{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:57:54Z","timestamp":1789138674075,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":89,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Natural Science Foundation of Hunan","award":["2022JJ30992"],"award-info":[{"award-number":["2022JJ30992"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Biol Lett"],"DOI":"10.1186\/s11658-026-00957-1","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T07:42:16Z","timestamp":1780299736000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lactate-activated astrocytes promote NSCLC brain metastasis through extracellular vesicle-mediated miR-8085\/TRIM67\/ELK1 signaling axis"],"prefix":"10.1186","volume":"31","author":[{"given":"Haiqin","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilong","family":"Tanzhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Michael","family":"Marti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"issue":"1","key":"957_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41568-019-0220-y","volume":"20","author":"A Boire","year":"2020","unstructured":"Boire A, Brastianos PK, Garzia L, Valiente M. Brain metastasis. Nat Rev Cancer. 2020;20(1):4\u201311.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"957_CR2","first-page":"7","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7\u201330.","journal-title":"CA Cancer J Clin"},{"issue":"9","key":"957_CR3","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1093\/neuonc\/noab101","volume":"23","author":"N Lamba","year":"2021","unstructured":"Lamba N, Wen PY, Aizer AA. Epidemiology of brain metastases and leptomeningeal disease. Neuro Oncol. 2021;23(9):1447\u201356.","journal-title":"Neuro Oncol"},{"issue":"10","key":"957_CR4","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1093\/neuonc\/noac118","volume":"24","author":"AA Aizer","year":"2022","unstructured":"Aizer AA, Lamba N, Ahluwalia MS, Aldape K, Boire A, Brastianos PK, et\u00a0al. Brain metastases: a Society for Neuro-Oncology (SNO) consensus review on current management and future directions. Neuro Oncol. 2022;24(10):1613\u201346.","journal-title":"Neuro Oncol"},{"issue":"10","key":"957_CR5","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1200\/JCO.2016.69.7144","volume":"35","author":"WJ Magnuson","year":"2017","unstructured":"Magnuson WJ, Lester-Coll NH, Wu AJ, Yang TJ, Lockney NA, Gerber NK, et\u00a0al. Management of brain metastases in tyrosine kinase inhibitor-naive epidermal growth factor receptor-mutant non-small-cell lung cancer: a retrospective multi-institutional analysis. J Clin Oncol. 2017;35(10):1070\u20137.","journal-title":"J Clin Oncol"},{"issue":"5","key":"957_CR6","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41571-019-0320-3","volume":"17","author":"JH Suh","year":"2020","unstructured":"Suh JH, Kotecha R, Chao ST, Ahluwalia MS, Sahgal A, Chang EL. Current approaches to the management of brain metastases. Nat Rev Clin Oncol. 2020;17(5):279\u201399.","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"957_CR7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12943-023-01818-7","volume":"22","author":"A Ahmad","year":"2023","unstructured":"Ahmad A, Khan P, Rehman AU, Batra SK, Nasser MW. Immunotherapy: an emerging modality to checkmate brain metastasis. Mol Cancer. 2023;22(1):111.","journal-title":"Mol Cancer"},{"issue":"1","key":"957_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41568-019-0205-x","volume":"20","author":"CD Arvanitis","year":"2020","unstructured":"Arvanitis CD, Ferraro GB, Jain RK. The blood-brain barrier and blood-tumour barrier in brain tumours and metastases. Nat Rev Cancer. 2020;20(1):26\u201341.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"957_CR9","doi-asserted-by":"publisher","first-page":"5983","DOI":"10.1038\/s41467-022-33365-y","volume":"13","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Abdo R, Iosef C, Kaneko T, Cecchini M, Han VK, et\u00a0al. The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis. Nat Commun. 2022;13(1):5983.","journal-title":"Nat Commun"},{"issue":"4","key":"957_CR10","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nm838","volume":"9","author":"T Wyss-Coray","year":"2003","unstructured":"Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, et\u00a0al. Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat Med. 2003;9(4):453\u20137.","journal-title":"Nat Med"},{"key":"957_CR11","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.semcancer.2019.10.010","volume":"60","author":"TT Lah","year":"2020","unstructured":"Lah TT, Novak M, Breznik B. Brain malignancies: glioblastoma and brain metastases. Semin Cancer Biol. 2020;60:262\u201373.","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"957_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13045-023-01518-1","volume":"16","author":"D Zhou","year":"2023","unstructured":"Zhou D, Gong Z, Wu D, Ma C, Hou L, Niu X, et\u00a0al. Harnessing immunotherapy for brain metastases: insights into tumor-brain microenvironment interactions and emerging treatment modalities. J Hematol Oncol. 2023;16(1):121.","journal-title":"J Hematol Oncol"},{"issue":"7576","key":"957_CR13","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/nature15376","volume":"527","author":"L Zhang","year":"2015","unstructured":"Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang WC, et\u00a0al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015;527(7576):100\u20134.","journal-title":"Nature"},{"issue":"1","key":"957_CR14","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1038\/s41467-023-38252-8","volume":"14","author":"W Ma","year":"2023","unstructured":"Ma W, Oliveira-Nunes MC, Xu K, Kossenkov A, Reiner BC, Crist RC, et\u00a0al. Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment. Nat Commun. 2023;14(1):2632.","journal-title":"Nat Commun"},{"issue":"5","key":"957_CR15","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.ccell.2015.10.010","volume":"28","author":"M Aleckovic","year":"2015","unstructured":"Aleckovic M, Kang Y. Welcoming treat: astrocyte-derived exosomes induce PTEN suppression to foster brain metastasis. Cancer Cell. 2015;28(5):554\u20136.","journal-title":"Cancer Cell"},{"issue":"6","key":"957_CR16","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s12195-021-00691-y","volume":"14","author":"PS Nakod","year":"2021","unstructured":"Nakod PS, Kim Y, Rao SS. The impact of astrocytes and endothelial cells on glioblastoma stemness marker expression in multicellular spheroids. Cell Mol Bioeng. 2021;14(6):639\u201351.","journal-title":"Cell Mol Bioeng"},{"issue":"1","key":"957_CR17","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41392-024-01851-y","volume":"9","author":"X Chu","year":"2024","unstructured":"Chu X, Tian W, Ning J, Xiao G, Zhou Y, Wang Z, et\u00a0al. Cancer stem cells: advances in knowledge and implications for cancer therapy. Signal Transduct Target Ther. 2024;9(1):170.","journal-title":"Signal Transduct Target Ther"},{"key":"957_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030621","author":"K Biserova","year":"2021","unstructured":"Biserova K, Jakovlevs A, Uljanovs R, Strumfa I. Cancer stem cells: significance in origin, pathogenesis and treatment of Glioblastoma. Cells. 2021. https:\/\/doi.org\/10.3390\/cells10030621.","journal-title":"Cells"},{"issue":"13","key":"957_CR19","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.1158\/0008-5472.CAN-18-3726","volume":"79","author":"JC Garcia-Canaveras","year":"2019","unstructured":"Garcia-Canaveras JC, Chen L, Rabinowitz JD. The tumor metabolic microenvironment: lessons from lactate. Cancer Res. 2019;79(13):3155\u201362.","journal-title":"Cancer Res"},{"issue":"12","key":"957_CR20","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.it.2022.10.005","volume":"43","author":"P Apostolova","year":"2022","unstructured":"Apostolova P, Pearce EL. Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment. Trends Immunol. 2022;43(12):969\u201377.","journal-title":"Trends Immunol"},{"issue":"8","key":"957_CR21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00018-022-04453-5","volume":"79","author":"H Deng","year":"2022","unstructured":"Deng H, Gao Y, Trappetti V, Hertig D, Karatkevich D, Losmanova T, et\u00a0al. Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. Cell Mol Life Sci. 2022;79(8):445\u2013445.","journal-title":"Cell Mol Life Sci"},{"key":"957_CR22","doi-asserted-by":"publisher","first-page":"217353","DOI":"10.1016\/j.canlet.2024.217353","volume":"611","author":"H Ge","year":"2024","unstructured":"Ge H, Malsiu F, Gao Y, Losmanova T, Blank F, Ott J, et\u00a0al. Inhibition of LDHB suppresses the metastatic potential of lung cancer by reducing mitochondrial GSH catabolism. Cancer Lett. 2024;611:217353.","journal-title":"Cancer Lett"},{"issue":"3","key":"957_CR23","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.devcel.2019.04.011","volume":"49","author":"I Wortzel","year":"2019","unstructured":"Wortzel I, Dror S, Kenific CM, Lyden D. Exosome-mediated metastasis: communication from a distance. Dev Cell. 2019;49(3):347\u201360.","journal-title":"Dev Cell"},{"issue":"12","key":"957_CR24","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/cgt.2016.48","volume":"23","author":"L Saadatpour","year":"2016","unstructured":"Saadatpour L, Fadaee E, Fadaei S, Nassiri Mansour R, Mohammadi M, Mousavi SM, et\u00a0al. Glioblastoma: exosome and microRNA as novel diagnosis biomarkers. Cancer Gene Ther. 2016;23(12):415\u20138.","journal-title":"Cancer Gene Ther"},{"key":"957_CR25","doi-asserted-by":"publisher","first-page":"215726","DOI":"10.1016\/j.canlet.2022.215726","volume":"540","author":"SR Sirkisoon","year":"2022","unstructured":"Sirkisoon SR, Wong GL, Aguayo NR, Doheny DL, Zhu D, Regua AT, et\u00a0al. Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2\u2013>CNTF axis to promote progression of brain metastases. Cancer Lett. 2022;540:215726.","journal-title":"Cancer Lett"},{"key":"957_CR26","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.canlet.2018.06.041","volume":"433","author":"T Yu","year":"2018","unstructured":"Yu T, Wang X, Zhi T, Zhang J, Wang Y, Nie E, et\u00a0al. Delivery of MGMT mRNA to glioma cells by reactive astrocyte-derived exosomes confers a temozolomide resistance phenotype. Cancer Lett. 2018;433:210\u201320.","journal-title":"Cancer Lett"},{"issue":"5","key":"957_CR27","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1124\/pharmrev.123.000841","volume":"75","author":"SI van de Wakker","year":"2023","unstructured":"van de Wakker SI, Meijers FM, Sluijter JPG, Vader P. Extracellular vesicle heterogeneity and its impact for regenerative medicine applications. Pharmacol Rev. 2023;75(5):1043\u201361.","journal-title":"Pharmacol Rev"},{"issue":"4","key":"957_CR28","doi-asserted-by":"publisher","first-page":"e12215","DOI":"10.1002\/jev2.12215","volume":"11","author":"S Dechantsreiter","year":"2022","unstructured":"Dechantsreiter S, Ambrose AR, Worboys JD, Lim JME, Liu S, Shah R, et\u00a0al. Heterogeneity in extracellular vesicle secretion by single human macrophages revealed by super-resolution microscopy. J Extracell Vesicles. 2022;11(4):e12215.","journal-title":"J Extracell Vesicles"},{"issue":"4","key":"957_CR29","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.cell.2021.12.043","volume":"185","author":"H Gonzalez","year":"2022","unstructured":"Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, et\u00a0al. Cellular architecture of human brain metastases. Cell. 2022;185(4):729\u201345.","journal-title":"Cell"},{"issue":"8","key":"957_CR30","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1093\/jnci\/djt022","volume":"105","author":"SM Nolte","year":"2013","unstructured":"Nolte SM, Venugopal C, McFarlane N, Morozova O, Hallett RM, O\u2019Farrell E, et\u00a0al. A cancer stem cell model for studying brain metastases from primary lung cancer. J Natl Cancer Inst. 2013;105(8):551\u201362.","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"957_CR31","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.cell.2014.10.032","volume":"159","author":"TS Gujral","year":"2014","unstructured":"Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 2014;159(4):844\u201356.","journal-title":"Cell"},{"issue":"2","key":"957_CR32","doi-asserted-by":"publisher","first-page":"765","DOI":"10.7150\/ijbs.91295","volume":"20","author":"W Shi","year":"2024","unstructured":"Shi W, Tanzhu G, Chen L, Ning J, Wang H, Xiao G, et\u00a0al. Radiotherapy in preclinical models of brain metastases: a review and recommendations for future studies. Int J Biol Sci. 2024;20(2):765\u201383.","journal-title":"Int J Biol Sci"},{"issue":"8","key":"957_CR33","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1038\/s43018-023-00595-y","volume":"4","author":"A P\u00e9rez-Gonz\u00e1lez","year":"2023","unstructured":"P\u00e9rez-Gonz\u00e1lez A, B\u00e9vant K, Blanpain C. Cancer cell plasticity during tumor progression, metastasis and response to therapy. Nat Cancer. 2023;4(8):1063\u201382.","journal-title":"Nat Cancer"},{"issue":"10","key":"957_CR34","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1158\/0008-5472.CAN-22-2213","volume":"83","author":"J Zhuang","year":"2023","unstructured":"Zhuang J, Shen L, Li M, Sun J, Hao J, Li J, et\u00a0al. Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance. Cancer Res. 2023;83(10):1611\u201327.","journal-title":"Cancer Res"},{"issue":"1","key":"957_CR35","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13046-023-02717-x","volume":"42","author":"J Yang","year":"2023","unstructured":"Yang J, Teng Y. Harnessing cancer stem cell-derived exosomes to improve cancer therapy. J Exp Clin Cancer Res. 2023;42(1):131.","journal-title":"J Exp Clin Cancer Res"},{"issue":"4","key":"957_CR36","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.tibs.2017.01.002","volume":"42","author":"S Hatakeyama","year":"2017","unstructured":"Hatakeyama S. TRIM family proteins: roles in autophagy, immunity, and carcinogenesis. Trends Biochem Sci. 2017;42(4):297\u2013311.","journal-title":"Trends Biochem Sci"},{"key":"957_CR37","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0186-18.2018","author":"NP Boyer","year":"2018","unstructured":"Boyer NP, Monkiewicz C, Menon S, Moy SS, Gupton SL. Mammalian TRIM67 functions in brain development and behavior. eNeuro. 2018. https:\/\/doi.org\/10.1523\/ENEURO.0186-18.2018.","journal-title":"eNeuro"},{"issue":"3","key":"957_CR38","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1002\/emmm.201201623","volume":"5","author":"F Xing","year":"2013","unstructured":"Xing F, Kobayashi A, Okuda H, Watabe M, Pai SK, Pandey PR, et\u00a0al. Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain. EMBO Mol Med. 2013;5(3):384\u201396.","journal-title":"EMBO Mol Med"},{"issue":"7604","key":"957_CR39","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nature18268","volume":"533","author":"Q Chen","year":"2016","unstructured":"Chen Q, Boire A, Jin X, Valiente M, Er EE, Lopez-Soto A, et\u00a0al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 2016;533(7604):493\u20138.","journal-title":"Nature"},{"issue":"10","key":"957_CR40","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1038\/s41556-023-01241-6","volume":"25","author":"F Qu","year":"2023","unstructured":"Qu F, Brough SC, Michno W, Madubata CJ, Hartmann GG, Puno A, et\u00a0al. Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis. Nat Cell Biol. 2023;25(10):1506\u201319.","journal-title":"Nat Cell Biol"},{"issue":"1","key":"957_CR41","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41388-019-0959-3","volume":"39","author":"SR Sirkisoon","year":"2020","unstructured":"Sirkisoon SR, Carpenter RL, Rimkus T, Doheny D, Zhu D, Aguayo NR, et\u00a0al. TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment. Oncogene. 2020;39(1):64\u201378.","journal-title":"Oncogene"},{"issue":"5","key":"957_CR42","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1182\/blood-2005-05-1795","volume":"107","author":"E Gottfried","year":"2006","unstructured":"Gottfried E, Kunz-Schughart LA, Ebner S, Mueller-Klieser W, Hoves S, Andreesen R, et\u00a0al. Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood. 2006;107(5):2013\u201321.","journal-title":"Blood"},{"issue":"9","key":"957_CR43","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.1182\/blood-2006-07-035972","volume":"109","author":"K Fischer","year":"2007","unstructured":"Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M, et\u00a0al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood. 2007;109(9):3812\u20139.","journal-title":"Blood"},{"issue":"11","key":"957_CR44","doi-asserted-by":"publisher","first-page":"e26383","DOI":"10.4161\/onci.26383","volume":"2","author":"Z Husain","year":"2013","unstructured":"Husain Z, Seth P, Sukhatme VP. Tumor-derived lactate and myeloid-derived suppressor cells: linking metabolism to cancer immunology. Oncoimmunology. 2013;2(11):e26383.","journal-title":"Oncoimmunology"},{"issue":"1","key":"957_CR45","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1186\/s12935-021-02197-z","volume":"21","author":"L Wei","year":"2021","unstructured":"Wei L, Wang G, Yang C, Zhang Y, Chen Y, Zhong C, et\u00a0al. MicroRNA-550a-3-5p controls the brain metastasis of lung cancer by directly targeting YAP1. Cancer Cell Int. 2021;21(1):491.","journal-title":"Cancer Cell Int"},{"issue":"6","key":"957_CR46","first-page":"1313","volume":"13","author":"H Liu","year":"2020","unstructured":"Liu H, Shu X, Ma Q, Wang R, Huang M, Gao X, et al. Identifying specific miRNAs and associated mRNAs in CD44 and CD90 cancer stem cell subtypes in gastric cancer cell line SNU-5. Int J Clin Exp Pathol. 2020;13(6):1313\u201323.","journal-title":"Int J Clin Exp Pathol"},{"issue":"3","key":"957_CR47","first-page":"2936","volume":"20","author":"R Liu","year":"2019","unstructured":"Liu R, Chen Y, Shou T, Hu J, Chen J, Qing C. TRIM67 promotes NF\u2011kappaB pathway and cell apoptosis in GA\u201113315\u2011treated lung cancer cells. Mol Med Rep. 2019;20(3):2936\u201344.","journal-title":"Mol Med Rep"},{"key":"957_CR48","doi-asserted-by":"publisher","first-page":"889106","DOI":"10.3389\/fneur.2022.889106","volume":"13","author":"Z Xuan","year":"2022","unstructured":"Xuan Z, Ma T, Qin Y, Guo Y. Role of ultrasound imaging in the prediction of TRIM67 in brain metastases from breast cancer. Front Neurol. 2022;13:889106.","journal-title":"Front Neurol"},{"issue":"4","key":"957_CR49","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.jhep.2021.12.014","volume":"76","author":"A Navarro-Corcuera","year":"2022","unstructured":"Navarro-Corcuera A, Sehrawat TS, Jalan-Sakrikar N, Gibbons HR, Pirius NE, Khanal S, et\u00a0al. Long non-coding RNA ACTA2-AS1 promotes ductular reaction by interacting with the p300\/ELK1 complex. J Hepatol. 2022;76(4):921\u201333.","journal-title":"J Hepatol"},{"issue":"8","key":"957_CR50","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1111\/jog.15710","volume":"49","author":"B Yang","year":"2023","unstructured":"Yang B, Wang H, Xiao J, Chen W, Chen W. ELK1\/KIFC1 axis promotes breast cancer cell proliferation by regulating glutathione metabolism. J Obstet Gynaecol Res. 2023;49(8):2175\u201384.","journal-title":"J Obstet Gynaecol Res"},{"key":"957_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042382","author":"L Zhao","year":"2024","unstructured":"Zhao L, Wang Y, Sun X, Zhang X, Simone N, He J. ELK1\/MTOR\/S6K1 pathway contributes to acquired resistance to Gefitinib in non-small cell lung cancer. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25042382.","journal-title":"Int J Mol Sci"},{"issue":"39","key":"957_CR52","doi-asserted-by":"publisher","first-page":"28152","DOI":"10.1074\/jbc.M113.504308","volume":"288","author":"FR Teixeira","year":"2013","unstructured":"Teixeira FR, Manfiolli AO, Soares CS, Baqui MM, Koide T, Gomes MD. The f-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. J Biol Chem. 2013;288(39):28152\u201362.","journal-title":"J Biol Chem"}],"container-title":["Cellular &amp; Molecular Biology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s11658-026-00957-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11658-026-00957-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11658-026-00957-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:42:53Z","timestamp":1787870573000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s11658-026-00957-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,31]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["957"],"URL":"https:\/\/doi.org\/10.1186\/s11658-026-00957-1","relation":{},"ISSN":["1689-1392"],"issn-type":[{"value":"1689-1392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,31]]},"assertion":[{"value":"25 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All studies involving human specimens were conducted in accordance with the ethical standards of the Helsinki Declaration and were approved by the Medical Ethics Committee of Xiangya Hospital of Central South University (no. 202207391; date issued: 9 August 2022). All animal experiments complied with the Guidelines for the Humane Treatment of Laboratory Animals issued by China's Ministry of Science and Technology, as well as relevant international animal welfare guidelines and regulations (including the ICLAS Statement). The study protocols were reviewed and approved by the Animal Care and Use Committee of Hunan SJA Institution (no. SJA202401701; date issued: 10 September 2024).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"138"}}