{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T07:03:06Z","timestamp":1793516586468,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270627"],"award-info":[{"award-number":["82270627"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol Lett"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Acute liver failure (ALF) is a life-threatening disease, but its pathogenesis is not fully understood. NETosis is a novel mode of cell death. Although the formation of neutrophil extracellular traps (NETs) has been found in various liver diseases, the specific mechanism by which NETosis regulates the development of ALF is unclear. In this article, we explore the role and mechanism of NETosis in the pathogenesis of ALF.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Clinically, we evaluated NETs-related markers in the liver and peripheral neutrophils of patients with ALF. In in\u00a0vitro experiments, HL-60 cells were first induced to differentiate into neutrophil-like cells (dHL-60 cells) with dimethyl sulfoxide (DMSO). NETs were formed by inducing dHL-60 cells with PMA. In in\u00a0vivo experiments, the ALF model in mice was established with LPS\/<jats:sc>d<\/jats:sc>-gal, and the release of NETs was detected by immunofluorescence staining and western blotting. Finally, the acetylation levels of IDH1 and MDH1 were detected in dHL-60 cells and liver samples by immunoprecipitation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Clinically, increased release of NETs in liver tissue was observed in patients with ALF, and NETs formation was detected in neutrophils from patients with liver failure. In dHL-60 cells, mutations at IDH1-K93 and MDH1-K118 deacetylate IDH1 and MDH1, which promotes the formation of NETs. In a mouse model of ALF, deacetylation of IDH1 and MDH1 resulted in NETosis and promoted the progression of acute liver failure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Deacetylation of IDH1 and MDH1 reduces their activity and promotes the formation of NETs. This change aggravates the progression of acute liver failure.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s11658-023-00529-7","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T17:02:19Z","timestamp":1704301339000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["IDH1\/MDH1 deacetylation promotes acute liver failure by regulating NETosis"],"prefix":"10.1186","volume":"29","author":[{"given":"Yukun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-5856","authenticated-orcid":false,"given":"Zuojiong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"529_CR1","doi-asserted-by":"publisher","first-page":"468","DOI":"10.7861\/clinmedicine.15-5-468","volume":"15","author":"L Blackmore","year":"2015","unstructured":"Blackmore L, Bernal W. Acute liver failure. Clin Med (Lond). 2015;15:468\u201372. https:\/\/doi.org\/10.7861\/clinmedicine.15-5-468.","journal-title":"Clin Med (Lond)"},{"key":"529_CR2","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","volume":"394","author":"RT Stravitz","year":"2019","unstructured":"Stravitz RT, Lee WM. Acute liver failure. Lancet. 2019;394:869\u201381. https:\/\/doi.org\/10.1016\/S0140-6736(19)31894-X.","journal-title":"Lancet"},{"key":"529_CR3","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1055\/s-0038-1673372","volume":"39","author":"P Rajaram","year":"2018","unstructured":"Rajaram P, Subramanian R. Acute Liver Failure. Semin Respir Crit Care Med. 2018;39:513\u201322. https:\/\/doi.org\/10.1055\/s-0038-1673372.","journal-title":"Semin Respir Crit Care Med"},{"key":"529_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1146\/annurev-cellbio-020520-111016","volume":"36","author":"HR Thiam","year":"2020","unstructured":"Thiam HR, Wong SL, Wagner DD, Waterman CM. Cellular mechanisms of NETosis. Annu Rev Cell Dev Biol. 2020;36:191\u2013218. https:\/\/doi.org\/10.1146\/annurev-cellbio-020520-111016.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"529_CR5","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.1007\/s00018-014-1683-3","volume":"71","author":"J Cools-Lartigue","year":"2014","unstructured":"Cools-Lartigue J, Spicer J, Najmeh S, Ferri L. Neutrophil extracellular traps in cancer progression. Cell Mol Life Sci. 2014;71:4179\u201394. https:\/\/doi.org\/10.1007\/s00018-014-1683-3.","journal-title":"Cell Mol Life Sci"},{"key":"529_CR6","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532\u20135. https:\/\/doi.org\/10.1126\/science.1092385.","journal-title":"Science"},{"key":"529_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.162","volume":"3","author":"J Huang","year":"2022","unstructured":"Huang J, Hong W, Wan M, Zheng L. Molecular mechanisms and therapeutic target of NETosis in diseases. MedComm. 2022;3: e162. https:\/\/doi.org\/10.1002\/mco2.162.","journal-title":"MedComm"},{"key":"529_CR8","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1134\/s0006297920100065","volume":"85","author":"NV Vorobjeva","year":"2020","unstructured":"Vorobjeva NV, Chernyak BV. NETosis: molecular mechanisms, role in physiology and pathology. Biochemistry (Mosc). 2020;85:1178\u201390. https:\/\/doi.org\/10.1134\/s0006297920100065.","journal-title":"Biochemistry (Mosc)"},{"key":"529_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176472","volume":"12","author":"T Hoppenbrouwers","year":"2017","unstructured":"Hoppenbrouwers T, Autar ASA, Sultan AR, Abraham TE, van Cappellen WA, Houtsmuller AB, et al. In vitro induction of NETosis: comprehensive live imaging comparison and systematic review. PLoS ONE. 2017;12: e0176472. https:\/\/doi.org\/10.1371\/journal.pone.0176472.","journal-title":"PLoS ONE"},{"key":"529_CR10","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/hep.32174","volume":"75","author":"FA von Meijenfeldt","year":"2022","unstructured":"von Meijenfeldt FA, Stravitz RT, Zhang J, Adelmeijer J, Zen Y, Durkalski V, et al. Generation of neutrophil extracellular traps in patients with acute liver failure is associated with poor outcome. Hepatology. 2022;75:623\u201333. https:\/\/doi.org\/10.1002\/hep.32174.","journal-title":"Hepatology"},{"key":"529_CR11","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jcmgh.2022.05.012","volume":"14","author":"D Ye","year":"2022","unstructured":"Ye D, Yao J, Du W, Chen C, Yang Y, Yan K, et al. Neutrophil extracellular traps mediate acute liver failure in regulation of miR-223\/Neutrophil elastase signaling in mice. Cell Mol Gastroenterol Hepatol. 2022;14:587\u2013607. https:\/\/doi.org\/10.1016\/j.jcmgh.2022.05.012.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"529_CR12","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/pap.0000000000000112","volume":"23","author":"JH Lefkowitch","year":"2016","unstructured":"Lefkowitch JH. The pathology of acute liver failure. Adv Anat Pathol. 2016;23:144\u201358. https:\/\/doi.org\/10.1097\/pap.0000000000000112.","journal-title":"Adv Anat Pathol"},{"key":"529_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.599180","volume":"12","author":"W Liao","year":"2021","unstructured":"Liao W, Jin Q, Liu J, Ruan Y, Li X, Shen Y, et al. Mahuang decoction antagonizes acute liver failure via modulating tricarboxylic acid cycle and amino acids metabolism. Front Pharmacol. 2021;12: 599180. https:\/\/doi.org\/10.3389\/fphar.2021.599180.","journal-title":"Front Pharmacol"},{"key":"529_CR14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/nbm.745","volume":"15","author":"RA Carvalho","year":"2002","unstructured":"Carvalho RA, Jones JG, McGuirk C, Sherry AD, Malloy CR. Hepatic gluconeogenesis and Krebs cycle fluxes in a CCl4 model of acute liver failure. NMR Biomed. 2002;15:45\u201351. https:\/\/doi.org\/10.1002\/nbm.745.","journal-title":"NMR Biomed"},{"key":"529_CR15","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.3748\/wjg.v17.i11.1457","volume":"17","author":"KJ Dabos","year":"2011","unstructured":"Dabos KJ, Whalen HR, Newsome PN, Parkinson JA, Henderson NC, Sadler IH, et al. Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure. World J Gastroenterol. 2011;17:1457\u201361. https:\/\/doi.org\/10.3748\/wjg.v17.i11.1457.","journal-title":"World J Gastroenterol"},{"key":"529_CR16","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.2147\/jir.S302391","volume":"14","author":"Y Wang","year":"2021","unstructured":"Wang Y, Li X, Chen Q, Jiao F, Shi C, Pei M, et al. Histone deacetylase 6 regulates the activation of m1 macrophages by the glycolytic pathway during acute liver failure. J Inflamm Res. 2021;14:1473\u201385. https:\/\/doi.org\/10.2147\/jir.S302391.","journal-title":"J Inflamm Res"},{"key":"529_CR17","doi-asserted-by":"publisher","first-page":"8173016","DOI":"10.1155\/2019\/8173016","volume":"2019","author":"Y Wang","year":"2019","unstructured":"Wang Y, Yang F, Jiao FZ, Chen Q, Zhang WB, Wang LW, et al. Modulations of histone deacetylase 2 offer a protective effect through the mitochondrial apoptosis pathway in acute liver failure. Oxid Med Cell Longev. 2019;2019:8173016. https:\/\/doi.org\/10.1155\/2019\/8173016.","journal-title":"Oxid Med Cell Longev"},{"key":"529_CR18","doi-asserted-by":"publisher","DOI":"10.1177\/1721727x221110989","author":"K Wang","year":"2022","unstructured":"Wang K, Zou Z, Zou T, Wei D, Deng M. Liver proteomic analysis reveals acute liver failure induced by lipopolysaccharide\/d-galactosamine in rats involved in neutrophil extracellular trap formation. Eur J Inflamm. 2022. https:\/\/doi.org\/10.1177\/1721727x221110989.","journal-title":"Eur J Inflamm."},{"key":"529_CR19","doi-asserted-by":"publisher","first-page":"7218","DOI":"10.1111\/jcmm.16751","volume":"25","author":"Q Chen","year":"2021","unstructured":"Chen Q, Wang Y, Jiao F, Cao P, Shi C, Pei M, et al. HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM\/F-actin signalling pathway. J Cell Mol Med. 2021;25:7218\u201328. https:\/\/doi.org\/10.1111\/jcmm.16751.","journal-title":"J Cell Mol Med"},{"key":"529_CR20","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.jcmgh.2022.07.014","volume":"14","author":"X Li","year":"2022","unstructured":"Li X, Gao Q, Wu W, Hai S, Hu J, You J, et al. FGL2-MCOLN3-autophagy axis-triggered neutrophil extracellular traps exacerbate liver injury in fulminant viral hepatitis. Cell Mol Gastroenterol Hepatol. 2022;14:1077\u2013101. https:\/\/doi.org\/10.1016\/j.jcmgh.2022.07.014.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"529_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13075-018-1800-z","volume":"21","author":"Q Hu","year":"2019","unstructured":"Hu Q, Shi H, Zeng T, Liu H, Su Y, Cheng X, et al. Increased neutrophil extracellular traps activate NLRP3 and inflammatory macrophages in adult-onset Still\u2019s disease. Arthritis Res Ther. 2019;21:9. https:\/\/doi.org\/10.1186\/s13075-018-1800-z.","journal-title":"Arthritis Res Ther"},{"key":"529_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.cca.2016.05.029","volume":"459","author":"S Masuda","year":"2016","unstructured":"Masuda S, Nakazawa D, Shida H, Miyoshi A, Kusunoki Y, Tomaru U, et al. NETosis markers: quest for specific, objective, and quantitative markers. Clin Chim Acta. 2016;459:89\u201393. https:\/\/doi.org\/10.1016\/j.cca.2016.05.029.","journal-title":"Clin Chim Acta"},{"key":"529_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/978-1-0716-1162-3_9","volume":"2255","author":"M Tong","year":"2021","unstructured":"Tong M, Abrahams VM. Visualization and quantification of neutrophil extracellular traps. Methods Mol Biol. 2021;2255:87\u201395. https:\/\/doi.org\/10.1007\/978-1-0716-1162-3_9.","journal-title":"Methods Mol Biol"},{"key":"529_CR24","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3892\/etm.2021.9784","volume":"21","author":"Y Guo","year":"2021","unstructured":"Guo Y, Gao F, Wang Q, Wang K, Pan S, Pan Z, et al. Differentiation of HL-60 cells in serum-free hematopoietic cell media enhances the production of neutrophil extracellular traps. Exp Ther Med. 2021;21:353. https:\/\/doi.org\/10.3892\/etm.2021.9784.","journal-title":"Exp Ther Med"},{"key":"529_CR25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1083\/jcb.200806072","volume":"184","author":"Y Wang","year":"2009","unstructured":"Wang Y, Li M, Stadler S, Correll S, Li P, Wang D, et al. Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol. 2009;184:205\u201313. https:\/\/doi.org\/10.1083\/jcb.200806072.","journal-title":"J Cell Biol"},{"key":"529_CR26","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41418-018-0261-x","volume":"26","author":"S Boeltz","year":"2019","unstructured":"Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, et al. To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death Differ. 2019;26:395\u2013408. https:\/\/doi.org\/10.1038\/s41418-018-0261-x.","journal-title":"Cell Death Differ"},{"key":"529_CR27","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1002\/hep.29914","volume":"68","author":"DJ van der Windt","year":"2018","unstructured":"van der Windt DJ, Sud V, Zhang H, Varley PR, Goswami J, Yazdani HO, et al. Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis. Hepatology. 2018;68:1347\u201360. https:\/\/doi.org\/10.1002\/hep.29914.","journal-title":"Hepatology"},{"key":"529_CR28","doi-asserted-by":"publisher","first-page":"591","DOI":"10.2174\/1568026615666150819110421","volume":"16","author":"Y Xu","year":"2016","unstructured":"Xu Y, Chou KC. Recent progress in predicting posttranslational modification sites in proteins. Curr Top Med Chem. 2016;16:591\u2013603. https:\/\/doi.org\/10.2174\/1568026615666150819110421.","journal-title":"Curr Top Med Chem"},{"key":"529_CR29","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nbt0303-255","volume":"21","author":"M Mann","year":"2003","unstructured":"Mann M, Jensen ON. Proteomic analysis of post-translational modifications. Nat Biotechnol. 2003;21:255\u201361. https:\/\/doi.org\/10.1038\/nbt0303-255.","journal-title":"Nat Biotechnol"},{"key":"529_CR30","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baab012","author":"S Ramazi","year":"2021","unstructured":"Ramazi S, Zahiri J. Post-translational modifications in proteins: resources, tools and prediction methods. Database. 2021. https:\/\/doi.org\/10.1093\/database\/baab012.","journal-title":"Database"},{"key":"529_CR31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/lci2.43","volume":"3","author":"J Adeva","year":"2022","unstructured":"Adeva J. Current development and future perspective of IDH1 inhibitors in cholangiocarcinoma. Liver Cancer Int. 2022;3:17\u201331. https:\/\/doi.org\/10.1002\/lci2.43.","journal-title":"Liver Cancer Int"},{"key":"529_CR32","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1097\/WCO.0b013e32834cd415","volume":"24","author":"C Guo","year":"2011","unstructured":"Guo C, Pirozzi CJ, Lopez GY, Yan H. Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target. Curr Opin Neurol. 2011;24:648\u201352. https:\/\/doi.org\/10.1097\/WCO.0b013e32834cd415.","journal-title":"Curr Opin Neurol"},{"key":"529_CR33","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.bbcan.2014.05.004","volume":"1846","author":"RJ Molenaar","year":"2014","unstructured":"Molenaar RJ, Radivoyevitch T, Maciejewski JP, van Noorden CJ, Bleeker FE. The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation. Biochim Biophys Acta. 2014;1846:326\u201341. https:\/\/doi.org\/10.1016\/j.bbcan.2014.05.004.","journal-title":"Biochim Biophys Acta"},{"key":"529_CR34","doi-asserted-by":"publisher","first-page":"33946","DOI":"10.1074\/jbc.M404298200","volume":"279","author":"X Xu","year":"2004","unstructured":"Xu X, Zhao J, Xu Z, Peng B, Huang Q, Arnold E, et al. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. J Biol Chem. 2004;279:33946\u201357. https:\/\/doi.org\/10.1074\/jbc.M404298200.","journal-title":"J Biol Chem"},{"key":"529_CR35","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/nature08617","volume":"462","author":"L Dang","year":"2009","unstructured":"Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462:739\u201344. https:\/\/doi.org\/10.1038\/nature08617.","journal-title":"Nature"},{"key":"529_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fasebj.2020.34.s1.02372","volume":"34","author":"A Strom","year":"2020","unstructured":"Strom A, Widjaja V, Weeks J, Alexander S, Pucher D, Nguyen TD, et al. The effect of acetylation on isocitrate dehydrogenase 1 regulation. FASEB J. 2020;34:1\u20131. https:\/\/doi.org\/10.1096\/fasebj.2020.34.s1.02372.","journal-title":"FASEB J"},{"key":"529_CR37","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1194\/jlr.M026567","volume":"53","author":"EY Kim","year":"2012","unstructured":"Kim EY, Kim WK, Kang HJ, Kim JH, Chung SJ, Seo YS, et al. Acetylation of malate dehydrogenase 1 promotes adipogenic differentiation via activating its enzymatic activity. J Lipid Res. 2012;53:1864\u201376. https:\/\/doi.org\/10.1194\/jlr.M026567.","journal-title":"J Lipid Res"},{"key":"529_CR38","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1007\/s00439-019-02063-z","volume":"138","author":"MH Broeks","year":"2019","unstructured":"Broeks MH, Shamseldin HE, Alhashem A, Hashem M, Abdulwahab F, Alshedi T, et al. MDH1 deficiency is a metabolic disorder of the malate-aspartate shuttle associated with early onset severe encephalopathy. Hum Genet. 2019;138:1247\u201357. https:\/\/doi.org\/10.1007\/s00439-019-02063-z.","journal-title":"Hum Genet"},{"key":"529_CR39","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1007\/s00018-022-04341-y","volume":"79","author":"M Wang","year":"2022","unstructured":"Wang M, Zhou C, Yu L, Kong D, Ma W, Lv B, et al. Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage. Cell Mol Life Sci. 2022;79:356. https:\/\/doi.org\/10.1007\/s00018-022-04341-y.","journal-title":"Cell Mol Life Sci"}],"container-title":["Cellular &amp; Molecular Biology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11658-023-00529-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s11658-023-00529-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11658-023-00529-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T17:02:21Z","timestamp":1704301341000},"score":1,"resource":{"primary":{"URL":"https:\/\/cmbl.biomedcentral.com\/articles\/10.1186\/s11658-023-00529-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,3]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["529"],"URL":"https:\/\/doi.org\/10.1186\/s11658-023-00529-7","relation":{},"ISSN":["1689-1392"],"issn-type":[{"value":"1689-1392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,3]]},"assertion":[{"value":"3 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The human experiments were approved by Ethics Committee of Renmin Hospital of Wuhan University according to the principles expressed in the Helsinki Declaration. The ethics number was WDRY-2021-K016 (approved 9 February 2021). All animal experiments were approved by Institutional Animal Care and Use Committee of Renmin Hospital of Wuhan University (approval number: WDRM (Welfare) 20181018; approved on 26 October 2018).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}