{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:11:57Z","timestamp":1778541117383,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T00:00:00Z","timestamp":1634428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T00:00:00Z","timestamp":1634428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100020749","name":"hubei key laboratory of wudang local chinese medicine research","doi-asserted-by":"crossref","award":["WDCM2019001)"],"award-info":[{"award-number":["WDCM2019001)"]}],"id":[{"id":"10.13039\/501100020749","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Open Project of Hunan Normal University Medical College","award":["KF2021004"],"award-info":[{"award-number":["KF2021004"]}]},{"name":"siyan\u00a0science\u00a0and\u00a0technology\u00a0bureau","award":["2020K36"],"award-info":[{"award-number":["2020K36"]}]},{"name":"Huxiang High-Level Talent Innovation Team","award":["2018RS3072"],"award-info":[{"award-number":["2018RS3072"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nanoscale Res Lett"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydrophilic polyethylene glycol monomethyl ether (mPEG) was grafted onto Icariin (ICA) by succinic anhydride to form a polyethylene glycol-Icariin (mPEG-ICA) polymer. The structure of the polymer was characterized by Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (NMR). mPEG-ICA nanoparticles loaded with ICA were prepared by physical embedding of ICA by dialysis. The particle size was determined to be (220\u2009\u00b1\u200913.7) nm, and the \u03b6 potential was (2.30\u2009\u00b1\u20091.33) mV by dynamic light scattering (DLS). Under a transmission electron microscope (TEM), the nanoparticles were spherical, and the morphology was regular. In the medium with pH 7.4, the drug release rate of mPEG-ICA nanoparticles reached (52.80\u2009\u00b1\u20091.70)% within 72\u00a0h. At pH 6.8, the cumulative drug release of nanoparticles reached (75.66\u2009\u00b1\u20090.17)% within 48\u00a0h. Treatment of the nanoparticles with LPS-treated H9c2 cells maintained cell viability, reduced LDH release and exerted antiapoptotic effects. Moreover, ICA-loaded mPEG-ICA nanoparticles significantly decreased the mRNA expression of the myocardial inflammatory cytokines TNF-\u03b1, IL-1\u03b2 and IL-6M. In conclusion, ICA-loaded mPEG-ICA nanoparticles protected against LPS-induced H9c2 cell injury.<\/jats:p>","DOI":"10.1186\/s11671-021-03609-9","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T21:04:48Z","timestamp":1634504688000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preparation of ICA-loaded mPEG-ICA nanoparticles and their application in the treatment of LPS-induced H9c2 cell damage"],"prefix":"10.1186","volume":"16","author":[{"given":"Lin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiarui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinrong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zexuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3451-9850","authenticated-orcid":false,"given":"Xiaojun","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiufang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,17]]},"reference":[{"key":"3609_CR1","doi-asserted-by":"publisher","first-page":"111361","DOI":"10.1016\/j.biopha.2021.111361","volume":"137","author":"Q Lu","year":"2021","unstructured":"Lu Q, Zheng R, Zhu P et al (2021) Hinokinin alleviates high fat diet\/streptozotocin-induced cardiac injury in mice through modulation in oxidative stress, inflammation and apoptosis. Biomed Pharmacother 137:111361","journal-title":"Biomed Pharmacother"},{"issue":"48","key":"3609_CR2","doi-asserted-by":"publisher","first-page":"3937","DOI":"10.1093\/eurheartj\/ehz283","volume":"40","author":"E Lutgens","year":"2019","unstructured":"Lutgens E, Atzler D, Doring Y et al (2019) Immunotherapy for cardiovascular disease. Eur Heart J 40(48):3937\u20133946","journal-title":"Eur Heart J"},{"issue":"1","key":"3609_CR3","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/eurheartj\/ehx261","volume":"39","author":"H Xiao","year":"2018","unstructured":"Xiao H, Li H, Wang JJ et al (2018) IL-18 cleavage triggers cardiac inflammation and fibrosis upon beta-adrenergic insult. Eur Heart J 39(1):60\u201369","journal-title":"Eur Heart J"},{"issue":"5","key":"3609_CR4","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1161\/CIRCRESAHA.115.305919","volume":"116","author":"M Hristov","year":"2015","unstructured":"Hristov M, Weber C (2015) Myocardial infarction and inflammation: lost in the biomarker labyrinth. Circ Res 116(5):781\u2013783","journal-title":"Circ Res"},{"key":"3609_CR5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.cytogfr.2019.05.009","volume":"47","author":"H Lu","year":"2019","unstructured":"Lu H, Zhang Z, Barnie PA et al (2019) Dual faced HMGB1 plays multiple roles in cardiomyocyte senescence and cardiac inflammatory injury. Cytokine Growth Factor Rev 47:74\u201382","journal-title":"Cytokine Growth Factor Rev"},{"key":"3609_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.theriogenology.2018.10.028","volume":"125","author":"JL Wang","year":"2019","unstructured":"Wang JL, Liu B, Zhang C et al (2019) Effects of icariin on ovarian function in d-galactose-induced aging mice. Theriogenology 125:157\u2013167","journal-title":"Theriogenology"},{"issue":"11","key":"3609_CR7","first-page":"20188","volume":"8","author":"Z Wei","year":"2015","unstructured":"Wei Z, Deng X, Hong M et al (2015) Icariin has synergistic effects with methylprednisolone to ameliorate EAE via modulating HPA function, promoting anti-inflammatory and anti-apoptotic effects. Int J Clin Exp Med 8(11):20188\u201320197","journal-title":"Int J Clin Exp Med"},{"issue":"11","key":"3609_CR8","doi-asserted-by":"publisher","first-page":"4242","DOI":"10.1111\/cas.14648","volume":"111","author":"L Song","year":"2020","unstructured":"Song L, Chen X, Mi L et al (2020) Icariin-induced inhibition of SIRT6\/NF-kappaB triggers redox mediated apoptosis and enhances anti-tumor immunity in triple-negative breast cancer. Cancer Sci 111(11):4242\u20134256","journal-title":"Cancer Sci"},{"key":"3609_CR9","first-page":"4684962","volume":"2017","author":"S Xu","year":"2017","unstructured":"Xu S, Yu J, Zhan J et al (2017) Pharmacokinetics, tissue distribution, and metabolism study of icariin in rat. Biomed Res Int 2017:4684962","journal-title":"Biomed Res Int"},{"issue":"2","key":"3609_CR10","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3390\/pharmaceutics11020051","volume":"11","author":"LY Han","year":"2019","unstructured":"Han LY, Wu YL, Zhu CY et al (2019) Improved pharmacokinetics of icariin (ICA) within formulation of PEG-PLLA\/PDLA-PNIPAM polymeric micelles. Pharmaceutics 11(2):51","journal-title":"Pharmaceutics"},{"key":"3609_CR11","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.colsurfb.2015.12.027","volume":"140","author":"P Pan","year":"2016","unstructured":"Pan P, Chen J, Fan T et al (2016) Facile preparation of biphasic-induced magnetic icariin-loaded composite microcapsules by automated in situ click technology. Colloids Surf B Biointerfaces 140:50\u201359","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"2","key":"3609_CR12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","volume":"20","author":"MJ Mitchell","year":"2021","unstructured":"Mitchell MJ, Billingsley MM, Haley RM et al (2021) Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov 20(2):101\u2013124","journal-title":"Nat Rev Drug Discov"},{"issue":"4","key":"3609_CR13","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s13346-017-0369-4","volume":"7","author":"AH Soleimani","year":"2017","unstructured":"Soleimani AH, Garg SM, Paiva IM et al (2017) Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma. Drug Deliv Transl Res 7(4):571\u2013581","journal-title":"Drug Deliv Transl Res"},{"key":"3609_CR14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.jconrel.2020.01.024","volume":"320","author":"Y Wang","year":"2020","unstructured":"Wang Y, Wu Q, Wang J et al (2020) Co-delivery of p38alpha MAPK and p65 siRNA by novel liposomal glomerulus-targeting nano carriers for effective immunoglobulin a nephropathy treatment. J Control Release 320:457\u2013468","journal-title":"J Control Release"},{"issue":"3","key":"3609_CR15","first-page":"197","volume":"9","author":"F Ghasemvand","year":"2016","unstructured":"Ghasemvand F, Biazar E, Tavakolifard S et al (2016) Synthesis and evaluation of multi-wall carbon nanotube-paclitaxel complex as an anti-cancer agent. Gastroenterol Hepatol Bed Bench 9(3):197\u2013204","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"3609_CR16","doi-asserted-by":"publisher","first-page":"110286","DOI":"10.1016\/j.eurpolymj.2021.110286","volume":"147","author":"CE Ziegler","year":"2021","unstructured":"Ziegler CE, Graf M, Beck S et al (2021) A novel anhydrous preparation of PEG hydrogels enables high drug loading with biologics for controlled release applications. Eur Polym J 147:110286","journal-title":"Eur Polym J"},{"issue":"6","key":"3609_CR17","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1080\/10837450.2018.1556689","volume":"24","author":"M Zamani","year":"2019","unstructured":"Zamani M, Shirinzadeh A, Aghajanzadeh M et al (2019) In vivo study of mPEG-PCL as a nanocarriers for anti-inflammatory drug delivery of simvastatin. Pharm Dev Technol 24(6):663\u2013670","journal-title":"Pharm Dev Technol"},{"issue":"Pt B","key":"3609_CR18","first-page":"906","volume":"582","author":"HS Yu","year":"2021","unstructured":"Yu HS, Woythe L, Pham S et al (2021) A structurally diverse library of glycerol monooleate\/oleic acid non-lamellar liquid crystalline nanodispersions stabilized with nonionic methoxypoly(ethylene glycol) (mPEG)-lipids showing variable complement activation properties. J Colloid Interface Sci 582(Pt B):906\u2013917","journal-title":"J Colloid Interface Sci"},{"issue":"5","key":"3609_CR19","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.3390\/molecules25051080","volume":"25","author":"X Zhang","year":"2020","unstructured":"Zhang X, Li Z, Gao J et al (2020) Preparation of nanocrystals for insoluble drugs by top-down nanotechnology with improved solubility and bioavailability. Molecules 25(5):1080","journal-title":"Molecules"},{"issue":"1","key":"3609_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1051\/medsci\/20173301003","volume":"33","author":"J Nicolas","year":"2017","unstructured":"Nicolas J, Couvreur P (2017) Polymer nanoparticles for the delivery of anticancer drug. Med Sci (Paris) 33(1):11\u201317","journal-title":"Med Sci (Paris)"},{"issue":"6","key":"3609_CR21","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/cgt.2017.16","volume":"24","author":"MA Zaimy","year":"2017","unstructured":"Zaimy MA, Saffarzadeh N, Mohammadi A et al (2017) New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles. Cancer Gene Ther 24(6):233\u2013243","journal-title":"Cancer Gene Ther"},{"issue":"1","key":"3609_CR22","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1517\/17425247.2014.955011","volume":"12","author":"H Nakamura","year":"2015","unstructured":"Nakamura H, Fang J, Maeda H (2015) Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls. Expert Opin Drug Deliv 12(1):53\u201364","journal-title":"Expert Opin Drug Deliv"},{"issue":"38","key":"3609_CR23","doi-asserted-by":"publisher","first-page":"e1901687","DOI":"10.1002\/smll.201901687","volume":"15","author":"L Li","year":"2019","unstructured":"Li L, Xi WS, Su Q et al (2019) Unexpected size effect: the interplay between different-sized nanoparticles in their cellular uptake. Small 15(38):e1901687","journal-title":"Small"},{"issue":"1","key":"3609_CR24","first-page":"801","volume":"47","author":"Y Zheng","year":"2019","unstructured":"Zheng Y, Lu L, Yan Z et al (2019) mPEG-icariin nanoparticles for treating myocardial ischaemia. Artif Cells Nanomed Biotechnol 47(1):801\u2013811","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"3609_CR25","doi-asserted-by":"publisher","first-page":"102123","DOI":"10.1016\/j.cis.2020.102123","volume":"278","author":"M Ashrafizadeh","year":"2020","unstructured":"Ashrafizadeh M, Mohammadinejad R, Kailasa SK et al (2020) Carbon dots as versatile nanoarchitectures for the treatment of neurological disorders and their theranostic applications: a review. Adv Colloid Interface Sci 278:102123","journal-title":"Adv Colloid Interface Sci"},{"key":"3609_CR26","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.snb.2015.02.104","volume":"213","author":"VN Mehta","year":"2015","unstructured":"Mehta VN, Jha S, Basu H et al (2015) One-step hydrothermal approach to fabricate carbon dots from apple juice for imaging of mycobacterium and fungal cells. Sens Actuators B Chem 213:434\u2013443","journal-title":"Sens Actuators B Chem"},{"issue":"12","key":"3609_CR27","doi-asserted-by":"publisher","first-page":"6152","DOI":"10.1039\/C4NJ00840E","volume":"38","author":"VN Mehta","year":"2014","unstructured":"Mehta VN, Jha S, Singhal RK, Kailasa SK (2014) Preparation of multicolor emitting carbon dots for HeLa cell imaging. New J Chem 38(12):6152\u20136160","journal-title":"New J Chem"},{"key":"3609_CR28","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.saa.2018.11.027","volume":"210","author":"ML Desai","year":"2019","unstructured":"Desai ML, Deshmukh B, Lenka N et al (2019) Influence of doping ion, capping agent and pH on the fluorescence properties of zinc sulfide quantum dots: Sensing of Cu(2+) and Hg(2+) ions and their biocompatibility with cancer and fungal cells. Spectrochim Acta A Mol Biomol Spectrosc 210:212\u2013221","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"issue":"1","key":"3609_CR29","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12951-020-00680-9","volume":"18","author":"C Yi-An","year":"2020","unstructured":"Yi-An C, Tung-Ho W, Yun-Ming W et al (2020) Humanized bispecific antibody (mPEG \u00d7 HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer. J Nanobiotechnol 18(1):118","journal-title":"J Nanobiotechnol"},{"issue":"8","key":"3609_CR30","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1016\/j.xphs.2020.05.001","volume":"109","author":"M Maraldi","year":"2020","unstructured":"Maraldi M, Ferrari R, Auriemma R et al (2020) Concentration of polymer nanoparticles through dialysis: efficacy and comparison with lyophilization for PEGylated and zwitterionic systems. J Pharm Sci 109(8):2607\u20132614","journal-title":"J Pharm Sci"},{"issue":"5","key":"3609_CR31","doi-asserted-by":"publisher","first-page":"3031","DOI":"10.1166\/jnn.2019.15876","volume":"19","author":"E Vaculikova","year":"2019","unstructured":"Vaculikova E, Pokorna A, Placha D et al (2019) Improvement of glibenclamide water solubility by nanoparticle preparation. J Nanosci Nanotechnol 19(5):3031\u20133034","journal-title":"J Nanosci Nanotechnol"},{"issue":"9","key":"3609_CR32","doi-asserted-by":"publisher","first-page":"723","DOI":"10.2174\/1389200219666171207120643","volume":"19","author":"J Hu","year":"2018","unstructured":"Hu J, Sheng Y, Shi J et al (2018) Long circulating polymeric nanoparticles for gene\/drug delivery. Curr Drug Metab 19(9):723\u2013738","journal-title":"Curr Drug Metab"},{"issue":"1","key":"3609_CR33","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1080\/10717544.2019.1639846","volume":"26","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Chen G, Meng Z et al (2019) A novel nanoparticle drug delivery system based on PEGylated hemoglobin for cancer therapy. Drug Deliv 26(1):717\u2013723","journal-title":"Drug Deliv"},{"key":"3609_CR34","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.actbio.2019.06.051","volume":"96","author":"W Li","year":"2019","unstructured":"Li W, Fu J, Ding Y et al (2019) Low density lipoprotein-inspired nanostructured lipid nanoparticles containing pro-doxorubicin to enhance tumor-targeted therapeutic efficiency. Acta Biomater 96:456\u2013467","journal-title":"Acta Biomater"},{"issue":"1","key":"3609_CR35","doi-asserted-by":"publisher","first-page":"20180","DOI":"10.1038\/s41598-019-56754-8","volume":"9","author":"S Park","year":"2019","unstructured":"Park S, Lee WJ, Park S et al (2019) Reversibly pH-responsive gold nanoparticles and their applications for photothermal cancer therapy. Sci Rep 9(1):20180","journal-title":"Sci Rep"},{"issue":"4","key":"3609_CR36","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1080\/17435390.2018.1553251","volume":"13","author":"RA Yokel","year":"2019","unstructured":"Yokel RA, Hancock ML, Grulke EA et al (2019) Carboxylic acids accelerate acidic environment-mediated nanoceria dissolution. Nanotoxicology 13(4):455\u2013475","journal-title":"Nanotoxicology"},{"key":"3609_CR37","doi-asserted-by":"publisher","first-page":"109345","DOI":"10.1016\/j.biopha.2019.109345","volume":"118","author":"X Huang","year":"2019","unstructured":"Huang X, Wang X, Zhang Y et al (2019) Absorption and utilisation of epimedin C and icariin from Epimedii herba, and the regulatory mechanism via the BMP2\/Runx2 signalling pathway. Biomed Pharmacother 118:109345","journal-title":"Biomed Pharmacother"},{"key":"3609_CR38","doi-asserted-by":"publisher","first-page":"3949","DOI":"10.2147\/DDDT.S203094","volume":"13","author":"S Zuo","year":"2019","unstructured":"Zuo S, Zou W, Wu RM et al (2019) Icariin alleviates IL-1beta-induced matrix degradation by activating The Nrf2\/ARE pathway in human chondrocytes. Drug Des Dev Ther 13:3949\u20133961","journal-title":"Drug Des Dev Ther"},{"issue":"1","key":"3609_CR39","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1186\/s13018-019-1307-6","volume":"14","author":"Y Zu","year":"2019","unstructured":"Zu Y, Mu Y, Li Q et al (2019) Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis. J Orthop Surg Res 14(1):307","journal-title":"J Orthop Surg Res"},{"key":"3609_CR40","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.actbio.2019.12.015","volume":"103","author":"C Wang","year":"2020","unstructured":"Wang C, Guan W, Peng J et al (2020) Gene\/paclitaxel co-delivering nanocarriers prepared by framework-induced self-assembly for the inhibition of highly drug-resistant tumors. Acta Biomater 103:247\u2013258","journal-title":"Acta Biomater"},{"issue":"20","key":"3609_CR41","first-page":"4902","volume":"45","author":"XI Hui-Rong","year":"2020","unstructured":"Hui-Rong XI, Hui-Ping MA, Ke-Ming C et al (2020) Preparation and characterization of icariin nanosuspension and lyophilized powder. Zhongguo Zhong Yao Za Zhi 45(20):4902\u20134908","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"9","key":"3609_CR42","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.recesp.2019.02.022","volume":"72","author":"S Martinez-Hervas","year":"2019","unstructured":"Martinez-Hervas S, Gonzalez-Navarro H (2019) Anti-inflammatory therapies for cardiovascular disease: signaling pathways and mechanisms. Rev Esp Cardiol (Engl Ed) 72(9):767\u2013773","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"3609_CR43","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cca.2019.02.022","volume":"493","author":"G Ndrepepa","year":"2019","unstructured":"Ndrepepa G (2019) Myeloperoxidase\u2014a bridge linking inflammation and oxidative stress with cardiovascular disease. Clin Chim Acta 493:36\u201351","journal-title":"Clin Chim Acta"},{"issue":"8","key":"3609_CR44","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1161\/ATVBAHA.119.311998","volume":"39","author":"H Ait-Oufella","year":"2019","unstructured":"Ait-Oufella H, Libby P, Tedgui A (2019) Anticytokine immune therapy and atherothrombotic cardiovascular risk. Arterioscler Thromb Vasc Biol 39(8):1510\u20131519","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Nanoscale Research Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11671-021-03609-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s11671-021-03609-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11671-021-03609-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T04:43:14Z","timestamp":1679287394000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s11671-021-03609-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,17]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3609"],"URL":"https:\/\/doi.org\/10.1186\/s11671-021-03609-9","relation":{},"ISSN":["1556-276X"],"issn-type":[{"value":"1556-276X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,17]]},"assertion":[{"value":"13 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"155"}}