{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:57:01Z","timestamp":1783339021887,"version":"3.54.6"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Key Research and Development Program Project of Shaanxi province","award":["2020SF-335"],"award-info":[{"award-number":["2020SF-335"]}]},{"name":"Young Talent Development Program of Xi'an Ninth Hospital","award":["2020-5"],"award-info":[{"award-number":["2020-5"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"DOI":"10.1186\/s10194-025-02090-4","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:54:00Z","timestamp":1751378040000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification of comorbid genes between type 2 diabetes and migraine through peripheral blood single-cell and Mendelian randomization analysis"],"prefix":"10.1186","volume":"26","author":[{"given":"Bobo","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guogang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"2090_CR1","doi-asserted-by":"crossref","unstructured":"Hameed A, Galli M, Adamska-Patruno E, Kr\u0119towski A, Ciborowski M (2020) Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications.\u00a0Nutrients\u00a012(9):2538.","DOI":"10.3390\/nu12092538"},{"key":"2090_CR2","doi-asserted-by":"crossref","unstructured":"Peng W, Jian W, Li T, Malowany M, Tang X, Huang M, Wang Y, Ren Y (2023) Disparities of obesity and non-communicable disease burden between the Tibetan Plateau and developed megacities in China. Front Public Health 10:1070918.","DOI":"10.3389\/fpubh.2022.1070918"},{"issue":"9","key":"2090_CR3","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1111\/dme.12791","volume":"32","author":"N Holman","year":"2015","unstructured":"Holman N, Young B, Gadsby R (2015) Current prevalence of type 1 and type 2 diabetes in adults and children in the UK[J]. Diabet Med 32(9):1119\u20131120","journal-title":"Diabet Med"},{"issue":"5","key":"2090_CR4","doi-asserted-by":"publisher","first-page":"667","DOI":"10.4093\/dmj.2022.0215","volume":"46","author":"HJ Kim","year":"2022","unstructured":"Kim HJ, Kim KI (2022) Blood pressure target in type 2 diabetes Mellitus[J]. Diabetes Metab J 46(5):667\u2013674","journal-title":"Diabetes Metab J"},{"key":"2090_CR5","doi-asserted-by":"publisher","first-page":"1118848","DOI":"10.3389\/fendo.2023.1118848","volume":"14","author":"P Majety","year":"2023","unstructured":"Majety P, Lozada OF, Edem D et al (2023) Pharmacological approaches to the prevention of type 2 diabetes mellitus[J]. Front Endocrinol (Lausanne) 14:1118848","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"2090_CR6","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S1474-4422(24)00003-6","volume":"23","author":"CC Chiang","year":"2024","unstructured":"Chiang CC, Porreca F, Robertson CE et al (2024) Potential treatment targets for migraine: emerging options and future prospects[J]. Lancet Neurol 23(3):313\u2013324","journal-title":"Lancet Neurol"},{"issue":"2","key":"2090_CR7","doi-asserted-by":"publisher","first-page":"102208","DOI":"10.1016\/j.aprim.2021.102208","volume":"54","author":"AL Aguilar-Shea","year":"2022","unstructured":"Aguilar-Shea AL, Membrilla MJ, Diaz-de-Teran J (2022) Migraine review for general practice[J]. Aten Primaria 54(2):102208","journal-title":"Aten Primaria"},{"issue":"2","key":"2090_CR8","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2174\/1874467215666220211100256","volume":"16","author":"R Tiwari","year":"2023","unstructured":"Tiwari R, Tiwari G, Mishra S et al (2023) Preventive and therapeutic aspects of migraine for patient care: an Insight[J]. Curr Mol Pharmacol 16(2):147\u2013160","journal-title":"Curr Mol Pharmacol"},{"issue":"1","key":"2090_CR9","first-page":"17","volume":"99","author":"H Ha","year":"2019","unstructured":"Ha H, Gonzalez A (2019) Migraine headache Prophylaxis[J]. Am Fam Physician 99(1):17\u201324","journal-title":"Am Fam Physician"},{"issue":"9","key":"2090_CR10","doi-asserted-by":"publisher","first-page":"5809","DOI":"10.1007\/s12035-022-02930-3","volume":"59","author":"P Chaturvedi","year":"2022","unstructured":"Chaturvedi P, Khan R, Sahu P et al (2022) Role of omics in migraine research and management: A narrative Review[J]. Mol Neurobiol 59(9):5809\u20135834","journal-title":"Mol Neurobiol"},{"issue":"2","key":"2090_CR11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10194-010-0282-4","volume":"12","author":"F Antonaci","year":"2011","unstructured":"Antonaci F, Nappi G, Galli F et al (2011) Migraine and psychiatric comorbidity: a review of clinical findings[J]. J Headache Pain 12(2):115\u2013125","journal-title":"J Headache Pain"},{"issue":"1","key":"2090_CR12","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s10194-024-01889-x","volume":"25","author":"A Raggi","year":"2024","unstructured":"Raggi A, Leonardi M, Arruda M et al (2024) Hallmarks of primary headache: part 1 - migraine[J]. J Headache Pain 25(1):189","journal-title":"J Headache Pain"},{"key":"2090_CR13","doi-asserted-by":"crossref","unstructured":"Islam MR, The I H G C, Nyholt DR (2022) Genetic overlap analysis identifies a shared etiology between migraine and headache with type 2 Diabetes[J]. Genes (Basel) 13(10).","DOI":"10.3390\/genes13101845"},{"issue":"11","key":"2090_CR14","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1177\/0333102417748573","volume":"38","author":"IC Antonazzo","year":"2018","unstructured":"Antonazzo IC, Riise T, Cortese M et al (2018) Diabetes is associated with decreased migraine risk: A nationwide cohort study[J]. Cephalalgia 38(11):1759\u20131764","journal-title":"Cephalalgia"},{"key":"2090_CR15","doi-asserted-by":"crossref","unstructured":"Hagen K, Asvold BO, Midthjell K et al (2018) Cephalalgia 38(3):417\u2013426Inverse relationship between type 1 diabetes mellitus and migraine. Data from the Nord-Trondelag Health Surveys 1995\u20131997 and 2006\u20132008[J]","DOI":"10.1177\/0333102417690488"},{"issue":"13","key":"2090_CR16","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","volume":"184","author":"Y Hao","year":"2021","unstructured":"Hao Y, Hao S, Andersen-Nissen E et al (2021) Integrated analysis of multimodal single-cell data[J]. Cell 184(13):3573\u20133587","journal-title":"Cell"},{"issue":"5","key":"2090_CR17","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nbt.3192","volume":"33","author":"R Satija","year":"2015","unstructured":"Satija R, Farrell JA, Gennert D et al (2015) Spatial reconstruction of single-cell gene expression data[J]. Nat Biotechnol 33(5):495\u2013502","journal-title":"Nat Biotechnol"},{"issue":"4","key":"2090_CR18","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/imm.13863","volume":"173","author":"P Cruz-Granados","year":"2024","unstructured":"Cruz-Granados P, Frejo L, Perez-Carpena P et al (2024) Multiomic-based immune response profiling in migraine, vestibular migraine and meniere\u2019s disease[J]. Immunology 173(4):768\u2013779","journal-title":"Immunology"},{"issue":"5","key":"2090_CR19","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y et al (2012) ClusterProfiler: an R package for comparing biological themes among gene clusters[J]. OMICS 16(5):284\u2013287","journal-title":"OMICS"},{"key":"2090_CR20","doi-asserted-by":"publisher","first-page":"6777","DOI":"10.2147\/IJGM.S331864","volume":"14","author":"C Zheng","year":"2021","unstructured":"Zheng C, He MH, Huang JR et al (2021) Causal relationships between social isolation and osteoarthritis: A Mendelian randomization study in European Population[J]. Int J Gen Med 14:6777\u20136786","journal-title":"Int J Gen Med"},{"issue":"4","key":"2090_CR21","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"J Bowden","year":"2016","unstructured":"Bowden J, Davey SG, Haycock PC et al (2016) Consistent Estimation in Mendelian randomization with some invalid instruments using a weighted median Estimator[J]. Genet Epidemiol 40(4):304\u2013314","journal-title":"Genet Epidemiol"},{"issue":"5","key":"2090_CR22","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00393-018-0505-7","volume":"78","author":"YH Lee","year":"2019","unstructured":"Lee YH (2019) Causal association between smoking behavior and the decreased risk of osteoarthritis: a Mendelian randomization[J]. Z Rheumatol 78(5):461\u2013466","journal-title":"Z Rheumatol"},{"key":"2090_CR23","doi-asserted-by":"publisher","first-page":"795049","DOI":"10.3389\/fgene.2022.795049","volume":"13","author":"C Li","year":"2022","unstructured":"Li C, Niu M, Guo Z et al (2022) A mild causal relationship between tea consumption and obesity in general population: A Two-Sample Mendelian randomization Study[J]. Front Genet 13:795049","journal-title":"Front Genet"},{"issue":"6","key":"2090_CR24","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1093\/ije\/dyx102","volume":"46","author":"FP Hartwig","year":"2017","unstructured":"Hartwig FP, Davey SG, Bowden J (2017) Robust inference in summary data Mendelian randomization via the zero modal Pleiotropy assumption[J]. Int J Epidemiol 46(6):1985\u20131998","journal-title":"Int J Epidemiol"},{"issue":"3","key":"2090_CR25","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nmeth.4150","volume":"14","author":"X Qiu","year":"2017","unstructured":"Qiu X, Hill A, Packer J et al (2017) Single-cell mRNA quantification and differential analysis with Census[J]. Nat Methods 14(3):309\u2013315","journal-title":"Nat Methods"},{"issue":"2","key":"2090_CR26","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41436-019-0686-8","volume":"22","author":"ER Riggs","year":"2020","unstructured":"Riggs ER, Andersen EF, Cherry AM et al (2020) Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American college of medical genetics and genomics (ACMG) and the clinical genome resource (ClinGen)[J]. Genet Med 22(2):245\u2013257","journal-title":"Genet Med"},{"issue":"5","key":"2090_CR27","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.ajhg.2015.10.007","volume":"97","author":"MH Raza","year":"2015","unstructured":"Raza MH, Mattera R, Morell R et al (2015) Association between rare variants in AP4E1, a component of intracellular trafficking, and persistent Stuttering[J]. Am J Hum Genet 97(5):715\u2013725","journal-title":"Am J Hum Genet"},{"issue":"6","key":"2090_CR28","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.ajhg.2011.04.019","volume":"88","author":"JR Abou","year":"2011","unstructured":"Abou JR, Philippe O, Raas-Rothschild A et al (2011) Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature[J]. Am J Hum Genet 88(6):788\u2013795","journal-title":"Am J Hum Genet"},{"issue":"3","key":"2090_CR29","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1080\/15548627.2019.1615302","volume":"16","author":"D Ivankovic","year":"2020","unstructured":"Ivankovic D, Drew J, Lesept F et al (2020) Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome[J]. Autophagy 16(3):391\u2013407","journal-title":"Autophagy"},{"issue":"1","key":"2090_CR30","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1038\/s41467-021-21823-y","volume":"12","author":"G Novikova","year":"2021","unstructured":"Novikova G, Kapoor M, Tcw J et al (2021) Integration of alzheimer\u2019s disease genetics and myeloid genomics identifies disease risk regulatory elements and genes[J]. Nat Commun 12(1):1610","journal-title":"Nat Commun"},{"issue":"4","key":"2090_CR31","doi-asserted-by":"publisher","first-page":"e1007363","DOI":"10.1371\/journal.pgen.1007363","volume":"14","author":"R De Pace","year":"2018","unstructured":"De Pace R, Skirzewski M, Damme M et al (2018) Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome[J]. PLoS Genet 14(4):e1007363","journal-title":"PLoS Genet"},{"issue":"1","key":"2090_CR32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/ahg.12579","volume":"89","author":"DG Nandhini","year":"2025","unstructured":"Nandhini DG, Yadav N, Jayashankaran C et al (2025) Genetic analyses of a large consanguineous South Indian family reveal novel variants in NAGPA and four hitherto unreported genes in developmental stuttering[J]. Ann Hum Genet 89(1):31\u201346","journal-title":"Ann Hum Genet"},{"key":"2090_CR33","first-page":"163","volume":"7","author":"RB Penney","year":"2014","unstructured":"Penney RB, Lundgreen A, Yao-Borengasser A et al (2014) CYP19A1 single nucleotide polymorphism associations with CYP19A1, NFkappaB1, and IL6 gene expression in human normal colon and normal liver samples[J]. Pharmgenomics Pers Med 7:163\u2013171","journal-title":"Pharmgenomics Pers Med"},{"issue":"1","key":"2090_CR34","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s10194-019-1017-9","volume":"20","author":"HG Sutherland","year":"2019","unstructured":"Sutherland HG, Albury CL, Griffiths LR (2019). Advances in genetics of migraine[J]. J Headache Pain 20(1):72","journal-title":"J Headache Pain"},{"issue":"3","key":"2090_CR35","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1177\/0333102417690891","volume":"38","author":"V Chauvel","year":"2018","unstructured":"Chauvel V, Multon S, Schoenen J (2018) Estrogen-dependent effects of 5-hydroxytryptophan on cortical spreading depression in rat: modelling the serotonin-ovarian hormone interaction in migraine aura[J]. Cephalalgia 38(3):427\u2013436","journal-title":"Cephalalgia"},{"issue":"1","key":"2090_CR36","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s10194-023-01664-4","volume":"24","author":"B Raffaelli","year":"2023","unstructured":"Raffaelli B, Do TP, Chaudhry BA et al (2023) Menstrual migraine is caused by Estrogen withdrawal: revisiting the evidence[J]. J Headache Pain 24(1):131","journal-title":"J Headache Pain"},{"issue":"17","key":"2090_CR37","doi-asserted-by":"publisher","first-page":"e70034","DOI":"10.1096\/fj.202400333RR","volume":"38","author":"H Heikela","year":"2024","unstructured":"Heikela H, Mairinoja L, Ruohonen ST et al (2024) Disruption of HSD17B12 in mouse hepatocytes leads to reduced body weight and defect in the lipid droplet expansion associated with microvesicular steatosis[J]. FASEB J 38(17):e70034","journal-title":"FASEB J"},{"key":"2090_CR38","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.2147\/OTT.S136006","volume":"10","author":"Z Zhang","year":"2017","unstructured":"Zhang Z, Zou Y, Zhu J et al (2017) HSD17B12 gene rs11037575 C\u2009>\u2009T polymorphism confers neuroblastoma susceptibility in a Southern Chinese population[J]. Onco Targets Ther 10:1969\u20131975","journal-title":"Onco Targets Ther"},{"issue":"7","key":"2090_CR39","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/ng.3011","volume":"46","author":"DW Loth","year":"2014","unstructured":"Loth DW, Soler AM, Gharib SA et al (2014) Genome-wide association analysis identifies six new loci associated with forced vital capacity[J]. Nat Genet 46(7):669\u2013677","journal-title":"Nat Genet"},{"issue":"2","key":"2090_CR40","doi-asserted-by":"publisher","first-page":"e737","DOI":"10.1002\/ctm2.737","volume":"12","author":"Q Wang","year":"2022","unstructured":"Wang Q, Chen Q, Zhang Y et al (2022) HSD17B12 dosage insufficiency induced premature ovarian insufficiency in humans and mice[J]. Clin Transl Med 12(2):e737","journal-title":"Clin Transl Med"},{"issue":"2","key":"2090_CR41","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1210\/me.2005-0058","volume":"20","author":"V Luu-The","year":"2006","unstructured":"Luu-The V, Tremblay P, Labrie F (2006) Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women[J]. Mol Endocrinol 20(2):437\u2013443","journal-title":"Mol Endocrinol"},{"issue":"10","key":"2090_CR42","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.1210\/en.2016-1252","volume":"157","author":"H Kemilainen","year":"2016","unstructured":"Kemilainen H, Adam M, Maki-Jouppila J et al (2016) The hydroxysteroid (17beta) dehydrogenase family gene HSD17B12 is involved in the prostaglandin synthesis pathway, the ovarian function, and regulation of Fertility[J]. Endocrinology 157(10):3719\u20133730","journal-title":"Endocrinology"},{"issue":"6","key":"2090_CR43","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.2337\/db21-0804","volume":"71","author":"A Kulyte","year":"2022","unstructured":"Kulyte A, Aman A, Strawbridge RJ et al (2022) Genome-Wide association study identifies genetic loci associated with fat cell number and overlap with genetic risk loci for type 2 Diabetes[J]. Diabetes 71(6):1350\u20131362","journal-title":"Diabetes"},{"key":"2090_CR44","doi-asserted-by":"crossref","unstructured":"Hachim MY, Aljaibeji H, Hamoudi RA et al (2020) An integrative Phenotype-Genotype approach using phenotypic characteristics from the UAE National diabetes study identifies HSD17B12 as a candidate gene for obesity and type 2 diabetes[J]. Genes (Basel) 11(4).","DOI":"10.3390\/genes11040461"},{"issue":"3","key":"2090_CR45","doi-asserted-by":"publisher","first-page":"E494","DOI":"10.1152\/ajpendo.00042.2020","volume":"319","author":"H Heikela","year":"2020","unstructured":"Heikela H, Ruohonen ST, Adam M et al (2020) Hydroxysteroid (17beta) dehydrogenase 12 is essential for metabolic homeostasis in adult mice[J]. Am J Physiol Endocrinol Metab 319(3):E494\u2013E508","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2090_CR46","doi-asserted-by":"crossref","unstructured":"Zhou C, Wang M, Liang J et al (2022) Ketogenic diet benefits to weight loss, glycemic control, and lipid profiles in overweight patients with type 2 diabetes mellitus: A Meta-Analysis of randomized controlled Trails[J]. Int J Environ Res Public Health 19(16).","DOI":"10.3390\/ijerph191610429"},{"issue":"6","key":"2090_CR47","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1007\/s11695-020-04429-z","volume":"30","author":"A Di Vincenzo","year":"2020","unstructured":"Di Vincenzo A, Beghetto M, Vettor R et al (2020) Effects of surgical and Non-surgical weight loss on migraine headache: a systematic review and Meta-Analysis[J]. Obes Surg 30(6):2173\u20132185","journal-title":"Obes Surg"},{"key":"2090_CR48","doi-asserted-by":"publisher","first-page":"112003","DOI":"10.1016\/j.fct.2021.112003","volume":"149","author":"Y Ding","year":"2021","unstructured":"Ding Y, Xu T, Mao G et al (2021) Di-(2-ethylhexyl) phthalate-induced hepatotoxicity exacerbated type 2 diabetes mellitus (T2DM) in female pubertal T2DM mice[J]. Food Chem Toxicol 149:112003","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"2090_CR49","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.gastrohep.2012.07.010","volume":"36","author":"A Fernandez-Atutxa","year":"2013","unstructured":"Fernandez-Atutxa A, Vergara M, Gil M et al (2013) [Rizatriptan-induced liver toxicity. Report of a case][J]. Gastroenterol Hepatol 36(4):261\u2013263","journal-title":"Gastroenterol Hepatol"},{"key":"2090_CR50","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.freeradbiomed.2024.01.018","volume":"213","author":"A Ardizzone","year":"2024","unstructured":"Ardizzone A, Capra AP, Repici A et al (2024) Rebalancing NOX2\/Nrf2 to limit inflammation and oxidative stress across gut-brain axis in migraine[J]. Free Radic Biol Med 213:65\u201378","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"2090_CR51","doi-asserted-by":"publisher","first-page":"e16340","DOI":"10.1016\/j.heliyon.2023.e16340","volume":"9","author":"W Jiang","year":"2023","unstructured":"Jiang W, Ding K, Huang W et al (2023) Potential effects of bisphenol A on diabetes mellitus and its chronic complications: A narrative review[J]. Heliyon 9(5):e16340","journal-title":"Heliyon"},{"issue":"2","key":"2090_CR52","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1093\/toxsci\/kft245","volume":"137","author":"LM Vermeer","year":"2014","unstructured":"Vermeer LM, Gregory E, Winter MK et al (2014) Exposure to bisphenol A exacerbates migraine-like behaviors in a multibehavior model of rat migraine[J]. Toxicol Sci 137(2):416\u2013427","journal-title":"Toxicol Sci"},{"key":"2090_CR53","doi-asserted-by":"crossref","unstructured":"Cho HM, Seok YM, Lee HA et al (2018) Repression of transcriptional activity of forkhead box O1 by histone deacetylase inhibitors ameliorates hyperglycemia in type 2 diabetic Rats[J]. Int J Mol Sci 19(11)","DOI":"10.3390\/ijms19113539"},{"issue":"1","key":"2090_CR54","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s10194-023-01594-1","volume":"24","author":"C Lampl","year":"2023","unstructured":"Lampl C, MaassenVanDenBrink A, Deligianni CI et al (2023) The comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis[J]. J Headache Pain 24(1):56","journal-title":"J Headache Pain"},{"issue":"3","key":"2090_CR55","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.humimm.2023.01.002","volume":"84","author":"Z Sardarmelli","year":"2023","unstructured":"Sardarmelli Z, Sheikh V, Solgi G et al (2023) Enhanced production of interleukin-29 and related genes are associated with T helper 1 cell parameters in patients with type 2 diabetes mellitus[J]. Hum Immunol 84(3):235\u2013240","journal-title":"Hum Immunol"},{"issue":"1","key":"2090_CR56","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5114\/ceji.2020.94670","volume":"45","author":"JM Guzman-Flores","year":"2020","unstructured":"Guzman-Flores JM, Ramirez-Emiliano J, Perez-Vazquez V et al (2020) Th17 and regulatory T cells in patients with different time of progression of type 2 diabetes mellitus[J]. Cent Eur J Immunol 45(1):29\u201336","journal-title":"Cent Eur J Immunol"},{"issue":"4","key":"2090_CR57","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1155\/2013\/931915","volume":"35","author":"F Mahmoud","year":"2013","unstructured":"Mahmoud F, Al-Ozairi E (2013) Inflammatory cytokines and the risk of cardiovascular complications in type 2 diabetes[J]. Dis Markers 35(4):235\u2013241","journal-title":"Dis Markers"},{"issue":"1","key":"2090_CR58","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/oby.21243","volume":"24","author":"B Ip","year":"2016","unstructured":"Ip B, Cilfone NA, Belkina AC et al (2016) Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFalpha production[J]. Obes (Silver Spring) 24(1):102\u2013112","journal-title":"Obes (Silver Spring)"},{"key":"2090_CR59","doi-asserted-by":"publisher","first-page":"678355","DOI":"10.3389\/fimmu.2021.678355","volume":"12","author":"S Zhang","year":"2021","unstructured":"Zhang S, Gang X, Yang S et al (2021) The alterations in and the role of the Th17\/Treg balance in metabolic Diseases[J]. Front Immunol 12:678355","journal-title":"Front Immunol"},{"key":"2090_CR60","doi-asserted-by":"publisher","first-page":"112156","DOI":"10.1016\/j.mce.2024.112156","volume":"584","author":"D Wang","year":"2024","unstructured":"Wang D, Zhang Q, Dong W et al (2024) SGLT2 knockdown restores the Th17\/Treg balance and suppresses diabetic nephropathy in db\/db mice by regulating SGK1 via Na()[J]. Mol Cell Endocrinol 584:112156","journal-title":"Mol Cell Endocrinol"},{"key":"2090_CR61","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.clim.2018.09.005","volume":"197","author":"M Wang","year":"2018","unstructured":"Wang M, Chen F, Wang J et al (2018) Th17 and Treg lymphocytes in obesity and type 2 diabetic patients[J]. Clin Immunol 197:77\u201385","journal-title":"Clin Immunol"},{"issue":"12","key":"2090_CR62","doi-asserted-by":"publisher","first-page":"9375","DOI":"10.1002\/jcp.26518","volume":"233","author":"K Xie","year":"2018","unstructured":"Xie K, Xu B, Zhang Y et al (2018) A multi-method evaluation of the effects of inflammatory cytokines (IL-1beta, IFN-gamma, TNF-alpha) on pancreatic beta-cells[J]. J Cell Physiol 233(12):9375\u20139382","journal-title":"J Cell Physiol"},{"issue":"12","key":"2090_CR63","doi-asserted-by":"publisher","first-page":"7165","DOI":"10.4049\/jimmunol.0902583","volume":"185","author":"S Augier","year":"2010","unstructured":"Augier S, Ciucci T, Luci C et al (2010) Inflammatory blood monocytes contribute to tumor development and represent a privileged target to improve host immunosurveillance[J]. J Immunol 185(12):7165\u20137173","journal-title":"J Immunol"},{"issue":"8","key":"2090_CR64","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/s41582-019-0216-y","volume":"15","author":"L Edvinsson","year":"2019","unstructured":"Edvinsson L, Haanes KA, Warfvinge K (2019) Does inflammation have a role in migraine?[J]. Nat Rev Neurol 15(8):483\u2013490","journal-title":"Nat Rev Neurol"},{"key":"2090_CR65","doi-asserted-by":"crossref","unstructured":"Yamanaka G, Suzuki S, Morishita N et al (2021) Role of neuroinflammation and Blood-Brain barrier permutability on Migraine[J]. Int J Mol Sci 22(16)","DOI":"10.3390\/ijms22168929"},{"issue":"3","key":"2090_CR66","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00281-018-0676-y","volume":"40","author":"R Ramachandran","year":"2018","unstructured":"Ramachandran R (2018) Neurogenic inflammation and its role in migraine[J]. Semin Immunopathol 40(3):301\u2013314","journal-title":"Semin Immunopathol"},{"key":"2090_CR67","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.npep.2015.03.006","volume":"52","author":"J Tajti","year":"2015","unstructured":"Tajti J, Szok D, Majlath Z et al (2015) Migraine and neuropeptides[J]. Neuropeptides 52:19\u201330","journal-title":"Neuropeptides"},{"issue":"2","key":"2090_CR68","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/BF02335750","volume":"14","author":"V Gallai","year":"1993","unstructured":"Gallai V, Sarchielli P, Trequattrini A et al (1993) Monocyte chemotactic and phagocytic responses in migraine and tension-type headache patients[J]. Ital J Neurol Sci 14(2):153\u2013164","journal-title":"Ital J Neurol Sci"},{"key":"2090_CR69","doi-asserted-by":"crossref","unstructured":"Lee SH, Kim JH, Kwon YS et al (2022) Role of peripheral inflammatory markers in patients with acute headache attack to differentiate between migraine and Non-Migraine headache[J]. J Clin Med 11(21).","DOI":"10.3390\/jcm11216538"},{"issue":"3","key":"2090_CR70","doi-asserted-by":"publisher","first-page":"277","DOI":"10.4103\/aian.AIAN_371_18","volume":"22","author":"D Han","year":"2019","unstructured":"Han D (2019) Association of serum levels of calcitonin Gene-related peptide and cytokines during migraine Attacks[J]. Ann Indian Acad Neurol 22(3):277\u2013281","journal-title":"Ann Indian Acad Neurol"},{"issue":"14","key":"2090_CR71","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1177\/03331024221118924","volume":"42","author":"J Thuraiaiyah","year":"2022","unstructured":"Thuraiaiyah J, Erritzoe-Jervild M, Al-Khazali HM et al (2022) The role of cytokines in migraine: A systematic review[J]. Cephalalgia 42(14):1565\u20131588","journal-title":"Cephalalgia"},{"issue":"8","key":"2090_CR72","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1038\/sj.bjp.0701306","volume":"121","author":"SE Rayner","year":"1997","unstructured":"Rayner SE, Van Helden DF (1997) Evidence that the substance P-induced enhancement of pacemaking in lymphatics of the guinea-pig mesentery occurs through endothelial release of thromboxane A2[J]. Br J Pharmacol 121(8):1589\u20131596","journal-title":"Br J Pharmacol"},{"issue":"4","key":"2090_CR73","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1177\/039463201202500403","volume":"25","author":"M Nicoletti","year":"2012","unstructured":"Nicoletti M, Neri G, Maccauro G et al (2012) Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation[J]. Int J Immunopathol Pharmacol 25(4):849\u2013857","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"5","key":"2090_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.JAA.0000000000000014","volume":"37","author":"T Hervias","year":"2024","unstructured":"Hervias T (2024) An update on migraine: current and new treatment options[J]. JAAPA 37(5):1\u20137","journal-title":"JAAPA"},{"key":"2090_CR75","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/B978-0-12-823357-3.00024-0","volume":"199","author":"E Caronna","year":"2024","unstructured":"Caronna E, Alpuente A, Torres-Ferrus M et al (2024) CGRP monoclonal antibodies and CGRP receptor antagonists (Gepants) in migraine prevention[J]. Handb Clin Neurol 199:107\u2013124","journal-title":"Handb Clin Neurol"},{"key":"2090_CR76","doi-asserted-by":"crossref","unstructured":"Zobdeh F, Eremenko II, Akan MA et al (2023) The epigenetics of Migraine[J]. Int J Mol Sci 24(11)","DOI":"10.3390\/ijms24119127"}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-025-02090-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10194-025-02090-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-025-02090-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T02:04:30Z","timestamp":1751421870000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejournalofheadacheandpain.biomedcentral.com\/articles\/10.1186\/s10194-025-02090-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":76,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2090"],"URL":"https:\/\/doi.org\/10.1186\/s10194-025-02090-4","relation":{},"ISSN":["1129-2377"],"issn-type":[{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"26 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All data analyzed during this study have been previously published.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"151"}}