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This study aimed to evaluate the diagnostic effectiveness of serum CRP, ESR, plasma <jats:sc>D<\/jats:sc>-dimer, and fibrinogen values in groups achieving treatment success or failure for PJI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 119 PJI cases between January 2012 and January 2017 were identified and included in this study. The most recent serum CRP, ESR, plasma <jats:sc>D<\/jats:sc>-dimer, and fibrinogen values obtained prior to performing second-stage revision or spacer exchange were collected for analysis. Treatment failure was defined as having been unable to undergo reimplantation due to clinically persistent infection or reinfection after reimplantation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All these tests showed significantly lower values in the treatment success group than in the treatment failure group. The optimal cutoff serum CRP, ESR, plasma <jats:sc>D<\/jats:sc>-dimer, and fibrinogen levels for predicting the success of reimplantation were 9.4\u00a0mg\/L, 29\u00a0mm\/h, 1740\u00a0ng\/mL, and 365.6\u00a0mg\/dL, respectively. All tests had the same sensitivity (72.7%) except for ESR (63.6%), while their specificities were 92.6%, 88.0%, 72.3%, and 83.2%, respectively. Plasma fibrinogen had the highest AUC value of 0.831 [95% confidence interval (CI), 0.685 to 0.978], followed by serum CRP (0.829) and ESR (0.795); plasma <jats:sc>D<\/jats:sc>-dimer had the lowest AUC value of 0.716 (95% CI, 0.573 to 0.859).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Plasma CRP and fibrinogen are good tests for predicting reimplantation success after two-stage revision procedures for patients with PJI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s10195-022-00664-5","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T10:04:54Z","timestamp":1663322694000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Which serum markers predict the success of reimplantation after periprosthetic joint infection?"],"prefix":"10.1186","volume":"23","author":[{"given":"Hongyi","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"664_CR1","doi-asserted-by":"crossref","unstructured":"Kapadia BH, Banerjee S, Cherian JJ, Bozic KJ, Mont MA (2016) The economic impact of periprosthetic infections after total hip arthroplasty at a specialized tertiary-care center. 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This work was approved by the Institutional Review Board at Beijing Jishuitan Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"We confirm that this manuscript has not been published elsewhere and is not under consideration by another journal. All authors have approved the manuscript and agree with its submission to Journal of Orthopaedics and Traumatology.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Each author confirmed that he has no commercial associations (e.g., consultancies, stock ownership, equity interest, patent\/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"45"}}