{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:43:25Z","timestamp":1791315805888,"version":"4.3.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000871","name":"Newlife \u2013 The Charity for Disabled Children","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/501100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000659","name":"Research Trainees Coordinating Centre","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/501100000659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["RG91365"],"award-info":[{"award-number":["RG91365"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Innovation Challenge Fund","award":["HICF-1009-003"],"award-info":[{"award-number":["HICF-1009-003"]}]},{"DOI":"10.13039\/100010269","name":"The Wellcome Trust","doi-asserted-by":"crossref","award":["WT098051"],"award-info":[{"award-number":["WT098051"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurodevelop Disord"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s11689-019-9278-9","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T11:02:32Z","timestamp":1565089352000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["STXBP1-associated neurodevelopmental disorder: a comparative study of behavioural characteristics"],"prefix":"10.1186","volume":"11","author":[{"name":"The DDD Study","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin\u00e9ad","family":"O\u2019Brien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Ng-Cordell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan E.","family":"Astle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Scerif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2986-0584","authenticated-orcid":false,"given":"Kate","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,6]]},"reference":[{"issue":"7509","key":"9278_CR1","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nature13394","volume":"511","author":"C Gilissen","year":"2014","unstructured":"Gilissen C, Hehir-Kwa JY, Thung DT, Van De Vorst M, Van Bon BWM, Willemsen MH, et al. Genome sequencing identifies major causes of severe intellectual disability. Nature. 2014;511(7509):344\u20137 Nature Publishing Group.","journal-title":"Nature"},{"issue":"8","key":"9278_CR2","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1002\/pro.3445","volume":"27","author":"J Rizo","year":"2018","unstructured":"Rizo J. Mechanism of neurotransmitter release coming into focus. Protein Sci. 2018;27(8):1364\u201391.","journal-title":"Protein Sci"},{"issue":"6","key":"9278_CR3","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/ng.150","volume":"40","author":"H Saitsu","year":"2008","unstructured":"Saitsu H, Kato M, Mizuguchi T, Hamada K, Osaka H, Tohyama J, et al. De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy. Nat Genet. 2008;40(6):782\u20138.","journal-title":"Nat Genet"},{"issue":"14","key":"9278_CR4","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1212\/WNL.0000000000000291","volume":"82","author":"GL Carvill","year":"2014","unstructured":"Carvill GL, Weckhuysen S, McMahon JM, Hartmann C, M\u00f8ller RS, Hjalgrim H, et al. GABRA1 and STXBP1: novel genetic causes of Dravet syndrome. Neurology. 2014;82(14):1245\u201353.","journal-title":"Neurology"},{"issue":"13","key":"9278_CR5","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1212\/WNL.0b013e3181f4d7bf","volume":"75","author":"L Deprez","year":"2010","unstructured":"Deprez L, Weckhuysen S, Holmgren P, Suls A, Van Dyck T, Goossens D, et al. Clinical spectrum of early-onset epileptic encephalopathies associated with STXBP1 mutations. Neurology. 2010;75(13):1159\u201365.","journal-title":"Neurology"},{"issue":"12","key":"9278_CR6","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1111\/epi.13214","volume":"56","author":"C Di Meglio","year":"2015","unstructured":"Di Meglio C, Lesca G, Villeneuve N, Lacoste C, Abidi A, Cacciagli P, et al. Epileptic patients with de novo STXBP1 mutations: key clinical features based on 24 cases. Epilepsia. 2015;56(12):1931\u201340.","journal-title":"Epilepsia"},{"issue":"10","key":"9278_CR7","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1212\/WNL.0000000000002457","volume":"86","author":"Hannah Stamberger","year":"2016","unstructured":"Stamberger H, Nikanorova M, Accorsi P, Angriman M, Benkel-herrenbrueck I, Capovilla G, et al. STXBP1 encephalopathy: a neurodevelopmental disorder including epilepsy. Neurology. 2016;86:954\u2013962.","journal-title":"Neurology"},{"issue":"7466","key":"9278_CR8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nature12439","volume":"501","author":"AS Allen","year":"2013","unstructured":"Allen AS, Berkovic SF, Cossette P, Delanty N, Dlugos D, Eichler EE, et al. De novo mutations in epileptic encephalopathies. Nature. 2013;501(7466):217\u201321 Nature Publishing Group.","journal-title":"Nature"},{"issue":"6","key":"9278_CR9","doi-asserted-by":"publisher","first-page":"e199","DOI":"10.1212\/NXG.0000000000000199","volume":"3","author":"A Chan","year":"2017","unstructured":"Chan A, Brunga L, Lamoureux S, Faheem M, Drake J, Shlien A, et al. Germline and somatic mutations in STXBP1 with diverse neurodevelopmental phenotypes. Neurol Genet. 2017;3(6):e199.","journal-title":"Neurol Genet"},{"issue":"1","key":"9278_CR10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejmg.2013.10.006","volume":"57","author":"G Barcia","year":"2014","unstructured":"Barcia G, Chemaly N, Gobin S, Milh M, Van Bogaert P, Barnerias C, et al. Early epileptic encephalopathies associated with STXBP1 mutations: could we better delineate the phenotype? Eur J Med Genet. 2014;57(1):15\u201320 Elsevier Masson SAS.","journal-title":"Eur J Med Genet"},{"issue":"4","key":"9278_CR11","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ejpn.2016.04.005","volume":"20","author":"J Gburek-Augustat","year":"2016","unstructured":"Gburek-Augustat J, Beck-Woedl S, Tzschach A, Bauer P, Schoening M, Riess A. Epilepsy is not a mandatory feature of STXBP1 associated ataxia-tremor-retardation syndrome. Eur J Paediatr Neurol. 2016;20(4):661\u20135 Elsevier Ltd.","journal-title":"Eur J Paediatr Neurol"},{"issue":"9854","key":"9278_CR12","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1016\/S0140-6736(12)61480-9","volume":"380","author":"A Rauch","year":"2012","unstructured":"Rauch A, Wieczorek D, Graf E, Wieland T, Endele S, Schwarzmayr T, et al. Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study. Lancet. 2012;380(9854):1674\u201382.","journal-title":"Lancet"},{"issue":"5","key":"9278_CR13","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/mgg3.304","volume":"5","author":"M Suri","year":"2017","unstructured":"Suri M, Evers JMG, Laskowski RA, O\u2019Brien S, Baker K, Clayton-Smith J, et al. Protein structure and phenotypic analysis of pathogenic and population missense variants in STXBP1. Mol Genet Genomic Med. 2017;5(5):495\u2013507.","journal-title":"Mol Genet Genomic Med"},{"issue":"6","key":"9278_CR14","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.braindev.2018.02.002","volume":"40","author":"K Yuge","year":"2018","unstructured":"Yuge K, Iwama K, Yonee C, Matsufuji M, Sano N, Saikusa T, et al. A novel STXBP1 mutation causes typical Rett syndrome in a Japanese girl. Brain Dev. 2018;40(6):493\u20137 The Japanese Society of Child Neurology.","journal-title":"Brain Dev"},{"issue":"7642","key":"9278_CR15","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature21062","volume":"542","author":"JF McRae","year":"2017","unstructured":"McRae JF, Clayton S, Fitzgerald TW, et al. Prevalence and architecture of de novo mutations in developmental disorders. Nature. 2017;542(7642):433\u20138.","journal-title":"Nature"},{"issue":"9975","key":"9278_CR16","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/S0140-6736(14)61705-0","volume":"385","author":"CF Wright","year":"2015","unstructured":"Wright CF, Fitzgerald TW, Jones WD, Clayton S, McRae JF, Van Kogelenberg M, et al. Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data. Lancet. 2015;385(9975):1305\u201314.","journal-title":"Lancet"},{"issue":"5","key":"9278_CR17","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/ejhg.2010.183","volume":"19","author":"FF Hamdan","year":"2011","unstructured":"Hamdan FF, Gauthier J, Dobrzeniecka S, Lortie A, Mottron L, Vanasse M, et al. Intellectual disability without epilepsy associated with STXBP1 disruption. Eur J Hum Genet. 2011;19(5):607\u20139.","journal-title":"Eur J Hum Genet"},{"issue":"10","key":"9278_CR18","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1111\/j.1528-1167.2011.03181.x","volume":"52","author":"M Milh","year":"2011","unstructured":"Milh M, Villeneuve N, Chouchane M, Kaminska A, Laroche C, Barthez MA, et al. Epileptic and nonepileptic features in patients with early onset epileptic encephalopathy and STXBP1 mutations. Epilepsia. 2011;52(10):1828\u201334.","journal-title":"Epilepsia"},{"issue":"1","key":"9278_CR19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1684\/epd.2013.0558","volume":"15","author":"Massimo Mastrangelo","year":"2013","unstructured":"Mastrangelo M, Peron A, Spaccini L, Novara F, Scelsa B, Introvini P, et al. Neonatal suppression-burst without epileptic seizures: expanding the electroclinical phenotype of STXBP1-related, early-onset encephalopathy. Epileptic Disord. 2013;15(1):55\u201361.","journal-title":"Epileptic Disorders"},{"issue":"3","key":"9278_CR20","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.braindev.2015.09.004","volume":"38","author":"T Yamamoto","year":"2016","unstructured":"Yamamoto T, Shimojima K, Yano T, Ueda Y, Takayama R, Ikeda H, et al. Loss-of-function mutations of STXBP1 in patients with epileptic encephalopathy. Brain Dev. 2016;38(3):280\u20134 The Japanese Society of Child Neurology.","journal-title":"Brain Dev"},{"issue":"9","key":"9278_CR21","doi-asserted-by":"publisher","first-page":"3560","DOI":"10.1172\/JCI78612","volume":"125","author":"C Patzke","year":"2015","unstructured":"Patzke C, Han Y, Covy J, Yi F, Maxeiner S, Wernig M, et al. Analysis of conditional heterozygous STXBP1 mutations in human neurons. J Clin Invest. 2015;125(9):3560\u201371.","journal-title":"J Clin Invest"},{"issue":"5454","key":"9278_CR22","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1126\/science.287.5454.864","volume":"287","author":"M Verhage","year":"2000","unstructured":"Verhage M. Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science. 2000;287(5454):864\u20139.","journal-title":"Science"},{"issue":"11","key":"9278_CR23","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.tins.2007.08.008","volume":"30","author":"RFG Toonen","year":"2007","unstructured":"Toonen RFG, Verhage M. Munc18-1 in secretion: lonely Munc joins SNARE team and takes control. Trends Neurosci. 2007;30(11):564\u201372.","journal-title":"Trends Neurosci"},{"issue":"3","key":"9278_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0151148","volume":"11","author":"BP Grone","year":"2016","unstructured":"Grone BP, Marchese M, Hamling KR, Kumar MG, Krasniak CS, Sicca F, et al. Epilepsy, behavioral abnormalities, and physiological comorbidities in syntaxin-binding protein 1 (STXBP1) mutant zebrafish. PLoS One. 2016;11(3):1\u201325.","journal-title":"PLoS One"},{"issue":"5","key":"9278_CR25","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1093\/brain\/awy046","volume":"141","author":"J Kova\u010devi\u0107","year":"2018","unstructured":"Kova\u010devi\u0107 J, Maroteaux G, Schut D, Loos M, Dubey M, Pitsch J, et al. Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy. Brain. 2018;141(5):1350\u201374.","journal-title":"Brain"},{"key":"9278_CR26","first-page":"199","volume-title":"Major psychological assessment instruments","author":"CB Sparrow","year":"2005","unstructured":"Sparrow CB. The Vineland Adaptive behavior Scales-Second Edition-VBAS II. In: Major psychological assessment instruments, vol. 2. Needham Heights: Allyn & Bacon; 2005. p. 199\u2013231."},{"key":"9278_CR27","volume-title":"Developmental Behavior Checklist","author":"SL Einfeld","year":"2002","unstructured":"Einfeld SL, Tonge BJ. Developmental Behavior Checklist. 2nd Edi ed. Australia: University of New South Wales and Monash University; 2002.","edition":"2nd Edi"},{"key":"9278_CR28","volume-title":"Conner\u2019s 3rd Edition Technical Manual","author":"CK Conners","year":"2008","unstructured":"Conners CK. Conner\u2019s 3rd Edition Technical Manual. 3rd Edit ed. Toronto: MHS Assessments; 2008.","edition":"3rd Edit"},{"key":"9278_CR29","volume-title":"The Social Responsiveness Scale Manual, Second Edition (SRS-2)","author":"JN Constantino","year":"2012","unstructured":"Constantino JN, Gruber CP. The Social Responsiveness Scale Manual, Second Edition (SRS-2). 2nd Edi ed. Torrance: WPS; 2012.","edition":"2nd Edi"},{"key":"9278_CR30","volume-title":"Movement ABC-2 Movement Assessment Battery for Children \u2013 Second Edition","author":"SE Henderson","year":"2013","unstructured":"Henderson SE, Sugden DA, Barnett A. Movement ABC-2 Movement Assessment Battery for Children \u2013 Second Edition. 2nd Edi ed. Pearson Education Ltd: Minneapolis; 2013.","edition":"2nd Edi"},{"issue":"1","key":"9278_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s11689-017-9217-6","volume":"9","author":"C Richards","year":"2017","unstructured":"Richards C, Powis L, Moss J, Stinton C, Nelson L, Oliver C. Prospective study of autism phenomenology and the behavioural phenotype of Phelan-McDermid syndrome: comparison to fragile X syndrome, Down syndrome and idiopathic autism spectrum disorder. J Neurodev Disord. 2017;9(1):1\u201315.","journal-title":"J Neurodev Disord"},{"key":"9278_CR32","doi-asserted-by":"crossref","unstructured":"Orock A, Logan S, Deak F. Molecular and Cellular Neuroscience Munc18-1 haploinsufficiency impairs learning and memory by reduced synaptic vesicular release in a model of Ohtahara syndrome. Mol Cell Neurosci 2018;88:33\u201342. Elsevier.","DOI":"10.1016\/j.mcn.2017.12.002"},{"issue":"6","key":"9278_CR33","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.tins.2011.04.001","volume":"34","author":"AM Mabb","year":"2011","unstructured":"Mabb AM, Judson MC, Zylka MJ, Philpot BD. Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes. Trends Neurosci. 2011;34(6):293\u2013303 Elsevier Ltd.","journal-title":"Trends Neurosci"},{"key":"9278_CR34","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.bbr.2013.11.033","volume":"260","author":"T Hager","year":"2014","unstructured":"Hager T, Maroteaux G, Julsing J, Van VR, Stiedl O. Munc18-1 haploinsufficiency results in enhanced anxiety-like behavior as determined by heart rate responses in mice. Behav Brain Res. 2014;260:44\u201352 Elsevier B.V.","journal-title":"Behav Brain Res"},{"issue":"1","key":"9278_CR35","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/j.1365-2788.2005.00730.x","volume":"50","author":"K Horsler","year":"2006","unstructured":"Horsler K, Oliver C. The behavioural phenotype of Angelman syndrome. J Intellect Disabil Res. 2006;50(1):33\u201353.","journal-title":"J Intellect Disabil Res"},{"issue":"1","key":"9278_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13229-017-0185-1","volume":"9","author":"KA Bakke","year":"2018","unstructured":"Bakke KA, Howlin P, Retterst\u00f8l L, Kanavin IJ, Heiberg A, N\u00e6rland T. Effect of epilepsy on autism symptoms in Angelman syndrome. Mol Autism. 2018;9(1):1\u20138.","journal-title":"Mol Autism"},{"issue":"3","key":"9278_CR37","first-page":"577","volume":"4","author":"K Pelc","year":"2008","unstructured":"Pelc K, Cheron G, Dan B. Behavior and neuropsychiatry manifestations in Angelman syndrome. Neuropsychiatr Dis Treat. 2008;4(3):577\u201384.","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"1","key":"9278_CR38","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bbr.2012.12.052","volume":"243","author":"HS Huang","year":"2013","unstructured":"Huang HS, Burns AJ, Nonneman RJ, Baker LK, Riddick NV, Nikolova VD, et al. Behavioral deficits in an Angelman syndrome model: effects of genetic background and age. Behav Brain Res. 2013;243(1):79\u201390 Elsevier B.V.","journal-title":"Behav Brain Res"},{"key":"9278_CR39","unstructured":"Oliver C, Woodcock K, Adams D. The importance of aetiology of intellectual disability. In: Grant G, Ramcharan P, Flynn M, Richardson M, editors. Learning disability: a life cycle approach to valuing people. Milton Keynes: Open University Press\/Wiley; 2010. p. 135\u201346."},{"issue":"4","key":"9278_CR40","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.tics.2012.02.007","volume":"16","author":"Coralie Chevallier","year":"2012","unstructured":"Chevallier C, Kohls G, Troiani V, Brodkin ES, Schultz RT. The social motivation theory of autism. Trends Cogn Sci. 2012;16(4):231\u20139.","journal-title":"Trends in Cognitive Sciences"},{"key":"9278_CR41","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.expneurol.2017.04.002","volume":"293","author":"DC Stoppel","year":"2017","unstructured":"Stoppel DC, Anderson MP. Hypersociability in the Angelman syndrome mouse model. Exp Neurol. 2017;293:137\u201343 Elsevier Inc.","journal-title":"Exp Neurol"},{"key":"9278_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms10702","volume":"7","author":"J Berrios","year":"2016","unstructured":"Berrios J, Stamatakis AM, Kantak PA, Mcelligott ZA, Judson MC, Aita M, et al. Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation. Nat Commun. 2016;7:1\u20138 Nature Publishing Group.","journal-title":"Nat Commun"}],"container-title":["Journal of Neurodevelopmental Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s11689-019-9278-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s11689-019-9278-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s11689-019-9278-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T23:06:21Z","timestamp":1596582381000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneurodevdisorders.biomedcentral.com\/articles\/10.1186\/s11689-019-9278-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,6]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["9278"],"URL":"https:\/\/doi.org\/10.1186\/s11689-019-9278-9","relation":{},"ISSN":["1866-1947","1866-1955"],"issn-type":[{"value":"1866-1947","type":"print"},{"value":"1866-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,6]]},"assertion":[{"value":"5 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Cambridge Central Research Ethics Committee (\u2018Phenotypes in Intellectual Disability\u2019, reference: 11\/EE\/0330). Parent or Carer gave written informed consent on behalf of participants under the age of 16. For participants aged 16 and over, lacking capacity to consent, a consultee was appointed. Prior to testing, research assistants ensured the project had been discussed with participants. The DDD study has UK Research Ethics Committee approval (10\/H0305\/83, granted by the Cambridge South REC, and GEN\/284\/12 granted by the Republic of Ireland REC).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Obtained within study participation consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17"}}