{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:35:26Z","timestamp":1772858126472,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"DOI":"10.1186\/s10194-025-02012-4","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T08:59:10Z","timestamp":1745830750000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Is there a role of calcitonin gene-related peptide in cortical spreading depression mechanisms?\u2013 argument con."],"prefix":"10.1186","volume":"26","author":[{"given":"Agustin","family":"Melo-Carrillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"issue":"46","key":"2012_CR1","doi-asserted-by":"publisher","first-page":"18985","DOI":"10.1073\/pnas.1215435109","volume":"109","author":"A Tozzi","year":"2012","unstructured":"Tozzi A, de Iure A, Filippo MD et al (2012) Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. Proc Natl Acad Sci U S A 109(46):18985. https:\/\/doi.org\/10.1073\/pnas.1215435109","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2012_CR2","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.pharep.2016.05.001","volume":"68","author":"Y Wang","year":"2016","unstructured":"Wang Y, Li Y, Wang M (2016) Involvement of CGRP receptors in retinal spreading depression. Pharmacol Rep 68(5):935\u2013938. https:\/\/doi.org\/10.1016\/j.pharep.2016.05.001","journal-title":"Pharmacol Rep"},{"issue":"3","key":"2012_CR3","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1177\/0333102416678388","volume":"39","author":"Y Wang","year":"2016","unstructured":"Wang Y, Tye AE, Zhao J et al (2016) Induction of calcitonin gene-related peptide expression in rats by cortical spreading depression. Cephalalgia Int J Headache 39(3):333. https:\/\/doi.org\/10.1177\/0333102416678388","journal-title":"Cephalalgia Int J Headache"},{"key":"2012_CR4","doi-asserted-by":"publisher","unstructured":"McLeod GA, Josephson CB, Engbers JDT, Cooke LJ, Wiebe S Mapping the migraine: Intracranial recording of cortical spreading depression in migraine with aura. Headache J Head Face Pain. n\/a(n\/a). https:\/\/doi.org\/10.1111\/head.14907","DOI":"10.1111\/head.14907"},{"issue":"8","key":"2012_CR5","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1073\/pnas.071582498","volume":"98","author":"N Hadjikhani","year":"2001","unstructured":"Hadjikhani N, Sanchez del Rio M, Wu O et al (2001) Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 98(8):4687\u20134692. https:\/\/doi.org\/10.1073\/pnas.071582498","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"2012_CR6","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1073\/pnas.071582498","volume":"98","author":"N Hadjikhani","year":"2001","unstructured":"Hadjikhani N, Del Sanchez M, Wu O et al (2001) Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 98(8):4687\u20134692. https:\/\/doi.org\/10.1073\/pnas.071582498","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2012_CR7","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/ana.22329","volume":"69","author":"X Zhang","year":"2011","unstructured":"Zhang X, Levy D, Kainz V, Noseda R, Jakubowski M, Burstein R (2011) Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol 69(5):855\u2013865. https:\/\/doi.org\/10.1002\/ana.22329","journal-title":"Ann Neurol"},{"issue":"26","key":"2012_CR8","doi-asserted-by":"publisher","first-page":"8807","DOI":"10.1523\/JNEUROSCI.0511-10.2010","volume":"30","author":"X Zhang","year":"2010","unstructured":"Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R (2010) Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci Off J Soc Neurosci 30(26):8807\u20138814. https:\/\/doi.org\/10.1523\/JNEUROSCI.0511-10.2010","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"30","key":"2012_CR9","doi-asserted-by":"publisher","first-page":"7149","DOI":"10.1523\/JNEUROSCI.0576-17.2017","volume":"37","author":"A Melo-Carrillo","year":"2017","unstructured":"Melo-Carrillo A, Noseda R, Nir RR et al (2017) Selective Inhibition of trigeminovascular neurons by fremanezumab: A humanized monoclonal Anti-CGRP antibody. J Neurosci Off J Soc Neurosci 37(30):7149\u20137163. https:\/\/doi.org\/10.1523\/JNEUROSCI.0576-17.2017","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"44","key":"2012_CR10","doi-asserted-by":"publisher","first-page":"10587","DOI":"10.1523\/JNEUROSCI.2211-17.2017","volume":"37","author":"A Melo-Carrillo","year":"2017","unstructured":"Melo-Carrillo A, Strassman AM, Nir RR et al (2017) Fremanezumab-A humanized monoclonal Anti-CGRP Antibody-Inhibits thinly myelinated (A\u03b4) but not unmyelinated (C) meningeal nociceptors. J Neurosci Off J Soc Neurosci 37(44):10587\u201310596. https:\/\/doi.org\/10.1523\/JNEUROSCI.2211-17.2017","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"8","key":"2012_CR11","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1093\/brain\/awae062","volume":"147","author":"A Melo-Carrillo","year":"2024","unstructured":"Melo-Carrillo A, Strassman AM, Broide R et al (2024) Novel insight into Atogepant mechanisms of action in migraine prevention. Brain J Neurol 147(8):2884\u20132896. https:\/\/doi.org\/10.1093\/brain\/awae062","journal-title":"Brain J Neurol"},{"issue":"9","key":"2012_CR12","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1177\/03331024221083544","volume":"42","author":"AM Strassman","year":"2022","unstructured":"Strassman AM, Melo-Carrillo A, Houle TT, Adams A, Brin MF, Burstein R (2022) Atogepant - an orally-administered CGRP antagonist - attenuates activation of meningeal nociceptors by CSD. Cephalalgia Int J Headache 42(9):933\u2013943. https:\/\/doi.org\/10.1177\/03331024221083544","journal-title":"Cephalalgia Int J Headache"},{"issue":"15","key":"2012_CR13","doi-asserted-by":"publisher","first-page":"e175616","DOI":"10.1172\/JCI175616","volume":"134","author":"NP Nelson-Maney","year":"2024","unstructured":"Nelson-Maney NP, B\u00e1lint L, Beeson AL et al (2024) Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models. J Clin Invest 134(15):e175616. https:\/\/doi.org\/10.1172\/JCI175616","journal-title":"J Clin Invest"},{"issue":"15","key":"2012_CR14","doi-asserted-by":"publisher","first-page":"e182556","DOI":"10.1172\/JCI182556","volume":"134","author":"JL Thomas","year":"2024","unstructured":"Thomas JL, Schindler EA, Gottschalk C (2024) Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice. J Clin Invest 134(15):e182556. https:\/\/doi.org\/10.1172\/JCI182556","journal-title":"J Clin Invest"},{"issue":"3","key":"2012_CR15","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1177\/0333102417735845","volume":"39","author":"A Filiz","year":"2019","unstructured":"Filiz A, Tepe N, Eftekhari S et al (2019) CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior. Cephalalgia 39(3):354\u2013365. https:\/\/doi.org\/10.1177\/0333102417735845","journal-title":"Cephalalgia"},{"issue":"5","key":"2012_CR16","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1097\/j.pain.0000000000001791","volume":"161","author":"A Melo-Carrillo","year":"2020","unstructured":"Melo-Carrillo A, Schain AJ, Stratton J, Strassman AM, Burstein R (2020) Fremanezumab and its isotype slow propagation rate and shorten cortical recovery period but do not prevent occurrence of cortical spreading depression in rats with compromised blood-brain barrier. Pain 161(5):1037\u20131043. https:\/\/doi.org\/10.1097\/j.pain.0000000000001791","journal-title":"Pain"},{"issue":"3","key":"2012_CR17","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1177\/0333102419896760","volume":"40","author":"R Noseda","year":"2020","unstructured":"Noseda R, Schain AJ, Melo-Carrillo A et al (2020) Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier. Cephalalgia Int J Headache 40(3):229\u2013240. https:\/\/doi.org\/10.1177\/0333102419896760","journal-title":"Cephalalgia Int J Headache"},{"issue":"3","key":"2012_CR18","doi-asserted-by":"publisher","first-page":"333102422114788","DOI":"10.1177\/03331024221147881","volume":"43","author":"S Ashina","year":"2023","unstructured":"Ashina S, Melo-Carrillo A, Szabo E, Borsook D, Burstein R (2023) Pre-treatment non-ictal cephalic allodynia identifies responders to prophylactic treatment of chronic and episodic migraine patients with galcanezumab: A prospective quantitative sensory testing study (NCT04271202). Cephalalgia Int J Headache 43(3):3331024221147881. https:\/\/doi.org\/10.1177\/03331024221147881","journal-title":"Cephalalgia Int J Headache"},{"issue":"1","key":"2012_CR19","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s10194-023-01560-x","volume":"24","author":"S Ashina","year":"2023","unstructured":"Ashina S, Melo-Carrillo A, Toluwanimi A et al (2023) Galcanezumab effects on incidence of headache after occurrence of triggers, premonitory symptoms, and aura in responders, non-responders, super-responders, and super non-responders. J Headache Pain 24(1):26. https:\/\/doi.org\/10.1186\/s10194-023-01560-x","journal-title":"J Headache Pain"},{"key":"2012_CR20","doi-asserted-by":"publisher","first-page":"103531","DOI":"10.1016\/j.nicl.2023.103531","volume":"40","author":"E Szabo","year":"2023","unstructured":"Szabo E, Ashina S, Melo-Carrillo A, Bolo NR, Borsook D, Burstein R (2023) Peripherally acting anti-CGRP monoclonal antibodies alter cortical Gray matter thickness in migraine patients: A prospective cohort study. NeuroImage Clin 40:103531. https:\/\/doi.org\/10.1016\/j.nicl.2023.103531","journal-title":"NeuroImage Clin"},{"key":"2012_CR21","doi-asserted-by":"publisher","unstructured":"Romozzi M, Calabresi P (2025) Is there a role of calcitonin gene-related peptide in cortical spreading depression mechanisms? \u2013 Argument pro. J Headache Pain 26 https:\/\/doi.org\/10.1186\/s10194-025-02011-5","DOI":"10.1186\/s10194-025-02011-5"}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-025-02012-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10194-025-02012-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-025-02012-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T08:59:11Z","timestamp":1745830751000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejournalofheadacheandpain.biomedcentral.com\/articles\/10.1186\/s10194-025-02012-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2012"],"URL":"https:\/\/doi.org\/10.1186\/s10194-025-02012-4","relation":{},"ISSN":["1129-2377"],"issn-type":[{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,28]]},"assertion":[{"value":"7 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declaration"}},{"value":"not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"91"}}