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However, the indications still remain uncertain for antibiotic prophylaxis in elective clean soft tissue surgeries of the hand and upper limb. Therefore, a systematic review of the literature and a meta-analysis was conducted to investigate the impact of antibiotic prophylaxis on the prevention of SSI in these types of surgeries.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>An electronic search was performed in the following databases: MEDLINE\/Pubmed, PMC\/Pubmed, Web of Science\/Clarivate Analytics, Embase\/Elsevier, Scopus\/Elsevier, BVS\/Lilacs, and the Cochrane Library, with no restrictions regarding publication language or date. The primary outcome of interest was the occurrence of SSI following elective clean soft tissue surgeries of the hand and upper limb according to the administration of preoperative antibiotic prophylaxis and no antibiotic prophylaxis. Surgeries involving simultaneous bone procedures or orthopedic implants were excluded. Study selection and data extraction were conducted independently by two reviewers. RoB 2.0 and ROBINS-I are Cochrane risk-of-bias tool for randomized trials and non-randomized studies of interventions. The magnitude of the intervention effect was estimated using the relative risk (RR). The meta-analysis was performed with the Review Manager and R software tools, using the Mantel\u2013Haenszel random-effects model and a 95% confidence interval (CI). Results with <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05 were considered statistically significant. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The initial search yielded 1175 titles, from which 12 articles met the inclusion criteria for the systematic review, and 10 were included in the subsequent meta-analysis. The majority of these studies were nonrandomized intervention trials, exhibiting a moderate risk of bias. According to our review, preoperative antibiotic prophylaxis did not have a statistically significant impact on the incidence of SSI (RR\u2009=\u20091.13, 95% CI 0.91\u20131.40, <jats:italic>p<\/jats:italic>\u2009=\u20090.28). The overall quality of evidence for this outcome was rated as low. Moderate statistical heterogeneity was observed (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200944%), and the prespecified sensitivity analysis highlighted the consistency of the results.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>While these results were consistent with the findings from individual studies included in this review, it is important to note that, given the threshold of <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05 for statistical significance, no definitive conclusions can be drawn from the quantitative analysis of the data obtained.<\/jats:p>\n                <jats:p><jats:italic>Level of evidence<\/jats:italic>: Level 2.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic>: CRD42023417786.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s10195-024-00748-4","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T18:02:03Z","timestamp":1706464923000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Preoperative antibiotic prophylaxis and the incidence of surgical site infections in elective clean soft tissue surgery of the hand and upper limb: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-4429","authenticated-orcid":false,"given":"Gabrielle Avelar","family":"Negri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-1568","authenticated-orcid":false,"given":"Ant\u00f4nio Clodoildo","family":"Andrade Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3737-2702","authenticated-orcid":false,"given":"Manuela Amoedo","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-0540","authenticated-orcid":false,"given":"Marcos Felipe","family":"Marcatto de Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5075-4474","authenticated-orcid":false,"given":"Simone","family":"Appenzeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6064-2027","authenticated-orcid":false,"given":"Rodrigo Gon\u00e7alves","family":"Pagnano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,28]]},"reference":[{"issue":"8","key":"748_CR1","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.2106\/JBJS.RVW.18.00168","volume":"7","author":"LM Shapiro","year":"2019","unstructured":"Shapiro LM, Zhuang T, Li K, Kamal RN (2019) The use of preoperative antibiotics in elective soft-tissue procedures in the hand: a critical analysis review. 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