{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:35:37Z","timestamp":1793835337875,"version":"4.6.1"},"reference-count":166,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Hunan Provincial Natural Science Foundation","award":["2024JJ6623"],"award-info":[{"award-number":["2024JJ6623"]}]},{"name":"the Hunan Provincial Natural Science Foundation","award":["2022JJ30328"],"award-info":[{"award-number":["2022JJ30328"]}]},{"name":"the Hunan Provincial Natural Science Foundation","award":["2025JJ50488"],"award-info":[{"award-number":["2025JJ50488"]}]},{"name":"the Hunan Provincial Natural Science Foundation","award":["2025JJ80826"],"award-info":[{"award-number":["2025JJ80826"]}]},{"name":"Scientific Research Project of Hunan Provincial Health Commission","award":["D202307016531"],"award-info":[{"award-number":["D202307016531"]}]},{"name":"independent exploration and innovation project of Central South University","award":["2024ZZTS0865"],"award-info":[{"award-number":["2024ZZTS0865"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol Lett"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Insulin-like growth factor 2 messenger RNA (mRNA)-binding protein 2 (IGF2BP2) is a widely studied N\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modification reader, primarily functioning to recognize and bind to m\n                    <jats:sup>6<\/jats:sup>\n                    A modification sites on the mRNA of downstream target genes, thereby enhancing their stability. Previous studies have suggested that the IGF2BP2-m\n                    <jats:sup>6<\/jats:sup>\n                    A modification plays an essential role in cellular functions and the progression of various diseases. In this review, we focus on summarizing the molecular mechanisms by which IGF2BP2 enhances the mRNA stability of downstream target genes through m\n                    <jats:sup>6<\/jats:sup>\n                    A modification, thereby regulating cell ferroptosis, epithelial\u2013mesenchymal transition (EMT), stemness, angiogenesis, inflammatory responses, and lipid metabolism, ultimately affecting disease progression. Additionally, we update the related research progress on IGF2BP2. This article aims to elucidate the effects of IGF2BP2 on cell ferroptosis, EMT, stemness, angiogenesis, inflammatory responses, and lipid metabolism, providing a new perspective for a comprehensive understanding of the relationship between IGF2BP2 and cell functions such as ferroptosis and EMT, as well as the potential for targeted IGF2BP2 therapy for tumors and other diseases.\n                  <\/jats:p>","DOI":"10.1186\/s11658-025-00723-9","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T18:51:46Z","timestamp":1744224706000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["IGF2BP2: an m6A reader that affects cellular function and disease progression"],"prefix":"10.1186","volume":"30","author":[{"given":"Siyi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9498-4439","authenticated-orcid":false,"given":"Yanhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"723_CR1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41576-020-00295-8","volume":"22","author":"D Wiener","year":"2021","unstructured":"Wiener D, Schwartz S. The epitranscriptome beyond m(6)A. Nat Rev Genet. 2021;22:119\u201331. https:\/\/doi.org\/10.1038\/s41576-020-00295-8.","journal-title":"Nat Rev Genet"},{"key":"723_CR2","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12943-019-1109-9","volume":"18","author":"L He","year":"2019","unstructured":"He L, Li H, Wu A, Peng Y, Shu G, Yin G. Functions of N6-methyladenosine and its role in cancer. Mol Cancer. 2019;18:176. https:\/\/doi.org\/10.1186\/s12943-019-1109-9.","journal-title":"Mol Cancer"},{"key":"723_CR3","doi-asserted-by":"publisher","first-page":"eaat8263","DOI":"10.1126\/sciadv.aar8263","volume":"4","author":"S Panneerdoss","year":"2018","unstructured":"Panneerdoss S, Eedunuri VK, Yadav P, Timilsina S, Rajamanickam S, Viswanadhapalli S, Abdelfattah N, Onyeagucha BC, Cui X, Lai Z, et al. Cross-talk among writers, readers, and erasers of m(6)A regulates cancer growth and progression. Sci Adv. 2018;4:eaat8263. https:\/\/doi.org\/10.1126\/sciadv.aar8263.","journal-title":"Sci Adv"},{"key":"723_CR4","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nchembio.1432","volume":"10","author":"J Liu","year":"2014","unstructured":"Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol. 2014;10:93\u20135. https:\/\/doi.org\/10.1038\/nchembio.1432.","journal-title":"Nat Chem Biol"},{"key":"723_CR5","doi-asserted-by":"publisher","first-page":"7719","DOI":"10.1093\/nar\/gkz619","volume":"47","author":"N van Tran","year":"2019","unstructured":"van Tran N, Ernst FGM, Hawley BR, Zorbas C, Ulryck N, Hackert P, Bohnsack KE, Bohnsack MT, Jaffrey SR, Graille M, Lafontaine DLJ. The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Res. 2019;47:7719\u201333. https:\/\/doi.org\/10.1093\/nar\/gkz619.","journal-title":"Nucleic Acids Res"},{"key":"723_CR6","doi-asserted-by":"publisher","first-page":"6051","DOI":"10.1093\/nar\/gkx141","volume":"45","author":"N Liu","year":"2017","unstructured":"Liu N, Zhou KI, Parisien M, Dai Q, Diatchenko L, Pan T. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res. 2017;45:6051\u201363. https:\/\/doi.org\/10.1093\/nar\/gkx141.","journal-title":"Nucleic Acids Res"},{"key":"723_CR7","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/nature14234","volume":"518","author":"N Liu","year":"2015","unstructured":"Liu N, Dai Q, Zheng G, He C, Parisien M, Pan T. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature. 2015;518:560\u20134. https:\/\/doi.org\/10.1038\/nature14234.","journal-title":"Nature"},{"key":"723_CR8","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1101\/gr.271635.120","volume":"31","author":"G Wei","year":"2021","unstructured":"Wei G, Almeida M, Pintacuda G, Coker H, Bowness JS, Ule J, Brockdorff N. Acute depletion of METTL3 implicates N (6)-methyladenosine in alternative intron\/exon inclusion in the nascent transcriptome. Genome Res. 2021;31:1395\u2013408. https:\/\/doi.org\/10.1101\/gr.271635.120.","journal-title":"Genome Res"},{"issue":"3125\u20133142","key":"723_CR9","doi-asserted-by":"publisher","first-page":"e3125","DOI":"10.1016\/j.cell.2021.03.062","volume":"184","author":"M Mendel","year":"2021","unstructured":"Mendel M, Delaney K, Pandey RR, Chen KM, Wenda JM, Vagbo CB, Steiner FA, Homolka D, Pillai RS. Splice site m(6)A methylation prevents binding of U2AF35 to inhibit RNA splicing. Cell. 2021;184(3125\u20133142):e3125. https:\/\/doi.org\/10.1016\/j.cell.2021.03.062.","journal-title":"Cell"},{"key":"723_CR10","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.molmed.2023.03.005","volume":"29","author":"Y Liu","year":"2023","unstructured":"Liu Y, Yang D, Liu T, Chen J, Yu J, Yi P. N6-methyladenosine-mediated gene regulation and therapeutic implications. Trends Mol Med. 2023;29:454\u201367. https:\/\/doi.org\/10.1016\/j.molmed.2023.03.005.","journal-title":"Trends Mol Med"},{"key":"723_CR11","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.trecan.2022.02.010","volume":"8","author":"Y Li","year":"2022","unstructured":"Li Y, Su R, Deng X, Chen Y, Chen J. FTO in cancer: functions, molecular mechanisms, and therapeutic implications. Trends Cancer. 2022;8:598\u2013614. https:\/\/doi.org\/10.1016\/j.trecan.2022.02.010.","journal-title":"Trends Cancer"},{"key":"723_CR12","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1016\/j.molcel.2022.04.012","volume":"82","author":"S Larivera","year":"2022","unstructured":"Larivera S, Meister G. Domain confusion 2: m(6)A-independent role of YTHDC2. Mol Cell. 2022;82:1608\u20139. https:\/\/doi.org\/10.1016\/j.molcel.2022.04.012.","journal-title":"Mol Cell"},{"key":"723_CR13","doi-asserted-by":"publisher","first-page":"100503","DOI":"10.1016\/j.mtbio.2022.100503","volume":"17","author":"X Xu","year":"2022","unstructured":"Xu X, Cui J, Wang H, Ma L, Zhang X, Guo W, Xue X, Wang Y, Qiu S, Tian X, et al. IGF2BP3 is an essential N(6)-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells. Mater Today Bio. 2022;17:100503. https:\/\/doi.org\/10.1016\/j.mtbio.2022.100503.","journal-title":"Mater Today Bio"},{"key":"723_CR14","doi-asserted-by":"publisher","first-page":"635329","DOI":"10.3389\/fonc.2021.635329","volume":"11","author":"XY Dai","year":"2021","unstructured":"Dai XY, Shi L, Li Z, Yang HY, Wei JF, Ding Q. Main N6-methyladenosine readers: YTH family proteins in cancers. Front Oncol. 2021;11:635329. https:\/\/doi.org\/10.3389\/fonc.2021.635329.","journal-title":"Front Oncol"},{"key":"723_CR15","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1101\/gad.2042311","volume":"25","author":"N Dai","year":"2011","unstructured":"Dai N, Rapley J, Angel M, Yanik MF, Blower MD, Avruch J. mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry. Genes Dev. 2011;25:1159\u201372. https:\/\/doi.org\/10.1101\/gad.2042311.","journal-title":"Genes Dev"},{"key":"723_CR16","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","volume":"20","author":"H Huang","year":"2018","unstructured":"Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, et al. Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018;20:285\u201395. https:\/\/doi.org\/10.1038\/s41556-018-0045-z.","journal-title":"Nat Cell Biol"},{"key":"723_CR17","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1007\/s00018-012-1186-z","volume":"70","author":"JL Bell","year":"2013","unstructured":"Bell JL, Wachter K, Muhleck B, Pazaitis N, Kohn M, Lederer M, Huttelmaier S. Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cell Mol Life Sci. 2013;70:2657\u201375. https:\/\/doi.org\/10.1007\/s00018-012-1186-z.","journal-title":"Cell Mol Life Sci"},{"key":"723_CR18","doi-asserted-by":"publisher","first-page":"e23882","DOI":"10.1371\/journal.pone.0023882","volume":"6","author":"M Salton","year":"2011","unstructured":"Salton M, Elkon R, Borodina T, Davydov A, Yaspo ML, Halperin E, Shiloh Y. Matrin 3 binds and stabilizes mRNA. PLoS ONE. 2011;6:e23882. https:\/\/doi.org\/10.1371\/journal.pone.0023882.","journal-title":"PLoS ONE"},{"key":"723_CR19","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/ncb2902","volume":"16","author":"Y Wang","year":"2014","unstructured":"Wang Y, Li Y, Toth JI, Petroski MD, Zhang Z, Zhao JC. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat Cell Biol. 2014;16:191\u20138. https:\/\/doi.org\/10.1038\/ncb2902.","journal-title":"Nat Cell Biol"},{"key":"723_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-01799-x","author":"JY Wang","year":"2021","unstructured":"Wang JY, Chen LJ, Qiang P. The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers. Cancer Cell Int. 2021. https:\/\/doi.org\/10.1186\/s12935-021-01799-x.","journal-title":"Cancer Cell Int"},{"key":"723_CR21","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1038\/s41418-020-00728-1","volume":"28","author":"X Chen","year":"2021","unstructured":"Chen X, Yu C, Kang R, Kroemer G, Tang D. Cellular degradation systems in ferroptosis. Cell Death Differ. 2021;28:1135\u201348. https:\/\/doi.org\/10.1038\/s41418-020-00728-1.","journal-title":"Cell Death Differ"},{"key":"723_CR22","doi-asserted-by":"publisher","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","volume":"23","author":"M Dodson","year":"2019","unstructured":"Dodson M, Castro-Portuguez R, Zhang DD. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol. 2019;23:101107. https:\/\/doi.org\/10.1016\/j.redox.2019.101107.","journal-title":"Redox Biol"},{"key":"723_CR23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, Sun B, Wang G. Ferroptosis: past, present and future. Cell Death Dis. 2020;11:88. https:\/\/doi.org\/10.1038\/s41419-020-2298-2.","journal-title":"Cell Death Dis"},{"key":"723_CR24","doi-asserted-by":"publisher","first-page":"156388","DOI":"10.1016\/j.cyto.2023.156388","volume":"173","author":"W Liu","year":"2024","unstructured":"Liu W, Zeng H. IGF2BP2 attenuates intestinal epithelial cell ferroptosis in colitis by stabilizing m(6)A-modified GPX4 mRNA. Cytokine. 2024;173:156388. https:\/\/doi.org\/10.1016\/j.cyto.2023.156388.","journal-title":"Cytokine"},{"key":"723_CR25","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/s41420-023-01727-0","volume":"9","author":"R Yang","year":"2023","unstructured":"Yang R, Wan J, Ma L, Zhou F, Yang Z, Li Z, Zhang M, Ming L. TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis. Cell Death Discov. 2023;9:431. https:\/\/doi.org\/10.1038\/s41420-023-01727-0.","journal-title":"Cell Death Discov"},{"key":"723_CR26","doi-asserted-by":"publisher","first-page":"e24514","DOI":"10.1002\/jcla.24514","volume":"36","author":"J Ye","year":"2022","unstructured":"Ye J, Chen X, Jiang X, Dong Z, Hu S, Xiao M. RNA demethylase ALKBH5 regulates hypopharyngeal squamous cell carcinoma ferroptosis by posttranscriptionally activating NFE2L2\/NRF2 in an m(6) A-IGF2BP2-dependent manner. J Clin Lab Anal. 2022;36:e24514. https:\/\/doi.org\/10.1002\/jcla.24514.","journal-title":"J Clin Lab Anal"},{"key":"723_CR27","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1093\/infdis\/jiad337","volume":"229","author":"W Wang","year":"2024","unstructured":"Wang W, Xu R, He P, Xiong Y, Zhao H, Fu X, Lin J, Ye L. CircEXOC5 aggravates sepsis-induced acute lung injury by promoting ferroptosis through the IGF2BP2\/ATF3 axis. J Infect Dis. 2024;229:522\u201334. https:\/\/doi.org\/10.1093\/infdis\/jiad337.","journal-title":"J Infect Dis"},{"key":"723_CR28","doi-asserted-by":"publisher","first-page":"e1389","DOI":"10.1002\/ctm2.1389","volume":"13","author":"H Zhang","year":"2023","unstructured":"Zhang H, Wu D, Wang Y, Guo K, Spencer CB, Ortoga L, Qu M, Shi Y, Shao Y, Wang Z, et al. METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury. Clin Transl Med. 2023;13:e1389. https:\/\/doi.org\/10.1002\/ctm2.1389.","journal-title":"Clin Transl Med"},{"key":"723_CR29","doi-asserted-by":"publisher","first-page":"111495","DOI":"10.1016\/j.intimp.2024.111495","volume":"128","author":"F Chen","year":"2024","unstructured":"Chen F, Su M, Han D, Wang Y, Song M. METTL14 depletion ameliorates ferroptosis in severe acute pancreatitis by increasing the N6-methyladenosine modification of ACSL4 and STA1. Int Immunopharmacol. 2024;128:111495. https:\/\/doi.org\/10.1016\/j.intimp.2024.111495.","journal-title":"Int Immunopharmacol"},{"key":"723_CR30","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317\u201331. https:\/\/doi.org\/10.1016\/j.cell.2013.12.010.","journal-title":"Cell"},{"key":"723_CR31","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060\u201372. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042.","journal-title":"Cell"},{"key":"723_CR32","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/s41556-019-0311-8","volume":"21","author":"RW Yao","year":"2019","unstructured":"Yao RW, Wang Y, Chen LL. Cellular functions of long noncoding RNAs. Nat Cell Biol. 2019;21:542\u201351. https:\/\/doi.org\/10.1038\/s41556-019-0311-8.","journal-title":"Nat Cell Biol"},{"key":"723_CR33","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1182\/bloodadvances.2022007719","volume":"7","author":"L Hou","year":"2023","unstructured":"Hou L, Voit RA, Shibamura-Fujiogi M, Koutsogiannaki S, Li Y, Chen Y, Luo H, Sankaran VG, Yuki K. CD11c regulates neutrophil maturation. Blood Adv. 2023;7:1312\u201325. https:\/\/doi.org\/10.1182\/bloodadvances.2022007719.","journal-title":"Blood Adv"},{"key":"723_CR34","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1165\/rcmb.2019-0433OC","volume":"63","author":"M Suzuki","year":"2020","unstructured":"Suzuki M, Ikari J, Anazawa R, Tanaka N, Katsumata Y, Shimada A, Suzuki E, Tatsumi K. PAD4 deficiency improves bleomycin-induced neutrophil extracellular traps and fibrosis in mouse lung. Am J Respir Cell Mol Biol. 2020;63:806\u201318. https:\/\/doi.org\/10.1165\/rcmb.2019-0433OC.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"723_CR35","doi-asserted-by":"publisher","first-page":"e2305142","DOI":"10.1002\/advs.202305142","volume":"11","author":"T Xia","year":"2024","unstructured":"Xia T, Dai XY, Sang MY, Zhang X, Xu F, Wu J, Shi L, Wei JF, Ding Q. IGF2BP2 drives cell cycle progression in triple-negative breast cancer by recruiting EIF4A1 to promote the m6A-modified CDK6 translation initiation process. Adv Sci. 2024;11:e2305142. https:\/\/doi.org\/10.1002\/advs.202305142.","journal-title":"Adv Sci"},{"key":"723_CR36","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev-pathmechdis-051222-122423","volume":"19","author":"R Fontana","year":"2024","unstructured":"Fontana R, Mestre-Farrera A, Yang J. Update on epithelial-mesenchymal plasticity in cancer progression. Annu Rev Pathol. 2024;19:133\u201356. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-051222-122423.","journal-title":"Annu Rev Pathol"},{"key":"723_CR37","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","volume":"20","author":"A Dongre","year":"2019","unstructured":"Dongre A, Weinberg RA. New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol. 2019;20:69\u201384. https:\/\/doi.org\/10.1038\/s41580-018-0080-4.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"723_CR38","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","volume":"29","author":"I Pastushenko","year":"2019","unstructured":"Pastushenko I, Blanpain C. EMT transition states during tumor progression and metastasis. Trends Cell Biol. 2019;29:212\u201326. https:\/\/doi.org\/10.1016\/j.tcb.2018.12.001.","journal-title":"Trends Cell Biol"},{"key":"723_CR39","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","volume":"139","author":"JP Thiery","year":"2009","unstructured":"Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139:871\u201390. https:\/\/doi.org\/10.1016\/j.cell.2009.11.007.","journal-title":"Cell"},{"key":"723_CR40","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1002\/jcb.24019","volume":"113","author":"M Xie","year":"2012","unstructured":"Xie M, Zhang L, He CS, Xu F, Liu JL, Hu ZH, Zhao LP, Tian Y. Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells. J Cell Biochem. 2012;113:1501\u201313. https:\/\/doi.org\/10.1002\/jcb.24019.","journal-title":"J Cell Biochem"},{"key":"723_CR41","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s11427-020-1736-5","volume":"64","author":"X Dai","year":"2021","unstructured":"Dai X, Xin Y, Xu W, Tian X, Wei X, Zhang H. CBP-mediated Slug acetylation stabilizes slug and promotes EMT and migration of breast cancer cells. Sci China Life Sci. 2021;64:563\u201374. https:\/\/doi.org\/10.1007\/s11427-020-1736-5.","journal-title":"Sci China Life Sci"},{"key":"723_CR42","first-page":"1613","volume":"62","author":"KM Hajra","year":"2002","unstructured":"Hajra KM, Chen DY, Fearon ER. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 2002;62:1613\u20138.","journal-title":"Cancer Res"},{"key":"723_CR43","doi-asserted-by":"publisher","first-page":"5364","DOI":"10.1158\/0008-5472.CAN-08-4135","volume":"69","author":"TA DiMeo","year":"2009","unstructured":"DiMeo TA, Anderson K, Phadke P, Fan C, Perou CM, Naber S, Kuperwasser C. A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res. 2009;69:5364\u201373. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-4135.","journal-title":"Cancer Res"},{"key":"723_CR44","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1182\/blood.V100.4.1274.h81602001274_1274_1286","volume":"100","author":"J Perez-Losada","year":"2002","unstructured":"Perez-Losada J, Sanchez-Martin M, Rodriguez-Garcia A, Sanchez ML, Orfao A, Flores T, Sanchez-Garcia I. Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway. Blood. 2002;100:1274\u201386.","journal-title":"Blood"},{"key":"723_CR45","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12943-022-01608-7","volume":"21","author":"B Yao","year":"2022","unstructured":"Yao B, Zhang Q, Yang Z, An F, Nie H, Wang H, Yang C, Sun J, Chen K, Zhou J, et al. CircEZH2\/miR-133b\/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA. Mol Cancer. 2022;21:140. https:\/\/doi.org\/10.1186\/s12943-022-01608-7.","journal-title":"Mol Cancer"},{"key":"723_CR46","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/nrc2271","volume":"7","author":"A Fusco","year":"2007","unstructured":"Fusco A, Fedele M. Roles of HMGA proteins in cancer. Nat Rev Cancer. 2007;7:899\u2013910. https:\/\/doi.org\/10.1038\/nrc2271.","journal-title":"Nat Rev Cancer"},{"key":"723_CR47","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1158\/0008-5472.CAN-09-1212","volume":"70","author":"LM Resar","year":"2010","unstructured":"Resar LM. The high mobility group A1 gene: transforming inflammatory signals into cancer? Cancer Res. 2010;70:436\u20139. https:\/\/doi.org\/10.1158\/0008-5472.CAN-09-1212.","journal-title":"Cancer Res"},{"key":"723_CR48","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13046-021-02212-1","volume":"41","author":"D Yu","year":"2022","unstructured":"Yu D, Pan M, Li Y, Lu T, Wang Z, Liu C, Hu G. RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner. J Exp Clin Cancer Res. 2022;41:6. https:\/\/doi.org\/10.1186\/s13046-021-02212-1.","journal-title":"J Exp Clin Cancer Res"},{"key":"723_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14215381","author":"J Ouyang","year":"2022","unstructured":"Ouyang J, Li J, Li D, Jiang J, Hao T, Xia Y, Lu X, Zhang C, He Y. IGF2BP2 promotes epithelial to mesenchymal transition and metastasis through stabilizing HMGA1 mRNA in gastric cancer. Cancers. 2022. https:\/\/doi.org\/10.3390\/cancers14215381.","journal-title":"Cancers"},{"key":"723_CR50","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13046-021-01857-2","volume":"40","author":"P Hou","year":"2021","unstructured":"Hou P, Meng S, Li M, Lin T, Chu S, Li Z, Zheng J, Gu Y, Bai J. LINC00460\/DHX9\/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification. J Exp Clin Cancer Res. 2021;40:52. https:\/\/doi.org\/10.1186\/s13046-021-01857-2.","journal-title":"J Exp Clin Cancer Res"},{"key":"723_CR51","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41419-021-03571-5","volume":"12","author":"H Shen","year":"2021","unstructured":"Shen H, Zhu H, Chen Y, Shen Z, Qiu W, Qian C, Zhang J. ZEB1-induced LINC01559 expedites cell proliferation, migration and EMT process in gastric cancer through recruiting IGF2BP2 to stabilize ZEB1 expression. Cell Death Dis. 2021;12:349. https:\/\/doi.org\/10.1038\/s41419-021-03571-5.","journal-title":"Cell Death Dis"},{"key":"723_CR52","doi-asserted-by":"publisher","first-page":"153908","DOI":"10.1016\/j.prp.2022.153908","volume":"235","author":"C Zhao","year":"2022","unstructured":"Zhao C, Sun J, Dang Z, Su Q, Yang J. Circ_0000775 promotes the migration, invasion and EMT of hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27. Pathol Res Pract. 2022;235:153908. https:\/\/doi.org\/10.1016\/j.prp.2022.153908.","journal-title":"Pathol Res Pract"},{"key":"723_CR53","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1080\/08977194.2023.2227272","volume":"41","author":"H Weng","year":"2023","unstructured":"Weng H, Feng W, Li F, Huang D, Lin L, Wang Z. Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes migration, invasion, and epithelial-mesenchymal transition of pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1 expression. Growth Factors. 2023;41:152\u201364. https:\/\/doi.org\/10.1080\/08977194.2023.2227272.","journal-title":"Growth Factors"},{"key":"723_CR54","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1111\/exd.14427","volume":"30","author":"Y Ma","year":"2021","unstructured":"Ma Y, Jin Y, Li C, Liu Y, Wang D. LncRNA MSC-AS1 motivates the development of melanoma by binding to miR-302a-3p and recruiting IGF2BP2 to elevate LEF1 expression. Exp Dermatol. 2021;30:1764\u201374. https:\/\/doi.org\/10.1111\/exd.14427.","journal-title":"Exp Dermatol"},{"key":"723_CR55","doi-asserted-by":"publisher","first-page":"818","DOI":"10.7150\/ijbs.91786","volume":"20","author":"CW Lin","year":"2024","unstructured":"Lin CW, Yang WE, Su CW, Lu HJ, Su SC, Yang SF. IGF2BP2 promotes cell invasion and epithelial-mesenchymal transition through Src-mediated upregulation of EREG in oral cancer. Int J Biol Sci. 2024;20:818\u201330. https:\/\/doi.org\/10.7150\/ijbs.91786.","journal-title":"Int J Biol Sci"},{"key":"723_CR56","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/abbs\/gmu111","volume":"47","author":"MX Yin","year":"2015","unstructured":"Yin MX, Zhang L. Hippo signaling in epithelial stem cells. Acta Biochim Biophys Sin. 2015;47:39\u201345. https:\/\/doi.org\/10.1093\/abbs\/gmu111.","journal-title":"Acta Biochim Biophys Sin"},{"key":"723_CR57","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1525\/embr.201438638","volume":"15","author":"JS Mo","year":"2014","unstructured":"Mo JS, Park HW, Guan KL. The hippo signaling pathway in stem cell biology and cancer. EMBO Rep. 2014;15:642\u201356. https:\/\/doi.org\/10.1525\/embr.201438638.","journal-title":"EMBO Rep"},{"key":"723_CR58","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1186\/s13287-020-02018-6","volume":"11","author":"F Rossi","year":"2020","unstructured":"Rossi F, Noren H, Jove R, Beljanski V, Grinnemo KH. Differences and similarities between cancer and somatic stem cells: therapeutic implications. Stem Cell Res Ther. 2020;11:489. https:\/\/doi.org\/10.1186\/s13287-020-02018-6.","journal-title":"Stem Cell Res Ther"},{"key":"723_CR59","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/nature07602","volume":"457","author":"N Barker","year":"2009","unstructured":"Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009;457:608\u201311. https:\/\/doi.org\/10.1038\/nature07602.","journal-title":"Nature"},{"key":"723_CR60","doi-asserted-by":"publisher","first-page":"4910","DOI":"10.1073\/pnas.1112499109","volume":"109","author":"X Xu","year":"2012","unstructured":"Xu X, Rock JR, Lu Y, Futtner C, Schwab B, Guinney J, Hogan BL, Onaitis MW. Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. Proc Natl Acad Sci USA. 2012;109:4910\u20135. https:\/\/doi.org\/10.1073\/pnas.1112499109.","journal-title":"Proc Natl Acad Sci USA"},{"key":"723_CR61","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/s41568-023-00615-0","volume":"23","author":"T Gebhardt","year":"2023","unstructured":"Gebhardt T, Park SL, Parish IA. Stem-like exhausted and memory CD8(+) T cells in cancer. Nat Rev Cancer. 2023;23:780\u201398. https:\/\/doi.org\/10.1038\/s41568-023-00615-0.","journal-title":"Nat Rev Cancer"},{"key":"723_CR62","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1056\/NEJMra061808","volume":"355","author":"CT Jordan","year":"2006","unstructured":"Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med. 2006;355:1253\u201361. https:\/\/doi.org\/10.1056\/NEJMra061808.","journal-title":"N Engl J Med"},{"key":"723_CR63","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nm.2304","volume":"17","author":"H Clevers","year":"2011","unstructured":"Clevers H. The cancer stem cell: premises, promises and challenges. Nat Med. 2011;17:313\u20139. https:\/\/doi.org\/10.1038\/nm.2304.","journal-title":"Nat Med"},{"key":"723_CR64","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.semcancer.2017.02.007","volume":"44","author":"CAM La Porta","year":"2017","unstructured":"La Porta CAM, Zapperi S. Complexity in cancer stem cells and tumor evolution: toward precision medicine. Semin Cancer Biol. 2017;44:3\u20139. https:\/\/doi.org\/10.1016\/j.semcancer.2017.02.007.","journal-title":"Semin Cancer Biol"},{"key":"723_CR65","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.semcancer.2018.10.001","volume":"53","author":"C Matteucci","year":"2018","unstructured":"Matteucci C, Balestrieri E, Argaw-Denboba A, Sinibaldi-Vallebona P. Human endogenous retroviruses role in cancer cell stemness. Semin Cancer Biol. 2018;53:17\u201330. https:\/\/doi.org\/10.1016\/j.semcancer.2018.10.001.","journal-title":"Semin Cancer Biol"},{"key":"723_CR66","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1038\/s41418-019-0461-z","volume":"27","author":"X Hu","year":"2020","unstructured":"Hu X, Peng WX, Zhou H, Jiang J, Zhou X, Huang D, Mo YY, Yang L. IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader. Cell Death Differ. 2020;27:1782\u201394. https:\/\/doi.org\/10.1038\/s41418-019-0461-z.","journal-title":"Cell Death Differ"},{"issue":"1566\u20131582","key":"723_CR67","doi-asserted-by":"publisher","first-page":"e1510","DOI":"10.1016\/j.ccell.2022.10.004","volume":"40","author":"H Weng","year":"2022","unstructured":"Weng H, Huang F, Yu Z, Chen Z, Prince E, Kang Y, Zhou K, Li W, Hu J, Fu C, et al. The m(6)A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022;40(1566\u20131582):e1510. https:\/\/doi.org\/10.1016\/j.ccell.2022.10.004.","journal-title":"Cancer Cell"},{"key":"723_CR68","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12943-019-1038-7","volume":"18","author":"T Li","year":"2019","unstructured":"Li T, Hu PS, Zuo Z, Lin JF, Li X, Wu QN, Chen ZH, Zeng ZL, Wang F, Zheng J, et al. METTL3 facilitates tumor progression via an m(6)A-IGF2BP2-dependent mechanism in colorectal carcinoma. Mol Cancer. 2019;18:112. https:\/\/doi.org\/10.1186\/s12943-019-1038-7.","journal-title":"Mol Cancer"},{"key":"723_CR69","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1038\/s41417-023-00650-x","volume":"30","author":"C Huang","year":"2023","unstructured":"Huang C, Xu R, Zhu X, Jiang H. m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1. Cancer Gene Ther. 2023;30:1426\u201340. https:\/\/doi.org\/10.1038\/s41417-023-00650-x.","journal-title":"Cancer Gene Ther"},{"key":"723_CR70","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1080\/15384101.2023.2283328","volume":"22","author":"T Wu","year":"2023","unstructured":"Wu T, Liao L, Wu T, Chen S, Yi Q, Xu M. IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification. Cell Cycle. 2023;22:2245\u201363. https:\/\/doi.org\/10.1080\/15384101.2023.2283328.","journal-title":"Cell Cycle"},{"key":"723_CR71","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1139\/bcb-2023-0067","volume":"102","author":"R Zhao","year":"2024","unstructured":"Zhao R, Li T, Zhao X, Yang Z, Ma L, Wang X. The m6A reader IGF2BP2 promotes the progression of esophageal squamous cell carcinoma cells by increasing the stability of OCT4 mRNA. Biochem Cell Biol. 2024;102:169\u201378. https:\/\/doi.org\/10.1139\/bcb-2023-0067.","journal-title":"Biochem Cell Biol"},{"key":"723_CR72","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nature21671","volume":"543","author":"Y Xiang","year":"2017","unstructured":"Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, et al. RNA m(6)A methylation regulates the ultraviolet-induced DNA damage response. Nature. 2017;543:573\u20136. https:\/\/doi.org\/10.1038\/nature21671.","journal-title":"Nature"},{"key":"723_CR73","doi-asserted-by":"publisher","first-page":"6350","DOI":"10.1038\/s41467-022-34209-5","volume":"13","author":"Y Li","year":"2022","unstructured":"Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, et al. METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions. Nat Commun. 2022;13:6350. https:\/\/doi.org\/10.1038\/s41467-022-34209-5.","journal-title":"Nat Commun"},{"key":"723_CR74","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s13578-023-01100-9","volume":"13","author":"M Ye","year":"2023","unstructured":"Ye M, Chen J, Lu F, Zhao M, Wu S, Hu C, Yu P, Kan J, Bai J, Tian Y, Tang Q. Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer. Cell Biosci. 2023;13:148. https:\/\/doi.org\/10.1186\/s13578-023-01100-9.","journal-title":"Cell Biosci"},{"key":"723_CR75","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13046-022-02254-z","volume":"41","author":"J Huang","year":"2022","unstructured":"Huang J, Sun W, Wang Z, Lv C, Zhang T, Zhang D, Dong W, Shao L, He L, Ji X, et al. FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner. J Exp Clin Cancer Res. 2022;41:42. https:\/\/doi.org\/10.1186\/s13046-022-02254-z.","journal-title":"J Exp Clin Cancer Res"},{"key":"723_CR76","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1126\/science.2898810","volume":"241","author":"GJ Spangrude","year":"1988","unstructured":"Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science. 1988;241:58\u201362. https:\/\/doi.org\/10.1126\/science.2898810.","journal-title":"Science"},{"key":"723_CR77","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1182\/blood-2014-12-570200","volume":"125","author":"CJ Eaves","year":"2015","unstructured":"Eaves CJ. Hematopoietic stem cells: concepts, definitions, and the new reality. Blood. 2015;125:2605\u201313. https:\/\/doi.org\/10.1182\/blood-2014-12-570200.","journal-title":"Blood"},{"key":"723_CR78","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41586-019-1244-x","volume":"571","author":"AC Wilkinson","year":"2019","unstructured":"Wilkinson AC, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo RV, Yamamoto R, Loh KM, Nakamura Y, Watanabe M, et al. Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. Nature. 2019;571:117\u201321. https:\/\/doi.org\/10.1038\/s41586-019-1244-x.","journal-title":"Nature"},{"key":"723_CR79","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nature08040","volume":"459","author":"J Liu","year":"2009","unstructured":"Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, et al. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature. 2009;459:387\u201392. https:\/\/doi.org\/10.1038\/nature08040.","journal-title":"Nature"},{"key":"723_CR80","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nature01587","volume":"423","author":"IK Park","year":"2003","unstructured":"Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003;423:302\u20135. https:\/\/doi.org\/10.1038\/nature01587.","journal-title":"Nature"},{"issue":"149\u2013159","key":"723_CR81","doi-asserted-by":"publisher","first-page":"e147","DOI":"10.1016\/j.stem.2021.09.014","volume":"29","author":"R Yin","year":"2022","unstructured":"Yin R, Chang J, Li Y, Gao Z, Qiu Q, Wang Q, Han G, Chai J, Feng M, Wang P, et al. Differential m(6)A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function. Cell Stem Cell. 2022;29(149\u2013159):e147. https:\/\/doi.org\/10.1016\/j.stem.2021.09.014.","journal-title":"Cell Stem Cell"},{"key":"723_CR82","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","volume":"8","author":"ZL Liu","year":"2023","unstructured":"Liu ZL, Chen HH, Zheng LL, Sun LP, Shi L. Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal Transduct Target Ther. 2023;8:198. https:\/\/doi.org\/10.1038\/s41392-023-01460-1.","journal-title":"Signal Transduct Target Ther"},{"key":"723_CR83","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.7150\/ijbs.58035","volume":"17","author":"H Li","year":"2021","unstructured":"Li H, Wang D, Yi B, Cai H, Wang Y, Lou X, Xi Z, Li Z. SUMOylation of IGF2BP2 promotes vasculogenic mimicry of glioma via regulating OIP5-AS1\/miR-495-3p axis. Int J Biol Sci. 2021;17:2912\u201330. https:\/\/doi.org\/10.7150\/ijbs.58035.","journal-title":"Int J Biol Sci"},{"key":"723_CR84","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12943-023-01791-1","volume":"22","author":"H Fang","year":"2023","unstructured":"Fang H, Sun Q, Zhou J, Zhang H, Song Q, Zhang H, Yu G, Guo Y, Huang C, Mou Y, et al. m(6)A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma. Mol Cancer. 2023;22:99. https:\/\/doi.org\/10.1186\/s12943-023-01791-1.","journal-title":"Mol Cancer"},{"key":"723_CR85","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/jcb.30358","volume":"124","author":"T Zhang","year":"2023","unstructured":"Zhang T, Tang X, Zhu Y, Wang C, Jiang Z, Yang N, Wang T, Shu L, Xu Y, Sun L. IGF2BP2 enhances LincRNA01116 stability via m(6) A: a potential biomarker and therapeutic target for patients with pre-eclampsia. J Cell Biochem. 2023;124:239\u201353. https:\/\/doi.org\/10.1002\/jcb.30358.","journal-title":"J Cell Biochem"},{"key":"723_CR86","doi-asserted-by":"publisher","first-page":"11267","DOI":"10.1080\/21655979.2021.2002495","volume":"12","author":"S Zhi","year":"2021","unstructured":"Zhi S, Li J, Kong X, Xie X, Zhang Q, Fang G. Insulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration, and angiogenesis of keratinocytes by modulating heparanase stability. Bioengineered. 2021;12:11267\u201376. https:\/\/doi.org\/10.1080\/21655979.2021.2002495.","journal-title":"Bioengineered"},{"key":"723_CR87","doi-asserted-by":"publisher","first-page":"110839","DOI":"10.1016\/j.cellsig.2023.110839","volume":"111","author":"X Zhao","year":"2023","unstructured":"Zhao X, Chen J, Zhang C, Xie G, Othmane B, Kuang X, Liu B. LncRNA AGAP2-AS1 interacts with IGF2BP2 to promote bladder cancer progression via regulating LRG1 mRNA stability. Cell Signal. 2023;111:110839. https:\/\/doi.org\/10.1016\/j.cellsig.2023.110839.","journal-title":"Cell Signal"},{"key":"723_CR88","doi-asserted-by":"publisher","first-page":"7351","DOI":"10.7150\/thno.74753","volume":"12","author":"H Zeng","year":"2022","unstructured":"Zeng H, Hou Y, Zhou X, Lang L, Luo H, Sun Y, Wan X, Yuan T, Wang R, Liu Y, et al. Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer. Theranostics. 2022;12:7351\u201370. https:\/\/doi.org\/10.7150\/thno.74753.","journal-title":"Theranostics"},{"key":"723_CR89","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.ymthe.2022.01.012","volume":"30","author":"MD Yao","year":"2022","unstructured":"Yao MD, Jiang Q, Ma Y, Zhu Y, Zhang QY, Shi ZH, Zhao C, Yan B. Targeting circular RNA-MET for anti-angiogenesis treatment via inhibiting endothelial tip cell specialization. Mol Ther. 2022;30:1252\u201364. https:\/\/doi.org\/10.1016\/j.ymthe.2022.01.012.","journal-title":"Mol Ther"},{"key":"723_CR90","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/s41577-019-0127-6","volume":"19","author":"DG DeNardo","year":"2019","unstructured":"DeNardo DG, Ruffell B. Macrophages as regulators of tumour immunity and immunotherapy. Nat Rev Immunol. 2019;19:369\u201382. https:\/\/doi.org\/10.1038\/s41577-019-0127-6.","journal-title":"Nat Rev Immunol"},{"key":"723_CR91","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12920-021-00991-2","volume":"14","author":"Y Shen","year":"2021","unstructured":"Shen Y, Xu LR, Tang X, Lin CP, Yan D, Xue S, Qian RZ, Guo DQ. Identification of potential therapeutic targets for atherosclerosis by analysing the gene signature related to different immune cells and immune regulators in atheromatous plaques. BMC Med Genomics. 2021;14:145. https:\/\/doi.org\/10.1186\/s12920-021-00991-2.","journal-title":"BMC Med Genomics"},{"key":"723_CR92","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12943-021-01313-x","volume":"20","author":"S Mohapatra","year":"2021","unstructured":"Mohapatra S, Pioppini C, Ozpolat B, Calin GA. Non-coding RNAs regulation of macrophage polarization in cancer. Mol Cancer. 2021;20:24. https:\/\/doi.org\/10.1186\/s12943-021-01313-x.","journal-title":"Mol Cancer"},{"key":"723_CR93","doi-asserted-by":"publisher","first-page":"106236","DOI":"10.1016\/j.phrs.2022.106236","volume":"179","author":"Y Wang","year":"2022","unstructured":"Wang Y, Shi R, Zhai R, Yang S, Peng T, Zheng F, Shen Y, Li M, Li L. Matrix stiffness regulates macrophage polarization in atherosclerosis. Pharmacol Res. 2022;179:106236. https:\/\/doi.org\/10.1016\/j.phrs.2022.106236.","journal-title":"Pharmacol Res"},{"key":"723_CR94","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cytogfr.2011.02.003","volume":"22","author":"MF Neurath","year":"2011","unstructured":"Neurath MF, Finotto S. IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev. 2011;22:83\u20139. https:\/\/doi.org\/10.1016\/j.cytogfr.2011.02.003.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"Suppl 1","key":"723_CR95","doi-asserted-by":"publisher","first-page":"i104","DOI":"10.1136\/ard.2010.140145","volume":"70","author":"SI Grivennikov","year":"2011","unstructured":"Grivennikov SI, Karin M. Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis. 2011;70(Suppl 1):i104-108. https:\/\/doi.org\/10.1136\/ard.2010.140145.","journal-title":"Ann Rheum Dis"},{"key":"723_CR96","doi-asserted-by":"publisher","first-page":"e109353","DOI":"10.1525\/embj.2021109353","volume":"41","author":"D Chen","year":"2022","unstructured":"Chen D, Nemazanyy I, Peulen O, Shostak K, Xu X, Tang SC, Wathieu C, Turchetto S, Tielens S, Nguyen L, et al. Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization. EMBO J. 2022;41:e109353. https:\/\/doi.org\/10.1525\/embj.2021109353.","journal-title":"EMBO J"},{"key":"723_CR97","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","volume":"32","author":"S Gordon","year":"2010","unstructured":"Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity. 2010;32:593\u2013604. https:\/\/doi.org\/10.1016\/j.immuni.2010.05.007.","journal-title":"Immunity"},{"key":"723_CR98","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.immuni.2014.06.010","volume":"41","author":"R Noy","year":"2014","unstructured":"Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity. 2014;41:49\u201361. https:\/\/doi.org\/10.1016\/j.immuni.2014.06.010.","journal-title":"Immunity"},{"key":"723_CR99","doi-asserted-by":"publisher","first-page":"2100209","DOI":"10.1002\/advs.202100209","volume":"8","author":"X Wang","year":"2021","unstructured":"Wang X, Ji Y, Feng P, Liu R, Li G, Zheng J, Xue Y, Wei Y, Ji C, Chen D, Li J. The m6A reader IGF2BP2 regulates macrophage phenotypic activation and inflammatory diseases by stabilizing TSC1 and PPARgamma. Adv Sci. 2021;8:2100209. https:\/\/doi.org\/10.1002\/advs.202100209.","journal-title":"Adv Sci"},{"key":"723_CR100","doi-asserted-by":"publisher","first-page":"113024","DOI":"10.1016\/j.yexcr.2022.113024","volume":"413","author":"L Zhu","year":"2022","unstructured":"Zhu L, Liu Y, Tang H, Wang P. FOXP3 activated-LINC01232 accelerates the stemness of non-small cell lung carcinoma by activating TGF-beta signaling pathway and recruiting IGF2BP2 to stabilize TGFBR1. Exp Cell Res. 2022;413:113024. https:\/\/doi.org\/10.1016\/j.yexcr.2022.113024.","journal-title":"Exp Cell Res"},{"key":"723_CR101","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13045-022-01272-w","volume":"15","author":"Y Liu","year":"2022","unstructured":"Liu Y, Shi M, He X, Cao Y, Liu P, Li F, Zou S, Wen C, Zhan Q, Xu Z, et al. LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma. J Hematol Oncol. 2022;15:52. https:\/\/doi.org\/10.1186\/s13045-022-01272-w.","journal-title":"J Hematol Oncol"},{"key":"723_CR102","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-004029","author":"H Li","year":"2022","unstructured":"Li H, Luo F, Jiang X, Zhang W, Xiang T, Pan Q, Cai L, Zhao J, Weng D, Li Y, et al. CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype. J Immunother Cancer. 2022. https:\/\/doi.org\/10.1136\/jitc-2021-004029.","journal-title":"J Immunother Cancer"},{"key":"723_CR103","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1093\/ibd\/izad113","volume":"29","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Guo J, Zhang L, Li Y, Sheng K, Zhang Y, Liu L, Gong W, Guo K. CircASPH enhances exosomal STING to facilitate M2 macrophage polarization in colorectal cancer. Inflamm Bowel Dis. 2023;29:1941\u201356. https:\/\/doi.org\/10.1093\/ibd\/izad113.","journal-title":"Inflamm Bowel Dis"},{"key":"723_CR104","doi-asserted-by":"publisher","first-page":"155436","DOI":"10.1016\/j.phymed.2024.155436","volume":"126","author":"X Liu","year":"2024","unstructured":"Liu X, Xiong H, Lu M, Liu B, Hu C, Liu P. Trans-3, 5, 4\u2019-trimethoxystilbene restrains non-small-cell lung carcinoma progression via suppressing M2 polarization through inhibition of m6A modified circPACRGL-mediated Hippo signaling. Phytomedicine. 2024;126:155436. https:\/\/doi.org\/10.1016\/j.phymed.2024.155436.","journal-title":"Phytomedicine"},{"key":"723_CR105","doi-asserted-by":"publisher","first-page":"108832","DOI":"10.1016\/j.envint.2024.108832","volume":"190","author":"J Lin","year":"2024","unstructured":"Lin J, Xia H, Yu J, Wang Y, Wang H, Xie D, Cheng C, Lu L, Bian T, Wu Y, Liu Q. circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization. Environ Int. 2024;190:108832. https:\/\/doi.org\/10.1016\/j.envint.2024.108832.","journal-title":"Environ Int"},{"key":"723_CR106","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1105-0","author":"Y Wang","year":"2019","unstructured":"Wang Y, Lu JH, Wu QN, Jin Y, Wang DS, Chen YX, Liu J, Luo XJ, Meng Q, Pu HY, et al. LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer. Mol Cancer. 2019. https:\/\/doi.org\/10.1186\/s12943-019-1105-0.","journal-title":"Mol Cancer"},{"key":"723_CR107","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.tcb.2022.07.005","volume":"33","author":"AJ Heo","year":"2023","unstructured":"Heo AJ, Ji CH, Kwon YT. The Cys\/N-degron pathway in the ubiquitin-proteasome system and autophagy. Trends Cell Biol. 2023;33:247\u201359. https:\/\/doi.org\/10.1016\/j.tcb.2022.07.005.","journal-title":"Trends Cell Biol"},{"key":"723_CR108","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","volume":"25","author":"A Mantovani","year":"2004","unstructured":"Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004;25:677\u201386. https:\/\/doi.org\/10.1016\/j.it.2004.09.015.","journal-title":"Trends Immunol"},{"key":"723_CR109","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1189\/jlb.0602325","volume":"73","author":"DM Mosser","year":"2003","unstructured":"Mosser DM. The many faces of macrophage activation. J Leukoc Biol. 2003;73:209\u201312. https:\/\/doi.org\/10.1189\/jlb.0602325.","journal-title":"J Leukoc Biol"},{"key":"723_CR110","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010051","author":"WP Lafuse","year":"2020","unstructured":"Lafuse WP, Wozniak DJ, Rajaram MVS. Role of cardiac macrophages on cardiac inflammation, fibrosis and tissue repair. Cells. 2020. https:\/\/doi.org\/10.3390\/cells10010051.","journal-title":"Cells"},{"key":"723_CR111","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/bs.apcsb.2019.11.002","volume":"120","author":"A Munjal","year":"2020","unstructured":"Munjal A, Khandia R. Atherosclerosis: orchestrating cells and biomolecules involved in its activation and inhibition. Adv Protein Chem Struct Biol. 2020;120:85\u2013122. https:\/\/doi.org\/10.1016\/bs.apcsb.2019.11.002.","journal-title":"Adv Protein Chem Struct Biol"},{"key":"723_CR112","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1097\/SHK.0000000000000604","volume":"46","author":"K Essandoh","year":"2016","unstructured":"Essandoh K, Li Y, Huo J, Fan GC. MiRNA-mediated macrophage polarization and its potential role in the regulation of inflammatory response. Shock. 2016;46:122\u201331. https:\/\/doi.org\/10.1097\/SHK.0000000000000604.","journal-title":"Shock"},{"key":"723_CR113","doi-asserted-by":"publisher","first-page":"1226962","DOI":"10.3389\/fimmu.2023.1226962","volume":"14","author":"Z Lin","year":"2023","unstructured":"Lin Z, Lv D, Liao X, Peng R, Liu H, Wu T, Wu K, Sun Y, Zhang Z. CircUBXN7 promotes macrophage infiltration and renal fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability in diabetic kidney disease. Front Immunol. 2023;14:1226962. https:\/\/doi.org\/10.3389\/fimmu.2023.1226962.","journal-title":"Front Immunol"},{"key":"723_CR114","doi-asserted-by":"publisher","first-page":"14742","DOI":"10.1021\/acs.jafc.3c03350","volume":"71","author":"ZH Ji","year":"2023","unstructured":"Ji ZH, Gao F, Xie WY, Wu HY, Ren WZ, Yuan B. Mammary epithelial cell-derived exosomal miR-221-3p regulates macrophage polarization by targeting Igf2bp2 during mastitis. J Agric Food Chem. 2023;71:14742\u201357. https:\/\/doi.org\/10.1021\/acs.jafc.3c03350.","journal-title":"J Agric Food Chem"},{"key":"723_CR115","doi-asserted-by":"publisher","first-page":"e23845","DOI":"10.1002\/jbt.23845","volume":"38","author":"X Du","year":"2024","unstructured":"Du X, Guo Y, Zhao X, Zhang L, Fan R, Li Y. METTL3-mediated TIM1 promotes macrophage M1 polarization and inflammation through IGF2BP2-dependent manner. J Biochem Mol Toxicol. 2024;38:e23845. https:\/\/doi.org\/10.1002\/jbt.23845.","journal-title":"J Biochem Mol Toxicol"},{"key":"723_CR116","doi-asserted-by":"publisher","first-page":"eabk2709","DOI":"10.1126\/scitranslmed.abk2709","volume":"14","author":"JN Wang","year":"2022","unstructured":"Wang JN, Wang F, Ke J, Li Z, Xu CH, Yang Q, Chen X, He XY, He Y, Suo XG, et al. Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms. Sci Transl Med. 2022;14:eabk2709. https:\/\/doi.org\/10.1126\/scitranslmed.abk2709.","journal-title":"Sci Transl Med"},{"key":"723_CR117","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/j.ymthe.2022.01.002","volume":"30","author":"L Jiang","year":"2022","unstructured":"Jiang L, Liu X, Hu X, Gao L, Zeng H, Wang X, Huang Y, Zhu W, Wang J, Wen J, et al. METTL3-mediated m(6)A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy. Mol Ther. 2022;30:1721\u201340. https:\/\/doi.org\/10.1016\/j.ymthe.2022.01.002.","journal-title":"Mol Ther"},{"key":"723_CR118","doi-asserted-by":"publisher","first-page":"575","DOI":"10.3892\/etm.2023.12273","volume":"26","author":"W Zhou","year":"2023","unstructured":"Zhou W, Dai Q, Su N, Liu Z, Hu J. IGF2BP2-dependent STIM1 inhibition protects against LPS-induced pneumonia in vitro by alleviating endoplasmic reticulum stress and the inflammatory response. Exp Ther Med. 2023;26:575. https:\/\/doi.org\/10.3892\/etm.2023.12273.","journal-title":"Exp Ther Med"},{"key":"723_CR119","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41419-023-06163-7","volume":"14","author":"R Ji","year":"2023","unstructured":"Ji R, Wu C, Yao J, Xu J, Lin J, Gu H, Fu M, Zhang X, Li Y, Zhang X. IGF2BP2-meidated m(6)A modification of CSF2 reprograms MSC to promote gastric cancer progression. Cell Death Dis. 2023;14:693. https:\/\/doi.org\/10.1038\/s41419-023-06163-7.","journal-title":"Cell Death Dis"},{"key":"723_CR120","doi-asserted-by":"publisher","first-page":"110467","DOI":"10.1016\/j.intimp.2023.110467","volume":"121","author":"Y Lu","year":"2023","unstructured":"Lu Y, Qie D, Yang F, Wu J. LncRNA MEG3 aggravates adipocyte inflammation and insulin resistance by targeting IGF2BP2 to activate TLR4\/NF-kappaB signaling pathway. Int Immunopharmacol. 2023;121:110467. https:\/\/doi.org\/10.1016\/j.intimp.2023.110467.","journal-title":"Int Immunopharmacol"},{"key":"723_CR121","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/mrd.23667","volume":"90","author":"X Huang","year":"2023","unstructured":"Huang X, Guo L. Circular RNA SESN2 aggravates gestational trophoblast cell damage induced by high glucose by binding to IGF2BP2. Mol Reprod Dev. 2023;90:73\u201386. https:\/\/doi.org\/10.1002\/mrd.23667.","journal-title":"Mol Reprod Dev"},{"key":"723_CR122","doi-asserted-by":"publisher","first-page":"101235","DOI":"10.1016\/j.plipres.2023.101235","volume":"91","author":"V Petrenko","year":"2023","unstructured":"Petrenko V, Sinturel F, Riezman H, Dibner C. Lipid metabolism around the body clocks. Prog Lipid Res. 2023;91:101235. https:\/\/doi.org\/10.1016\/j.plipres.2023.101235.","journal-title":"Prog Lipid Res"},{"key":"723_CR123","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201606","author":"X Bian","year":"2021","unstructured":"Bian X, Liu R, Meng Y, Xing D, Xu D, Lu Z. Lipid metabolism and cancer. J Exp Med. 2021. https:\/\/doi.org\/10.1084\/jem.20201606.","journal-title":"J Exp Med"},{"key":"723_CR124","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bbrc.2019.08.018","volume":"518","author":"W Xie","year":"2019","unstructured":"Xie W, Ma LL, Xu YQ, Wang BH, Li SM. METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism. Biochem Biophys Res Commun. 2019;518:120\u20136. https:\/\/doi.org\/10.1016\/j.bbrc.2019.08.018.","journal-title":"Biochem Biophys Res Commun"},{"key":"723_CR125","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1126\/science.1151710","volume":"318","author":"T Gerken","year":"2007","unstructured":"Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. 2007;318:1469\u201372. https:\/\/doi.org\/10.1126\/science.1151710.","journal-title":"Science"},{"key":"723_CR126","doi-asserted-by":"publisher","first-page":"7948","DOI":"10.1002\/jcp.28014","volume":"234","author":"Z Bi","year":"2019","unstructured":"Bi Z, Liu Y, Zhao Y, Yao Y, Wu R, Liu Q, Wang Y, Wang X. A dynamic reversible RNA N(6) -methyladenosine modification: current status and perspectives. J Cell Physiol. 2019;234:7948\u201356. https:\/\/doi.org\/10.1002\/jcp.28014.","journal-title":"J Cell Physiol"},{"key":"723_CR127","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.gendis.2021.01.005","volume":"9","author":"Z Yang","year":"2022","unstructured":"Yang Z, Yu GL, Zhu X, Peng TH, Lv YC. Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: implications in lipid metabolic disorders. Genes Dis. 2022;9:51\u201361. https:\/\/doi.org\/10.1016\/j.gendis.2021.01.005.","journal-title":"Genes Dis"},{"key":"723_CR128","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/j.mayocp.2015.06.013","volume":"90","author":"EK Spengler","year":"2015","unstructured":"Spengler EK, Loomba R. Recommendations for diagnosis, referral for liver biopsy, and treatment of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Mayo Clin Proc. 2015;90:1233\u201346. https:\/\/doi.org\/10.1016\/j.mayocp.2015.06.013.","journal-title":"Mayo Clin Proc"},{"key":"723_CR129","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1146\/annurev-physiol-031620-093815","volume":"83","author":"B Chaurasia","year":"2021","unstructured":"Chaurasia B, Summers SA. Ceramides in metabolism: key lipotoxic players. Annu Rev Physiol. 2021;83:303\u201330. https:\/\/doi.org\/10.1146\/annurev-physiol-031620-093815.","journal-title":"Annu Rev Physiol"},{"key":"723_CR130","doi-asserted-by":"publisher","first-page":"147747","DOI":"10.1016\/j.gene.2023.147747","volume":"887","author":"P Wang","year":"2023","unstructured":"Wang P, Wang X, He D, Zhuang C. LncRNA AK142643 promotes hepatic lipid accumulation by upregulating CD36 via interacting with IGF2BP2. Gene. 2023;887:147747. https:\/\/doi.org\/10.1016\/j.gene.2023.147747.","journal-title":"Gene"},{"key":"723_CR131","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1038\/s42255-021-00488-3","volume":"3","author":"Y Jiang","year":"2021","unstructured":"Jiang Y, Peng J, Song J, He J, Jiang M, Wang J, Ma L, Wang Y, Lin M, Wu H, et al. Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2. Nat Metab. 2021;3:1569\u201384. https:\/\/doi.org\/10.1038\/s42255-021-00488-3.","journal-title":"Nat Metab"},{"key":"723_CR132","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1186\/s12967-023-04578-6","volume":"21","author":"J Chen","year":"2023","unstructured":"Chen J, Ye M, Bai J, Gong Z, Yan L, Gu D, Hu C, Lu F, Yu P, Xu L, et al. ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner. J Transl Med. 2023;21:741. https:\/\/doi.org\/10.1186\/s12967-023-04578-6.","journal-title":"J Transl Med"},{"key":"723_CR133","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41580-021-00350-0","volume":"22","author":"P Cohen","year":"2021","unstructured":"Cohen P, Kajimura S. The cellular and functional complexity of thermogenic fat. Nat Rev Mol Cell Biol. 2021;22:393\u2013409. https:\/\/doi.org\/10.1038\/s41580-021-00350-0.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"723_CR134","doi-asserted-by":"publisher","first-page":"103680","DOI":"10.1016\/j.isci.2021.103680","volume":"25","author":"JR Alvarez-Dominguez","year":"2022","unstructured":"Alvarez-Dominguez JR, Winther S, Hansen JB, Lodish HF, Knoll M. An adipose lncRAP2-Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs. iScience. 2022;25:103680. https:\/\/doi.org\/10.1016\/j.isci.2021.103680.","journal-title":"iScience"},{"issue":"69\u201385","key":"723_CR135","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1016\/j.stem.2022.12.003","volume":"30","author":"Y Cheng","year":"2023","unstructured":"Cheng Y, Gao Z, Zhang T, Wang Y, Xie X, Han G, Li Y, Yin R, Chen Y, Wang P, et al. Decoding m(6)A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance. Cell Stem Cell. 2023;30(69\u201385):e67. https:\/\/doi.org\/10.1016\/j.stem.2022.12.003.","journal-title":"Cell Stem Cell"},{"key":"723_CR136","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.semcancer.2014.02.006","volume":"25","author":"J Paulsson","year":"2014","unstructured":"Paulsson J, Micke P. Prognostic relevance of cancer-associated fibroblasts in human cancer. Semin Cancer Biol. 2014;25:61\u20138. https:\/\/doi.org\/10.1016\/j.semcancer.2014.02.006.","journal-title":"Semin Cancer Biol"},{"key":"723_CR137","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3389\/fmolb.2020.00068","volume":"7","author":"X Deng","year":"2020","unstructured":"Deng X, Jiang Q, Liu Z, Chen W. Clinical significance of an m6A reader gene, IGF2BP2, in head and neck squamous cell carcinoma. Front Mol Biosci. 2020;7:68. https:\/\/doi.org\/10.3389\/fmolb.2020.00068.","journal-title":"Front Mol Biosci"},{"key":"723_CR138","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20221311","author":"Y Hu","year":"2022","unstructured":"Hu Y, Chen J, Liu M, Feng Q, Peng H. IGF2BP2 serves as a core m6A regulator in head and neck squamous cell carcinoma. 2022. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20221311."},{"key":"723_CR139","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20212119","author":"X Wang","year":"2022","unstructured":"Wang X, Xu H, Zhou Z, Guo S, Chen R. IGF2BP2 maybe a novel prognostic biomarker in oral squamous cell carcinoma. 2022. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20212119."},{"key":"723_CR140","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1007\/s00432-022-04093-z","volume":"148","author":"K Xu","year":"2022","unstructured":"Xu K, Dai X, Wu J, Wen K. N(6)-methyladenosine (m(6)A) reader IGF2BP2 stabilizes HK2 stability to accelerate the Warburg effect of oral squamous cell carcinoma progression. J Cancer Res Clin Oncol. 2022;148:3375\u201384. https:\/\/doi.org\/10.1007\/s00432-022-04093-z.","journal-title":"J Cancer Res Clin Oncol"},{"key":"723_CR141","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.7150\/ijms.74751","volume":"19","author":"SH Lin","year":"2022","unstructured":"Lin SH, Lin CW, Lu JW, Yang WE, Lin YM, Lu HJ, Yang SF. Cytoplasmic IGF2BP2 protein expression in human patients with oral squamous cell carcinoma: prognostic and clinical implications. Int J Med Sci. 2022;19:1198\u2013204. https:\/\/doi.org\/10.7150\/ijms.74751.","journal-title":"Int J Med Sci"},{"key":"723_CR142","doi-asserted-by":"publisher","first-page":"809589","DOI":"10.3389\/fonc.2022.809589","volume":"12","author":"L Zhou","year":"2022","unstructured":"Zhou L, Li H, Cai H, Liu W, Pan E, Yu D, He S. Upregulation of IGF2BP2 promotes oral squamous cell carcinoma progression that is related to cell proliferation, metastasis and tumor-infiltrating immune cells. Front Oncol. 2022;12:809589. https:\/\/doi.org\/10.3389\/fonc.2022.809589.","journal-title":"Front Oncol"},{"key":"723_CR143","doi-asserted-by":"publisher","first-page":"101948","DOI":"10.1016\/j.mcp.2023.101948","volume":"73","author":"H Deng","year":"2024","unstructured":"Deng H, Yao H, Zhou S, He C, Huang Y, Li Y, Chen H, Shu J. Pancancer analysis uncovers an immunological role and prognostic value of the m6A reader IGF2BP2 in pancreatic cancer. Mol Cell Probes. 2024;73:101948. https:\/\/doi.org\/10.1016\/j.mcp.2023.101948.","journal-title":"Mol Cell Probes"},{"key":"723_CR144","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1093\/abbs\/gmz048","volume":"51","author":"S Huang","year":"2019","unstructured":"Huang S, Wu Z, Cheng Y, Wei W, Hao L. Insulin-like growth factor 2 mRNA binding protein 2 promotes aerobic glycolysis and cell proliferation in pancreatic ductal adenocarcinoma via stabilizing GLUT1 mRNA. Acta Biochim Biophys Sin. 2019;51:743\u201352. https:\/\/doi.org\/10.1093\/abbs\/gmz048.","journal-title":"Acta Biochim Biophys Sin"},{"key":"723_CR145","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/s41420-021-00674-y","volume":"7","author":"H Liu","year":"2021","unstructured":"Liu H, Qin S, Liu C, Jiang L, Li C, Yang J, Zhang S, Yan Z, Liu X, Yang J, Sun X. m(6)A reader IGF2BP2-stabilized CASC9 accelerates glioblastoma aerobic glycolysis by enhancing HK2 mRNA stability. Cell Death Discov. 2021;7:292. https:\/\/doi.org\/10.1038\/s41420-021-00674-y.","journal-title":"Cell Death Discov"},{"key":"723_CR146","doi-asserted-by":"publisher","first-page":"4405","DOI":"10.1002\/cam4.5096","volume":"12","author":"P Cao","year":"2023","unstructured":"Cao P, Wu Y, Sun D, Zhang W, Qiu J, Tang Z, Xue X, Qin L. IGF2BP2 promotes pancreatic carcinoma progression by enhancing the stability of B3GNT6 mRNA via m6A methylation. Cancer Med. 2023;12:4405\u201320. https:\/\/doi.org\/10.1002\/cam4.5096.","journal-title":"Cancer Med"},{"key":"723_CR147","doi-asserted-by":"publisher","first-page":"578816","DOI":"10.3389\/fonc.2020.578816","volume":"10","author":"J Pu","year":"2020","unstructured":"Pu J, Wang J, Qin Z, Wang A, Zhang Y, Wu X, Wu Y, Li W, Xu Z, Lu Y, et al. IGF2BP2 promotes liver cancer growth through an m6a-FEN1-dependent mechanism. Front Oncol. 2020;10:578816. https:\/\/doi.org\/10.3389\/fonc.2020.578816.","journal-title":"Front Oncol"},{"key":"723_CR148","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010025","author":"M Jia","year":"2021","unstructured":"Jia M, Shi Y, Xie Y, Li W, Deng J, Fu D, Bai J, Ma Y, Zuberi Z, Li J, Li Z. WT1-AS\/IGF2BP2 axis is a potential diagnostic and prognostic biomarker for lung adenocarcinoma according to ceRNA network comprehensive analysis combined with experiments. Cells. 2021. https:\/\/doi.org\/10.3390\/cells11010025.","journal-title":"Cells"},{"key":"723_CR149","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/s41419-022-04950-2","volume":"13","author":"X Liu","year":"2022","unstructured":"Liu X, He H, Zhang F, Hu X, Bi F, Li K, Yu H, Zhao Y, Teng X, Li J, et al. m6A methylated EphA2 and VEGFA through IGF2BP2\/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K\/AKT and ERK1\/2 signaling. Cell Death Dis. 2022;13:483. https:\/\/doi.org\/10.1038\/s41419-022-04950-2.","journal-title":"Cell Death Dis"},{"key":"723_CR150","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/s41420-023-01707-4","volume":"9","author":"J Wang","year":"2023","unstructured":"Wang J, Zhu M, Zhu J, Li J, Zhu X, Wang K, Shen K, Yang K, Ni X, Liu X, et al. HES1 promotes aerobic glycolysis and cancer progression of colorectal cancer via IGF2BP2-mediated GLUT1 m6A modification. Cell Death Discov. 2023;9:411. https:\/\/doi.org\/10.1038\/s41420-023-01707-4.","journal-title":"Cell Death Discov"},{"key":"723_CR151","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1007\/s11547-016-0674-x","volume":"121","author":"P Franzone","year":"2016","unstructured":"Franzone P, Fiorentino A, Barra S, Cante D, Masini L, Cazzulo E, Todisco L, Gabriele P, Garibaldi E, Merlotti A, et al. Image-guided radiation therapy (IGRT): practical recommendations of Italian association of radiation oncology (AIRO). Radiol Med. 2016;121:958\u201365. https:\/\/doi.org\/10.1007\/s11547-016-0674-x.","journal-title":"Radiol Med"},{"key":"723_CR152","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.2147\/IJN.S290438","volume":"16","author":"L Gong","year":"2021","unstructured":"Gong L, Zhang Y, Liu C, Zhang M, Han S. Application of radiosensitizers in cancer radiotherapy. Int J Nanomed. 2021;16:1083\u2013102. https:\/\/doi.org\/10.2147\/IJN.S290438.","journal-title":"Int J Nanomed"},{"key":"723_CR153","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1007\/s00216-011-4712-1","volume":"400","author":"A Kulakowski","year":"2011","unstructured":"Kulakowski A. The contribution of Marie Sklodowska-Curie to the development of modern oncology. Anal Bioanal Chem. 2011;400:1583\u20136. https:\/\/doi.org\/10.1007\/s00216-011-4712-1.","journal-title":"Anal Bioanal Chem"},{"key":"723_CR154","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13046-024-02959-3","volume":"43","author":"Z Zhou","year":"2024","unstructured":"Zhou Z, Zhang B, Deng Y, Deng S, Li J, Wei W, Wang Y, Wang J, Feng Z, Che M, et al. FBW7\/GSK3beta mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer. J Exp Clin Cancer Res. 2024;43:34. https:\/\/doi.org\/10.1186\/s13046-024-02959-3.","journal-title":"J Exp Clin Cancer Res"},{"issue":"2440\u20132454","key":"723_CR155","doi-asserted-by":"publisher","first-page":"e2446","DOI":"10.1016\/j.devcel.2021.07.006","volume":"56","author":"MR Ippolito","year":"2021","unstructured":"Ippolito MR, Martis V, Martin S, Tijhuis AE, Hong C, Wardenaar R, Dumont M, Zerbib J, Spierings DCJ, Fachinetti D, et al. Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy. Dev Cell. 2021;56(2440\u20132454):e2446. https:\/\/doi.org\/10.1016\/j.devcel.2021.07.006.","journal-title":"Dev Cell"},{"key":"723_CR156","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41417-023-00702-2","volume":"31","author":"W Wang","year":"2024","unstructured":"Wang W, Ding Y, Zhao Y, Li X. m6A reader IGF2BP2 promotes lymphatic metastasis by stabilizing DPP4 in papillary thyroid carcinoma. Cancer Gene Ther. 2024;31:285\u201399. https:\/\/doi.org\/10.1038\/s41417-023-00702-2.","journal-title":"Cancer Gene Ther"},{"key":"723_CR157","doi-asserted-by":"publisher","first-page":"659228","DOI":"10.3389\/fcell.2021.659228","volume":"9","author":"J Han","year":"2021","unstructured":"Han J, Yu X, Wang S, Wang Y, Liu Q, Xu H, Wang X. IGF2BP2 Induces U251 glioblastoma cell chemoresistance by inhibiting FOXO1-mediated PID1 expression through stabilizing lncRNA DANCR. Front Cell Dev Biol. 2021;9:659228. https:\/\/doi.org\/10.3389\/fcell.2021.659228.","journal-title":"Front Cell Dev Biol"},{"key":"723_CR158","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2023.5482","author":"SJ Shi","year":"2023","unstructured":"Shi SJ, Han DH, Zhang JL, Li Y, Yang AG, Zhang R. VIM-AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2-mediated HMGCS1 mRNA stabilization. Int J Oncol. 2023. https:\/\/doi.org\/10.3892\/ijo.2023.5482.","journal-title":"Int J Oncol"},{"key":"723_CR159","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1007\/s13577-022-00748-8","volume":"35","author":"L Fu","year":"2022","unstructured":"Fu L, Zhang D, Yi N, Cao Y, Wei Y, Wang W, Li L. Circular RNA circPBX3 promotes cisplatin resistance of ovarian cancer cells via interacting with IGF2BP2 to stabilize ATP7A mRNA expression. Hum Cell. 2022;35:1560\u201376. https:\/\/doi.org\/10.1007\/s13577-022-00748-8.","journal-title":"Hum Cell"},{"key":"723_CR160","doi-asserted-by":"publisher","first-page":"759267","DOI":"10.3389\/fphar.2021.759267","volume":"12","author":"M Zhang","year":"2021","unstructured":"Zhang M, Wang Q, Ke Z, Liu Y, Guo H, Fang S, Lu K. LINC01001 promotes progression of crizotinib-resistant NSCLC by modulating IGF2BP2\/MYC axis. Front Pharmacol. 2021;12:759267. https:\/\/doi.org\/10.3389\/fphar.2021.759267.","journal-title":"Front Pharmacol"},{"key":"723_CR161","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1038\/s41375-022-01651-9","volume":"36","author":"P Feng","year":"2022","unstructured":"Feng P, Chen D, Wang X, Li Y, Li Z, Li B, Zhang Y, Li W, Zhang J, Ye J, et al. Inhibition of the m(6)A reader IGF2BP2 as a strategy against T-cell acute lymphoblastic leukemia. Leukemia. 2022;36:2180\u20138. https:\/\/doi.org\/10.1038\/s41375-022-01651-9.","journal-title":"Leukemia"},{"key":"723_CR162","doi-asserted-by":"publisher","first-page":"20730","DOI":"10.1038\/s41598-023-47956-2","volume":"13","author":"J Wang","year":"2023","unstructured":"Wang J, Xu J, Zheng J. A1BG-AS1 promotes adriamycin resistance of breast cancer by recruiting IGF2BP2 to upregulate ABCB1 in an m6A-dependent manner. Sci Rep. 2023;13:20730. https:\/\/doi.org\/10.1038\/s41598-023-47956-2.","journal-title":"Sci Rep"},{"key":"723_CR163","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1158\/0008-5472.CAN-21-2988","volume":"82","author":"X Jiang","year":"2022","unstructured":"Jiang X, Guo S, Wang S, Zhang Y, Chen H, Wang Y, Liu R, Niu Y, Xu Y. EIF4A3-induced circARHGAP29 promotes aerobic glycolysis in docetaxel-resistant prostate cancer through IGF2BP2\/c-Myc\/LDHA signaling. Cancer Res. 2022;82:831\u201345. https:\/\/doi.org\/10.1158\/0008-5472.CAN-21-2988.","journal-title":"Cancer Res"},{"key":"723_CR164","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s10565-021-09614-z","volume":"38","author":"X Wang","year":"2022","unstructured":"Wang X, Li X, Zhou Y, Huang X, Jiang X. Long non-coding RNA OIP5-AS1 inhibition upregulates microRNA-129-5p to repress resistance to temozolomide in glioblastoma cells via downregulating IGF2BP2. Cell Biol Toxicol. 2022;38:963\u201377. https:\/\/doi.org\/10.1007\/s10565-021-09614-z.","journal-title":"Cell Biol Toxicol"},{"key":"723_CR165","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1002\/kjm2.12593","volume":"38","author":"EY Wu","year":"2022","unstructured":"Wu EY, Huang LP, Bao JH. miR-96-5p regulates cervical cancer cell resistance to cisplatin by inhibiting lncRNA TRIM52-AS1 and promoting IGF2BP2. Kaohsiung J Med Sci. 2022;38:1178\u201389. https:\/\/doi.org\/10.1002\/kjm2.12593.","journal-title":"Kaohsiung J Med Sci"},{"key":"723_CR166","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1021\/acschembio.1c00833","volume":"17","author":"C Dahlem","year":"2022","unstructured":"Dahlem C, Abuhaliema A, Kessler SM, Krohler T, Zoller BGE, Chanda S, Wu Y, Both S, Muller F, Lepikhov K, et al. First small-molecule inhibitors targeting the RNA-binding protein IGF2BP2\/IMP2 for cancer therapy. ACS Chem Biol. 2022;17:361\u201375. https:\/\/doi.org\/10.1021\/acschembio.1c00833.","journal-title":"ACS Chem Biol"}],"container-title":["Cellular &amp; Molecular Biology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11658-025-00723-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s11658-025-00723-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11658-025-00723-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T18:51:49Z","timestamp":1744224709000},"score":1,"resource":{"primary":{"URL":"https:\/\/cmbl.biomedcentral.com\/articles\/10.1186\/s11658-025-00723-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":166,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["723"],"URL":"https:\/\/doi.org\/10.1186\/s11658-025-00723-9","relation":{"references":[{"id-type":"doi","id":"10.1042\/BSR20221311","asserted-by":"subject"},{"id-type":"doi","id":"10.1042\/BSR20212119","asserted-by":"subject"}]},"ISSN":["1689-1392"],"issn-type":[{"value":"1689-1392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"assertion":[{"value":"30 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43"}}