{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:25:25Z","timestamp":1787019925675,"version":"build-2736575974"},"reference-count":120,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol Lett"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Human Gb3\/CD77 synthase (\u03b11,4-galactosyltransferase, P1\/P\n                    <jats:sup>k<\/jats:sup>\n                    synthase, UDP-galactose: \u03b2-\n                    <jats:sc>d<\/jats:sc>\n                    -galactosyl-\u03b21-R 4-\u03b1-\n                    <jats:sc>d<\/jats:sc>\n                    -galactosyltransferase, EC 2.4.1.228) forms Gal\u03b11\u2009\u2192\u20094Gal structures on glycosphingolipids and glycoproteins. These glycans are recognized by bacterial adhesins and toxins. Globotriaosylceramide (Gb3), the major product of Gb3\/CD77 synthase, is a glycosphingolipid located predominantly in plasma membrane lipid rafts, where it serves as a main receptor for Shiga toxins released by enterohemorrhagic\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Shigella dysenteriae<\/jats:italic>\n                    of serotype 1. On the other hand, accumulation of glycans formed by Gb3\/CD77 synthase contributes to the symptoms of Anderson\u2013Fabry disease caused by \u03b1-galactosidase A deficiency. Moreover, variation in Gb3\/CD77 synthase expression and activity underlies the P1PK histo-blood group system. Glycosphingolipids synthesized by the enzyme are overproduced in colorectal, gastric, pancreatic, and ovarian cancer, and elevated Gb3 biosynthesis is associated with cancer cell chemo- and radioresistance. Furthermore, Gb3\/CD77 synthase acts as a key glycosyltransferase modulating ovarian cancer cell plasticity. Here, we describe the role of human Gb3\/CD77 synthase and its products in the P1PK histo-blood group system, Anderson\u2013Fabry disease, and bacterial infections. Additionally, we provide an overview of emerging evidence that Gb3\/CD77 synthase and its glycosphingolipid products are involved in cancer metastasis and chemoresistance.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1186\/s11658-024-00658-7","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T11:29:30Z","timestamp":1730978970000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Human Gb3\/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research"],"prefix":"10.1186","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-3662","authenticated-orcid":false,"given":"Katarzyna","family":"Szymczak-Kulus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2859-3699","authenticated-orcid":false,"given":"Marcin","family":"Czerwinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8084-1958","authenticated-orcid":false,"given":"Radoslaw","family":"Kaczmarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"658_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.sbi.2016.07.007","volume":"40","author":"D Albesa-Jov\u00e9","year":"2016","unstructured":"Albesa-Jov\u00e9 D, Guerin ME. 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