{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:57:00Z","timestamp":1787763420915,"version":"build-2784847793"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"DOI":"10.1186\/s10194-025-02011-5","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T08:22:22Z","timestamp":1745828542000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Is there a role of calcitonin gene-related peptide in cortical spreading depression mechanisms?\u2013 Argument pro"],"prefix":"10.1186","volume":"26","author":[{"given":"Marina","family":"Romozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Calabresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"issue":"2019","key":"2011_CR1","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.ncl.2019.06.001","volume":"37","author":"RC Burch","year":"2019","unstructured":"Burch RC, Buse DC, Lipton RB, Migraine (2019) Epidemiology, burden, and comorbidity. Neurol Clin 37(2019):631\u2013649","journal-title":"Neurol Clin"},{"key":"2011_CR2","doi-asserted-by":"crossref","unstructured":"Ferrari MD, Goadsby PJ, Burstein R, Kurth T, Ayata C, Charles A et al (2022) Migraine. Nature Reviews Disease Primers.;8(2022):2","DOI":"10.1038\/s41572-021-00328-4"},{"key":"2011_CR3","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia (2018);38(2018):1-211","DOI":"10.1177\/0333102417738202"},{"key":"2011_CR4","doi-asserted-by":"crossref","unstructured":"Goadsby PJ, Holland PR, Martins-Oliveira M, Hoffmann J, Schankin C, Akerman S (2017) Pathophysiology of migraine: A disorder of sensory processing. Physiol Rev 97(2017):553\u2013622","DOI":"10.1152\/physrev.00034.2015"},{"issue":"2009","key":"2011_CR5","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1111\/j.1468-2982.2009.01983.x","volume":"29","author":"A Charles","year":"2009","unstructured":"Charles A, Brennan K (2009) Cortical spreading depression-new insights and persistent questions. Cephalalgia 29(2009):1115\u20131124","journal-title":"Cephalalgia"},{"key":"2011_CR6","doi-asserted-by":"crossref","unstructured":"Tozzi A, de Iure A, Di Filippo M, Costa C, Caproni S, Pisani A et al (2012) Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. Proc Natl Acad Sci U S A.;109(2012):18985-90","DOI":"10.1073\/pnas.1215435109"},{"issue":"2018","key":"2011_CR7","first-page":"428","volume":"39","author":"LN Close","year":"2018","unstructured":"Close LN, Eftekhari S, Wang M, Charles AC, Russo AF (2018) Cortical spreading depression as a site of origin for migraine: role of CGRP. Cephalalgia 39(2018):428\u2013434","journal-title":"Cephalalgia"},{"issue":"1981","key":"2011_CR8","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/ana.410090406","volume":"9","author":"J Olesen","year":"1981","unstructured":"Olesen J, Larsen B, Lauritzen M (1981) Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 9(1981):344\u2013352","journal-title":"Ann Neurol"},{"issue":"1983","key":"2011_CR9","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/ana.410130609","volume":"13","author":"M Lauritzen","year":"1983","unstructured":"Lauritzen M, Skyh\u00f8j Olsen T, Lassen NA, Paulson OB (1983) Changes in regional cerebral blood flow during the course of classic migraine attacks. Ann Neurol 13(1983):633\u2013641","journal-title":"Ann Neurol"},{"issue":"2010","key":"2011_CR10","doi-asserted-by":"publisher","first-page":"8807","DOI":"10.1523\/JNEUROSCI.0511-10.2010","volume":"30","author":"X Zhang","year":"2010","unstructured":"Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R (2010) Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci 30(2010):8807\u20138814","journal-title":"J Neurosci"},{"issue":"1988","key":"2011_CR11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/335073a0","volume":"335","author":"SD Brain","year":"1988","unstructured":"Brain SD, Williams TJ (1988) Substance P regulates the vasodilator activity of calcitonin gene-related peptide. Nature 335(1988):73\u201375","journal-title":"Nature"},{"issue":"Suppl 2","key":"2011_CR12","doi-asserted-by":"publisher","first-page":"S86","DOI":"10.1007\/s10072-006-0577-z","volume":"27","author":"T Dalkara","year":"2006","unstructured":"Dalkara T, Zervas NT, Moskowitz MA (2006) From spreading depression to the trigeminovascular system. Neurol Sci 27(Suppl 2):S86\u201390","journal-title":"Neurol Sci"},{"key":"2011_CR13","doi-asserted-by":"crossref","unstructured":"Mehnert J, Fischer-Schulte L, May A (2023) Aura phenomena do not initiate migraine attacks-Findings from neuroimaging. Headache. (2023)","DOI":"10.1111\/head.14597"},{"issue":"2001","key":"2011_CR14","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1073\/pnas.071582498","volume":"98","author":"N Hadjikhani","year":"2001","unstructured":"Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B et al (2001) Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 98(2001):4687\u20134692","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2011_CR15","doi-asserted-by":"crossref","unstructured":"Sanchez del Rio M, Bakker D, Wu O, Agosti R, Mitsikostas DD, Ostergaard L et al (1999) Perfusion weighted imaging during migraine: spontaneous visual aura and headache. Cephalalgia.;19(1999):701-7","DOI":"10.1046\/j.1468-2982.1999.019008701.x"},{"key":"2011_CR16","doi-asserted-by":"crossref","unstructured":"Edvinsson L, Haanes KA, Warfvinge K, Krause DN (2018) CGRP as the target of new migraine therapies \u2014 successful translation from bench to clinic. Nature Reviews Neurology.;14(2018):338\u2013\u200950","DOI":"10.1038\/s41582-018-0003-1"},{"key":"2011_CR17","doi-asserted-by":"crossref","unstructured":"Charles AC, Digre KB, Goadsby PJ, Robbins MS, Hershey A (2024) Calcitonin gene-related peptide-targeting therapies are a first-line option for the prevention of migraine: An American Headache Society position statement update. Headache. (2024)","DOI":"10.1111\/head.14692"},{"issue":"2010","key":"2011_CR18","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.neuroscience.2010.05.016","volume":"169","author":"S Eftekhari","year":"2010","unstructured":"Eftekhari S, Salvatore CA, Calamari A, Kane SA, Tajti J, Edvinsson L (2010) Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion. Neuroscience 169(2010):683\u2013696","journal-title":"Neuroscience"},{"issue":"1990","key":"2011_CR19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/ana.410280213","volume":"28","author":"PJ Goadsby","year":"1990","unstructured":"Goadsby PJ, Edvinsson L, Ekman R (1990) Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 28(1990):183\u2013187","journal-title":"Ann Neurol"},{"issue":"1993","key":"2011_CR20","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/ana.410330109","volume":"33","author":"PJ Goadsby","year":"1993","unstructured":"Goadsby PJ, Edvinsson L (1993) The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol 33(1993):48\u201356","journal-title":"Ann Neurol"},{"issue":"2002","key":"2011_CR21","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1046\/j.1468-2982.2002.00310.x","volume":"22","author":"LH Lassen","year":"2002","unstructured":"Lassen LH, Haderslev PA, Jacobsen VB, Iversen HK, Sperling B, Olesen J (2002) CGRP May play a causative role in migraine. Cephalalgia 22(2002):54\u201361","journal-title":"Cephalalgia"},{"key":"2011_CR22","doi-asserted-by":"crossref","unstructured":"Christensen CE, Younis S, Deen M, Khan S, Ghanizada H, Ashina M (2018) Migraine induction with calcitonin gene-related peptide in patients from erenumab trials. The Journal of Headache and Pain.;19(2018):105","DOI":"10.1186\/s10194-018-0927-2"},{"issue":"2019","key":"2011_CR23","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1177\/0333102419856640","volume":"39","author":"K Kamm","year":"2019","unstructured":"Kamm K, Straube A, Ruscheweyh R (2019) Calcitonin gene-related peptide levels in tear fluid are elevated in migraine patients compared to healthy controls. Cephalalgia 39(2019):1535\u20131543","journal-title":"Cephalalgia"},{"issue":"2022","key":"2011_CR24","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/WCO.0000000000001053","volume":"35","author":"B Tesfay","year":"2022","unstructured":"Tesfay B, Karlsson WK, Moreno RD, Hay DL, Hougaard A (2022) Is calcitonin gene-related peptide a reliable biochemical marker of migraine? Curr Opin Neurol 35(2022):343\u2013352","journal-title":"Curr Opin Neurol"},{"issue":"2022","key":"2011_CR25","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S1474-4422(21)00409-9","volume":"21","author":"L Al-Hassany","year":"2022","unstructured":"Al-Hassany L, Goadsby PJ, Danser AHJ, MaassenVanDenBrink A (2022) Calcitonin gene-related peptide-targeting drugs for migraine: how Pharmacology might inform treatment decisions. Lancet Neurol 21(2022):284\u2013294","journal-title":"Lancet Neurol"},{"issue":"2019","key":"2011_CR26","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1177\/0333102418774299","volume":"39","author":"LN Close","year":"2019","unstructured":"Close LN, Eftekhari S, Wang M, Charles AC, Russo AF (2019) Cortical spreading depression as a site of origin for migraine: role of CGRP. Cephalalgia 39(2019):428\u2013434","journal-title":"Cephalalgia"},{"key":"2011_CR27","doi-asserted-by":"crossref","unstructured":"Shatillo A, Koroleva K, Giniatullina R, Naumenko N, Slastnikova AA, Aliev RR et al (2013) Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system. Neuroscience.;253(2013):341-9","DOI":"10.1016\/j.neuroscience.2013.09.002"},{"issue":"2002","key":"2011_CR28","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/nm0202-136","volume":"8","author":"H Bolay","year":"2002","unstructured":"Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA (2002) Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 8(2002):136\u2013142","journal-title":"Nat Med"},{"issue":"2019","key":"2011_CR29","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1177\/0333102416678388","volume":"39","author":"Y Wang","year":"2019","unstructured":"Wang Y, Tye AE, Zhao J, Ma D, Raddant AC, Bu F et al (2019) Induction of calcitonin gene-related peptide expression in rats by cortical spreading depression. Cephalalgia 39(2019):333\u2013341","journal-title":"Cephalalgia"},{"issue":"1994","key":"2011_CR30","doi-asserted-by":"publisher","first-page":"H1095","DOI":"10.1152\/ajpheart.1994.266.3.H1095","volume":"266","author":"DM Colonna","year":"1994","unstructured":"Colonna DM, Meng W, Deal DD, Busija DW (1994) Calcitonin gene-related peptide promotes cerebrovascular dilation during cortical spreading depression in rabbits. Am J Physiol Heart Circ Physiol 266(1994):H1095\u2013H102","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1994","key":"2011_CR31","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/0006-8993(94)91234-3","volume":"637","author":"M Wahl","year":"1994","unstructured":"Wahl M, Schilling L, Parsons AA, Kaumann A (1994) Involvement of calcitonin gene-related peptide (CGRP) and nitric oxide (NO) in the Pial artery dilatation elicited by cortical spreading depression. Brain Res 637(1994):204\u2013210","journal-title":"Brain Res"},{"key":"2011_CR32","first-page":"295","volume":"37","author":"S Eftekhari","year":"2017","unstructured":"Eftekhari S, Kechechyan GM, Faas G, Charles A (2017) The CGRP receptor antagonist olcegepant modulates cortical spreading depression in vivo. Cephalalgia 37:295\u2013296","journal-title":"Cephalalgia"},{"key":"2011_CR33","doi-asserted-by":"crossref","unstructured":"Melo-Carrillo A, Noseda R, Nir RR, Schain AJ, Stratton J, Strassman AM, Burstein R (2017) Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody. J Neurosci.;37(2017):7149-63","DOI":"10.1523\/JNEUROSCI.0576-17.2017"},{"issue":"2019","key":"2011_CR34","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1177\/0333102417735845","volume":"39","author":"A Filiz","year":"2019","unstructured":"Filiz A, Tepe N, Eftekhari S, Boran HE, Dilekoz E, Edvinsson L, Bolay H (2019) CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior. Cephalalgia 39(2019):354\u2013365","journal-title":"Cephalalgia"},{"issue":"2018","key":"2011_CR35","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neuroscience.2018.04.025","volume":"382","author":"L Jiang","year":"2018","unstructured":"Jiang L, Wang Y, Xu Y, Ma D, Wang M (2018) The transient receptor potential Ankyrin type 1 plays a critical role in cortical spreading depression. Neuroscience 382(2018):23\u201334","journal-title":"Neuroscience"},{"issue":"2015","key":"2011_CR36","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.npep.2015.03.008","volume":"51","author":"W Yisarakun","year":"2015","unstructured":"Yisarakun W, Chantong C, Supornsilpchai W, Thongtan T, Srikiatkhachorn A, Reuangwechvorachai P, Maneesri-le Grand S (2015) Up-regulation of calcitonin gene-related peptide in trigeminal ganglion following chronic exposure to Paracetamol in a CSD migraine animal model. Neuropeptides 51(2015):9\u201316","journal-title":"Neuropeptides"},{"key":"2011_CR37","doi-asserted-by":"crossref","unstructured":"Shibata M, Kitagawa S, Unekawa M, Takizawa T, Nakahara J (2023) Calcitonin Gene-Related Peptide mRNA Synthesis in Trigeminal Ganglion Neurons after Cortical Spreading Depolarization. Int J Mol Sci.;24(2023)","DOI":"10.20944\/preprints202305.0088.v1"},{"issue":"2024","key":"2011_CR38","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1126\/science.adl0544","volume":"385","author":"M Kaag Rasmussen","year":"2024","unstructured":"Kaag Rasmussen M, M\u00f8llg\u00e5rd K, Bork PAR, Weikop P, Esmail T, Drici L et al (2024) Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model. Science 385(2024):80\u201386","journal-title":"Science"},{"issue":"1998","key":"2011_CR39","first-page":"H1979","volume":"274","author":"U Reuter","year":"1998","unstructured":"Reuter U, Weber JR, Gold L, Arnold G, Wolf T, Dreier J et al (1998) Perivascular nerves contribute to cortical spreading depression-associated hyperemia in rats. Am J Physiol 274(1998):H1979\u2013H1987","journal-title":"Am J Physiol"},{"issue":"2016","key":"2011_CR40","doi-asserted-by":"publisher","first-page":"12624","DOI":"10.1523\/JNEUROSCI.1300-16.2016","volume":"36","author":"KJ Kim","year":"2016","unstructured":"Kim KJ, Ramiro Diaz J, Iddings JA, Filosa JA (2016) Vasculo-Neuronal coupling: retrograde vascular communication to brain neurons. J Neurosci 36(2016):12624\u201312639","journal-title":"J Neurosci"},{"issue":"2018","key":"2011_CR41","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1177\/0333102416684344","volume":"38","author":"H Ashina","year":"2018","unstructured":"Ashina H, Schytz HW, Ashina M (2018) CGRP in human models of primary headaches. Cephalalgia 38(2018):353\u2013360","journal-title":"Cephalalgia"},{"issue":"2010","key":"2011_CR42","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1177\/0333102410368444","volume":"30","author":"JM Hansen","year":"2010","unstructured":"Hansen JM, Hauge AW, Olesen J, Ashina M (2010) Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura. Cephalalgia 30(2010):1179\u20131186","journal-title":"Cephalalgia"},{"key":"2011_CR43","doi-asserted-by":"crossref","unstructured":"Al-Khazali HM, Ashina H, Wiggers A, Rose K, Iljazi A, Christensen RH et al (2023) Calcitonin gene-related peptide causes migraine aura. J Headache Pain 24(2023):124","DOI":"10.1186\/s10194-023-01656-4"},{"issue":"2022","key":"2011_CR44","doi-asserted-by":"publisher","first-page":"107169","DOI":"10.1016\/j.clineuro.2022.107169","volume":"214","author":"D Mahovi\u0107","year":"2022","unstructured":"Mahovi\u0107 D, Bra\u010di\u0107 M, Jaku\u0161 L, Vukovic Cvetkovic V, Krpan M (2022) Effectiveness and safety of erenumab in chronic migraine: A Croatian real-world experience. Clin Neurol Neurosurg 214(2022):107169","journal-title":"Clin Neurol Neurosurg"},{"key":"2011_CR45","doi-asserted-by":"crossref","unstructured":"Romozzi M, Burgalassi A, Vollono C, Albanese M, Vigani G, De Cesaris F et al (2024) Prospective evaluation of aura during anti-calcitonin gene-related peptide monoclonal antibody therapy after 52 weeks of treatment. Confinia Cephalalgica.;34(2024)","DOI":"10.4081\/cc.2024.15762"},{"issue":"2023","key":"2011_CR46","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s40120-022-00410-3","volume":"12","author":"H Igarashi","year":"2023","unstructured":"Igarashi H, Shibata M, Ozeki A, Matsumura T (2023) Galcanezumab effects on migraine severity and symptoms in Japanese patients with episodic migraine: secondary analysis of a phase 2 randomized trial. Neurol Ther 12(2023):73\u201387","journal-title":"Neurol Ther"},{"issue":"2022","key":"2011_CR47","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1177\/03331024221077646","volume":"42","author":"M Ashina","year":"2022","unstructured":"Ashina M, McAllister P, Cady R, Hirman J, Ettrup A (2022) Efficacy and safety of eptinezumab in patients with migraine and self-reported aura: post hoc analysis of PROMISE-1 and PROMISE-2. Cephalalgia 42(2022):696\u2013704","journal-title":"Cephalalgia"},{"issue":"2022","key":"2011_CR48","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1001\/jamaneurol.2021.4678","volume":"79","author":"M Ashina","year":"2022","unstructured":"Ashina M, Goadsby PJ, Dodick DW, Tepper SJ, Xue F, Zhang F et al (2022) Assessment of erenumab safety and efficacy in patients with migraine with and without aura: A secondary analysis of randomized clinical trials. JAMA Neurol 79(2022):159\u2013168","journal-title":"JAMA Neurol"},{"issue":"2021","key":"2011_CR49","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s10194-021-01344-1","volume":"22","author":"A Straube","year":"2021","unstructured":"Straube A, Stude P, Gaul C, Schuh K, Koch M (2021) Real-world evidence data on the monoclonal antibody erenumab in migraine prevention: perspectives of treating physicians in Germany. J Headache Pain 22(2021):133","journal-title":"J Headache Pain"},{"key":"2011_CR50","doi-asserted-by":"crossref","unstructured":"Iannone LF, De Cesaris F, Ferrari A, Benemei S, Fattori D, Chiarugi A (2022) Effectiveness of anti-CGRP monoclonal antibodies on central symptoms of migraine. Cephalalgia.;42(2022):1323-30","DOI":"10.1177\/03331024221111526"},{"key":"2011_CR51","doi-asserted-by":"crossref","unstructured":"Ashina S, Melo-Carrillo A, Toluwanimi A, Bolo N, Szabo E, Borsook D, Burstein R (2023) Galcanezumab effects on incidence of headache after occurrence of triggers, premonitory symptoms, and aura in responders, non-responders, super-responders, and super non-responders. The Journal of Headache and Pain.;24(2023):26","DOI":"10.1186\/s10194-023-01560-x"},{"key":"2011_CR52","doi-asserted-by":"crossref","unstructured":"Matteo E, Pensato U, Favoni V, Giannini G, Pierangeli G, Cevoli S (2021) Do anti-CGRP drugs have a role in migraine aura therapy? J Neurol.;268(2021):2273-4","DOI":"10.1007\/s00415-021-10546-1"},{"key":"2011_CR53","doi-asserted-by":"crossref","unstructured":"Albanese M, Mercuri NB (2022) Could the New Anti-CGRP Monoclonal Antibodies Be Effective in Migraine Aura? Case Reports and Literature Review. J Clin Med.;11(2022)","DOI":"10.3390\/jcm11051228"},{"key":"2011_CR54","doi-asserted-by":"crossref","unstructured":"Danno D, Ishizaki K, Kikui S, Takeshima T (2023) Treatment of hemiplegic migraine with anti-calcitonin gene-related peptide monoclonal antibodies: A case series in a tertiary-care headache center. Headache. (2023)","DOI":"10.1111\/head.14591"},{"key":"2011_CR55","doi-asserted-by":"crossref","unstructured":"Jansen NA, Dehghani A, Linssen MML, Breukel C, Tolner EA, van den Maagdenberg A (2020) First FHM3 mouse model shows spontaneous cortical spreading depolarizations. Ann Clin Transl Neurol.;7(2020):132-8","DOI":"10.1002\/acn3.50971"},{"issue":"2020","key":"2011_CR56","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1177\/0333102419896760","volume":"40","author":"R Noseda","year":"2020","unstructured":"Noseda R, Schain AJ, Melo-Carrillo A, Tien J, Stratton J, Mai F et al (2020) Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier. Cephalalgia 40(2020):229\u2013240","journal-title":"Cephalalgia"},{"key":"2011_CR57","doi-asserted-by":"crossref","unstructured":"Johnson KW, Morin SM, Wroblewski VJ, Johnson MP (2019) Peripheral and central nervous system distribution of the CGRP neutralizing antibody [(125)I] galcanezumab in male rats. Cephalalgia.;39(2019):1241-8","DOI":"10.1177\/0333102419844711"},{"key":"2011_CR58","doi-asserted-by":"crossref","unstructured":"Basedau H, Sturm LM, Mehnert J, Peng KP, Schellong M, May A (2022) Migraine monoclonal antibodies against CGRP change brain activity depending on ligand or receptor target - an fMRI study. Elife.;11(2022)","DOI":"10.7554\/eLife.77146"},{"key":"2011_CR59","doi-asserted-by":"crossref","unstructured":"Wiggers A, Ashina H, Hadjikhani N, Sagare A, Zlokovic BV, Lauritzen M, Ashina M (2022) Brain barriers and their potential role in migraine pathophysiology. J Headache Pain.;23(2022):16","DOI":"10.1186\/s10194-021-01365-w"},{"key":"2011_CR60","doi-asserted-by":"publisher","unstructured":"Melo-Carrillo, A. (2025) Is there a role of calcitonin gene-related peptide in cortical spreading depression mechanisms?\u2013 Argument con. J Headache Pain 26 https:\/\/doi.org\/10.1186\/s10194-025-02012-4","DOI":"10.1186\/s10194-025-02012-4"},{"key":"2011_CR61","doi-asserted-by":"crossref","unstructured":"Gimeno-Ferrer F, Eitner A, Bauer R, Lehmenk\u00fchler A, Edenhofer M-L, Kress M et al (2022) From spreading depolarization to epilepsy with neuroinflammation: The role of CGRP in cortex. Experimental Neurology.;356(2022):114152","DOI":"10.1016\/j.expneurol.2022.114152"},{"issue":"1988","key":"2011_CR62","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/0006-8993(88)91414-X","volume":"441","author":"PD Ryu","year":"1988","unstructured":"Ryu PD, Gerber G, Murase K, Randic M (1988) Actions of calcitonin gene-related peptide on rat spinal dorsal Horn neurons. Brain Res 441(1988):357\u2013361","journal-title":"Brain Res"},{"key":"2011_CR63","doi-asserted-by":"crossref","unstructured":"Han JS, Adwanikar H, Li Z, Ji G, Neugebauer V (2010) Facilitation of Synaptic Transmission and Pain Responses by CGRP in the Amygdala of Normal Rats. Molecular Pain.;6(2010):1744-8069-6-10","DOI":"10.1186\/1744-8069-6-10"},{"key":"2011_CR64","doi-asserted-by":"crossref","unstructured":"Han JS, Li W, Neugebauer V (2005) Critical role of calcitonin gene-related peptide 1 receptors in the amygdala in synaptic plasticity and pain behavior. J Neurosci.;25(2005):10717-28","DOI":"10.1523\/JNEUROSCI.4112-05.2005"},{"issue":"2018","key":"2011_CR65","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s13311-018-0616-5","volume":"15","author":"J Hoffmann","year":"2018","unstructured":"Hoffmann J, Charles A (2018) Glutamate and its receptors as therapeutic targets for migraine. Neurotherapeutics 15(2018):361\u2013370","journal-title":"Neurotherapeutics"},{"key":"2011_CR66","doi-asserted-by":"crossref","unstructured":"Alpuente A, Torre-Sune A, Caronna E, Gine-Cipres E, Torres-Ferr\u00fas M, Pozo-Rosich P (2023) Impact of anti-CGRP monoclonal antibodies on migraine attack accompanying symptoms: A real-world evidence study. Cephalalgia.;43(2023):3331024231177636","DOI":"10.1177\/03331024231177636"},{"issue":"2022","key":"2011_CR67","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1177\/03331024211040467","volume":"42","author":"A Alpuente","year":"2022","unstructured":"Alpuente A, Gallardo VJ, Asskour L, Caronna E, Torres-Ferrus M, Pozo-Rosich P (2022) Salivary CGRP can monitor the different migraine phases: CGRP (in)dependent attacks. Cephalalgia 42(2022):186\u2013196","journal-title":"Cephalalgia"},{"issue":"2009","key":"2011_CR68","doi-asserted-by":"publisher","first-page":"8798","DOI":"10.1523\/JNEUROSCI.1727-09.2009","volume":"29","author":"A Recober","year":"2009","unstructured":"Recober A, Kuburas A, Zhang Z, Wemmie JA, Anderson MG, Russo AF (2009) Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine. J Neurosci 29(2009):8798\u20138804","journal-title":"J Neurosci"},{"issue":"2014","key":"2011_CR69","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/brain\/awt320","volume":"137","author":"FH Maniyar","year":"2014","unstructured":"Maniyar FH, Sprenger T, Monteith T, Schankin C, Goadsby PJ (2014) Brain activations in the premonitory phase of nitroglycerin-triggered migraine attacks. Brain 137(2014):232\u2013241","journal-title":"Brain"},{"key":"2011_CR70","doi-asserted-by":"crossref","unstructured":"Ziegeler C, Mehnert J, Asmussen K, May A (2020) Central effects of erenumab in migraine patients: An event-related functional imaging study. Neurology.;95(2020):e2794-e802","DOI":"10.1212\/WNL.0000000000010740"},{"key":"2011_CR71","doi-asserted-by":"crossref","unstructured":"de Tommaso M, La Rocca M, Quitadamo SG, Ricci K, Tancredi G, Clemente L et al (2022) Central effects of galcanezumab in migraine: a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response in migraine patients. The Journal of Headache and Pain.;23(2022):52","DOI":"10.1186\/s10194-022-01421-z"},{"key":"2011_CR72","doi-asserted-by":"crossref","unstructured":"Vu T, Ma P, Chen JS, de Hoon J, Van Hecken A, Yan L et al (2017) Pharmacokinetic-Pharmacodynamic Relationship of Erenumab (AMG 334) and Capsaicin-Induced Dermal Blood Flow in Healthy and Migraine Subjects. Pharm Res.;34(2017):1784-95","DOI":"10.1007\/s11095-017-2183-6"},{"issue":"2016","key":"2011_CR73","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1093\/brain\/aww096","volume":"139","author":"CJ Schankin","year":"2016","unstructured":"Schankin CJ, Maniyar FH, Seo Y, Kori S, Eller M, Chou DE et al (2016) Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11\u00a0C-dihydroergotamine during Glyceryl trinitrate-induced migraine. Brain 139(2016):1994\u20132001","journal-title":"Brain"},{"key":"2011_CR74","doi-asserted-by":"crossref","unstructured":"Gursoy-Ozdemir Y, Qiu J, Matsuoka N, Bolay H, Bermpohl D, Jin H et al (2004) Cortical spreading depression activates and upregulates MMP-9. J Clin Invest.;113(2004):1447-55","DOI":"10.1172\/JCI200421227"},{"issue":"1985","key":"2011_CR75","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/cne.902340306","volume":"234","author":"RE Shapiro","year":"1985","unstructured":"Shapiro RE, Miselis RR (1985) The central neural connections of the area Postrema of the rat. J Comp Neurol 234(1985):344\u2013364","journal-title":"J Comp Neurol"}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-025-02011-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10194-025-02011-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-025-02011-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T07:08:28Z","timestamp":1745996908000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejournalofheadacheandpain.biomedcentral.com\/articles\/10.1186\/s10194-025-02011-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2011"],"URL":"https:\/\/doi.org\/10.1186\/s10194-025-02011-5","relation":{},"ISSN":["1129-2377"],"issn-type":[{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,28]]},"assertion":[{"value":"6 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original publication was amended to update the DOI of reference 60.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"90"}}