{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:37:46Z","timestamp":1790681866418,"version":"4.1.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100008222","name":"Universit\u00e9 de Montpellier","doi-asserted-by":"publisher","award":["CBS2"],"award-info":[{"award-number":["CBS2"]}],"id":[{"id":"10.13039\/501100008222","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ATIP-Avenir program","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-21-CE17-0061"],"award-info":[{"award-number":["ANR-21-CE17-0061"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["REP202110014140"],"award-info":[{"award-number":["REP202110014140"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"R\u00e9gion Occitanie"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol Lett"],"DOI":"10.1186\/s11658-025-00804-9","type":"journal-article","created":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:41:46Z","timestamp":1762083706000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Decoding epithelial regeneration in the cornea: multi-omic analysis reveals cellular plasticity as central mechanism"],"prefix":"10.1186","volume":"30","author":[{"given":"Nad\u00e8ge","family":"Feret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia Caballero","family":"Megido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Kuony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Marangoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fichter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Garcia Llorens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Attina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Nhiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Jacquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Vialaret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Daien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Hirtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Loulier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ophir D.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Michon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,2]]},"reference":[{"issue":"2","key":"804_CR1","doi-asserted-by":"publisher","first-page":"190","DOI":"10.4103\/ijo.IJO_646_17","volume":"66","author":"MS Sridhar","year":"2018","unstructured":"Sridhar MS. Anatomy of cornea and ocular surface. Indian J Ophthalmol. 2018;66(2):190\u20134.","journal-title":"Indian J Ophthalmol"},{"key":"804_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2019.107709","volume":"186","author":"B Barrientez","year":"2019","unstructured":"Barrientez B, Nicholas SE, Whelchel A, Sharif R, Hjortdal J, Karamichos D. Corneal injury: clinical and molecular aspects. Exp Eye Res. 2019;186:107709.","journal-title":"Exp Eye Res"},{"key":"804_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-1-59745-507-7_4","volume-title":"Age-related changes of the human eye","author":"L Cerulli","year":"2008","unstructured":"Cerulli L, Missiroli F. Aging of the cornea. In: Cavallotti CAP, Cerulli L, editors. Age-related changes of the human eye. Totowa, NJ: Humana Press; 2008. p. 45\u201360."},{"key":"804_CR4","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.visres.2017.03.002","volume":"139","author":"AV Ljubimov","year":"2017","unstructured":"Ljubimov AV. Diabetic complications in the cornea. Vis Res. 2017;139:138\u201352.","journal-title":"Vis Res"},{"issue":"3","key":"804_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2021.101559","volume":"45","author":"J Santodomingo-Rubido","year":"2022","unstructured":"Santodomingo-Rubido J, Carracedo G, Suzaki A, Villa-Collar C, Vincent SJ, Wolffsohn JS. Keratoconus: an updated review. Contact Lens Anterior Eye. 2022;45(3):101559.","journal-title":"Contact Lens Anterior Eye"},{"issue":"23","key":"804_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-4-7","volume":"4","author":"GK Klintworth","year":"2009","unstructured":"Klintworth GK. Corneal dystrophies. Orphanet J Rare Dis. 2009;4(23):7.","journal-title":"Orphanet J Rare Dis"},{"issue":"4","key":"804_CR7","doi-asserted-by":"publisher","first-page":"e327","DOI":"10.1016\/j.jcjo.2023.05.008","volume":"59","author":"NM Binczyk","year":"2024","unstructured":"Binczyk NM, Nazarali SA, Damji KF, Solarte C. Epidemiology of ocular emergencies in a large Canadian eye centre. Can J Ophthalmol. 2024;59(4):e327\u201330.","journal-title":"Can J Ophthalmol"},{"issue":"3","key":"804_CR8","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1001\/jamaophthalmol.2015.5778","volume":"134","author":"R Channa","year":"2016","unstructured":"Channa R, Zafar SN, Canner JK, Haring RS, Schneider EB, Friedman DS. Epidemiology of eye-related emergency department visits. JAMA Ophthalmol. 2016;134(3):312\u20139.","journal-title":"JAMA Ophthalmol"},{"issue":"1","key":"804_CR9","first-page":"6","volume":"5","author":"K Loh","year":"2010","unstructured":"Loh K, Agarwal P. Contact lens related corneal ulcer. Malays Fam Physician. 2010;5(1):6\u20138.","journal-title":"Malays Fam Physician"},{"issue":"5","key":"804_CR10","first-page":"71","volume":"112","author":"EM Messmer","year":"2015","unstructured":"Messmer EM. The pathophysiology, diagnosis, and treatment of dry eye disease. Dtsch Arztebl Int. 2015;112(5):71\u201382.","journal-title":"Dtsch Arztebl Int"},{"issue":"2","key":"804_CR11","first-page":"114","volume":"87","author":"JL Wipperman","year":"2013","unstructured":"Wipperman JL, Dorsch JN. Evaluation and management of corneal abrasions. afp. 2013;87(2):114\u201320.","journal-title":"afp."},{"issue":"4","key":"804_CR12","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.4103\/ijo.IJO_2137_22","volume":"71","author":"SP Srinivas","year":"2023","unstructured":"Srinivas SP, Rao SK. Ocular surface staining: current concepts and techniques. Indian J Ophthalmol. 2023;71(4):1080\u20139.","journal-title":"Indian J Ophthalmol"},{"issue":"5","key":"804_CR13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2478\/abm-2021-0026","volume":"15","author":"NA Ghafar","year":"2021","unstructured":"Ghafar NA, Jalil NAA, Kamarudin TA. Wound healing of the corneal epithelium: a review. Asian Biomed (Res Rev News). 2021;15(5):199\u2013212.","journal-title":"Asian Biomed (Res Rev News)"},{"key":"804_CR14","unstructured":"MD SAW, MD AL. Management of corneal abrasions. afp. 2004;70(1):123\u20138."},{"issue":"3","key":"804_CR15","first-page":"163","volume":"8","author":"U Vaidyanathan","year":"2019","unstructured":"Vaidyanathan U, Hopping GC, Liu HY, Somani AN, Ronquillo YC, Hoopes PC, et al. Persistent corneal epithelial defects: a review article. Med Hypothesis Discov Innov Ophthalmol. 2019;8(3):163\u201376.","journal-title":"Med Hypothesis Discov Innov Ophthalmol"},{"issue":"4","key":"804_CR16","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1080\/17469899.2016.1203254","volume":"11","author":"L Hazlett","year":"2016","unstructured":"Hazlett L, Suvas S, McClellan S, Ekanayaka S. Challenges of corneal infections. Expert Rev Ophthalmol. 2016;11(4):285\u201397.","journal-title":"Expert Rev Ophthalmol"},{"issue":"1","key":"804_CR17","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/MS9.0000000000001566","volume":"86","author":"TM Liyew","year":"2023","unstructured":"Liyew TM, Mersha AT, Admassie BM, Arefayne NR. Risk stratification, prevention and management of perioperative corneal abrasion for non-ocular surgery: systematic review. Ann Med Surg (Lond). 2023;86(1):373\u201381.","journal-title":"Ann Med Surg (Lond)"},{"issue":"1","key":"804_CR18","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1076\/soph.18.1.2.14074","volume":"18","author":"R Ambr\u00f3sio","year":"2003","unstructured":"Ambr\u00f3sio R, Wilson SE. LASIK vs LASEK vs PRK: advantages and indications. Semin Ophthalmol. 2003;18(1):2\u201310.","journal-title":"Semin Ophthalmol"},{"issue":"23","key":"804_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17238729","volume":"17","author":"G Castro-Luna","year":"2020","unstructured":"Castro-Luna G, Jim\u00e9nez-Rodr\u00edguez D, P\u00e9rez-Rueda A, Alaskar-Alani H. Long term follow-up safety and effectiveness of myopia refractive surgery. Int J Environ Res Public Health. 2020;17(23):8729.","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"804_CR20","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.joco.2017.09.003","volume":"30","author":"M Miraftab","year":"2017","unstructured":"Miraftab M, Hashemi H, Asgari S. Two-year results of femtosecond assisted LASIK versus PRK for different severity of astigmatism. J Curr Ophthalmol. 2017;30(1):48\u201353.","journal-title":"J Curr Ophthalmol"},{"issue":"3","key":"804_CR21","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1755-3768.2010.01894.x","volume":"90","author":"I Kremer","year":"2012","unstructured":"Kremer I, Ehrenberg M, Levinger S. Delayed epithelial healing following photorefractive keratectomy with mitomycin c treatment. Acta Ophthalmol. 2012;90(3):271\u20136.","journal-title":"Acta Ophthalmol"},{"issue":"2","key":"804_CR22","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/00003226-200103000-00008","volume":"20","author":"SE Ti","year":"2001","unstructured":"Ti SE, Tan DTH. Recurrent corneal erosion after laser in situ keratomileusis. Cornea. 2001;20(2):156.","journal-title":"Cornea"},{"issue":"12","key":"804_CR23","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.1016\/j.jcrs.2015.06.037","volume":"41","author":"KS Bower","year":"2015","unstructured":"Bower KS, Sia RK, Ryan DS, Mines MJ, Dartt DA. Chronic dry eye in PRK and LASIK: manifestations, incidence and predictive factors. J Cataract Refract Surg. 2015;41(12):2624\u201334.","journal-title":"J Cataract Refract Surg"},{"issue":"6","key":"804_CR24","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1167\/iovs.03-1194","volume":"45","author":"S Pal-Ghosh","year":"2004","unstructured":"Pal-Ghosh S, Pajoohesh-Ganji A, Brown M, Stepp MA. A mouse model for the study of recurrent corneal epithelial erosions: \u03b19\u03b21 integrin implicated in progression of the disease. Invest Ophthalmol Vis Sci. 2004;45(6):1775\u201388.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"804_CR25","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1038\/s41385-018-0031-6","volume":"11","author":"Y Xue","year":"2018","unstructured":"Xue Y, He J, Xiao C, Guo Y, Fu T, Liu J, et al. The mouse autonomic nervous system modulates inflammation and epithelial renewal after corneal abrasion through the activation of distinct local macrophages. Mucosal Immunol. 2018;11(5):1496\u2013511.","journal-title":"Mucosal Immunol"},{"key":"804_CR26","first-page":"58071","volume":"137","author":"S Kalha","year":"2018","unstructured":"Kalha S, Kuony A, Michon F. Corneal epithelial abrasion with ocular burr as a model for cornea wound healing. J Vis Exp. 2018;137:58071.","journal-title":"J Vis Exp"},{"issue":"202","key":"804_CR27","volume":"8","author":"L Meneux","year":"2023","unstructured":"Meneux L, Caballero A, Boukhaddaoui H, Michon F, Meneux L, Caballero A. Three strategies to induce neurotrophic keratitis and nerve regeneration in murine cornea. J Vis Exp (JoVE). 2023;8(202):e66182.","journal-title":"J Vis Exp (JoVE)"},{"issue":"1","key":"804_CR28","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20199111","volume":"16","author":"T M\u00fcller","year":"2020","unstructured":"M\u00fcller T, Kalxdorf M, Longuesp\u00e9e R, Kazdal DN, Stenzinger A, Krijgsveld J. Automated sample preparation with SP3 for low-input clinical proteomics. Mol Syst Biol. 2020;16(1):e9111.","journal-title":"Mol Syst Biol"},{"issue":"11","key":"804_CR29","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1074\/mcp.TIR118.000853","volume":"17","author":"N Bache","year":"2018","unstructured":"Bache N, Geyer PE, Bekker-Jensen DB, Hoerning O, Falkenby L, Treit PV, et al. A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics. Mol Cell Proteomics. 2018;17(11):2284\u201396.","journal-title":"Mol Cell Proteomics"},{"issue":"27","key":"804_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.omtm.2022.08.006","volume":"8","author":"B Gautier","year":"2022","unstructured":"Gautier B, Meneux L, Feret N, Audrain C, Hudecek L, Kuony A, et al. AAV2\/9-mediated gene transfer into murine lacrimal gland leads to a long-term targeted tear film modification. Mol Ther Methods Clin Dev. 2022;8(27):1\u201316.","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"3","key":"804_CR31","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/iovs.66.3.9","volume":"66","author":"ZJ Lu","year":"2025","unstructured":"Lu ZJ, Ye JG, Li JN, Liang JB, Zhou M, Hu QL, et al. Single-cell multiomics analysis of early wound response programs in the mouse corneal epithelium. Invest Ophthalmol Vis Sci. 2025;66(3):9.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"81","key":"804_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101700","volume":"1","author":"A Wagner","year":"2022","unstructured":"Wagner A, Schosserer M. The epitranscriptome in ageing and stress resistance: a systematic review. Ageing Res Rev. 2022;1(81):101700.","journal-title":"Ageing Res Rev"},{"issue":"3","key":"804_CR33","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41576-022-00534-0","volume":"24","author":"K Boulias","year":"2023","unstructured":"Boulias K, Greer EL. Biological roles of adenine methylation in RNA. Nat Rev Genet. 2023;24(3):143\u201360.","journal-title":"Nat Rev Genet"},{"issue":"10","key":"804_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.915685","volume":"3","author":"A Alagia","year":"2022","unstructured":"Alagia A, Gullerova M. The methylation game: epigenetic and epitranscriptomic dynamics of 5-methylcytosine. Front Cell Dev Biol. 2022;3(10):915685.","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"804_CR35","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/iovs.62.4.8","volume":"62","author":"SE Wilson","year":"2021","unstructured":"Wilson SE. Interleukin-1 and transforming growth factor beta: commonly opposing, but sometimes supporting, master regulators of the corneal wound healing response to injury. Invest Ophthalmol Vis Sci. 2021;62(4):8.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"229","key":"804_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.109337","volume":"1","author":"C Bonnet","year":"2023","unstructured":"Bonnet C, Ruiz M, Gonzalez S, Tseng CH, Bourges JL, Behar-Cohen F, et al. Single mRNA detection of Wnt signaling pathway in the human limbus. Exp Eye Res. 2023;1(229):109337.","journal-title":"Exp Eye Res"},{"issue":"33","key":"804_CR37","doi-asserted-by":"publisher","first-page":"20448","DOI":"10.1074\/jbc.M115.662940","volume":"290","author":"G Li","year":"2015","unstructured":"Li G, Xu F, Zhu J, Krawczyk M, Zhang Y, Yuan J, et al. Transcription factor PAX6 (paired box 6) controls limbal stem cell lineage in development and disease. J Biol Chem. 2015;290(33):20448\u201354.","journal-title":"J Biol Chem"},{"issue":"4","key":"804_CR38","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.stemcr.2017.08.015","volume":"9","author":"A Richardson","year":"2017","unstructured":"Richardson A, Lobo EP, Delic NC, Myerscough MR, Lyons JG, Wakefield D, et al. Keratin-14-positive precursor cells spawn a population of migratory corneal epithelia that maintain tissue mass throughout life. Stem Cell Rep. 2017;9(4):1081\u201396.","journal-title":"Stem Cell Rep"},{"issue":"8","key":"804_CR39","doi-asserted-by":"publisher","first-page":"8627","DOI":"10.3390\/cimb46080508","volume":"46","author":"DD Romashin","year":"2024","unstructured":"Romashin DD, Tolstova TV, Varshaver AM, Kozhin PM, Rusanov AL, Luzgina NG. Keratins 6, 16, and 17 in health and disease: a summary of recent findings. Curr Issues Mol Biol. 2024;46(8):8627\u201341.","journal-title":"Curr Issues Mol Biol"},{"key":"804_CR40","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.actbio.2014.10.007","volume":"12","author":"J Gao","year":"2015","unstructured":"Gao J, Raghunathan VK, Reid B, Wei D, Diaz RC, Russell P, et al. Biomimetic stochastic topography and electric fields synergistically enhance directional migration of corneal epithelial cells in a MMP-3-dependent manner. Acta Biomater. 2015;12:102\u201312.","journal-title":"Acta Biomater"},{"issue":"12","key":"804_CR41","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1242\/dev.121160","volume":"142","author":"DC LeBert","year":"2015","unstructured":"LeBert DC, Squirrell JM, Rindy J, Broadbridge E, Lui Y, Zakrzewska A, et al. Matrix metalloproteinase 9 modulates collagen matrices and wound repair. Development. 2015;142(12):2136\u201346.","journal-title":"Development"},{"issue":"1","key":"804_CR42","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bbamcr.2010.01.003","volume":"1803","author":"K Brew","year":"2010","unstructured":"Brew K, Nagase H. The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochim Biophys Acta. 2010;1803(1):55\u201371.","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"804_CR43","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1369\/0022155420953922","volume":"68","author":"S Islam","year":"2020","unstructured":"Islam S, Watanabe H. Versican: a dynamic regulator of the extracellular matrix. J Histochem Cytochem. 2020;68(11):763\u201375.","journal-title":"J Histochem Cytochem"},{"issue":"4","key":"804_CR44","doi-asserted-by":"publisher","first-page":"374","DOI":"10.4161\/cam.20832","volume":"6","author":"H Kiefel","year":"2012","unstructured":"Kiefel H, Bondong S, Hazin J, Ridinger J, Schirmer U, Riedle S, et al. L1CAM. Cell Adh Migr. 2012;6(4):374\u201384.","journal-title":"Cell Adh Migr"},{"issue":"9","key":"804_CR45","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1089\/scd.2016.0039","volume":"25","author":"Y Eghtedari","year":"2016","unstructured":"Eghtedari Y, Richardson A, Mai K, Heng B, Guillemin GJ, Wakefield D, et al. Keratin 14 expression in epithelial progenitor cells of the developing human cornea. Stem Cells Dev. 2016;25(9):699\u2013711.","journal-title":"Stem Cells Dev"},{"issue":"2","key":"804_CR46","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1167\/iovs.05-1182","volume":"47","author":"N Tanifuji-Terai","year":"2006","unstructured":"Tanifuji-Terai N, Terai K, Hayashi Y, Chikama TI, Kao WWY. Expression of keratin 12 and maturation of corneal epithelium during development and postnatal growth. Investig Ophthalmol Vis Sci. 2006;47(2):545\u201351.","journal-title":"Investig Ophthalmol Vis Sci."},{"issue":"12","key":"804_CR47","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1097\/ICO.0000000000000264","volume":"33","author":"W Stevenson","year":"2014","unstructured":"Stevenson W, Chen Y, Lee SM, Lee HS, Hua J, Dohlman T, et al. Extraorbital lacrimal gland excision: a reproducible model of severe aqueous tear-deficient dry eye disease. Cornea. 2014;33(12):1336.","journal-title":"Cornea"},{"issue":"10","key":"804_CR48","doi-asserted-by":"publisher","first-page":"3264","DOI":"10.1167\/iovs.18-26457","volume":"60","author":"NE Mecum","year":"2019","unstructured":"Mecum NE, Cyr D, Malon J, Demers D, Cao L, Meng ID. Evaluation of corneal damage after lacrimal gland excision in male and female mice. Invest Ophthalmol Vis Sci. 2019;60(10):3264\u201374.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"804_CR49","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/s41598-021-04086-x","volume":"12","author":"K Ikkala","year":"2022","unstructured":"Ikkala K, Stratoulias V, Michon F. Unilateral zebrafish corneal injury induces bilateral cell plasticity supporting wound closure. Sci Rep. 2022;12(1):161.","journal-title":"Sci Rep"},{"issue":"14","key":"804_CR50","doi-asserted-by":"publisher","first-page":"dev176693","DOI":"10.1242\/dev.176693","volume":"146","author":"A Kuony","year":"2019","unstructured":"Kuony A, Ikkala K, Kalha S, Magalh\u00e3es AC, Pirttiniemi A, Michon F. Ectodysplasin-a signaling is a key integrator in the lacrimal gland-cornea feedback loop. Development. 2019;146(14):dev176693.","journal-title":"Development"},{"issue":"6","key":"804_CR51","first-page":"565","volume":"10","author":"A Tandon","year":"2010","unstructured":"Tandon A, Tovey JCK, Sharma A, Gupta R, Mohan RR. Role of transforming growth factor beta in corneal function, biology and pathology. Curr Mol Med. 2010;10(6):565\u201378.","journal-title":"Curr Mol Med"},{"issue":"48","key":"804_CR52","doi-asserted-by":"publisher","first-page":"17272","DOI":"10.1073\/pnas.1407227111","volume":"111","author":"VH Guaiquil","year":"2014","unstructured":"Guaiquil VH, Pan Z, Karagianni N, Fukuoka S, Alegre G, Rosenblatt MI. VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions. Proc Natl Acad Sci. 2014;111(48):17272\u20137.","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"804_CR53","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/ame2.12192","volume":"4","author":"K Pang","year":"2021","unstructured":"Pang K, Lennikov A, Yang M. Hypoxia adaptation in the cornea: current animal models and underlying mechanisms. Anim Model Exp Med. 2021;4(4):300\u201310.","journal-title":"Anim Model Exp Med"},{"issue":"13","key":"804_CR54","doi-asserted-by":"publisher","first-page":"12988","DOI":"10.1074\/jbc.M412458200","volume":"280","author":"T Li","year":"2005","unstructured":"Li T, Lu L. Epidermal growth factor-induced proliferation requires down-regulation of Pax6 in corneal epithelial cells. J Biol Chem. 2005;280(13):12988\u201395.","journal-title":"J Biol Chem"},{"key":"804_CR55","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jtos.2020.10.006","volume":"19","author":"S Kamil","year":"2021","unstructured":"Kamil S, Mohan RR. Corneal stromal wound healing: Major regulators and therapeutic targets. Ocul Surf. 2021;19:290\u2013306.","journal-title":"Ocul Surf"},{"issue":"4","key":"804_CR56","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.4103\/IJO.IJO_2851_22","volume":"71","author":"R Kannan","year":"2023","unstructured":"Kannan R, Das S, Shetty R, Zhou L, Ghosh A, Deshpande V. Tear proteomics in dry eye disease. Indian J Ophthalmol. 2023;71(4):1203\u201314.","journal-title":"Indian J Ophthalmol"},{"issue":"19","key":"804_CR57","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.1242\/dev.125393","volume":"142","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Yeh LK, Zhang S, Call M, Yuan Y, Yasunaga M, et al. Wnt\/\u03b2-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development. Development. 2015;142(19):3383\u201393.","journal-title":"Development"},{"issue":"21","key":"804_CR58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111975","volume":"22","author":"SYT Robertson","year":"2021","unstructured":"Robertson SYT, Roberts JS, Deng SX. Regulation of limbal epithelial stem cells: importance of the niche. Int J Mol Sci. 2021;22(21):11975.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"804_CR59","doi-asserted-by":"publisher","first-page":"910","DOI":"10.3390\/genes13050910","volume":"13","author":"H Jin","year":"2022","unstructured":"Jin H, Huo C, Zhou T, Xie S. m1A RNA modification in gene expression regulation. Genes (Basel). 2022;13(5):910.","journal-title":"Genes (Basel)"},{"issue":"9","key":"804_CR60","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1080\/15476286.2016.1203504","volume":"13","author":"TP Hoernes","year":"2016","unstructured":"Hoernes TP, H\u00fcttenhofer A, Erlacher MD. mRNA modifications: Dynamic regulators of gene expression? RNA Biol. 2016;13(9):760\u20135.","journal-title":"RNA Biol"},{"issue":"1","key":"804_CR61","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12935-022-02452-x","volume":"22","author":"S Wang","year":"2022","unstructured":"Wang S, Lv W, Li T, Zhang S, Wang H, Li X, et al. Dynamic regulation and functions of mRNA m6A modification. Cancer Cell Int. 2022;22(1):48.","journal-title":"Cancer Cell Int"},{"issue":"8","key":"804_CR62","doi-asserted-by":"publisher","first-page":"782","DOI":"10.3389\/fcell.2020.00782","volume":"11","author":"M Zhang","year":"2020","unstructured":"Zhang M, Zhai Y, Zhang S, Dai X, Li Z. Roles of N6-methyladenosine (m6A) in stem cell fate decisions and early embryonic development in mammals. Front Cell Dev Biol. 2020;11(8):782.","journal-title":"Front Cell Dev Biol"},{"issue":"127","key":"804_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110098","volume":"1","author":"S Liu","year":"2020","unstructured":"Liu S, Li Q, Chen K, Zhang Q, Li G, Zhuo L, et al. The emerging molecular mechanism of m6A modulators in tumorigenesis and cancer progression. Biomed Pharmacother. 2020;1(127):110098.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"804_CR64","doi-asserted-by":"publisher","first-page":"zcae009","DOI":"10.1093\/narcan\/zcae009","volume":"6","author":"M Esteva-Socias","year":"2024","unstructured":"Esteva-Socias M, Aguilo F. METTL3 as a master regulator of translation in cancer: mechanisms and implications. NAR Cancer. 2024;6(1):zcae009.","journal-title":"NAR Cancer."},{"issue":"11","key":"804_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.634542","volume":"26","author":"W Li","year":"2021","unstructured":"Li W, Xu S, Peng N, Zhang Z, He H, Chen R, et al. Downregulation of METTL7B inhibits proliferation of human clear cell renal cancer cells in vivo and in vitro. Front Oncol. 2021;26(11):634542.","journal-title":"Front Oncol"},{"issue":"11","key":"804_CR66","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3389\/fphar.2020.00178","volume":"28","author":"D Liu","year":"2020","unstructured":"Liu D, Li W, Zhong F, Yin J, Zhou W, Li S, et al. METTL7B is required for cancer cell proliferation and tumorigenesis in non-small cell lung cancer. Front Pharmacol. 2020;28(11):178.","journal-title":"Front Pharmacol"},{"issue":"6","key":"804_CR67","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/s43018-021-00223-7","volume":"2","author":"J Jeschke","year":"2021","unstructured":"Jeschke J, Collignon E, Wardi CA, Krayem M, Bizet M, Jia Y, et al. Downregulation of the FTO m6A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors. Nat Cancer. 2021;2(6):611\u201328.","journal-title":"Nat Cancer"},{"issue":"271","key":"804_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119180","volume":"15","author":"K Zhu","year":"2021","unstructured":"Zhu K, Li Y, Xu Y. The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels. Life Sci. 2021;15(271):119180.","journal-title":"Life Sci"},{"issue":"2","key":"804_CR69","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.devcel.2007.06.012","volume":"13","author":"S Vauclair","year":"2007","unstructured":"Vauclair S, Majo F, Durham AD, Ghyselinck NB, Barrandon Y, Radtke F. Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism. Dev Cell. 2007;13(2):242\u201353.","journal-title":"Dev Cell"},{"issue":"14","key":"804_CR70","first-page":"1041","volume":"5","author":"AR Djalilian","year":"2008","unstructured":"Djalilian AR, Namavari A, Ito A, Balali S, Afshar A, Lavker RM, et al. Down-regulation of Notch signaling during corneal epithelial proliferation. Mol Vis. 2008;5(14):1041\u20139.","journal-title":"Mol Vis"},{"issue":"18","key":"804_CR71","first-page":"403","volume":"9","author":"H Lu","year":"2012","unstructured":"Lu H, Lu Q, Zheng Y, Li Q. Notch signaling promotes the corneal epithelium wound healing. Mol Vis. 2012;9(18):403\u201311.","journal-title":"Mol Vis"},{"issue":"33","key":"804_CR72","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.scr.2018.11.001","volume":"1","author":"N Sagga","year":"2018","unstructured":"Sagga N, Kuffov\u00e1 L, Vargesson N, Erskine L, Collinson JM. Limbal epithelial stem cell activity and corneal epithelial cell cycle parameters in adult and aging mice. Stem Cell Res. 2018;1(33):185\u201398.","journal-title":"Stem Cell Res"},{"issue":"4","key":"804_CR73","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1034\/j.1600-0420.2001.079004389.x","volume":"79","author":"S Estil","year":"2001","unstructured":"Estil S, Haaskjold E, Bjerknes R, Refsum SB. A previous abrasion in the contralateral eye influences the cell kinetics during healing of a central corneal abrasion. Acta Ophthalmol Scand. 2001;79(4):389\u201393.","journal-title":"Acta Ophthalmol Scand"}],"container-title":["Cellular & Molecular Biology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11658-025-00804-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s11658-025-00804-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11658-025-00804-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:02:43Z","timestamp":1762088563000},"score":1,"resource":{"primary":{"URL":"https:\/\/cmbl.biomedcentral.com\/articles\/10.1186\/s11658-025-00804-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,2]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["804"],"URL":"https:\/\/doi.org\/10.1186\/s11658-025-00804-9","relation":{},"ISSN":["1689-1392"],"issn-type":[{"value":"1689-1392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,2]]},"assertion":[{"value":"20 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the experiments conducted on mice were approved by the local ethical committee and the Minist\u00e8re de la Recherche et de l\u2019enseignement Sup\u00e9rieur (authorization 2016080510211993 version2). All of the procedures were carried out in accordance with the French regulation for the animal procedure (French decree 2013\u2013118) and with specific European Union guidelines for the protection of animal welfare (Directive 2010\/63\/EU).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"131"}}