{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T10:23:06Z","timestamp":1787307786651,"version":"build-2736575974"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discover Nano"],"DOI":"10.1186\/s11671-026-04863-5","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:26:35Z","timestamp":1787304395000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photodynamic therapy mediated by a selective nanoemulsion for breast cancer treatment: in vitro and in vivo evaluation"],"prefix":"10.1186","volume":"21","author":[{"given":"Cristiano Ceron","family":"Jayme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Silvestrini","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via S.","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara","family":"Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Barcelos","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4198-9321","authenticated-orcid":false,"given":"Antonio Claudio","family":"Tedesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"issue":"10286","key":"4863_CR1","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1016\/S0140-6736(20)32381-3","volume":"397","author":"S Loibl","year":"2021","unstructured":"Loibl S, Poortmans P, Morrow M, Denkert C, Curigliano G. Breast cancer. Lancet. 2021;397(10286):1750\u201369.","journal-title":"Lancet"},{"issue":"8","key":"4863_CR2","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s12032-023-02111-9","volume":"40","author":"H Swaminathan","year":"2023","unstructured":"Swaminathan H, Saravanamurali K, Yadav SA. Extensive review on breast cancer its etiology, progression, prognostic markers, and treatment. Med Oncol. 2023;40(8):238.","journal-title":"Med Oncol"},{"issue":"1","key":"4863_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-020-0167-z","volume":"6","author":"N Harbeck","year":"2020","unstructured":"Harbeck N. Breast cancer is a systemic disease optimally treated by a multidisciplinary team. Nat Rev Dis Primers. 2020;6(1):1\u20132.","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"4863_CR4","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1001\/jama.2018.19323","volume":"321","author":"AG Waks","year":"2019","unstructured":"Waks AG, Winer EP. Breast cancer treatment: a review. JAMA. 2019;321(3):288\u2013300.","journal-title":"JAMA"},{"issue":"3","key":"4863_CR5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.32725\/jab.2022.013","volume":"20","author":"J Gustalik","year":"2022","unstructured":"Gustalik J, Aebisher D, Bartusik-Aebisher D. Photodynamic therapy in breast cancer treatment. J Appl Biomed. 2022;20(3):98.","journal-title":"J Appl Biomed"},{"issue":"5","key":"4863_CR6","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nrc1071","volume":"3","author":"DE Dolmans","year":"2003","unstructured":"Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer. 2003;3(5):380.","journal-title":"Nat Rev Cancer"},{"key":"4863_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2025.12.014","author":"A Jamil","year":"2025","unstructured":"Jamil A, Zahid A, Khan RA, Saleem M, Hassan SMU, Anwar S, et al. Aluminum phthalocyanine chloride loaded poly (lactic-co-glycolic acid) nanoparticles based photodynamic therapy for antibacterial and anticancer applications. J Biotechnol. 2025. https:\/\/doi.org\/10.1016\/j.jbiotec.2025.12.014.","journal-title":"J Biotechnol"},{"key":"4863_CR8","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.saa.2018.05.009","volume":"201","author":"CC Jayme","year":"2018","unstructured":"Jayme CC, Calori IR, Cunha EMF, Tedesco AC. Evaluation of aluminum phthalocyanine chloride and DNA interactions for the design of an advanced drug delivery system in photodynamic therapy. Spectrochim Acta A Mol Biomol Spectrosc. 2018;201:242\u20138.","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"4863_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.101843","volume":"31","author":"DN de Ara\u00fajo Silva","year":"2020","unstructured":"de Ara\u00fajo Silva DN, da Silva NT, de Ara\u00fajo Sena IA, da Silva Azevedo ML, da Silva J\u00fanior FL, da Silva RCM, et al. Efficacy of antimicrobial photodynamic therapy with chloro-aluminum phthalocyanine on periodontal clinical parameters and salivary GSH and MDA levels in patients with periodontitis. Photodiagnosis Photodyn Ther. 2020;31:101843.","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"1","key":"4863_CR10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41392-022-00906-2","volume":"7","author":"R Li","year":"2022","unstructured":"Li R, Zhou Y, Liu Y, Jiang X, Zeng W, Gong Z, et al. Asymmetric, amphiphilic RGD conjugated phthalocyanine for targeted photodynamic therapy of triple negative breast cancer. Signal Transduct Target Ther. 2022;7(1):64.","journal-title":"Signal Transduct Target Ther"},{"key":"4863_CR11","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.biomaterials.2014.11.054","volume":"42","author":"CS Schneider","year":"2015","unstructured":"Schneider CS, Perez JG, Cheng E, Zhang C, Mastorakos P, Hanes J, et al. Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells. Biomaterials. 2015;42:42\u201351.","journal-title":"Biomaterials"},{"key":"4863_CR12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1590\/S1679-45082016RB3475","volume":"14","author":"DB Vieira","year":"2016","unstructured":"Vieira DB, Gamarra LF. Advances in the use of nanocarriers for cancer diagnosis and treatment. Einstein (S\u00e3o Paulo). 2016;14:99\u2013103.","journal-title":"Einstein (S\u00e3o Paulo)"},{"key":"4863_CR13","doi-asserted-by":"crossref","unstructured":"Jayme CC, Calori IR, Tedesco AC (2015) Spectroscopic analysis of aluminum chloride phthalocyanine in binary water\/ethanol systems as a new drug delivery system for photodynamic therapy cancer treatment. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 153: 178","DOI":"10.1016\/j.saa.2015.08.027"},{"issue":"02","key":"4863_CR14","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1055\/s-0042-1751036","volume":"4","author":"Y-Q Zhao","year":"2022","unstructured":"Zhao Y-Q, Li L-J, Zhou E-F, Wang J-Y, Wang Y, Guo L-M, et al. Lipid-based nanocarrier systems for drug delivery: advances and applications. Pharmaceutical Fronts. 2022;4(02):e43\u201360.","journal-title":"Pharmaceutical Fronts"},{"key":"4863_CR15","first-page":"2538","volume-title":"Frontiers in pharmaceutical nanotechnology","author":"MG Wacker","year":"2019","unstructured":"Wacker MG. Frontiers in pharmaceutical nanotechnology, vol. Vol. 10. Beilstein-Institut; 2019. p. 2538\u201340."},{"issue":"2","key":"4863_CR16","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s10068-019-00731-4","volume":"29","author":"SJ Choi","year":"2020","unstructured":"Choi SJ, McClements DJ. Nanoemulsions as delivery systems for lipophilic nutraceuticals: strategies for improving their formulation, stability, functionality and bioavailability: SJ Choi DJ McClements. Food Sci Biotechnol. 2020;29(2):149\u201368.","journal-title":"Food Sci Biotechnol"},{"key":"4863_CR17","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jconrel.2017.03.008","volume":"252","author":"Y Singh","year":"2017","unstructured":"Singh Y, Meher JG, Raval K, Khan FA, Chaurasia M, Jain NK, et al. Nanoemulsion: concepts, development and applications in drug delivery. J Control Release. 2017;252:28\u201349.","journal-title":"J Control Release"},{"issue":"1","key":"4863_CR18","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s11671-024-04086-6","volume":"19","author":"R Dhiman","year":"2024","unstructured":"Dhiman R, Bazad N, Mukherjee R, Himanshu G, Leal E, et al. Enhanced drug delivery with nanocarriers: a comprehensive review of recent advances in breast cancer detection and treatment. Discover Nano. 2024;19(1):143.","journal-title":"Discover Nano"},{"issue":"1","key":"4863_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12645-019-0055-y","volume":"10","author":"E Beltr\u00e1n-Gracia","year":"2019","unstructured":"Beltr\u00e1n-Gracia E, L\u00f3pez-Camacho A, Higuera-Ciapara I, Vel\u00e1zquez-Fern\u00e1ndez JB, Vallejo-Cardona AA. Nanomedicine review: clinical developments in liposomal applications. Cancer Nanotechnol. 2019;10(1):1\u201340.","journal-title":"Cancer Nanotechnol"},{"issue":"1","key":"4863_CR20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1631\/jzus.B1600303","volume":"18","author":"M Zhao","year":"2017","unstructured":"Zhao M, Ding X-F, Shen J-Y, Zhang X-P, Ding X-W, Xu B. Use of liposomal doxorubicin for adjuvant chemotherapy of breast cancer in clinical practice. J Zhejiang Univ Sci B. 2017;18(1):15\u201326.","journal-title":"J Zhejiang Univ Sci B"},{"key":"4863_CR21","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.2147\/IJN.S127329","volume":"12","author":"JJ Lee","year":"2017","unstructured":"Lee JJ, Yazan LS, Abdullah CAC. A review on current nanomaterials and their drug conjugate for targeted breast cancer treatment. Int J Nanomedicine. 2017;12:2373.","journal-title":"Int J Nanomedicine"},{"key":"4863_CR22","doi-asserted-by":"crossref","unstructured":"Overchuk, M., Choi, A. M., Rickard, B. P., Schnoor, B., Ehrmann, B. M., Girotti, A. W., et al. (2025). Photodynamic therapy simultaneously induces ferroptosis-and apoptosis-like lipid signatures in ovarian cancer cells. Cell Death & Disease, 16(1): 899","DOI":"10.1038\/s41419-025-08189-5"},{"issue":"9","key":"4863_CR23","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.3390\/pharmaceutics16091158","volume":"16","author":"A Giordano","year":"2024","unstructured":"Giordano A, Provenza AC, Reverchon G, Baldino L, Reverchon E. Lipid-based nanocarriers: bridging diagnosis and cancer therapy. Pharmaceutics. 2024;16(9):1158.","journal-title":"Pharmaceutics"},{"issue":"1","key":"4863_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/nano9010014","volume":"9","author":"P-T Wu","year":"2019","unstructured":"Wu P-T, Lin C-L, Lin C-W, Chang N-C, Tsai W-B, Yu J. Methylene-blue-encapsulated liposomes as photodynamic therapy nano agents for breast cancer cells. Nanomaterials Basel. 2019;9(1):14.","journal-title":"Nanomaterials Basel"},{"key":"4863_CR25","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jphotobiol.2016.11.006","volume":"166","author":"G Nam","year":"2017","unstructured":"Nam G, Rangasamy S, Ju H, Samson AAS, Song JM. Cell death mechanistic study of photodynamic therapy against breast cancer cells utilizing liposomal delivery of 5, 10, 15, 20-tetrakis (benzo [b] thiophene) porphyrin. J Photochem Photobiol B. 2017;166:116\u201325.","journal-title":"J Photochem Photobiol B"},{"key":"4863_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.111984","author":"AC Tedesco","year":"2021","unstructured":"Tedesco AC, Silva EP, Jayme CC, Piva HL, Franchi LP. Cholesterol-rich nanoemulsion (LDE) as a novel drug delivery system to diagnose, delineate, and treat human glioblastoma. Mater Sci Eng C Mater Biol Appl. 2021. https:\/\/doi.org\/10.1016\/j.msec.2021.111984.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"4863_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.102992","volume":"39","author":"CC Jayme","year":"2022","unstructured":"Jayme CC, Rezende N, Fernandes DS, de Paula LB, de Castro BG, Takahashi LAU, et al. Target selectivity of cholesterol-phosphatidylcholine liposome loaded with phthalocyanine for breast cancer diagnosis and treatment by photodynamic therapy. Photodiagnosis Photodyn Ther. 2022;39:102992.","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"3","key":"4863_CR28","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1016\/j.msec.2012.12.088","volume":"33","author":"MP Siqueira-Moura","year":"2013","unstructured":"Siqueira-Moura MP, Primo FL, Espreafico EM, Tedesco AC. Development, characterization, and photocytotoxicity assessment on human melanoma of chloroaluminum phthalocyanine nanocapsules. Mater Sci Eng C Mater Biol Appl. 2013;33(3):1744\u201352.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"1","key":"4863_CR29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.31083\/ph.2010.9217","volume":"65","author":"M Siqueira-Moura","year":"2010","unstructured":"Siqueira-Moura M, Primo F, Peti A, Tedesco A. Validated spectrophotometric and spectrofluorimetric methods for determination of chloroaluminum phthalocyanine in nanocarriers. Pharmazie. 2010;65(1):9\u201314.","journal-title":"Pharmazie"},{"issue":"83","key":"4863_CR30","doi-asserted-by":"publisher","first-page":"79631","DOI":"10.1039\/C6RA16015H","volume":"6","author":"E Silva","year":"2016","unstructured":"Silva E, Franchi L, Tedesco A. Chloro-aluminium phthalocyanine loaded in ultradeformable liposomes for photobiology studies on human glioblastoma. RSC Adv. 2016;6(83):79631\u201340.","journal-title":"RSC Adv"},{"issue":"9","key":"4863_CR31","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1080\/03602559.2012.680561","volume":"51","author":"H-T Chiu","year":"2012","unstructured":"Chiu H-T, Yang H-M, Liu C-S, Hsu H-Y. Synthesis, stability and properties of polyurethane\/acrylic hybrids using m-TMXDI-based anionic poly (urethane-urea) dispersion. Polym-Plast Technol Eng. 2012;51(9):945\u201353.","journal-title":"Polym-Plast Technol Eng"},{"issue":"8","key":"4863_CR32","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.jsps.2017.07.004","volume":"25","author":"A Fernandes","year":"2017","unstructured":"Fernandes A, Ferreira N, Fangueiro J, Santos A, Veiga F, Cabral C, et al. Ibuprofen nanocrystals developed by 22 factorial design experiment: a new approach for poorly water-soluble drugs. Saudi Pharm J. 2017;25(8):1117\u201324.","journal-title":"Saudi Pharm J"},{"key":"4863_CR33","doi-asserted-by":"crossref","unstructured":"Jayme, C. C., de Paula, L. B., Rezende, N., Calori, I. R., Franchi, L. P., & Tedesco, A. C. (2017). DNA polymeric films as a support for cell growth as a new material for regenerative medicine: compatibility and applicability. Experimental Cell Research, 360(2): 404","DOI":"10.1016\/j.yexcr.2017.09.033"},{"issue":"12","key":"4863_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051525","volume":"7","author":"R Nachat-Kappes","year":"2012","unstructured":"Nachat-Kappes R, Pinel A, Combe K, Lamas B, Farges M-C, Rossary A, et al. Effects of enriched environment on COX-2, leptin and eicosanoids in a mouse model of breast cancer. PLoS ONE. 2012;7(12):e51525.","journal-title":"PLoS ONE"},{"key":"4863_CR35","doi-asserted-by":"crossref","unstructured":"Souza, C., Jayme, C. C., Rezende, N., & Tedesco, A. C. (2021). Photobiomodulation-associated phthalocyanine influences fibroblast signaling responses in an in vitro three-dimensional microenvironment. Journal of Photochemistry and Photobiology B: Biology, 112256.","DOI":"10.1016\/j.jphotobiol.2021.112256"},{"key":"4863_CR36","doi-asserted-by":"crossref","unstructured":"Jayme, C. C., Souza, C., Fernandes, D. S., & Tedesco, A. C. (2021). Tailoring the growth and proliferation of human dermal fibroblasts by DNA\u2010based polymer films for skin regeneration. Journal of Biomedical Materials Research Part A, 109(11): 2381","DOI":"10.1002\/jbm.a.37220"},{"issue":"2","key":"4863_CR37","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1021\/acs.langmuir.3c03019","volume":"40","author":"Y Guo","year":"2024","unstructured":"Guo Y, Zhang X, Wang X, Zhang L, Xu Z, Sun D. Nanoemulsions stable against Ostwald ripening. Langmuir. 2024;40(2):1364\u201372.","journal-title":"Langmuir"},{"issue":"4","key":"4863_CR38","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.cocis.2008.01.005","volume":"13","author":"J Guti\u00e9rrez","year":"2008","unstructured":"Guti\u00e9rrez J, Gonz\u00e1lez C, Maestro A, Sol\u00e8 I, Pey C, Nolla J. Nano-emulsions: new applications and optimization of their preparation. Curr Opin Colloid Interface Sci. 2008;13(4):245\u201351.","journal-title":"Curr Opin Colloid Interface Sci"},{"issue":"11","key":"4863_CR39","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1142\/S1088424622500559","volume":"26","author":"M Benhaliliba","year":"2022","unstructured":"Benhaliliba M, Ahmed AB, Ayeshamariam A. Optical-electrical properties and global reactivity analysis of aluminum phthalocyanine chloride. J Porphyrins Phthalocyanines. 2022;26(11):732\u201340.","journal-title":"J Porphyrins Phthalocyanines"},{"key":"4863_CR40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.5c05406","author":"A Elkihel","year":"2026","unstructured":"Elkihel A, Cressey P, Abuillan W, Rich P, Mekhloufi G, Arteni AA, et al. Interfacial behavior, supramolecular assembly, and photophysics of phospholipid\u2013porphyrin and phospholipid\u2013phthalocyanine conjugates. Langmuir. 2026. https:\/\/doi.org\/10.1021\/acs.langmuir.5c05406.","journal-title":"Langmuir"},{"issue":"32","key":"4863_CR41","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1039\/C7CC09954A","volume":"54","author":"C Jing","year":"2018","unstructured":"Jing C, Wang R, Ou H, Li A, An Y, Guo S, et al. Axial modification inhibited H-aggregation of phthalocyanines in polymeric micelles for enhanced PDT efficacy. Chem Commun (Camb). 2018;54(32):3985\u20138.","journal-title":"Chem Commun (Camb)"},{"issue":"22","key":"4863_CR42","doi-asserted-by":"publisher","first-page":"5735","DOI":"10.1039\/D0SC01351J","volume":"11","author":"E Lee","year":"2020","unstructured":"Lee E, Li X, Oh J, Kwon N, Kim G, Kim D, et al. A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria. Chem Sci. 2020;11(22):5735\u20139.","journal-title":"Chem Sci"},{"key":"4863_CR43","doi-asserted-by":"crossref","unstructured":"Honary, S., & Zahir, F. (2013). Effect of zeta potential on the properties of nano-drug delivery systems-a review (Part 1).","DOI":"10.4314\/tjpr.v12i2.19"},{"issue":"3","key":"4863_CR44","doi-asserted-by":"publisher","first-page":"305","DOI":"10.15171\/apb.2015.043","volume":"5","author":"N Naseri","year":"2015","unstructured":"Naseri N, Valizadeh H, Zakeri-Milani P. Solid lipid nanoparticles and nanostructured lipid carriers: structure, preparation and application. Adv Pharm Bull. 2015;5(3):305.","journal-title":"Adv Pharm Bull"},{"issue":"6","key":"4863_CR45","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1039\/C2SM06903B","volume":"8","author":"DJ McClements","year":"2012","unstructured":"McClements DJ. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter. 2012;8(6):1719\u201329.","journal-title":"Soft Matter"},{"issue":"4","key":"4863_CR46","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1039\/C9CS00129H","volume":"49","author":"P-C Lo","year":"2020","unstructured":"Lo P-C, Rodr\u00edguez-Morgade MS, Pandey RK, Ng DK, Torres T, Dumoulin F. The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer. Chem Soc Rev. 2020;49(4):1041\u201356.","journal-title":"Chem Soc Rev"},{"key":"4863_CR47","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.jphotobiol.2016.03.050","volume":"160","author":"IR Calori","year":"2016","unstructured":"Calori IR, Tedesco AC. Lipid vesicles loading aluminum phthalocyanine chloride: formulation properties and disaggregation upon intracellular delivery. J Photochem Photobiol, B. 2016;160:240\u20137.","journal-title":"J Photochem Photobiol, B"},{"issue":"3","key":"4863_CR48","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.ejps.2013.03.011","volume":"49","author":"CS de Paula","year":"2013","unstructured":"de Paula CS, Tedesco AC, Primo FL, Vilela JMC, Andrade MS, Mosqueira VCF. Chloroaluminium phthalocyanine polymeric nanoparticles as photosensitisers: photophysical and physicochemical characterisation, release and phototoxicity in vitro. Eur J Pharm Sci. 2013;49(3):371\u201381.","journal-title":"Eur J Pharm Sci"},{"key":"4863_CR49","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.pdpdt.2019.05.004","volume":"26","author":"N Rezende","year":"2019","unstructured":"Rezende N, Jayme CC, Brassesco MS, Tedesco AC, de Oliveira HF. Standardization of a resazurin-based assay for the evaluation of metabolic activity in oral squamous carcinoma and glioblastoma cells. Photodiagnosis Photodyn Ther. 2019;26:371\u20134.","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"3","key":"4863_CR50","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0009-8981(80)90442-8","volume":"107","author":"S Barnes","year":"1980","unstructured":"Barnes S, Spenney JG. Stoichiometry of the NADH-oxidoreductase reaction for dehydrogenase determinations. Clin Chim Acta. 1980;107(3):149\u201354.","journal-title":"Clin Chim Acta"},{"key":"4863_CR51","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/978-1-4939-7201-2_14","volume-title":"Proteomics for drug discovery","author":"J\u00c1 Rodr\u00edguez-Corrales","year":"2017","unstructured":"Rodr\u00edguez-Corrales J\u00c1, Josan JS. Resazurin live cell assay: setup and fine-tuning for reliable cytotoxicity results. In: Proteomics for drug discovery. Springer; 2017. p. 207\u201319."},{"issue":"17","key":"4863_CR52","doi-asserted-by":"publisher","first-page":"5421","DOI":"10.1046\/j.1432-1327.2000.01606.x","volume":"267","author":"J O\u2019Brien","year":"2000","unstructured":"O\u2019Brien J, Wilson I, Orton T, Pognan F. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem. 2000;267(17):5421\u20136.","journal-title":"Eur J Biochem"},{"issue":"1","key":"4863_CR53","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.yexcr.2017.08.014","volume":"359","author":"A Razaghi","year":"2017","unstructured":"Razaghi A, Villacr\u00e9s C, Jung V, Mashkour N, Butler M, Owens L, et al. Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells. Exp Cell Res. 2017;359(1):20\u20139.","journal-title":"Exp Cell Res"},{"issue":"1","key":"4863_CR54","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10396-018-0899-5","volume":"46","author":"Y Liu","year":"2019","unstructured":"Liu Y, Bai H, Wang H, Wang X, Liu Q, Zhang K, et al. Comparison of hypocrellin B-mediated sonodynamic responsiveness between sensitive and multidrug-resistant human gastric cancer cell lines. J Med Ultrason. 2019;46(1):15\u201326.","journal-title":"J Med Ultrason"},{"key":"4863_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2021.102575","author":"CC Jayme","year":"2021","unstructured":"Jayme CC, Pires AF, Fernandes DS, Bi H, Tedesco AC. DNA polymer films used as drug delivery systems to early-stage diagnose and treatment of breast cancer using 3D tumor spheroids as a model. Photodiagnosis Photodyn Ther. 2021. https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102575.","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"1","key":"4863_CR56","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-025-04413-5","volume":"20","author":"DS Fernandes","year":"2025","unstructured":"Fernandes DS, Jayme CC, Matsuo FS, de Lima SCG, Fantacini DMC, de Souza LEB, et al. Evaluation of silver nitroprusside nanoparticles: selective toxicity against MCF-7 cells and in vivo antitumor activity. Discover Nano. 2025;20(1):230.","journal-title":"Discover Nano"},{"issue":"1\u20132","key":"4863_CR57","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0168-3659(99)00248-5","volume":"65","author":"H Maeda","year":"2000","unstructured":"Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release. 2000;65(1\u20132):271\u201384.","journal-title":"J Control Release"},{"issue":"9","key":"4863_CR58","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/nbt.3330","volume":"33","author":"E Blanco","year":"2015","unstructured":"Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol. 2015;33(9):941\u201351.","journal-title":"Nat Biotechnol"}],"container-title":["Discover Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11671-026-04863-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s11671-026-04863-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s11671-026-04863-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:26:38Z","timestamp":1787304398000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s11671-026-04863-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4863"],"URL":"https:\/\/doi.org\/10.1186\/s11671-026-04863-5","relation":{},"ISSN":["2731-9229"],"issn-type":[{"value":"2731-9229","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]},"assertion":[{"value":"21 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The animal study protocol was approved by the Ethical Principles in Animal Experimentation established by the National Council for Animal Experimentation Control (CONCEA) and the Ethics Committee on Animal Use (CEUA) of the Faculty of Philosophy, Sciences and Letters of Ribeir\u00e3o Preto (FFCLRP), Ribeir\u00e3o Preto (Protocol No. 2020.1.539.59.9). All procedures were performed in strict accordance with the Guidelines for the Care and Use of Laboratory Animals.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing financial interests or personal relationships that could influence the work reported in this paper.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"407"}}