{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:44:12Z","timestamp":1790246652936,"version":"4.1.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"nathan gantcher foundation"},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P30 HD071593"],"award-info":[{"award-number":["P30 HD071593"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurodevelop Disord"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s11689-017-9218-5","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T08:48:28Z","timestamp":1510217308000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Saccade adaptation deficits in developmental dyslexia suggest disruption of cerebellar-dependent learning"],"prefix":"10.1186","volume":"9","author":[{"given":"Edward G.","family":"Freedman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Molholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Belyusar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Foxe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"issue":"1","key":"9218_CR1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.cortex.2009.10.005","volume":"47","author":"CJ Stoodley","year":"2011","unstructured":"Stoodley CJ, Stein JF. The cerebellum and dyslexia. Cortex. 2011;47(1):101\u201316.","journal-title":"Cortex"},{"issue":"9165","key":"9218_CR2","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1016\/S0140-6736(98)09165-X","volume":"353","author":"RI Nicolson","year":"1999","unstructured":"Nicolson RI, Fawcett AJ, Berry EL, Jenkins IH, Dean P, Brooks DJ. Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults. Lancet. 1999;353(9165):1662\u20137.","journal-title":"Lancet"},{"issue":"9","key":"9218_CR3","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/S0166-2236(00)01896-8","volume":"24","author":"RI Nicolson","year":"2001","unstructured":"Nicolson RI, Fawcett AJ, Dean P. A TINS debate\u2014hindbrain versus the forebrain: a case for cerebellar deficit in developmental dyslexia. Trends Neurosci. 2001;24(9):508\u201311.","journal-title":"Trends Neurosci"},{"key":"9218_CR4","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.neubiorev.2014.09.007","volume":"47","author":"N Hahn","year":"2014","unstructured":"Hahn N, Foxe JJ, Molholm S. Impairments of multisensory integration and cross-sensory learning as pathways to dyslexia. Neurosci Biobehav Rev. 2014;47:384\u201392.","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"9218_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/14640749408401142","volume":"47","author":"RI Nicolson","year":"1994","unstructured":"Nicolson RI, Fawcett AJ. Reaction times and dyslexia. Q J Exp Psychol A. 1994;47(1):29\u201348.","journal-title":"Q J Exp Psychol A"},{"issue":"1","key":"9218_CR6","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/BF02648159","volume":"44","author":"RI Nicolson","year":"1994","unstructured":"Nicolson RI, Fawcett AJ. Comparison of deficits in cognitive and motor skills among children with dyslexia. Ann Dyslexia. 1994;44(1):147\u201364.","journal-title":"Ann Dyslexia"},{"issue":"1","key":"9218_CR7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.cortex.2009.08.016","volume":"47","author":"RI Nicolson","year":"2011","unstructured":"Nicolson RI, Fawcett AJ. Dyslexia, dysgraphia, procedural learning and the cerebellum. Cortex. 2011;47(1):117\u201327.","journal-title":"Cortex"},{"issue":"5","key":"9218_CR8","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1068\/p2666a","volume":"29","author":"M Biscaldi","year":"2000","unstructured":"Biscaldi M, Fischer B, Hartnegg K. Voluntary saccadic control in dyslexia. Perception. 2000;29(5):509\u201321.","journal-title":"Perception"},{"issue":"11","key":"9218_CR9","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/S0028-3932(97)00170-X","volume":"36","author":"M Biscaldi","year":"1998","unstructured":"Biscaldi M, Gezeck S, Stuhr V. Poor saccadic control correlates with dyslexia. Neuropsychologia. 1998;36(11):1189\u2013202.","journal-title":"Neuropsychologia"},{"key":"9218_CR10","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1007\/BF00228706","volume":"97","author":"B Fischer","year":"1993","unstructured":"Fischer B, Weber H, Biscaldi M. The time of secondary saccades to primary targets. Exp Brain Res. 1993;97:356\u201360.","journal-title":"Exp Brain Res"},{"issue":"1","key":"9218_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00221-008-1345-5","volume":"188","author":"MP Bucci","year":"2008","unstructured":"Bucci MP, Bremond-Gignac D, Kapoula Z. Latency of saccades and vergence eye movements in dyslexic children. Exp Brain Res. 2008;188(1):1\u201312.","journal-title":"Exp Brain Res"},{"issue":"2","key":"9218_CR12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1076\/0927-3972(200006)8:2;1-2;FT119","volume":"8","author":"B Fischer","year":"2000","unstructured":"Fischer B, Hartnegg K. Stability of gaze control in dyslexia. Strabismus. 2000;8(2):119\u201322.","journal-title":"Strabismus"},{"issue":"10","key":"9218_CR13","doi-asserted-by":"publisher","first-page":"4401","DOI":"10.1167\/iovs.05-1657","volume":"47","author":"R Ram-Tsur","year":"2006","unstructured":"Ram-Tsur R, Faust M, Caspi A, Gordon C, Zivotofsky A. Evidence for ocular motor deficits in developmental dyslexia: application of the double-step paradigm. Invest Ophthalmol Vis Sci. 2006;47(10):4401\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"9218_CR14","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/0042-6989(88)90137-X","volume":"28","author":"GW McConkie","year":"1988","unstructured":"McConkie GW, Kerr PW, Reddix MD, Zola D. Eye movement control during reading: I. The location of initial eye fixations on words. Vis Res. 1988;28(10):1107\u201318.","journal-title":"Vis Res"},{"issue":"5","key":"9218_CR15","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/0042-6989(92)90032-E","volume":"32","author":"GS Rubin","year":"1992","unstructured":"Rubin GS, Turano K. Reading without saccadic eye movements. Vis Res. 1992;32(5):895\u2013902.","journal-title":"Vis Res"},{"issue":"5","key":"9218_CR16","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1152\/jn.1998.80.5.2405","volume":"80","author":"J Wallman","year":"1998","unstructured":"Wallman J, Fuchs AF. Saccadic gain modification: visual error drives motor adaptation. J Neurophysiol. 1998;80(5):2405\u201316.","journal-title":"J Neurophysiol"},{"key":"9218_CR17","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1146\/annurev.ne.15.030192.002155","volume":"15","author":"WT Thach","year":"1992","unstructured":"Thach WT, Goodkin HP, Keating JG. The cerebellum and the adaptive coordination of movement. Annu Rev Neurosci. 1992;15:403\u201342.","journal-title":"Annu Rev Neurosci"},{"issue":"6","key":"9218_CR18","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1152\/jn.1980.44.6.1058","volume":"44","author":"LM Optican","year":"1980","unstructured":"Optican LM, Robinson DA. Cerebellar-dependent adaptive control of primate saccadic system. J Neurophysiol. 1980;44(6):1058\u201376.","journal-title":"J Neurophysiol"},{"key":"9218_CR19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1152\/jn.1985.54.1.110","volume":"54","author":"LM Optican","year":"1985","unstructured":"Optican LM, Zee DS, Chu FC. Adaptive response to ocular muscle weakness in human pursuit and saccadic eye movements. J Neurophysiol. 1985;54:110\u201322.","journal-title":"J Neurophysiol"},{"key":"9218_CR20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3758\/BF03210071","volume":"2","author":"SC McLaughlin","year":"1967","unstructured":"McLaughlin SC. Parametric adjustment in saccadic eye movements. Percept Psychophys. 1967;2:359\u201362.","journal-title":"Percept Psychophys"},{"key":"9218_CR21","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1037\/0096-1523.7.2.356","volume":"7","author":"J Miller","year":"1981","unstructured":"Miller J, Anstis T, Templeton W. Saccadic plasticity: parametric adaptive control of retinal feedback. J Exp Psychol Hum Percept Perform. 1981;7:356\u201366.","journal-title":"J Exp Psychol Hum Percept Perform"},{"issue":"4","key":"9218_CR22","first-page":"245","volume":"5","author":"H Deubel","year":"1986","unstructured":"Deubel H, Wolf W, Hauske G. Adaptive gain control of saccadic eye movements. Hum Neurobiol. 1986;5(4):245\u201353.","journal-title":"Hum Neurobiol"},{"issue":"5","key":"9218_CR23","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0361-9230(97)80001-9","volume":"43","author":"MA Frens","year":"1997","unstructured":"Frens MA, Van Opstal AJ. Monkey superior colliculus activity during short-term saccadic adaptation. Brain Res Bull. 1997;43(5):473\u201383.","journal-title":"Brain Res Bull"},{"issue":"5","key":"9218_CR24","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1152\/jn.1997.78.5.2817","volume":"78","author":"JO Phillips","year":"1997","unstructured":"Phillips JO, Fuchs AF, Ling L, Iwamoto Y, Votaw S. Gain adaptation of eye and head movement components of simian gaze shifts. J Neurophysiol. 1997;78(5):2817\u201321.","journal-title":"J Neurophysiol"},{"issue":"1","key":"9218_CR25","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1167\/iovs.03-0570","volume":"45","author":"N Alahyane","year":"2004","unstructured":"Alahyane N, Pelisson D. Eye position specificity of saccadic adaptation. Invest Ophthalmol Vis Sci. 2004;45(1):123\u201330.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"9218_CR26","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1101\/lm.96405","volume":"12","author":"N Alahyane","year":"2005","unstructured":"Alahyane N, Pelisson D. Long-lasting modifications of saccadic eye movements following adaptation induced in the double-step target paradigm. Learn Mem. 2005;12(4):433\u201343.","journal-title":"Learn Mem"},{"issue":"2","key":"9218_CR27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.visres.2007.10.029","volume":"48","author":"AL Cecala","year":"2008","unstructured":"Cecala AL, Freedman EG. Amplitude changes in response to target displacements during human eye-head movements. Vis Res. 2008;48(2):149\u201366.","journal-title":"Vis Res"},{"issue":"51","key":"9218_CR28","doi-asserted-by":"publisher","first-page":"13929","DOI":"10.1523\/JNEUROSCI.3470-08.2008","volume":"28","author":"V Ethier","year":"2008","unstructured":"Ethier V, Zee DS, Shadmehr R. Changes in control of saccades during gain adaptation. J Neurosci %R 101523\/JNEUROSCI3470\u2013082008. 2008;28(51):13929\u201337.","journal-title":"J Neurosci %R 101523\/JNEUROSCI3470\u2013082008"},{"issue":"1","key":"9218_CR29","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1152\/jn.90735.2008","volume":"101","author":"AL Cecala","year":"2009","unstructured":"Cecala AL, Freedman EG. Head-unrestrained gaze adaptation in the rhesus macaque. J Neurophysiol. 2009;101(1):164\u201383.","journal-title":"J Neurophysiol"},{"issue":"19","key":"9218_CR30","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1016\/j.visres.2006.03.028","volume":"46","author":"JJ Hopp","year":"2006","unstructured":"Hopp JJ, Fuchs AF. Amplitude adaptation occurs where a saccade is represented as a vector and not as its components. Vis Res. 2006;46(19):3121\u20138.","journal-title":"Vis Res"},{"issue":"23\u201324","key":"9218_CR31","doi-asserted-by":"publisher","first-page":"3451","DOI":"10.1016\/0042-6989(95)00076-Q","volume":"35","author":"A Straube","year":"1995","unstructured":"Straube A, Deubel H. Rapid gain adaptation affects the dynamics of saccadic eye movements in humans. Vis Res. 1995;35(23\u201324):3451\u20138.","journal-title":"Vis Res"},{"key":"9218_CR32","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1152\/jn.1999.81.6.2798","volume":"81","author":"CT Noto","year":"1999","unstructured":"Noto CT, Watanabe S, Fuchs AF. Characteristics of simian adaptation fields produced by behavioral changes in saccade size and direction. J Neurophysiol. 1999;81:2798\u2013813.","journal-title":"J Neurophysiol"},{"issue":"2","key":"9218_CR33","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1152\/jn.1997.77.2.874","volume":"77","author":"A Straube","year":"1997","unstructured":"Straube A, Fuchs AF, Usher S, Robinson FR. Characteristics of saccadic gain adaptation in rhesus macaques. J Neurophysiol. 1997;77(2):874\u201395.","journal-title":"J Neurophysiol"},{"issue":"1","key":"9218_CR34","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.pneurobio.2003.12.002","volume":"72","author":"JJ Hopp","year":"2004","unstructured":"Hopp JJ, Fuchs AF. The characteristics and neuronal substrate of saccadic eye movement plasticity. Prog Neurobiol. 2004;72(1):27\u201353.","journal-title":"Prog Neurobiol"},{"issue":"1","key":"9218_CR35","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.1460-9568.2007.05996.x","volume":"27","author":"H Golla","year":"2008","unstructured":"Golla H, Tziridis K, Haarmeier T, Catz N, Barash S, Thier P. Reduced saccadic resilience and impaired saccadic adaptation due to cerebellar disease. Eur J Neurosci. 2008;27(1):132\u201344.","journal-title":"Eur J Neurosci"},{"key":"9218_CR36","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1523\/JNEUROSCI.19-24-10931.1999","volume":"19","author":"S Barash","year":"1999","unstructured":"Barash S, Melikyan A, Sivakov A, Zhang M, Glickstein M, Thier P. Saccadic dysmetria and adaptation after lesions of the cerebellar cortex. J Neurosci. 1999;19:10931\u20139.","journal-title":"J Neurosci"},{"issue":"14","key":"9218_CR37","doi-asserted-by":"publisher","first-page":"5471","DOI":"10.1523\/JNEUROSCI.4064-14.2015","volume":"35","author":"MT Panouilleres","year":"2015","unstructured":"Panouilleres MT, Miall RC, Jenkinson N. The role of the posterior cerebellum in saccadic adaptation: a transcranial direct current stimulation study. J Neurosci. 2015;35(14):5471\u20139.","journal-title":"J Neurosci"},{"issue":"6","key":"9218_CR38","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s12311-013-0486-7","volume":"12","author":"H Block","year":"2013","unstructured":"Block H, Celnik P. Stimulating the cerebellum affects visuomotor adaptation but not intermanual transfer of learning. Cerebellum. 2013;12(6):781\u201393.","journal-title":"Cerebellum"},{"key":"9218_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fnhum.2013.00027","volume":"7","author":"JA Bernard","year":"2013","unstructured":"Bernard JA, Seidler RD. Cerebellar contributions to visuomotor adaptation and motor sequence learning: an ALE meta-analysis. Front Hum Neurosci. 2013;7:27.","journal-title":"Front Hum Neurosci"},{"issue":"11","key":"9218_CR40","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1212\/WNL.57.11.2105","volume":"57","author":"A Straube","year":"2001","unstructured":"Straube A, Deubel H, Ditterich J, Eggert T. Cerebellar lesions impair rapid saccade amplitude adaptation. Neurology. 2001;57(11):2105\u20138.","journal-title":"Neurology"},{"key":"9218_CR41","doi-asserted-by":"publisher","first-page":"968970","DOI":"10.1155\/2015\/968970","volume":"2015","author":"E Avila","year":"2015","unstructured":"Avila E, van der Geest JN, Kengne Kamga S, Verhage MC, Donchin O, Frens MA. Cerebellar transcranial direct current stimulation effects on saccade adaptation. Neural Plast. 2015;2015:968970.","journal-title":"Neural Plast"},{"issue":"4","key":"9218_CR42","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1177\/1073858404263596","volume":"10","author":"M Eckert","year":"2004","unstructured":"Eckert M. Neuroanatomical markers for dyslexia: a review of dyslexia structural imaging studies. Neuroscientist. 2004;10(4):362\u201371.","journal-title":"Neuroscientist"},{"issue":"4","key":"9218_CR43","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1212\/01.WNL.0000134673.95020.EE","volume":"63","author":"SM Brambati","year":"2004","unstructured":"Brambati SM, Termine C, Ruffino M, Stella G, Fazio F, Cappa SF, Perani D. Regional reductions of gray matter volume in familial dyslexia. Neurology. 2004;63(4):742\u20135.","journal-title":"Neurology"},{"key":"9218_CR44","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s12311-012-0407-1","volume":"12","author":"C Stoodley","year":"2013","unstructured":"Stoodley C, Stein J. Cerebellar function in developmental dyslexia. Cerebellum. 2013;12:267\u201376.","journal-title":"Cerebellum"},{"issue":"2","key":"9218_CR45","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.ejpn.2016.07.025","volume":"21","author":"M Biotteau","year":"2017","unstructured":"Biotteau M, Peran P, Vayssiere N, Tallet J, Albaret JM, Chaix Y. Neural changes associated to procedural learning and automatization process in developmental coordination disorder and\/or developmental dyslexia. Eur J Paediatr Neurol. 2017;21(2):286\u201399.","journal-title":"Eur J Paediatr Neurol"},{"issue":"10","key":"9218_CR46","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1002\/hbm.20752","volume":"30","author":"F Richlan","year":"2009","unstructured":"Richlan F, Kronbichler M, Wimmer H. Functional abnormalities in the dyslexic brain: a quantitative meta-analysis of neuroimaging studies. Hum Brain Mapp. 2009;30(10):3299\u2013308.","journal-title":"Hum Brain Mapp"},{"issue":"6","key":"9218_CR47","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1212\/WNL.56.6.781","volume":"56","author":"WE Brown","year":"2001","unstructured":"Brown WE, Eliez S, Menon V, Rumsey JM, White CD, Reiss AL. Preliminary evidence of widespread morphological variations of the brain in dyslexia. Neurology. 2001;56(6):781\u20133.","journal-title":"Neurology"},{"issue":"8","key":"9218_CR48","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/S0028-3932(01)00216-0","volume":"40","author":"C Rae","year":"2002","unstructured":"Rae C, Harasty JA, Dzendrowskyj TE, Talcott JB, Simpson JM, Blamire AM, Dixon RM, Lee MA, Thompson CH, Styles P, et al. Cerebellar morphology in developmental dyslexia. Neuropsychologia. 2002;40(8):1285\u201392.","journal-title":"Neuropsychologia"},{"issue":"4","key":"9218_CR49","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0010-9452(08)70021-2","volume":"38","author":"AJ Finch","year":"2002","unstructured":"Finch AJ, Nicolson RI, Fawcett AJ. Evidence for a neuroanatomical difference within the olivo-cerebellar pathway of adults with dyslexia. Cortex. 2002;38(4):529\u201339.","journal-title":"Cortex"},{"issue":"Pt 2","key":"9218_CR50","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1093\/brain\/awg026","volume":"126","author":"MA Eckert","year":"2003","unstructured":"Eckert MA, Leonard CM, Richards TL, Aylward EH, Thomson J, Berninger VW. Anatomical correlates of dyslexia: frontal and cerebellar findings. Brain. 2003;126(Pt 2):482\u201394.","journal-title":"Brain"},{"issue":"4","key":"9218_CR51","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1016\/j.neuroimage.2006.08.024","volume":"33","author":"D Menghini","year":"2006","unstructured":"Menghini D, Hagberg GE, Caltagirone C, Petrosini L, Vicari S. Implicit learning deficits in dyslexic adults: an fMRI study. NeuroImage. 2006;33(4):1218\u201326.","journal-title":"NeuroImage"},{"issue":"1","key":"9218_CR52","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s00221-001-0969-5","volume":"143","author":"RI Nicolson","year":"2002","unstructured":"Nicolson RI, Daum I, Schugens MM, Fawcett AJ, Schulz A. Eyeblink conditioning indicates cerebellar abnormality in dyslexia. Exp Brain Res. 2002;143(1):42\u201350.","journal-title":"Exp Brain Res"},{"key":"9218_CR53","first-page":"155","volume":"5","author":"RI Nicolson","year":"1999","unstructured":"Nicolson RI, Fawcett AJ. Developmental dyslexia: the role of the cerebellum. Dyslexia Int J Res Pract. 1999;5:155\u201377.","journal-title":"Dyslexia Int J Res Pract"},{"key":"9218_CR54","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1007\/s00221-002-1077-x","volume":"144","author":"JJ Hopp","year":"2002","unstructured":"Hopp JJ, Fuchs AF. Investigating the site of human saccadic adaptation with express and targeting saccades. Exp Brain Res. 2002;144:538\u201348.","journal-title":"Exp Brain Res"},{"issue":"3","key":"9218_CR55","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1046\/j.0953-816x.2001.01669.x","volume":"14","author":"B Gaymard","year":"2001","unstructured":"Gaymard B, Rivaud-Pechoux S, Yelnik J, Pidoux B, Ploner CJ. Involvement of the cerebellar thalamus in human saccade adaptation. Eur J Neurosci. 2001;14(3):554\u201360.","journal-title":"Eur J Neurosci"},{"issue":"2","key":"9218_CR56","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/BF00236319","volume":"65","author":"RC Miall","year":"1987","unstructured":"Miall RC, Weir DJ, Stein JF. Visuo-motor tracking during reversible inactivation of the cerebellum. Exp Brain Res. 1987;65(2):455\u201364.","journal-title":"Exp Brain Res"},{"issue":"12","key":"9218_CR57","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1177\/7010.2006.00238","volume":"21","author":"MS Salman","year":"2006","unstructured":"Salman MS, Sharpe JA, Eizenman M, Lillakas L, To T, Westall C, Dennis M, Steinbach MJ. Saccadic adaptation in children. J Child Neurol. 2006;21(12):1025\u201331.","journal-title":"J Child Neurol"},{"issue":"2","key":"9218_CR58","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1152\/jn.00656.2002","volume":"90","author":"FR Robinson","year":"2003","unstructured":"Robinson FR, Noto CT, Bevans SE. Effect of visual error size on saccade adaptation in monkey. J Neurophysiol. 2003;90(2):1235\u201344.","journal-title":"J Neurophysiol"},{"issue":"2","key":"9218_CR59","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1152\/jn.1998.79.2.704","volume":"79","author":"CA Scudder","year":"1998","unstructured":"Scudder CA, Batourina EY, Tunder GS. Comparison of two methods of producing adaptation of saccade size and implications for the site of plasticity. J Neurophysiol. 1998;79(2):704\u201315.","journal-title":"J Neurophysiol"},{"key":"9218_CR60","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1152\/jn.1997.77.2.874","volume":"77","author":"A Straube","year":"1997","unstructured":"Straube A, Fuchs AF, Usher S, Robinson FR. Characteristics of saccadic gain adaptation in rhesus macaques. J Neurophysiol. 1997;77:874\u201395.","journal-title":"J Neurophysiol"},{"issue":"5","key":"9218_CR61","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0361-9230(97)80001-9","volume":"43","author":"MA Frens","year":"1997","unstructured":"Frens MA, Opstal AJ. Monkey superior colliculus activity during short-term saccadic adaptation. Brain Res Bull. 1997;43(5):473\u201383.","journal-title":"Brain Res Bull"},{"issue":"3","key":"9218_CR62","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1152\/jn.00113.2005","volume":"94","author":"N Takeichi","year":"2005","unstructured":"Takeichi N, Kaneko CR, Fuchs AF. Discharge of monkey nucleus reticularis tegmenti pontis neurons changes during saccade adaptation. J Neurophysiol. 2005;94(3):1938\u201351.","journal-title":"J Neurophysiol"},{"issue":"6","key":"9218_CR63","doi-asserted-by":"publisher","first-page":"4096","DOI":"10.1152\/jn.01278.2006","volume":"97","author":"N Takeichi","year":"2007","unstructured":"Takeichi N, Kaneko CR, Fuchs AF. Activity changes in monkey superior colliculus during saccade adaptation. J Neurophysiol. 2007;97(6):4096\u2013107.","journal-title":"J Neurophysiol"},{"issue":"51","key":"9218_CR64","doi-asserted-by":"publisher","first-page":"13929","DOI":"10.1523\/JNEUROSCI.3470-08.2008","volume":"28","author":"V Ethier","year":"2008","unstructured":"Ethier V, Zee DS, Shadmehr R. Changes in control of saccades during gain adaptation. J Neurosci. 2008;28(51):13929\u201337.","journal-title":"J Neurosci"},{"issue":"41","key":"9218_CR65","doi-asserted-by":"publisher","first-page":"12930","DOI":"10.1523\/JNEUROSCI.3115-09.2009","volume":"29","author":"M Xu-Wilson","year":"2009","unstructured":"Xu-Wilson M, Chen-Harris H, Zee DS, Shadmehr R. Cerebellar contributions to adaptive control of saccades in humans. J Neurosci. 2009;29(41):12930\u20139.","journal-title":"J Neurosci"},{"issue":"7573","key":"9218_CR66","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nature15693","volume":"526","author":"DJ Herzfeld","year":"2015","unstructured":"Herzfeld DJ, Kojima Y, Soetedjo R, Shadmehr R. Encoding of action by the Purkinje cells of the cerebellum. Nature. 2015;526(7573):439\u201342.","journal-title":"Nature"},{"issue":"4","key":"9218_CR67","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1152\/jn.90526.2008","volume":"100","author":"R Soetedjo","year":"2008","unstructured":"Soetedjo R, Kojima Y, Fuchs AF. Complex spike activity in the oculomotor vermis of the cerebellum: a vectorial error signal for saccade motor learning? J Neurophysiol. 2008;100(4):1949\u201366.","journal-title":"J Neurophysiol"},{"key":"9218_CR68","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1471-2202-10-67","volume":"10","author":"C Pernet","year":"2009","unstructured":"Pernet C, Poline J, Demonet J, Rousselet G. Brain classification reveals the right cerebellum as the best biomarker of dyslexia. BMC Neurosci. 2009;10:67.","journal-title":"BMC Neurosci"},{"key":"9218_CR69","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.cortex.2009.10.005","volume":"47","author":"C Stoodley","year":"2011","unstructured":"Stoodley C, Stein J. The cerebellum and dyslexia. Cortex. 2011;47:101\u201316.","journal-title":"Cortex"},{"issue":"4","key":"9218_CR70","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1177\/002221940003300406","volume":"33","author":"MW Lovett","year":"2000","unstructured":"Lovett MW, Steinbach KA, Frijters JC. Remediating the core deficits of developmental reading disability: a double-deficit perspective. J Learn Disabil. 2000;33(4):334\u201358.","journal-title":"J Learn Disabil"},{"issue":"1","key":"9218_CR71","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1177\/002221940103400104","volume":"34","author":"JK Torgesen","year":"2001","unstructured":"Torgesen JK, Alexander AW, Wagner RK, Rashotte CA, Voeller KK, Conway T. Intensive remedial instruction for children with severe reading disabilities: immediate and long-term outcomes from two instructional approaches. J Learn Disabil. 2001;34(1):33\u201358. 78","journal-title":"J Learn Disabil"},{"issue":"4","key":"9218_CR72","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/dys.1466","volume":"19","author":"A van der Leij","year":"2013","unstructured":"van der Leij A. Dyslexia and early intervention: what did we learn from the Dutch Dyslexia Programme? Dyslexia. 2013;19(4):241\u201355.","journal-title":"Dyslexia"},{"issue":"4","key":"9218_CR73","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s11145-007-9085-7","volume":"21","author":"J Wexler","year":"2008","unstructured":"Wexler J, Vaughn S, Edmonds M, Reutebuch CK. A synthesis of fluency interventions for secondary struggling readers. Read Writ. 2008;21(4):317\u201347.","journal-title":"Read Writ"}],"container-title":["Journal of Neurodevelopmental Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s11689-017-9218-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s11689-017-9218-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s11689-017-9218-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T10:31:11Z","timestamp":1589452271000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneurodevdisorders.biomedcentral.com\/articles\/10.1186\/s11689-017-9218-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["9218"],"URL":"https:\/\/doi.org\/10.1186\/s11689-017-9218-5","relation":{},"ISSN":["1866-1947","1866-1955"],"issn-type":[{"value":"1866-1947","type":"print"},{"value":"1866-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,9]]},"assertion":[{"value":"6 December 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All study procedures were approved by the Institutional Review Board of Albert Einstein College of Medicine. Participants provided assent in addition to written consent from their legal guardian.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"36"}}