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The research was approved by the Research Ethics Committee of the First Affiliated Hospital of Harbin Medical University (approval no. 2022185, date: 11 March 2022) and adhered to the tenets of the\n                      Declaration of Helsinki\n                      . All animal studies were approved by the Animal Welfare Ethics Committee of the First Affiliated Hospital of Harbin Medical University (approval no. 2023139, date: 6 February 2023), and in accordance with the Basel Declaration. 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