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KYLL-2025172, 24 February 2025) and performed in accordance with the principles of the Declaration of Helsinki. Informed consent was obtained from all subjects involved in the study. All animal studies were approved by the Laboratory Animal Committee of Qilu Hospital of Shandong University DWLL-2024-260, 16 May 2024). The Animal Care and Ethics Committee of Shandong University adheres to the principles and guidelines set forth by the International Council for Laboratory Animal Science (ICLAS), ensuring that our animal research meets international ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This manuscript does not contain any individual person\u2019s data in any form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"73"}}