{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:16:08Z","timestamp":1791918968433,"version":"4.3.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Reina Sofia Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nanoscale Res Lett"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s11671-019-2863-8","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T13:03:31Z","timestamp":1548421411000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Novel Contrast Agent Based on Magnetic Nanoparticles for Cholesterol Detection as Alzheimer\u2019s Disease Biomarker"],"prefix":"10.1186","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-8845","authenticated-orcid":false,"given":"Tamara","family":"Fern\u00e1ndez-Cabada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros","family":"Ramos-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"issue":"3","key":"2863_CR1","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.bbadis.2017.12.017","volume":"1864","author":"H McHale-Owen","year":"2018","unstructured":"McHale-Owen H, Bate C (2018) Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-\u03b2 oligomers. Biochim Biophys Acta Mol Basis Dis 1864(3):649\u2013659","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2863_CR2","doi-asserted-by":"publisher","first-page":"117906951773309","DOI":"10.1177\/1179069517733096","volume":"11","author":"C Bate","year":"2017","unstructured":"Bate C (2017) Breaking the cycle, cholesterol cycling, and synapse damage in response to amyloid-\u03b2. J Exp Neurosci 11:1179069517733096 Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29238218%0Ahttp:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=PMC5721958","journal-title":"J Exp Neurosci"},{"key":"2863_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s40618-015-0332-5","volume":"39","author":"A Peri","year":"2016","unstructured":"Peri A (2016) Neuroprotective effects of estrogens: the role of cholesterol. J Endocrinol Investig 39:11\u201318","journal-title":"J Endocrinol Investig"},{"key":"2863_CR4","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1083\/jcb.200410090","volume":"167","author":"C Kaether","year":"2004","unstructured":"Kaether C, Haass C (2004) A lipid boundary separates APP and secretases and limits amyloid \u03b2-peptide generation. J Cell Biol 167:809\u2013812","journal-title":"J Cell Biol"},{"issue":"2","key":"2863_CR5","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/sj.emboj.7600938","volume":"25","author":"A Crameri","year":"2006","unstructured":"Crameri A, Biondi E, Kuehnle K, L\u00fctjohann D, Thelen KM, Perga S et al (2006) The role of seladin-1\/DHCR24 in cholesterol biosynthesis, APP processing and A\u03b2 generation in vivo. EMBO J 25(2):432\u2013443","journal-title":"EMBO J"},{"key":"2863_CR6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/ddrr.1114","volume":"17","author":"S Kanungo","year":"2013","unstructured":"Kanungo S, Soares N, He M, Steiner RD (2013) Sterol metabolism disorders and neurodevelopment-an update. Dev Disabil Res Rev 17:197\u2013210","journal-title":"Dev Disabil Res Rev"},{"issue":"12","key":"2863_CR7","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1096\/fj.02-0829com","volume":"16","author":"ARISPE N","year":"2002","unstructured":"ARISPE N (2002) Plasma membrane cholesterol controls the cytotoxicity of Alzheimer\u2019s disease AbetaP (1-40) and (1-42) peptides. FASEB J 16(12):1526\u20131536 Available from: http:\/\/www.fasebj.org\/content\/16\/12\/1526.abstract%5Cnhttp:\/\/www.fasebj.org\/content\/16\/12\/1526.short%5Cnhttp:\/\/www.fasebj.org\/cgi\/doi\/10.1096\/fj.02-0829com","journal-title":"FASEB J"},{"issue":"1","key":"2863_CR8","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s11064-008-9673-1","volume":"34","author":"JK Yao","year":"2009","unstructured":"Yao JK, Wengenack TM, Curran GL, Poduslo JF (2009) Reduced membrane lipids in the cortex of Alzheimer\u2019s disease transgenic mice. Neurochem Res 34(1):102\u2013108","journal-title":"Neurochem Res"},{"issue":"8","key":"2863_CR9","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1093\/jnen\/60.8.778","volume":"60","author":"T Mori","year":"2001","unstructured":"Mori T, Paris D, Town T, Rojiani AM, Sparks DL, Delledonne A et al (2001) Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APPsw mice. J Neuropathol Exp Neurol 60(8):778\u2013785","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"2863_CR10","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0169-328X(02)00647-2","volume":"110","author":"MP Burns","year":"2003","unstructured":"Burns MP, Noble WJ, Olm V, Gaynor K, Casey E, LaFrancois J et al (2003) Co-localization of cholesterol, apolipoprotein E and fibrillar A\u03b2 in amyloid plaques. Mol Brain Res 110(1):119\u2013125","journal-title":"Mol Brain Res"},{"issue":"3","key":"2863_CR11","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1194\/jlr.M001859","volume":"51","author":"M Panchal","year":"2010","unstructured":"Panchal M, Loeper J, Cossec J-C, Perruchini C, Lazar A, Pompon D et al (2010) Enrichment of cholesterol in microdissected Alzheimer\u2019s disease senile plaques as assessed by mass spectrometry. J Lipid Res 51(3):598\u2013605 Available from: http:\/\/www.jlr.org\/lookup\/doi\/10.1194\/jlr.M001859","journal-title":"J Lipid Res"},{"key":"2863_CR12","doi-asserted-by":"publisher","first-page":"13489","DOI":"10.1038\/srep13489","volume":"5","author":"J Kiskis","year":"2015","unstructured":"Kiskis J, Fink H, Nyberg L, Thyr J, Li JY, Enejder A (2015) Plaque-associated lipids in Alzheimer\u2019s diseased brain tissue visualized by nonlinear microscopy. Sci Rep 5:13489","journal-title":"Sci Rep"},{"key":"2863_CR13","doi-asserted-by":"crossref","unstructured":"Hu B, Dai F, Fan Z, Ma G, Tang Q, Zhang X (2015) Nanotheranostics: Congo red\/Rutin-MNPs with enhanced magnetic resonance imaging and H2 O2 -responsive therapy of Alzheimer\u2019s disease in APPswe\/PS1dE9 transgenic mice. Adv Mater:1\u20137 Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26270904","DOI":"10.1002\/adma.201502227"},{"issue":"4","key":"2863_CR14","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1016\/j.neuroimage.2011.01.023","volume":"55","author":"J Yang","year":"2011","unstructured":"Yang J, Wadghiri YZ, Minh Hoang D, Tsui W, Sun Y, Chung E et al (2011) Detection of amyloid plaques targeted by USPIO-A\u03b21-42 in Alzheimer\u2019s disease transgenic mice using magnetic resonance microimaging. NeuroImage 55(4):1600\u20131609","journal-title":"NeuroImage"},{"issue":"2","key":"2863_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0057097","volume":"8","author":"YZ Wadghiri","year":"2013","unstructured":"Wadghiri YZ, Li J, Wang J, Hoang DM, Sun Y, Xu H et al (2013) Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer\u2019s disease transgenic mice using magnetic resonance microimaging. PLoS One 8(2):1\u201310","journal-title":"PLoS One"},{"key":"2863_CR16","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez T, Mart\u00ednez-Serrano A, Cuss\u00f3 L, Desco M, Ramos-G\u00f3mez M. Functionalization and characterization of magnetic nanoparticles for the detection of ferritin accumulation in Alzheimer\u2019s disease. ACS Chem Neurosci 2018;acschemneuro.7b00260. Available from: http:\/\/pubs.acs.org\/doi\/10.1021\/acschemneuro.7b00260","DOI":"10.1021\/acschemneuro.7b00260"},{"key":"2863_CR17","unstructured":"World Alzheimer Report 2016 Improving healthcare for people living with dementia coverage, Quality and costs now and in the future [Internet]. 2016. Available from: https:\/\/www.alz.co.uk\/research\/WorldAlzheimerReport2016.pdf"},{"key":"2863_CR18","doi-asserted-by":"crossref","unstructured":"Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L. A DNA-binding Gd chelate for the detection of cell death by MRI. Chem Commun (Camb) 2009;(29):4444\u20136. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2754278&tool=pmcentrez&rendertype=abstract","DOI":"10.1039\/b907375b"},{"key":"2863_CR19","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1126\/science.1090585","volume":"302","author":"HR Herschman","year":"2003","unstructured":"Herschman HR (2003) Molecular imaging: looking at problems, seeing solutions. Science 302:605\u2013608","journal-title":"Science"},{"key":"2863_CR20","unstructured":"Massoud TF, Gambhir SS (2003) Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 17(5):545\u2013580."},{"issue":"1","key":"2863_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1556-276X-8-449","volume":"8","author":"M Pourbaghi-Masouleh","year":"2013","unstructured":"Pourbaghi-Masouleh M, Hosseini V (2013) Amorphous calcium phosphate nanoparticles could function as a novel cancer therapeutic agent by employing a suitable targeted drug delivery platform. Nanoscale Res Lett 8(1):1\u20136","journal-title":"Nanoscale Res Lett"},{"key":"2863_CR22","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.drudis.2006.10.013","volume":"12","author":"WM Pardridge","year":"2007","unstructured":"Pardridge WM (2007) Blood-brain barrier delivery. Drug Discov Today 12:54\u201361","journal-title":"Drug Discov Today"},{"issue":"1","key":"2863_CR23","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","volume":"37","author":"NJ Abbott","year":"2010","unstructured":"Abbott NJ, Patabendige AAK, Dolman DEM, Yusof SR, Begley DJ (2010) Structure and function of the blood-brain barrier. Neurobiol Dis 37(1):13\u201325 Available from: https:\/\/doi.org\/10.1016\/j.nbd.2009.07.030","journal-title":"Neurobiol Dis"},{"issue":"3","key":"2863_CR24","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1080\/10611860410001701706","volume":"12","author":"CC Visser","year":"2004","unstructured":"Visser CC, Stevanovi\u0107 S, Voorwinden LH, Gaillard PJ, Crommelin DJA, Danhof M et al (2004) Validation of the transferrin receptor for drug targeting to brain capillary endothelial cells in vitro. J Drug Target 12(3):145\u2013150","journal-title":"J Drug Target"},{"issue":"10","key":"2863_CR25","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1007\/s10856-013-4993-3","volume":"24","author":"F Yan","year":"2013","unstructured":"Yan F, Wang Y, He S, Ku S, Gu W, Ye L (2013) Transferrin-conjugated, fluorescein-loaded magnetic nanoparticles for targeted delivery across the blood-brain barrier. J Mater Sci Mater Med 24(10):2371\u20132379","journal-title":"J Mater Sci Mater Med"},{"issue":"11","key":"2863_CR26","doi-asserted-by":"publisher","first-page":"4889","DOI":"10.1002\/jps.21335","volume":"97","author":"A Dalpiaz","year":"2008","unstructured":"Dalpiaz A, Gavini E, Colombo G, Russo P, Bortolotti F, Ferraro L et al (2008) Brain uptake of an anti-ischemic agent by nasal administration of microparticles. J Pharm Sci 97(11):4889\u20134903","journal-title":"J Pharm Sci"},{"issue":"1\u20132","key":"2863_CR27","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.ijpharm.2016.01.043","volume":"500","author":"OD Akilo","year":"2016","unstructured":"Akilo OD, Choonara YE, Strydom AM, Du Toit LC, Kumar P, Modi G et al (2016) AN in vitro evaluation of a carmustine-loaded Nano-co-Plex for potential magnetic-targeted intranasal delivery to the brain. Int J Pharm 500(1\u20132):196\u2013209","journal-title":"Int J Pharm"},{"issue":"3","key":"2863_CR28","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1166\/jbn.2016.2193","volume":"12","author":"TD Do","year":"2016","unstructured":"Do TD, Amin FU, Noh Y, Kim MO, Yoon J (2016) Guidance of magnetic nanocontainers for treating Alzheimer\u2019s disease using an electromagnetic, targeted drug-delivery actuator. J Biomed Nanotechnol 12(3):569\u2013574","journal-title":"J Biomed Nanotechnol"},{"issue":"4","key":"2863_CR29","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s10237-015-0730-9","volume":"15","author":"J Xi","year":"2016","unstructured":"Xi J, Zhang Z, Si XA, Yang J, Deng W (2016) Optimization of magnetophoretic-guided drug delivery to the olfactory region in a human nose model. Biomech Model Mechanobiol 15(4):877\u2013891","journal-title":"Biomech Model Mechanobiol"},{"issue":"30","key":"2863_CR30","doi-asserted-by":"publisher","first-page":"10619","DOI":"10.1039\/C7NR00772H","volume":"9","author":"FU Amin","year":"2017","unstructured":"Amin FU, Hoshiar AK, Do TD, Noh Y, Shah SA, Khan MS et al (2017) Osmotin-loaded magnetic nanoparticles with electromagnetic guidance for the treatment of Alzheimer\u2019s disease. Nanoscale 9(30):10619\u201310632 Available from: http:\/\/xlink.rsc.org\/?DOI=C7NR00772H","journal-title":"Nanoscale"},{"key":"2863_CR31","volume-title":"Caracterizaci\u00f3n de nanopart\u00edculas magn\u00e9ticas y de oro para posibles aplicaciones biom\u00e9 dicas en diagn\u00f3stico y terapia","author":"T Fern\u00e1ndez Cabada","year":"2014","unstructured":"Fern\u00e1ndez Cabada T (2014) Caracterizaci\u00f3n de nanopart\u00edculas magn\u00e9ticas y de oro para posibles aplicaciones biom\u00e9 dicas en diagn\u00f3stico y terapia"},{"key":"2863_CR32","doi-asserted-by":"publisher","unstructured":"Urbano-Bojorge AL, Flix-Gon?lez N, Fer?ndez T, Pozo-Guerrero FD, Ramos M, Serrano-Olmedo JJ (2015) A comparison of magnetometry and relaxometry measures of magnetic nanoparticles deposited in biological samples. J Nano Res 31:129\u2013137. https:\/\/doi.org\/10.4028\/www.scientific.net\/JNanoR.31.129","DOI":"10.4028\/www.scientific.net\/JNanoR.31.129"},{"key":"2863_CR33","volume-title":"Subject category\u00a0: subject areas\u00a0: synthesis and characterization of dextran-coated iron oxide nanoparticles","author":"AM Predescu","year":"2018","unstructured":"Predescu AM, Matei E, Berbecaru C, Pantilimon C, Vidu R, Predescu C, et al. Subject category\u00a0: subject areas\u00a0: synthesis and characterization of dextran-coated iron oxide nanoparticles. 2018;"},{"issue":"8","key":"2863_CR34","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1002\/adfm.201001658","volume":"21","author":"D Liu","year":"2011","unstructured":"Liu D, Wu W, Ling J, Wen S, Gu N, Zhang X (2011) Effective PEGylation of iron oxide nanoparticles for high performance in vivo cancer imaging. Adv Funct Mater 21(8):1498\u20131504","journal-title":"Adv Funct Mater"},{"key":"2863_CR35","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.colsurfb.2016.08.059","volume":"148","author":"M Nag","year":"2016","unstructured":"Nag M, Gajbhiye V, Kesharwani P, Jain NK (2016) Transferrin functionalized chitosan-PEG nanoparticles for targeted delivery of paclitaxel to cancer cells. Colloids Surf B Biointerfaces 148:363\u2013370 Available from: https:\/\/doi.org\/10.1016\/j.colsurfb.2016.08.059","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"2","key":"2863_CR36","doi-asserted-by":"publisher","first-page":"174","DOI":"10.7150\/ijbs.5115","volume":"9","author":"Q Xue","year":"2013","unstructured":"Xue Q, Liu Y, Qi H, Ma Q, Xu L, Chen W et al (2013) A novel brain neurovascular unit model with neurons, astrocytes and microvascular endothelial cells of rat. Int J Biol Sci 9(2):174\u2013189","journal-title":"Int J Biol Sci"},{"issue":"40","key":"2863_CR37","doi-asserted-by":"publisher","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","volume":"26","author":"H Oakley","year":"2006","unstructured":"Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J et al (2006) Intraneuronal \u03b2-Amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation. J Neurosci 26(40):10129\u201310140 Available from: http:\/\/www.jneurosci.org\/content\/26\/40\/10129.abstract","journal-title":"J Neurosci"},{"issue":"1","key":"2863_CR38","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1093\/toxsci\/kfj027","volume":"89","author":"JS Kim","year":"2006","unstructured":"Kim JS, Yoon T-J, Yu KN, Kim BG, Park SJ, Kim HW et al (2006) Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicol Sci 89(1):338\u2013347","journal-title":"Toxicol Sci"},{"issue":"4","key":"2863_CR39","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.bbrc.2010.02.046","volume":"393","author":"C Lasagna-Reeves","year":"2010","unstructured":"Lasagna-Reeves C, Gonzalez-Romero D, Barria MA, Olmedo I, Clos A, Sadagopa Ramanujam VM et al (2010) Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice. Biochem Biophys Res Commun 393(4):649\u2013655","journal-title":"Biochem Biophys Res Commun"},{"key":"2863_CR40","doi-asserted-by":"publisher","first-page":"7930","DOI":"10.1038\/srep07930","volume":"5","author":"HJ Lee","year":"2015","unstructured":"Lee HJ, Zhang W, Zhang D, Yang Y, Liu B, Barker EL et al (2015) Assessing cholesterol storage in live cells and C. elegans by stimulated Raman scattering imaging of phenyl-diyne cholesterol. Sci Rep 5:7930","journal-title":"Sci Rep"},{"issue":"2","key":"2863_CR41","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/mrm.10529","volume":"50","author":"YZ Wadghiri","year":"2003","unstructured":"Wadghiri YZ, Sigurdsson EM, Sadowski M, Elliott JI, Li Y, Scholtzova H et al (2003) Detection of Alzheimer\u2019s amyloid in transgenic mice using magnetic resonance microimaging. Magn Reson Med 50(2):293\u2013302","journal-title":"Magn Reson Med"},{"issue":"6","key":"2863_CR42","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.neurobiolaging.2006.12.018","volume":"29","author":"EM Sigurdsson","year":"2008","unstructured":"Sigurdsson EM, Wadghiri YZ, Mosconi L, Blind JA, Knudsen E, Asuni A et al (2008) A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice. Neurobiol Aging 29(6):836\u2013847","journal-title":"Neurobiol Aging"},{"issue":"8","key":"2863_CR43","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1097\/NEN.0b013e318225038c","volume":"70","author":"JF Poduslo","year":"2011","unstructured":"Poduslo JF, Hultman KL, Curran GL, Preboske GM, Chamberlain R, Marja\u0144ska M et al (2011) Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid \u03b2 protein antibody-coated nanoparticles. J Neuropathol Exp Neurol 70(8):653\u2013661","journal-title":"J Neuropathol Exp Neurol"},{"issue":"37","key":"2863_CR44","doi-asserted-by":"publisher","first-page":"11080","DOI":"10.1021\/bi026173d","volume":"41","author":"AE Roher","year":"2002","unstructured":"Roher AE, Weiss N, Kokjohn TA, Kuo YM, Kalback W, Anthony J et al (2002) Increased A\u03b2 peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer\u2019s disease. Biochemistry 41(37):11080\u201311090","journal-title":"Biochemistry"}],"container-title":["Nanoscale Research Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s11671-019-2863-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s11671-019-2863-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s11671-019-2863-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T04:37:45Z","timestamp":1679287065000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s11671-019-2863-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,25]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2863"],"URL":"https:\/\/doi.org\/10.1186\/s11671-019-2863-8","relation":{},"ISSN":["1931-7573","1556-276X"],"issn-type":[{"value":"1931-7573","type":"print"},{"value":"1556-276X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,25]]},"assertion":[{"value":"12 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"36"}}