key":"1929_CR32","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1111\/head.14599","volume":"63","author":"L Yang","year":"2023","unstructured":"Yang L, Zhou Y, Zhang L, Wang Y, Zhang Y, Xiao Z (2023) Aryl hydrocarbon receptors improve migraine-like pain behaviors in rats through the regulation of regulatory T cell\/T-helper 17 cell-related homeostasis. Headache 63:1045\u20131060. https:\/\/doi.org\/10.1111\/head.14599","journal-title":"Headache"},{"key":"1929_CR33","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.ajem.2017.03.063","volume":"35","author":"U Eryigit","year":"2017","unstructured":"Eryigit U, Altunayoglu Cakmak V, Sahin A, Tatli O, Pasli S, Gazioglu G, Karaca Y (2017) The diagnostic value of the neutrophil-lymphocyte ratio in distinguishing between subarachnoid hemorrhage and migraine. Am J Emerg Med 35:1276\u20131280. https:\/\/doi.org\/10.1016\/j.ajem.2017.03.063","journal-title":"Am J Emerg Med"},{"key":"1929_CR34","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1007\/s10072-012-1218-3","volume":"34","author":"A Cseh","year":"2013","unstructured":"Cseh A, Farkas KM, Derzbach L, Muller K, Vasarhelyi B, Szalay B, Treszl A, Farkas V (2013) Lymphocyte subsets in pediatric migraine. Neurol Sci 34:1151\u20131155. https:\/\/doi.org\/10.1007\/s10072-012-1218-3","journal-title":"Neurol Sci"},{"key":"1929_CR35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.imlet.2021.09.004","volume":"240","author":"M Arumugam","year":"2021","unstructured":"Arumugam M, Sugin L, Jabaris S (2021) Recent preclinical study offers a promising clue: role of regulatory T cells as biomarkers in migraine. Immunol Lett 240:9\u201311. https:\/\/doi.org\/10.1016\/j.imlet.2021.09.004","journal-title":"Immunol Lett"},{"key":"1929_CR36","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1080\/01616412.2021.1915077","volume":"43","author":"F Faraji","year":"2021","unstructured":"Faraji F, Shojapour M, Farahani I, Ganji A, Mosayebi G (2021) Reduced regulatory T lymphocytes in migraine patients. Neurol Res 43:677\u2013682. https:\/\/doi.org\/10.1080\/01616412.2021.1915077","journal-title":"Neurol Res"},{"key":"1929_CR37","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s13760-020-01362-x","volume":"121","author":"G Sar\u0131cam","year":"2021","unstructured":"Sar\u0131cam G (2021) Relationship between migraine headache and hematological parameters. Acta Neurol Belg 121:899\u2013905. https:\/\/doi.org\/10.1007\/s13760-020-01362-x","journal-title":"Acta Neurol Belg"},{"key":"1929_CR38","doi-asserted-by":"publisher","first-page":"12277","DOI":"10.1038\/s41598-020-69285-4","volume":"10","author":"Z Pavelek","year":"2020","unstructured":"Pavelek Z, Sou\u010dek O, Krejsek J, Sob\u00ed\u0161ek L, Kl\u00edmov\u00e1 B, Masopust J, Ku\u010da K, Vali\u0161 M (2020) The role of the immune system and the biomarker CD3\u2009+\u2009CD4\u2009+\u2009CD45RA-CD62L- in the pathophysiology of migraine. Sci Rep 10:12277. https:\/\/doi.org\/10.1038\/s41598-020-69285-4","journal-title":"Sci Rep"},{"key":"1929_CR39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0165-5728(88)90131-2","volume":"18","author":"P Martelletti","year":"1988","unstructured":"Martelletti P, Alteri E, Pesce A, Rinaldi-Garaci C, Giacovazzo M (1988) In vitro interactions of serotonin (5-HT) with mononuclear cells from migraine patients: alterations related to the phase of the attack. J Neuroimmunol 18:17\u201324. https:\/\/doi.org\/10.1016\/0165-5728(88)90131-2","journal-title":"J Neuroimmunol"},{"key":"1929_CR40","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s10194-005-0181-2","volume":"6","author":"P Lulli","year":"2005","unstructured":"Lulli P, Trabace S, Morellini M, Cicciarelli G, Coloprisco G, Piane M, de Filippis S, Santi PG, Avramakou O, Ferlicca E et al (2005) Cytotoxic T lymphocyte antigen 4 polymorphism 49 (A\u2009>\u2009G) and migraine. J Headache Pain 6:188\u2013190. https:\/\/doi.org\/10.1007\/s10194-005-0181-2","journal-title":"J Headache Pain"},{"key":"1929_CR41","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/s001090050130","volume":"75","author":"P Martelletti","year":"1997","unstructured":"Martelletti P, Stirparo G, Morrone S, Rinaldi C, Giacovazzo M (1997) Inhibition of intercellular adhesion molecule-1 (ICAM-1), soluble ICAM-1 and interleukin-4 by nitric oxide expression in migraine patients. J Mol Med (Berl) 75:448\u2013453. https:\/\/doi.org\/10.1007\/s001090050130","journal-title":"J Mol Med (Berl)"},{"key":"1929_CR42","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/s0140-6736(78)92222-5","volume":"2","author":"E Hanington","year":"1978","unstructured":"Hanington E, Migraine (1978) A blood disorder? Lancet 2:501\u2013503. https:\/\/doi.org\/10.1016\/s0140-6736(78)92222-5","journal-title":"Lancet"},{"key":"1929_CR43","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/0753-3322(89)90160-1","volume":"43","author":"E Hanington","year":"1989","unstructured":"Hanington E (1989) Migraine: the platelet hypothesis after 10 years. Biomed Pharmacother 43:719\u2013726. https:\/\/doi.org\/10.1016\/0753-3322(89)90160-1","journal-title":"Biomed Pharmacother"},{"key":"1929_CR44","doi-asserted-by":"publisher","unstructured":"Greco R, Bighiani F, Demartini C, Zanaboni A, Francavilla M, Facchetti S, Vaghi G, Allena M, Martinelli D, Guaschino E et al (2024) Expression of miR-155 in monocytes of people with migraine: association with phenotype, disease severity and inflammatory profile. J Headache Pain 25. https:\/\/doi.org\/10.1186\/s10194-024-01842-y","DOI":"10.1186\/s10194-024-01842-y"},{"key":"1929_CR45","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2217\/pmt-2021-0036","volume":"12","author":"HO Albayrak","year":"2022","unstructured":"Albayrak HO, Gurbuz H, Basaran S, Y\u0131lmaz S (2022) Assessment of inflammation with hematological parameters in patients with migraine and tension-type headache: a prospective study from a tertiary care center. Pain Manag 12:141\u2013148. https:\/\/doi.org\/10.2217\/pmt-2021-0036","journal-title":"Pain Manag"},{"key":"1929_CR46","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1055\/s-0041-1730124","volume":"12","author":"HH \u00d6zdemir","year":"2021","unstructured":"\u00d6zdemir HH, D\u00f6nder A (2021) Evaluation of Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and C-Reactive protein in tension-type headache patients. J Neurosci Rural Pract 12:566\u2013570. https:\/\/doi.org\/10.1055\/s-0041-1730124","journal-title":"J Neurosci Rural Pract"},{"key":"1929_CR47","doi-asserted-by":"publisher","unstructured":"Lee SH, Kim JH, Kwon YS, Sohn JH (2022) Role of peripheral inflammatory markers in patients with Acute Headache attack to Differentiate between Migraine and Non-migraine Headache. J Clin Med 11. https:\/\/doi.org\/10.3390\/jcm11216538","DOI":"10.3390\/jcm11216538"},{"key":"1929_CR48","doi-asserted-by":"publisher","first-page":"482","DOI":"10.5455\/medarh.2023.77.482-488","volume":"77","author":"KP Surbakti","year":"2023","unstructured":"Surbakti KP, Batubara CA, Mahendrayana E (2023) Hematologic Differences between Migraineurs and Tension-Type Headache patients. Med Arch 77:482\u2013488. https:\/\/doi.org\/10.5455\/medarh.2023.77.482-488","journal-title":"Med Arch"},{"key":"1929_CR49","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1186\/s12883-023-03496-w","volume":"23","author":"C Acarsoy","year":"2023","unstructured":"Acarsoy C, Ruiter R, Bos D, Ikram MK (2023) No association between blood-based markers of immune system and migraine status: a population-based cohort study. BMC Neurol 23:445. https:\/\/doi.org\/10.1186\/s12883-023-03496-w","journal-title":"BMC Neurol"},{"key":"1929_CR50","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.3760\/cma.j.cn115330-20220406-00170","volume":"57","author":"TX Diao","year":"2022","unstructured":"Diao TX, Wang J, Zhao YX, Zhang SL, Jing YY, Han L, Zheng HW, Wang YX, Yu LS, Ma X (2022) [The peripheral blood inflammatory markers in M\u00e9ni\u00e8re\u2019s disease patients with and without migraine]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 57:1426\u20131432. https:\/\/doi.org\/10.3760\/cma.j.cn115330-20220406-00170","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"1929_CR51","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ejphar.2004.07.040","volume":"500","author":"R Dantzer","year":"2004","unstructured":"Dantzer R (2004) Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur J Pharmacol 500:399\u2013411. https:\/\/doi.org\/10.1016\/j.ejphar.2004.07.040","journal-title":"Eur J Pharmacol"},{"key":"1929_CR52","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/s0166-2236(00)02088-9","volume":"25","author":"JP Konsman","year":"2002","unstructured":"Konsman JP, Parnet P, Dantzer R (2002) Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci 25:154\u2013159. https:\/\/doi.org\/10.1016\/s0166-2236(00)02088-9","journal-title":"Trends Neurosci"},{"key":"1929_CR53","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.ncl.2006.03.003","volume":"24","author":"R Dantzer","year":"2006","unstructured":"Dantzer R (2006) Cytokine, sickness behavior, and depression. Neurol Clin 24:441\u2013460. https:\/\/doi.org\/10.1016\/j.ncl.2006.03.003","journal-title":"Neurol Clin"},{"key":"1929_CR54","first-page":"271","volume":"5","author":"R Dantzer","year":"1994","unstructured":"Dantzer R (1994) How do cytokines say hello to the brain? Neural versus humoral mediation. Eur Cytokine Netw 5:271\u2013273","journal-title":"Eur Cytokine Netw"},{"key":"1929_CR55","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.bbi.2006.09.006","volume":"21","author":"R Dantzer","year":"2007","unstructured":"Dantzer R, Kelley KW (2007) Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun 21:153\u2013160. https:\/\/doi.org\/10.1016\/j.bbi.2006.09.006","journal-title":"Brain Behav Immun"},{"key":"1929_CR56","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.psyneuen.2007.10.008","volume":"33","author":"R Dantzer","year":"2008","unstructured":"Dantzer R, Capuron L, Irwin MR, Miller AH, Ollat H, Perry VH, Rousey S, Yirmiya R (2008) Identification and treatment of symptoms associated with inflammation in medically ill patients. Psychoneuroendocrinology 33:18\u201329. https:\/\/doi.org\/10.1016\/j.psyneuen.2007.10.008","journal-title":"Psychoneuroendocrinology"},{"key":"1929_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2003.09.008","volume":"18","author":"R Dantzer","year":"2004","unstructured":"Dantzer R (2004) Innate immunity at the forefront of psychoneuroimmunology. Brain Behav Immun 18:1\u20136. https:\/\/doi.org\/10.1016\/j.bbi.2003.09.008","journal-title":"Brain Behav Immun"},{"key":"1929_CR58","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.psyneuen.2005.03.011","volume":"30","author":"R Dantzer","year":"2005","unstructured":"Dantzer R (2005) Somatization: a psychoneuroimmune perspective. Psychoneuroendocrinology 30:947\u2013952. https:\/\/doi.org\/10.1016\/j.psyneuen.2005.03.011","journal-title":"Psychoneuroendocrinology"},{"key":"1929_CR59","first-page":"43","volume":"640","author":"R Dantzer","year":"1997","unstructured":"Dantzer R (1997) Stress and immunity: what have we learned from psychoneuroimmunology? Acta Physiol Scand Suppl 640:43\u201346","journal-title":"Acta Physiol Scand Suppl"},{"key":"1929_CR60","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.3389\/fimmu.2019.02699","volume":"10","author":"AM Zaaqoq","year":"2019","unstructured":"Zaaqoq AM, Namas RA, Abdul-Malak O, Almahmoud K, Barclay D, Yin J, Zamora R, Rosengart MR, Billiar TR, Vodovotz Y (2019) Diurnal variation in systemic Acute inflammation and clinical outcomes following severe Blunt Trauma. Front Immunol 10:2699. https:\/\/doi.org\/10.3389\/fimmu.2019.02699","journal-title":"Front Immunol"}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-024-01929-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10194-024-01929-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-024-01929-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T07:02:42Z","timestamp":1736492562000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejournalofheadacheandpain.biomedcentral.com\/articles\/10.1186\/s10194-024-01929-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1929"],"URL":"https:\/\/doi.org\/10.1186\/s10194-024-01929-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5209065\/v1","asserted-by":"object"}]},"ISSN":["1129-2377"],"issn-type":[{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,10]]},"assertion":[{"value":"5 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was received from Western Health IRB, Australia with approval number QA2014\/24.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7"}}