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Our study explores the platelet (PLT) proteome from uncomplicated\n                      <jats:italic>P. vivax<\/jats:italic>\n                      patients, to fingerprint molecular pathways related to platelet function. Plasma levels of Platelet factor 4 (PF4\/CXCL4) and Von Willebrand factor (VWf), as well as in vitro PLTs\u2014\n                      <jats:italic>P. vivax<\/jats:italic>\n                      infected erythrocytes (\n                      <jats:italic>Pv<\/jats:italic>\n                      -IEs) interactions were also evaluated to explore the PLT response and effect on parasite development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cohort of 48 patients and 25 healthy controls were enrolled. PLTs were purified from 5 patients and 5 healthy controls for Liquid Chromatography\u2013Mass spectrometry (LC\u2013MS\/MS) analysis. Plasma levels of PF4\/CXCL4 and VWf were measured in all participants. Additionally,\n                      <jats:italic>P. vivax<\/jats:italic>\n                      isolates (n\u2009=\u200910) were co-cultured with PLTs to measure PLT activation by PF4\/CXCL4 and\n                      <jats:italic>Pv-<\/jats:italic>\n                      IE schizonts formation by light microscopy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The proteome from uncomplicated\n                      <jats:italic>P. vivax<\/jats:italic>\n                      patients showed 26 out of 215 proteins significantly decreased. PF4\/CXCL4 was significantly decreased followed by other proteins involved in platelet activation, cytoskeletal remodeling, and endothelial adhesion, including glycoprotein V that was significantly decreased in thrombocytopenic patients. In contrast, acute phase proteins, including SERPINs and Amyloid Serum A1 were increased. High levels of VWf in plasma from patients suggested endothelial activation while PF4\/CXCL4 plasma levels were similar between patients and controls. Interestingly, high levels of PF4\/CXCL4 were released from PLTs\u2014\n                      <jats:italic>Pv<\/jats:italic>\n                      -IEs co-cultures while\n                      <jats:italic>Pv<\/jats:italic>\n                      -IEs schizont formation was inhibited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The PLT proteome analyzed in this study suggests that PLTs actively respond to\n                      <jats:italic>P. vivax<\/jats:italic>\n                      infection. Altogether, our findings suggest important roles of PF4\/CXCL4 during uncomplicated\n                      <jats:italic>P. vivax<\/jats:italic>\n                      infection through a possible intracellular localization. Our study shows that platelets are active responders to\n                      <jats:italic>P. vivax<\/jats:italic>\n                      infection, inhibiting intraerythrocytic parasite development. Future studies are needed to further investigate the molecular pathways of interaction between platelet proteins found in this study and host response, which could affect parasite control as well as disease progression.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12014-021-09337-7","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T11:02:38Z","timestamp":1641466958000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets"],"prefix":"10.1186","volume":"19","author":[{"given":"Diana","family":"Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Segura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f2nica","family":"Arman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"McGill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Burchmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9401-2779","authenticated-orcid":false,"given":"Tatiana","family":"Lopera-Mesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"9337_CR1","unstructured":"WHO. 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