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The sacral slope (SS) is key to the vertical shear of the sacrum but has not been investigated for its biomechanical role in lumbar\u2013iliac fixation. The aim of this study is to evaluate the biomechanical effects of different LIF and SS on Tile C1.3 pelvic fracture under two-legged standing load in human cadavers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Eight male fresh-frozen human lumbar\u2013pelvic specimens were used in this study. Compressive force of 500\u00a0N was applied to the L4 vertebrae in the two-legged standing position of the pelvis. The Tile C1.3 pelvic fracture was prepared, and the posterior pelvic ring was fixed with L5 ULIF, L4\u2013L5 ULIF, L5 TOS, L4\u2013L5 TOS, and L4\u2013L5 BLIF, respectively. Displacement and rotation of the anterior S1 foramen at 30\u00b0 and 40\u00b0 sacral slope (SS) were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The displacement of L4\u2013L5\/L5 TOS in the left\u2013right and vertical direction, total displacement, and rotation in lateral bending decreased significantly, which is more pronounced at 40\u00b0 SS. The difference in stability between L4\u2013L5 and L5 ULIF was not significant. BLIF significantly limited left\u2013right displacement. The ULIF vertical displacement at 40\u00b0 SS was significantly higher than that at 30\u00b0 SS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study developed an in vitro two-legged standing pelvic model and demonstrated that TOS enhanced pelvic stability in the coronal plane and cephalad\u2013caudal direction, and BLIF enhanced stability in the left\u2013right direction. L4\u2013L5 ULIF did not further improve the immediate stability, whereas TOS is required to increase the vertical stability at greater SS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s10195-024-00776-0","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T18:20:02Z","timestamp":1719426002000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of different lumbar\u2013iliac fixation and sacral slope for Tile C1.3 pelvic fractures: a biomechanical study"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1993-6074","authenticated-orcid":false,"given":"Shicai","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiguang","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"issue":"3","key":"776_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.5435\/00124635-199605000-00004","volume":"4","author":"M Tile","year":"1996","unstructured":"Tile M (1996) Acute pelvic fractures: I. 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