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LLSC20240063, approved on 15 March 2024). This committee adheres to the principles and guidelines set forth by the International Council for Laboratory Animal Science (ICLAS), ensuring that our animal research meets international ethical standards. All experiments involving human samples and clinical data were reviewed and approved by the Clinical Ethics Committee of the First Affiliated Hospital of Anhui Medical University (approval no. PJ2024-10-50, approved on 10 October 2024). The committee conducted its review in strict accordance with the principles of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"12"}}