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The study was approved by the Ethics Committee of Renmin Hospital of Wuhan University on 5 October 2023 (Approval Number: WDRY2023-K173). All animal experiments were approved by the Institutional Animal Care and Ethics Committee of Renmin Hospital of Wuhan University on 17 July 2024 (approval number: WDRM 20240717 C). The local ethics committee operates in accordance with the guidelines of the International Council for Laboratory Animal Science.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"144"}}