{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:44:55Z","timestamp":1762674295117,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T00:00:00Z","timestamp":1548460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Health Prev Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12199-019-0762-3","type":"journal-article","created":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T07:02:37Z","timestamp":1548486157000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan"],"prefix":"10.1186","volume":"24","author":[{"given":"Toru","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5376-8844","authenticated-orcid":false,"given":"Hyogo","family":"Horiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Oguma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Komatsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhito","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehisa","family":"Matsukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momoko","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Omori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Kamikomaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,26]]},"reference":[{"key":"762_CR1","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/B978-0-444-59453-2.00032-9","volume-title":"Handbook on the toxicology of metals","author":"GF Nordberg","year":"2015","unstructured":"Nordberg GF, Nogawa K, Nordberg M. Cadmium. In: Nordberg GF, Fowler BA, Nordberg M, editors. Handbook on the toxicology of metals. 4th ed. Burlington: Academic Press; 2015. p. 667\u2013716.","edition":"4"},{"key":"762_CR2","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00420-010-0510-x","volume":"83","author":"H Horiguchi","year":"2010","unstructured":"Horiguchi H, Aoshima K, Oguma E, Sasaki S, Miyamoto K, Hosoi Y, et al. Latest status of cadmium accumulation and its effects on kidneys, bone, and erythropoiesis in inhabitants of the formerly cadmium-polluted Jinzu River basin in Toyama, Japan, after restoration of rice paddies. Int Arch Occup Environ Health. 2010;83:953\u201370.","journal-title":"Int Arch Occup Environ Health"},{"key":"762_CR3","first-page":"241","volume":"77","author":"H Horiguchi","year":"2014","unstructured":"Horiguchi H. Diagnosis and social measures of cadmium nephropathy. Kidney Dial. 2014;77:241\u20136. (in Japanese)","journal-title":"Kidney Dial"},{"key":"762_CR4","volume-title":"Current situation of enforcing the Anti-Farm Soil Pollution Law in Japan","author":"Ministry of the Environment of Japan","year":"2017","unstructured":"Ministry of the Environment of Japan. Current situation of enforcing the Anti-Farm Soil Pollution Law in Japan. 2017. \n                    https:\/\/www.env.go.jp\/press\/files\/jp\/107776.pdf\n                    \n                  . [Accessed 17 Jul 2018]."},{"key":"762_CR5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S0013-9351(03)00142-7","volume":"95","author":"H Horiguchi","year":"2004","unstructured":"Horiguchi H, Oguma E, Sasaki S, Miyamoto K, Ikeda Y, Machida M, et al. Dietary exposure to cadmium at close to the current provisional tolerable weekly intake does not affect renal function among female Japanese farmers. Environ Res. 2004;95:20\u201331.","journal-title":"Environ Res"},{"key":"762_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1620\/tjem.152.151","volume":"152","author":"K Aoshima","year":"1987","unstructured":"Aoshima K. Epidemiology of renal tubular dysfunction in the inhabitants of a cadmium-polluted area in the Jinzu River basin in Toyama prefecture. Tohoku J Exp Med. 1987;152:151\u201372.","journal-title":"Tohoku J Exp Med"},{"key":"762_CR7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2166\/wst.1992.0286","volume":"25","author":"M Kasuya","year":"1992","unstructured":"Kasuya M, Teranishi H, Aoshima K, Katoh T, Horiguchi H, Morikawa Y, et al. Water pollution by cadmium and the onset of Itai-itai disease. Wat Sci Tech. 1992;25:149\u201356.","journal-title":"Wat Sci Tech"},{"key":"762_CR8","first-page":"124","volume-title":"Kankyo Hoken Report No. 36","author":"S Kamiyama","year":"1976","unstructured":"Kamiyama S. Health examinations for inhabitants in cadmium-polluted areas in Akita prefecture (in the years of 1972\u20131973). In: Kankyo Hoken Report No. 36. Tokyo: Japanese Association of Public Health; 1976. p. 124\u20135. (in Japanese)."},{"key":"762_CR9","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/0013-9351(77)90051-2","volume":"14","author":"S Kojima","year":"1977","unstructured":"Kojima S, Haga Y, Kurihara T, Yamawaki T. A comparison between fecal cadmium and urinary beta2-microglobulin, total protein, and cadmium among Japanese farmers. An epidemiological study of cooperation between Japan and Sweden. Environ Res. 1977;14:436\u201351.","journal-title":"Environ Res"},{"key":"762_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000399746","volume":"6","author":"H Saito","year":"1977","unstructured":"Saito H, Shioji R, Hurukawa Y, Nagai K, Arikawa T. Cadmium-induced proximal tubular dysfunction in a cadmium-polluted area. Contrib Nephrol. 1977;6:1\u201312.","journal-title":"Contrib Nephrol"},{"key":"762_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.envint.2013.03.001","volume":"56","author":"H Horiguchi","year":"2013","unstructured":"Horiguchi H, Oguma E, Sasaki S, Okubo H, Murakami K, Miyamoto K, et al. Age-relevant renal effects of cadmium exposure through consumption of home-harvested rice in female Japanese farmers. Environ Int. 2013;56:1\u20139.","journal-title":"Environ Int"},{"key":"762_CR12","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.scitotenv.2005.05.043","volume":"362","author":"T Yamagami","year":"2006","unstructured":"Yamagami T, Ezaki T, Moriguchi J, Fukui Y, Okamoto S, Ukai H, et al. Low-level cadmium exposure in Toyama City and its surroundings in Toyama prefecture, Japan, with references to possible contribution of shellfish intake to increase urinary cadmium levels. Sci Total Environ. 2006;362:56\u201367.","journal-title":"Sci Total Environ"},{"key":"762_CR13","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0009-8981(89)90024-7","volume":"179","author":"MD Donaldson","year":"1989","unstructured":"Donaldson MD, Chambers RE, Woolridge MW, Whicher JT. Stability of \u03b11-microglobulin, \u00df2-microglobulin and retinol binding protein in urine. Clin Chim Acta. 1989;179:73\u20137.","journal-title":"Clin Chim Acta"},{"key":"762_CR14","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1159\/000416509","volume":"68","author":"Y Itoh","year":"1988","unstructured":"Itoh Y, Enomoto H, Kawai T. A latex agglutination test for urinary \u03b22-microglobulin. Contrib Nephrol. 1988;68:172\u20138.","journal-title":"Contrib Nephrol"},{"key":"762_CR15","first-page":"889","volume":"24","author":"WG Guder","year":"1986","unstructured":"Guder WG, Hoffmann GE, Hubbuch A, Poppe WA, Siedel J, Price CP. Multicentre evaluation of an enzymatic method for creatinine determination using a sensitive colour reagent. J Clin Chem Clin Biochem. 1986;24:889\u2013902.","journal-title":"J Clin Chem Clin Biochem"},{"key":"762_CR16","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1039\/b801927d","volume":"23","author":"JM Jarrett","year":"2008","unstructured":"Jarrett JM, Xiao G, Caldwell KL, Henahan D, Shakirova G, Jones RL. Eliminating molybdenum oxide interference in urine cadmium biomonitoring using ICP-DRC-MS. J Anal At Spectrom. 2008;23:962\u20137.","journal-title":"J Anal At Spectrom"},{"key":"762_CR17","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1023\/B:BIOM.0000045731.75602.b9","volume":"17","author":"A Bernard","year":"2004","unstructured":"Bernard A. Renal dysfunction induced by cadmium: biomarkers of critical effects. Biometals. 2004;17:519\u201323.","journal-title":"Biometals"},{"key":"762_CR18","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0378-4274(02)00389-2","volume":"137","author":"M Ikeda","year":"2003","unstructured":"Ikeda M, Ezaki T, Tsukahara T, Moriguchi J, Furuki K, Fukui Y, et al. Threshold levels of urinary cadmium in relation to increases in urinary \u03b22-microglobulin among general Japanese populations. Toxicol Lett. 2003;137:135\u201341.","journal-title":"Toxicol Lett"},{"key":"762_CR19","first-page":"37","volume":"50","author":"H Roels","year":"1993","unstructured":"Roels H, Bernard AM, C\u00e1rdenas A, Buchet JP, Lauwerys RR, Hotter G, et al. Markers of early renal changes induced by industrial pollutants. III. Application to workers exposed to cadmium. Br J Ind Med. 1993;50:37\u201348.","journal-title":"Br J Ind Med"},{"key":"762_CR20","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1007\/BF03208342","volume":"68","author":"H Horiguchi","year":"1994","unstructured":"Horiguchi H, Teranishi H, Niiya K, Aoshima K, Katoh T, Sakuragawa N, et al. Hypoproduction of erythropoietin contributes to anemia in chronic cadmium intoxication: clinical study on Itai-Itai disease in Japan. Arch Toxicol. 1994;68:632\u20136.","journal-title":"Arch Toxicol"}],"container-title":["Environmental Health and Preventive Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12199-019-0762-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12199-019-0762-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12199-019-0762-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T19:03:09Z","timestamp":1579978989000},"score":1,"resource":{"primary":{"URL":"https:\/\/environhealthprevmed.biomedcentral.com\/articles\/10.1186\/s12199-019-0762-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,26]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["762"],"URL":"https:\/\/doi.org\/10.1186\/s12199-019-0762-3","relation":{},"ISSN":["1342-078X","1347-4715"],"issn-type":[{"type":"print","value":"1342-078X"},{"type":"electronic","value":"1347-4715"}],"subject":[],"published":{"date-parts":[[2019,1,26]]},"assertion":[{"value":"24 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The objectives and content of this research, management of personal information, and anonymity of answers were all explained in writing, and written consent was received. The Committees on Medical Ethics of Akita Rosai Hospital and Akita University approved the research protocol, and we performed the study in accordance with the ethical guidelines for epidemiological research presented by the Ministry of Health, Labor, and Welfare as well as the ethical standards laid down in the Declaration of Helsinki by the World Medical Association.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"8"}}