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This patient population has a higher risk of recurrent infections and hospitalization. The aim of this study is to compare the profile of microorganisms in patients with CKD and PJI of the hip versus controls and to individuate potentially unusual and drug-resistant microorganisms among the causative bacteria.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>A total of 4261 patients affected by PJI of the hip were retrospectively studied. Patients affected by CKD in this population were identified and compared with a control group of patients with PJI but without CKD. Data on patient characteristics and comorbidities were collected. The microorganisms responsible for PJI were identified and compared between both groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The CKD group included 409 patients, 54.3% male, mean age of 73.8\u2009\u00b1\u20098.9\u00a0years, a higher body mass index (BMI) than the general population (29.88\u2009\u00b1\u20095.90\u00a0kg\/m<jats:sup>2<\/jats:sup>), and higher age-adjusted CCI of 6.15\u2009\u00b1\u20092.35. Overall, 70 different isolates of microorganisms were identified, including 52 Gram-positive spp., 28 Gram-negative spp., 3 fungi, and 1 mycobacterium. Polymicrobial infections were more common in CKD group than controls (47.9% versus 30.9%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). <jats:italic>Staphylococcus<\/jats:italic> spp. were the most common bacteria in both groups, followed by Gram-negative Enterobacteriaceae and <jats:italic>Streptococcus<\/jats:italic> spp. CKD group showed a higher risk of developing infections caused by <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009=\u20090.003), Gram-negative bacteria, and <jats:italic>Candida<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009=\u20090.035).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Renal failure exposes patients who undergo THA to PJI caused by microorganisms that are potentially more drug resistant, leading to a higher risk of treatment failure. Knowing in advance the different microorganism profiles could help to plan a different surgical strategy.<\/jats:p>\n                <jats:p><jats:italic>Level of Evidence<\/jats:italic> III.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s10195-024-00806-x","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T18:32:57Z","timestamp":1734633177000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Differences in microorganism profile in periprosthetic joint infections of the hip in patients affected by chronic kidney disease"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-4848","authenticated-orcid":false,"given":"Davide","family":"Stimolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Budin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"De Mauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Suero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Gehrke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Citak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"806_CR1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","volume":"382","author":"V Jha","year":"2013","unstructured":"Jha V, Garcia-Garcia G, Iseki K et al (2013) Chronic kidney disease: global dimension and perspectives. 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