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Addressing this challenge is essential for effectively managing\n                    <jats:italic>Candida<\/jats:italic>\n                    infections. The overarching objective is to advance the development of more efficient and precise therapies tailored to counter\n                    <jats:italic>Candida<\/jats:italic>\n                    infections. This study focuses on developing antifungal combined drugs using curcumin-enhanced silver-functionalized graphene nanocomposites (Cur-AgrGO) to effectively target key virulence factors of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    ,\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    , and\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    (\n                    <jats:italic>Candida<\/jats:italic>\n                    spp.). The green reduction of graphene oxide (GO) using bioentities and active molecules makes this approach cost-effective and environmentally friendly. The nanocomposites were characterized using various techniques. Combining Cur-AgrGO with photodynamic therapy (PDT) demonstrated effective antifungal and antibiofilm activity with delayed growth and metabolism. The nanocomposites effectively suppressed hyphal transition and reduced key virulence factors, including proteinases, phospholipases, ergosterol levels, and cell membrane integrity. The findings suggest that Cur-AgrGO\u2009+\u2009PDT has potential as a treatment option for\n                    <jats:italic>Candida<\/jats:italic>\n                    infections. This innovative approach holds promise for treating\n                    <jats:italic>Candida<\/jats:italic>\n                    infections.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1186\/s11671-024-04017-5","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T08:01:56Z","timestamp":1714377716000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Photodynamic impact of curcumin enhanced silver functionalized graphene nanocomposites on Candida virulence"],"prefix":"10.1186","volume":"19","author":[{"given":"Dhivyabharathi","family":"Balakrishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-I","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"4017_CR1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/pathogens8020053","volume":"8","author":"SA Nikou","year":"2019","unstructured":"Nikou SA, Kichik N, Brown R, Ponde NO, Ho J, Naglik JR, Richardson JP. 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