{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T13:56:47Z","timestamp":1794405407997,"version":"4.9.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"overall innovation plan projects of science and technology of Shaanxi Province in China","award":["No.2015KTZDSF02-01-02"],"award-info":[{"award-number":["No.2015KTZDSF02-01-02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nanoscale Res Lett"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s11671-017-2346-8","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T02:42:59Z","timestamp":1510195379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Improved Antitumor Efficacy and Pharmacokinetics of Bufalin via PEGylated Liposomes"],"prefix":"10.1186","volume":"12","author":[{"given":"Jiani","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanxuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"2346_CR1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s10552-015-0603-7","volume":"26","author":"B Baldur-Felskov","year":"2015","unstructured":"Baldur-Felskov B, Munk C, Nielsen TS, Dehlendorff C, Kirschner B, Junge J et al (2015) Trends in the incidence of cervical cancer and severe precancerous lesions in Denmark, 1997-2012. Cancer Causes Control 26:1105\u20131116","journal-title":"Cancer Causes Control"},{"key":"2346_CR2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/glia.440150313","volume":"15","author":"KH Plate","year":"1995","unstructured":"Plate KH, Risau W (1995) Angiogenesis in malignant gliomas. Glia 15:339\u2013347","journal-title":"Glia"},{"key":"2346_CR3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.intimp.2010.12.007","volume":"11","author":"F Qi","year":"2011","unstructured":"Qi F, Li A, Inagaki Y, Kokudo N, Tamura S, Nakata M et al (2011) Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor. Int Immunopharmacol 11:342\u2013349","journal-title":"Int Immunopharmacol"},{"key":"2346_CR4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1472-8206.2009.00696.x","volume":"23","author":"Y Cao","year":"2009","unstructured":"Cao Y, Song Y, An N, Zeng S, Wang D, Yu L et al (2009) The effects of telocinobufagin isolated from Chan Su on the activation and cytokine secretion of immunocytes in vitro. Fundam Clin Pharmacol 23:457\u2013464","journal-title":"Fundam Clin Pharmacol"},{"key":"2346_CR5","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1248\/bpb.33.1728","volume":"33","author":"X Cui","year":"2010","unstructured":"Cui X, Inagaki Y, Xu H, Wang D, Qi F, Kokudo N et al (2010) Anti-hepatitis B virus activities of cinobufacini and its active components bufalin and cinobufagin in HepG2.2.15 cells. Biol Pharm Bull 33:1728\u20131732","journal-title":"Biol Pharm Bull"},{"key":"2346_CR6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/00007691-199802000-00019","volume":"20","author":"A Dasgupta","year":"1998","unstructured":"Dasgupta A, Datta P (1998) Rapid detection of cardioactive bufalin toxicity using fluorescence polarization immunoassay for digitoxin. Ther Drug Monit 20:104\u2013108","journal-title":"Ther Drug Monit"},{"key":"2346_CR7","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.7314\/APJCP.2012.13.11.5339","volume":"13","author":"PH Yin","year":"2012","unstructured":"Yin PH, Liu X, Qiu YY, Cai JF, Qin JM, Zhu HR et al (2012) Anti-tumor activity and apoptosis-regulation mechanisms of bufalin in various cancers: new hope for cancer patients. Asian Pac J Cancer Prev 13:5339\u20135343","journal-title":"Asian Pac J Cancer Prev"},{"key":"2346_CR8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/chromsci\/46.1.81","volume":"46","author":"Z Yang","year":"2008","unstructured":"Yang Z, Luo H, Wang H, Hou H (2008) Preparative isolation of bufalin and cinobufagin from Chinese traditional medicine ChanSu. J Chromatogr Sci 46:81\u201385","journal-title":"J Chromatogr Sci"},{"key":"2346_CR9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3892\/ijo.2014.2706","volume":"46","author":"E Agostinelli","year":"2015","unstructured":"Agostinelli E, Vianello F, Magliulo G, Thomas T, Thomas TJ (2015) Nanoparticle strategies for cancer therapeutics: nucleic acids, polyamines, bovine serum amine oxidase and iron oxide nanoparticles (review). Int J Oncol 46:5\u201316","journal-title":"Int J Oncol"},{"key":"2346_CR10","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1002\/jps.24186","volume":"103","author":"T Zong","year":"2014","unstructured":"Zong T, Mei L, Gao H, Shi K, Chen J, Wang Y et al (2014) Enhanced glioma targeting and penetration by dual-targeting liposome co-modified with T7 and TAT. J Pharm Sci 103:3891\u20133901","journal-title":"J Pharm Sci"},{"key":"2346_CR11","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/jps.2600840904","volume":"84","author":"VP Torchilin","year":"1995","unstructured":"Torchilin VP, Trubetskoy VS, Whiteman KR, Caliceti P, Ferruti P, Veronese FM (1995) New synthetic amphiphilic polymers for steric protection of liposomes in vivo. J Pharm Sci 84:1049\u20131053","journal-title":"J Pharm Sci"},{"key":"2346_CR12","first-page":"5683","volume":"9","author":"Y Li","year":"2014","unstructured":"Li Y, Yuan J, Yang Q, Cao W, Zhou X, Xie Y et al (2014) Immunoliposome co-delivery of bufalin and anti-CD40 antibody adjuvant induces synergetic therapeutic efficacy against melanoma. Int J Nanomedicine 9:5683\u20135700","journal-title":"Int J Nanomedicine"},{"key":"2346_CR13","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1080\/03639040902762987","volume":"35","author":"F Li","year":"2009","unstructured":"Li F, Yang R, Weng Y, Tang X (2009) Preparation and evaluation of lyophilized liposome-encapsulated bufadienolides. Drug Dev Ind Pharm 35:1048\u20131058","journal-title":"Drug Dev Ind Pharm"},{"key":"2346_CR14","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1124\/jpet.106.101154","volume":"317","author":"HL Wong","year":"2006","unstructured":"Wong HL, Bendayan R, Rauth AM, Xue HY, Babakhanian K, Wu XY (2006) A mechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle system. J Pharmacol Exp Ther 317:1372\u20131381","journal-title":"J Pharmacol Exp Ther"},{"key":"2346_CR15","first-page":"205","volume":"12","author":"M Akiyama","year":"1999","unstructured":"Akiyama M, Ogura M, Iwai M, Iijima M, Numazawa S, Yoshida T (1999) Effect of bufalin on growth and differentiation of human skin carcinoma cells in vitro. Hum Cell 12:205\u2013209","journal-title":"Hum Cell"},{"key":"2346_CR16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3736\/jcim20070211","volume":"5","author":"W Gu","year":"2007","unstructured":"Gu W, Han KQ, Su YH, Huang XQ, Ling CQ (2007) Inhibition action of bufalin on human transplanted hepatocellular tumor and its effects on expressions of Bcl-2 and Bax proteins in nude mice. Zhong Xi Yi Jie He Xue Bao 5:155\u2013159","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"2346_CR17","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10616-010-9310-0","volume":"62","author":"Y Jiang","year":"2010","unstructured":"Jiang Y, Zhang Y, Luan J, Duan H, Zhang F, Yagasaki K et al (2010) Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action. Cytotechnology 62:573\u2013583","journal-title":"Cytotechnology"},{"key":"2346_CR18","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1007\/s13277-014-1911-3","volume":"35","author":"L Jiang","year":"2014","unstructured":"Jiang L, Zhao MN, Liu TY, Wu XS, Weng H, Ding Q et al (2014) Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells. Tumour Biol 35:10931\u201310941","journal-title":"Tumour Biol"},{"key":"2346_CR19","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1007\/s13277-013-1342-6","volume":"35","author":"YY Qiu","year":"2014","unstructured":"Qiu YY, Hu Q, Tang QF, Feng W, Hu SJ, Liang B et al (2014) MicroRNA-497 and bufalin act synergistically to inhibit colorectal cancer metastasis. Tumour Biol 35:2599\u20132606","journal-title":"Tumour Biol"},{"key":"2346_CR20","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1007\/s13277-014-1640-7","volume":"35","author":"D Wang","year":"2014","unstructured":"Wang D, Bi Z (2014) Bufalin inhibited the growth of human osteosarcoma MG-63 cells via down-regulation of Bcl-2\/Bax and triggering of the mitochondrial pathway. Tumour Biol 35:4885\u20134890","journal-title":"Tumour Biol"},{"key":"2346_CR21","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1159\/000244188","volume":"67","author":"WY Chan","year":"1995","unstructured":"Chan WY, Ng TB, Yeung HW (1995) Examination for toxicity of a Chinese drug, the toad glandular secretory product chan su, in pregnant mice and embryos. Biol Neonate 67:376\u2013380","journal-title":"Biol Neonate"},{"key":"2346_CR22","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.biomaterials.2012.10.029","volume":"34","author":"LM Luo","year":"2013","unstructured":"Luo LM, Huang Y, Zhao BX, Zhao X, Duan Y, Du R et al (2013) Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel. Biomaterials 34:1102\u20131114","journal-title":"Biomaterials"},{"key":"2346_CR23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tibtech.2013.09.007","volume":"32","author":"GT Noble","year":"2014","unstructured":"Noble GT, Stefanick JF, Ashley JD, Kiziltepe T, Bilgicer B (2014) Ligand-targeted liposome design: challenges and fundamental considerations. Trends Biotechnol 32:32\u201345","journal-title":"Trends Biotechnol"},{"key":"2346_CR24","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1023\/A:1011965423986","volume":"15","author":"K Vrhovnik","year":"1998","unstructured":"Vrhovnik K, Kristl J, Sentjurc M, Smid-Korbar J (1998) Influence of liposome bilayer fluidity on the transport of encapsulated substance into the skin as evaluated by EPR. Pharm Res 15:525\u2013530","journal-title":"Pharm Res"},{"key":"2346_CR25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jconrel.2012.10.010","volume":"165","author":"HJ Jung","year":"2013","unstructured":"Jung HJ, Abou-Jaoude M, Carbia BE, Plummer C, Chauhan A (2013) Glaucoma therapy by extended release of timolol from nanoparticle loaded silicone-hydrogel contact lenses. J Control Release 165:82\u201389","journal-title":"J Control Release"},{"key":"2346_CR26","first-page":"1500","volume":"276","author":"OV Zamorin","year":"1984","unstructured":"Zamorin OV (1984) Liposome oxidation. Dokl Akad Nauk SSSR 276:1500\u20131503","journal-title":"Dokl Akad Nauk SSSR"},{"key":"2346_CR27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0306-9877(84)90120-8","volume":"15","author":"PI Campbell","year":"1984","unstructured":"Campbell PI (1984) Amino conjugates of a phosphatidylglycerol oxidation product: novel adjuncts for liposome preparation. Med Hypotheses 15:149\u2013153","journal-title":"Med Hypotheses"}],"container-title":["Nanoscale Research Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s11671-017-2346-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s11671-017-2346-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s11671-017-2346-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:33:49Z","timestamp":1679272429000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s11671-017-2346-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2346"],"URL":"https:\/\/doi.org\/10.1186\/s11671-017-2346-8","relation":{},"ISSN":["1931-7573","1556-276X"],"issn-type":[{"value":"1931-7573","type":"print"},{"value":"1556-276X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,9]]},"article-number":"585"}}