{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:08:30Z","timestamp":1789002510259,"version":"build-2803163510"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":77,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"DOI":"10.1186\/s10194-026-02433-9","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:26:05Z","timestamp":1782390365000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dissecting the shared genetic architecture between migraine subtypes and cardiovascular diseases: a multi-layered genomic analysis"],"prefix":"10.1186","volume":"27","author":[{"given":"Yiming","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"issue":"19","key":"2433_CR1","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1056\/NEJMra1915327","volume":"383","author":"M Ashina","year":"2020","unstructured":"Ashina M, Migraine (2020) N Engl J Med 383(19):1866\u20131876","journal-title":"N Engl J Med"},{"key":"2433_CR2","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) (2018) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 38(1):1\u2013211","DOI":"10.1177\/0333102417738202"},{"issue":"1","key":"2433_CR3","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s10194-022-01402-2","volume":"23","author":"LJ Stovner","year":"2022","unstructured":"Stovner LJ, Hagen K, Linde M, Steiner TJ (2022) The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates. J Headache Pain 23(1):34","journal-title":"J Headache Pain"},{"issue":"10258","key":"2433_CR4","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","volume":"396","author":"GBD Diseases","year":"2020","unstructured":"Diseases GBD, Injuries C (2020) Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396(10258):1204\u20131222","journal-title":"Lancet"},{"issue":"1","key":"2433_CR5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41572-021-00328-4","volume":"8","author":"MD Ferrari","year":"2022","unstructured":"Ferrari MD, Goadsby PJ, Burstein R, Kurth T, Ayata C, Charles A et al (2022) Migraine Nat Rev Dis Primers 8(1):2","journal-title":"Migraine Nat Rev Dis Primers"},{"issue":"2","key":"2433_CR6","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/s41588-021-00990-0","volume":"54","author":"H Hautakangas","year":"2022","unstructured":"Hautakangas H, Winsvold BS, Ruotsalainen SE, Bjornsdottir G, Harder AVE, Kogelman LJA et al (2022) Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles. Nat Genet 54(2):152\u2013160","journal-title":"Nat Genet"},{"issue":"25","key":"2433_CR7","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","volume":"76","author":"GA Roth","year":"2020","unstructured":"Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM et al (2020) Global Burden of Cardiovascular Diseases and Risk Factors, 1990\u20132019: Update From the GBD 2019 Study. J Am Coll Cardiol 76(25):2982\u20133021","journal-title":"J Am Coll Cardiol"},{"key":"2433_CR8","doi-asserted-by":"publisher","first-page":"k96","DOI":"10.1136\/bmj.k96","volume":"360","author":"K Adelborg","year":"2018","unstructured":"Adelborg K, Szepligeti SK, Holland-Bill L, Ehrenstein V, Horvath-Puho E, Henderson VW et al (2018) Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ 360:k96","journal-title":"BMJ"},{"key":"2433_CR9","doi-asserted-by":"publisher","first-page":"i2610","DOI":"10.1136\/bmj.i2610","volume":"353","author":"T Kurth","year":"2016","unstructured":"Kurth T, Winter AC, Eliassen AH, Dushkes R, Mukamal KJ, Rimm EB et al (2016) Migraine and risk of cardiovascular disease in women: prospective cohort study. BMJ 353:i2610","journal-title":"BMJ"},{"key":"2433_CR10","doi-asserted-by":"publisher","first-page":"b3914","DOI":"10.1136\/bmj.b3914","volume":"339","author":"M Schurks","year":"2009","unstructured":"Schurks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T (2009) Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 339:b3914","journal-title":"BMJ"},{"issue":"30","key":"2433_CR11","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1093\/eurheartj\/ehad363","volume":"44","author":"DN Kalkman","year":"2023","unstructured":"Kalkman DN, Couturier EGM, El Bouziani A, Dahdal J, Neefs J, Woudstra J et al (2023) Migraine and cardiovascular disease: what cardiologists should know. Eur Heart J 44(30):2815\u20132828","journal-title":"Eur Heart J"},{"issue":"34","key":"2433_CR12","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","volume":"42","author":"FLJ Visseren","year":"2021","unstructured":"Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Back M et al (2021) 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J 42(34):3227\u20133337","journal-title":"Eur Heart J"},{"issue":"8","key":"2433_CR13","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1212\/WNL.0b013e3181d0cc8b","volume":"74","author":"ME Bigal","year":"2010","unstructured":"Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M et al (2010) Migraine and cardiovascular disease: a population-based study. Neurology 74(8):628\u2013635","journal-title":"Neurology"},{"issue":"15","key":"2433_CR14","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1212\/WNL.0000000000201699","volume":"100","author":"S Sacco","year":"2023","unstructured":"Sacco S, Harriott AM, Ayata C, Ornello R, Bagur R, Jimenez-Ruiz A et al (2023) Microembolism and Other Links Between Migraine and Stroke: Clinical and Pathophysiologic Update. Neurology 100(15):716\u2013726","journal-title":"Neurology"},{"issue":"9","key":"2433_CR15","doi-asserted-by":"publisher","first-page":"e0185663","DOI":"10.1371\/journal.pone.0185663","volume":"12","author":"BS Winsvold","year":"2017","unstructured":"Winsvold BS, Bettella F, Witoelar A, Anttila V, Gormley P, Kurth T et al (2017) Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants. PLoS ONE 12(9):e0185663","journal-title":"PLoS ONE"},{"issue":"1","key":"2433_CR16","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1212\/NXG.0000000000000010","volume":"1","author":"BS Winsvold","year":"2015","unstructured":"Winsvold BS, Nelson CP, Malik R, Gormley P, Anttila V, Vander Heiden J et al (2015) Genetic analysis for a shared biological basis between migraine and coronary artery disease. Neurol Genet 1(1):e10","journal-title":"Neurol Genet"},{"issue":"1","key":"2433_CR17","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s10194-024-01836-w","volume":"25","author":"X Duan","year":"2024","unstructured":"Duan X, Du X, Zheng G, Zhou X, Tan N, Li G et al (2024) Causality between migraine and cardiovascular disease: a bidirectional Mendelian randomization study. J Headache Pain 25(1):130","journal-title":"J Headache Pain"},{"issue":"3","key":"2433_CR18","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.jaci.2020.07.004","volume":"147","author":"Z Zhu","year":"2021","unstructured":"Zhu Z, Hasegawa K, Camargo CA Jr., Liang L (2021) Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis. J Allergy Clin Immunol 147(3):796\u2013807","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"2433_CR19","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/j.ajhg.2022.05.015","volume":"109","author":"X Wu","year":"2022","unstructured":"Wu X, Xiao C, Han Z, Zhang L, Zhao X, Hao Y et al (2022) Investigating the shared genetic architecture of uterine leiomyoma and breast cancer: A genome-wide cross-trait analysis. Am J Hum Genet 109(7):1272\u20131285","journal-title":"Am J Hum Genet"},{"issue":"5","key":"2433_CR20","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE et al (2016) Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet 48(5):481\u2013487","journal-title":"Nat Genet"},{"issue":"7","key":"2433_CR21","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/gepi.21998","volume":"40","author":"S Burgess","year":"2016","unstructured":"Burgess S, Davies NM, Thompson SG (2016) Bias due to participant overlap in two-sample Mendelian randomization. Genet Epidemiol 40(7):597\u2013608","journal-title":"Genet Epidemiol"},{"issue":"11","key":"2433_CR22","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ng.3406","volume":"47","author":"B Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan B, Finucane HK, Anttila V, Gusev A, Day FR, Loh PR et al (2015) An atlas of genetic correlations across human diseases and traits. Nat Genet 47(11):1236\u20131241","journal-title":"Nat Genet"},{"issue":"8","key":"2433_CR23","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/s41588-020-0653-y","volume":"52","author":"Z Ning","year":"2020","unstructured":"Ning Z, Pawitan Y, Shen X (2020) High-definition likelihood inference of genetic correlations across human complex traits. Nat Genet 52(8):859\u2013864","journal-title":"Nat Genet"},{"issue":"3","key":"2433_CR24","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng.3211","volume":"47","author":"BK Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan BK, Loh PR, Finucane HK, Ripke S, Yang J, Schizophrenia Working Group of the Psychiatric Genomics C (2015) LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 47(3):291\u2013295","journal-title":"Nat Genet"},{"issue":"7571","key":"2433_CR25","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","volume":"526","author":"C Genomes Project","year":"2015","unstructured":"Genomes Project C, Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM et al (2015) A global reference for human genetic variation. Nature 526(7571):68\u201374","journal-title":"Nature"},{"issue":"1","key":"2433_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1023\/A:1008800423698","volume":"9","author":"FMTA Busing","year":"1999","unstructured":"Busing FMTA, Meijer E, Leeden RVD (1999) Delete-m Jackknife for Unequal m. Stat Comput 9(1):3\u20138","journal-title":"Stat Comput"},{"key":"2433_CR27","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/978-1-4939-7274-6_22","volume":"1666","author":"X Li","year":"2017","unstructured":"Li X, Zhu X (2017) Cross-Phenotype Association Analysis Using Summary Statistics from GWAS. Methods Mol Biol 1666:455\u2013467","journal-title":"Methods Mol Biol"},{"issue":"12","key":"2433_CR28","doi-asserted-by":"publisher","first-page":"e1009218","DOI":"10.1371\/journal.pgen.1009218","volume":"16","author":"D Ray","year":"2020","unstructured":"Ray D, Chatterjee N (2020) A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer. PLoS Genet 16(12):e1009218","journal-title":"PLoS Genet"},{"issue":"3","key":"2433_CR29","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81(3):559\u2013575","journal-title":"Am J Hum Genet"},{"issue":"5","key":"2433_CR30","doi-asserted-by":"publisher","first-page":"e1004383","DOI":"10.1371\/journal.pgen.1004383","volume":"10","author":"C Giambartolomei","year":"2014","unstructured":"Giambartolomei C, Vukcevic D, Schadt EE, Franke L, Hingorani AD, Wallace C et al (2014) Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet 10(5):e1004383","journal-title":"PLoS Genet"},{"issue":"12","key":"2433_CR31","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/s10038-023-01186-6","volume":"68","author":"H Li","year":"2023","unstructured":"Li H, Zhang Z, Qiu Y, Weng H, Yuan S, Zhang Y et al (2023) Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development. J Hum Genet 68(12):805\u2013812","journal-title":"J Hum Genet"},{"issue":"D1","key":"2433_CR32","doi-asserted-by":"publisher","first-page":"D925","DOI":"10.1093\/nar\/gkae977","volume":"53","author":"L Phan","year":"2025","unstructured":"Phan L, Zhang H, Wang Q, Villamarin R, Hefferon T, Ramanathan A et al (2025) The evolution of dbSNP: 25 years of impact in genomic research. Nucleic Acids Res 53(D1):D925\u2013D31","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"2433_CR33","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1038\/s41588-020-0684-4","volume":"52","author":"V Orru","year":"2020","unstructured":"Orru V, Steri M, Sidore C, Marongiu M, Serra V, Olla S et al (2020) Complex genetic signatures in immune cells underlie autoimmunity and inform therapy. Nat Genet 52(10):1036\u20131045","journal-title":"Nat Genet"},{"issue":"3","key":"2433_CR34","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/ije\/dyr036","volume":"40","author":"S Burgess","year":"2011","unstructured":"Burgess S, Thompson SG, Collaboration CCG (2011) Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol 40(3):755\u2013764","journal-title":"Int J Epidemiol"},{"issue":"4","key":"2433_CR35","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"J Bowden","year":"2016","unstructured":"Bowden J, Davey Smith G, Haycock PC, Burgess S (2016) Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Genet Epidemiol 40(4):304\u2013314","journal-title":"Genet Epidemiol"},{"issue":"20","key":"2433_CR36","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1002\/(SICI)1097-0258(19991030)18:20<2693::AID-SIM235>3.0.CO;2-V","volume":"18","author":"SG Thompson","year":"1999","unstructured":"Thompson SG, Sharp SJ (1999) Explaining heterogeneity in meta-analysis: a comparison of methods. Stat Med 18(20):2693\u20132708","journal-title":"Stat Med"},{"issue":"6","key":"2433_CR37","first-page":"1961","volume":"45","author":"J Bowden","year":"2016","unstructured":"Bowden J, Del Greco MF, Minelli C, Davey Smith G, Sheehan NA, Thompson JR (2016) Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic. Int J Epidemiol 45(6):1961\u20131974","journal-title":"Int J Epidemiol"},{"issue":"5","key":"2433_CR38","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","volume":"32","author":"S Burgess","year":"2017","unstructured":"Burgess S, Thompson SG (2017) Interpreting findings from Mendelian randomization using the MR-Egger method. Eur J Epidemiol 32(5):377\u2013389","journal-title":"Eur J Epidemiol"},{"issue":"1","key":"2433_CR39","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/ng.3154","volume":"47","author":"S Debette","year":"2015","unstructured":"Debette S, Kamatani Y, Metso TM, Kloss M, Chauhan G, Engelter ST et al (2015) Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection. Nat Genet 47(1):78\u201383","journal-title":"Nat Genet"},{"key":"2433_CR40","doi-asserted-by":"publisher","first-page":"958677","DOI":"10.3389\/fimmu.2022.958677","volume":"13","author":"X Ma","year":"2022","unstructured":"Ma X, Su M, He Q, Zhang Z, Zhang F, Liu Z et al (2022) PHACTR1, a coronary artery disease risk gene, mediates endothelial dysfunction. Front Immunol 13:958677","journal-title":"Front Immunol"},{"issue":"3","key":"2433_CR41","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.cell.2017.06.049","volume":"170","author":"RM Gupta","year":"2017","unstructured":"Gupta RM, Hadaya J, Trehan A, Zekavat SM, Roselli C, Klarin D et al (2017) A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression. Cell 170(3):522\u2013533 e15","journal-title":"Cell"},{"issue":"5","key":"2433_CR42","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1161\/ATVBAHA.122.317539","volume":"42","author":"RM Gupta","year":"2022","unstructured":"Gupta RM (2022) Causal Gene Confusion: The Complicated EDN1\/PHACTR1 Locus for Coronary Artery Disease. Arterioscler Thromb Vasc Biol 42(5):610\u2013612","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"2433_CR43","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1038\/s41588-022-01233-6","volume":"54","author":"KG Aragam","year":"2022","unstructured":"Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS et al (2022) Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Nat Genet 54(12):1803\u20131815","journal-title":"Nat Genet"},{"key":"2433_CR44","first-page":"641917","volume":"2012","author":"H Zhang","year":"2012","unstructured":"Zhang H, Mooney CJ, Reilly MP (2012) ABO Blood Groups and Cardiovascular Diseases. Int J Vasc Med 2012:641917","journal-title":"Int J Vasc Med"},{"issue":"21","key":"2433_CR45","doi-asserted-by":"publisher","first-page":"5298","DOI":"10.1182\/blood-2008-11-190389","volume":"113","author":"DA Tregouet","year":"2009","unstructured":"Tregouet DA, Heath S, Saut N, Biron-Andreani C, Schved JF, Pernod G et al (2009) Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood 113(21):5298\u20135303","journal-title":"Blood"},{"issue":"6","key":"2433_CR46","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1161\/CIRCGENETICS.111.960682","volume":"4","author":"S Kiechl","year":"2011","unstructured":"Kiechl S, Pare G, Barbalic M, Qi L, Dupuis J, Dehghan A et al (2011) Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis. Circ Cardiovasc Genet 4(6):681\u2013686","journal-title":"Circ Cardiovasc Genet"},{"issue":"1","key":"2433_CR47","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1038\/s41467-024-47178-8","volume":"15","author":"XY He","year":"2024","unstructured":"He XY, Wu BS, Yang L, Guo Y, Deng YT, Li ZY et al (2024) Genetic associations of protein-coding variants in venous thromboembolism. Nat Commun 15(1):2819","journal-title":"Nat Commun"},{"issue":"4","key":"2433_CR48","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/ng.784","volume":"43","author":"H Schunkert","year":"2011","unstructured":"Schunkert H, Konig IR, Kathiresan S, Reilly MP, Assimes TL, Holm H et al (2011) Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 43(4):333\u2013338","journal-title":"Nat Genet"},{"issue":"1","key":"2433_CR49","doi-asserted-by":"publisher","first-page":"e653","DOI":"10.1212\/NXG.0000000000000653","volume":"8","author":"I Daghlas","year":"2022","unstructured":"Daghlas I, Sargurupremraj M, Danning R, Gormley P, Malik R, Amouyel P et al (2022) Migraine, Stroke, and Cervical Arterial Dissection: Shared Genetics for a Triad of Brain Disorders With Vascular Involvement. Neurol Genet 8(1):e653","journal-title":"Neurol Genet"},{"key":"2433_CR50","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.semcdb.2016.07.021","volume":"63","author":"AJ Lilly","year":"2017","unstructured":"Lilly AJ, Lacaud G, Kouskoff V (2017) SOXF transcription factors in cardiovascular development. Semin Cell Dev Biol 63:50\u201357","journal-title":"Semin Cell Dev Biol"},{"issue":"12","key":"2433_CR51","doi-asserted-by":"publisher","first-page":"e0143650","DOI":"10.1371\/journal.pone.0143650","volume":"10","author":"Y Zhou","year":"2015","unstructured":"Zhou Y, Williams J, Smallwood PM, Nathans J (2015) Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PLoS ONE 10(12):e0143650","journal-title":"PLoS ONE"},{"issue":"43","key":"2433_CR52","doi-asserted-by":"publisher","first-page":"29873","DOI":"10.1074\/jbc.M109.059303","volume":"284","author":"K Taniguchi","year":"2009","unstructured":"Taniguchi K, Takeya R, Suetsugu S, Kan OM, Narusawa M, Shiose A et al (2009) Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles. J Biol Chem 284(43):29873\u201329881","journal-title":"J Biol Chem"},{"issue":"20","key":"2433_CR53","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1016\/j.jacc.2018.10.001","volume":"72","author":"JP Ochoa","year":"2018","unstructured":"Ochoa JP, Sabater-Molina M, Garcia-Pinilla JM, Mogensen J, Restrepo-Cordoba A, Palomino-Doza J et al (2018) Formin Homology 2 Domain Containing 3 (FHOD3) Is a Genetic Basis for Hypertrophic Cardiomyopathy. J Am Coll Cardiol 72(20):2457\u20132467","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2433_CR54","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13287-026-04902-z","volume":"17","author":"M Wei","year":"2026","unstructured":"Wei M, Hou X, Zhang S, Hu X, Chen X, Gao Z et al (2026) FHOD3 deficiency disrupts sarcomere organization and activates caMKII signaling in human stem cell-derived cardiomyocytes. Stem Cell Res Ther 17(1):82","journal-title":"Stem Cell Res Ther"},{"issue":"22","key":"2433_CR55","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1001\/jama.2020.7172","volume":"323","author":"T Kurth","year":"2020","unstructured":"Kurth T, Rist PM, Ridker PM, Kotler G, Bubes V, Buring JE (2020) Association of Migraine With Aura and Other Risk Factors With Incident Cardiovascular Disease in Women. JAMA 323(22):2281\u20132289","journal-title":"JAMA"},{"issue":"26","key":"2433_CR56","doi-asserted-by":"publisher","first-page":"15706","DOI":"10.1073\/pnas.2432067100","volume":"100","author":"BJ Libby","year":"2003","unstructured":"Libby BJ, Reinholdt LG, Schimenti JC (2003) Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice. Proc Natl Acad Sci U S A 100(26):15706\u201315711","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6144","key":"2433_CR57","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1126\/science.1236758","volume":"341","author":"J Suzuki","year":"2013","unstructured":"Suzuki J, Denning DP, Imanishi E, Horvitz HR, Nagata S (2013) Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 341(6144):403\u2013406","journal-title":"Science"},{"issue":"7538","key":"2433_CR58","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature14177","volume":"518","author":"AE Locke","year":"2015","unstructured":"Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR et al (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature 518(7538):197\u2013206","journal-title":"Nature"},{"issue":"3","key":"2433_CR59","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1152\/physrev.00027.2014","volume":"95","author":"C Ayata","year":"2015","unstructured":"Ayata C, Lauritzen M, Spreading, Depression (2015) Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev 95(3):953\u2013993","journal-title":"Physiol Rev"},{"key":"2433_CR60","doi-asserted-by":"publisher","first-page":"173205","DOI":"10.1016\/j.ejphar.2020.173205","volume":"881","author":"I Sohn","year":"2020","unstructured":"Sohn I, Sheykhzade M, Edvinsson L, Sams A (2020) The effects of CGRP in vascular tissue - Classical vasodilation, shadowed effects and systemic dilemmas. Eur J Pharmacol 881:173205","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"2433_CR61","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1161\/CIRCULATIONAHA.117.028388","volume":"136","author":"AA Aubdool","year":"2017","unstructured":"Aubdool AA, Thakore P, Argunhan F, Smillie SJ, Schnelle M, Srivastava S et al (2017) A Novel alpha-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure. Circulation 136(4):367\u2013383","journal-title":"Circulation"},{"issue":"9","key":"2433_CR62","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.tips.2016.06.002","volume":"37","author":"A MaassenVanDenBrink","year":"2016","unstructured":"MaassenVanDenBrink A, Meijer J, Villalon CM, Ferrari MD (2016) Wiping Out CGRP: Potential Cardiovascular Risks. Trends Pharmacol Sci 37(9):779\u2013788","journal-title":"Trends Pharmacol Sci"},{"issue":"17","key":"2433_CR63","doi-asserted-by":"publisher","first-page":"e1897","DOI":"10.1212\/WNL.0000000000201008","volume":"99","author":"S de Vries Lentsch","year":"2022","unstructured":"de Vries Lentsch S, van der Arend BWH, Maassen VanDenBrink A, Terwindt GM (2022) Blood Pressure in Patients With Migraine Treated With Monoclonal Anti-CGRP (Receptor) Antibodies: A Prospective Follow-up Study. Neurology 99(17):e1897\u2013e904","journal-title":"Neurology"}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10194-026-02433-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-026-02433-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-026-02433-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:02:49Z","timestamp":1789002169000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s10194-026-02433-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2433"],"URL":"https:\/\/doi.org\/10.1186\/s10194-026-02433-9","relation":{},"ISSN":["1129-2377"],"issn-type":[{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"12 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval was obtained for all the original studies involved. Furthermore, since no individual-level data were utilized in this study, no additional ethical review board approval was necessary.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This manuscript does not include details, images, or videos relating to an individual person; therefore, consent for publication is not needed beyond the informed consent provided by all study participants as described above.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"223"}}