{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:26:20Z","timestamp":1764433580113,"version":"3.37.3"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["140284","140284","140284"],"award-info":[{"award-number":["140284","140284","140284"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Emerg Med"],"DOI":"10.1186\/s12245-024-00718-x","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:03:00Z","timestamp":1727679780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anaphylactic reaction to tranexamic acid infusion in a six-year-old child: a case report"],"prefix":"10.1186","volume":"17","author":[{"given":"Nazanin","family":"Zibanejad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikta","family":"Nouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharareh","family":"Babaie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"718_CR1","doi-asserted-by":"publisher","first-page":"836222","DOI":"10.3389\/fimmu.2022.836222","volume":"13","author":"E Nu\u00f1ez-Borque","year":"2022","unstructured":"Nu\u00f1ez-Borque E, Fernandez-Bravo S, Yuste-Montalvo A, Esteban V. Pathophysiological, cellular, and molecular events of the vascular system in anaphylaxis. Front Immunol. 2022;13:836222. https:\/\/doi.org\/10.3389\/fimmu.2022.836222.","journal-title":"Front Immunol."},{"issue":"3","key":"718_CR2","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/pai.13034","volume":"30","author":"M Atanaskovic-Markovic","year":"2019","unstructured":"Atanaskovic-Markovic M, Gomes E, Cernadas JR, du Toit G, Kidon M, Kuyucu S, et al. Diagnosis and management of drug-induced anaphylaxis in children: an EAACI position paper. Pediatr Allergy Immunol. 2019;30(3):269\u201376. https:\/\/doi.org\/10.1111\/pai.13034.","journal-title":"Pediatr Allergy Immunol."},{"key":"718_CR3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.2165\/11209070-000000000-00000","volume":"72","author":"PL McCormack","year":"2012","unstructured":"McCormack PL. Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs. 2012;72:585\u2013617. https:\/\/doi.org\/10.2165\/11209070-000000000-00000.","journal-title":"Drugs."},{"issue":"04","key":"718_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4172\/2329-6887.1000171","volume":"3","author":"G Calapai","year":"2015","unstructured":"Calapai G, Gangemi S, Mannucci C, Minciullo PL, Casciaro M, Calapai F, et al. Systematic review of tranexamic acid adverse reactions. J Pharmacovigil. 2015;3(04):3\u20137. https:\/\/doi.org\/10.4172\/2329-6887.1000171.","journal-title":"J Pharmacovigil."},{"key":"718_CR5","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s13312-021-2169-7","volume":"58","author":"MS Randhawa","year":"2021","unstructured":"Randhawa MS, Revaiah VC, Jayashree M. AHA Pediatric Advanced Life Support Update 2020-\u201cMore Breaths, Less Fluids, and a Focus on Recovery\u2019\u2019. Indian Pediatr. 2021;58:273\u20138. https:\/\/doi.org\/10.1007\/s13312-021-2169-7.","journal-title":"Indian Pediatr."},{"key":"718_CR6","doi-asserted-by":"publisher","first-page":"351","DOI":"10.18176\/jiaci.0651","volume":"31","author":"H El\u00a0Hanache","year":"2020","unstructured":"El\u00a0Hanache H, Verdaguer M, Collin L, Babin M, Favreli\u00e8re S, Maissiat M, et al. Two Cases of Anaphylaxis to Tranexamic Acid Confirmed by Drug Provocation Test: What About Skin Tests? J Investig Allergol Clin Immunol. 2020;31:351\u20133. https:\/\/doi.org\/10.18176\/jiaci.0651.","journal-title":"J Investig Allergol Clin Immunol."},{"issue":"5","key":"718_CR7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1097\/ACI.0000000000000469","volume":"18","author":"MV Aun","year":"2018","unstructured":"Aun MV, Kalil J, Giavina-Bianchi P. Adults and children with anaphylaxis in the emergency room: why it is not recognized? Curr Opin Allergy Clin Immunol. 2018;18(5):377\u201381. https:\/\/doi.org\/10.1097\/ACI.0000000000000469.","journal-title":"Curr Opin Allergy Clin Immunol."},{"key":"718_CR8","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s12016-020-08777-7","volume":"58","author":"E Passia","year":"2020","unstructured":"Passia E, Jandus P. Using baseline and peak serum tryptase levels to diagnose anaphylaxis: a review. Clin Rev Allergy Immunol. 2020;58:366\u201376. https:\/\/doi.org\/10.1007\/s12016-020-08777-7.","journal-title":"Clin Rev Allergy Immunol."},{"key":"718_CR9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ajem.2022.01.069","volume":"55","author":"E Kornelsen","year":"2022","unstructured":"Kornelsen E, Kuppermann N, Nishijima DK, Ren LY, Rumantir M, Gill PJ, et al. Effectiveness and safety of tranexamic acid in pediatric trauma: a systematic review and meta-analysis. Am J Emerg Med. 2022;55:103\u201310. https:\/\/doi.org\/10.1016\/j.ajem.2022.01.069.","journal-title":"Am J Emerg Med."},{"issue":"3","key":"718_CR10","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/ACO.0000000000000728","volume":"32","author":"SM Goobie","year":"2019","unstructured":"Goobie SM, Faraoni D. Tranexamic acid and perioperative bleeding in children: what do we still need to know? Curr Opin Anesthesiol. 2019;32(3):343\u201352. https:\/\/doi.org\/10.1097\/ACO.0000000000000728.","journal-title":"Curr Opin Anesthesiol."},{"key":"718_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12948-020-00131-8","volume":"18","author":"G Murdaca","year":"2020","unstructured":"Murdaca G, Greco M, Vassallo C, Gangemi S. Tranexamic acid adverse reactions: a brief summary for internists and emergency doctors. Clin Mol Allergy. 2020;18:1\u20134. https:\/\/doi.org\/10.1186\/s12948-020-00131-8.","journal-title":"Clin Mol Allergy."},{"issue":"6","key":"718_CR12","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.annfar.2004.04.012","volume":"23","author":"MM Lucas-Polomeni","year":"2004","unstructured":"Lucas-Polomeni MM, Delaval Y, Menestret P, Delaval P, Ecoffey C. A case of anaphylactic shock with tranexamique acid (Exacyl). Ann Fr Anesth Reanim. 2004;23(6):607\u20139. https:\/\/doi.org\/10.1016\/j.annfar.2004.04.012.","journal-title":"Ann Fr Anesth Reanim."},{"key":"718_CR13","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1007\/s11096-010-9415-8","volume":"32","author":"S Imbesi","year":"2010","unstructured":"Imbesi S, Nettis E, Minciullo PL, Di Leo E, Saija A, Vacca A, et al. Hypersensitivity to tranexamic acid: a wide spectrum of adverse reactions. Pharm World Sci. 2010;32:416\u20139. https:\/\/doi.org\/10.1007\/s11096-010-9415-8.","journal-title":"Pharm World Sci."},{"key":"718_CR14","doi-asserted-by":"publisher","first-page":"7828351","DOI":"10.1155\/2016\/7828351","volume":"2016","author":"R Bansal","year":"2016","unstructured":"Bansal R, Nicholas A, Bansal A, et al. Tranexamic acid: an exceedingly rare cause of anaphylaxis during anaesthesia. Case Rep Immunol. 2016;2016:7828351. https:\/\/doi.org\/10.1155\/2016\/7828351.","journal-title":"Case Rep Immunol."},{"issue":"3","key":"718_CR15","doi-asserted-by":"publisher","first-page":"20.00130","DOI":"10.2106\/JBJS.CC.20.00130","volume":"10","author":"S Plaster","year":"2020","unstructured":"Plaster S, Holy F, Antony AK. Anaphylactic reaction to tranexamic acid during posterior spinal fusion: a case report. JBJS Case Connect. 2020;10(3):20.00130. https:\/\/doi.org\/10.2106\/JBJS.CC.20.00130.","journal-title":"JBJS Case Connect."},{"issue":"3","key":"718_CR16","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.jaip.2016.12.014","volume":"5","author":"PH Li","year":"2017","unstructured":"Li PH, Trigg C, Rutkowski R, Rutkowski K. Anaphylaxis to tranexamic acid-a rare reaction to a common drug. J Allergy Clin Immunol Pract. 2017;5(3):839\u201341. https:\/\/doi.org\/10.1016\/j.jaip.2016.12.014.","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"7","key":"718_CR17","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1111\/pan.13141","volume":"27","author":"J Chiem","year":"2017","unstructured":"Chiem J, Ivanova I, Parker A, Krengel W III, Jimenez N. Anaphylactic reaction to tranexamic acid in an adolescent undergoing posterior spinal fusion. Paediatr Anaesth. 2017;27(7):774\u20135. https:\/\/doi.org\/10.1111\/pan.13141.","journal-title":"Paediatr Anaesth."},{"issue":"2","key":"718_CR18","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/all.15032","volume":"77","author":"A Muraro","year":"2022","unstructured":"Muraro A, Worm M, Alviani C, Cardona V, DunnGalvin A, Garvey LH, et al. EAACI guidelines: anaphylaxis (2021 update). Allergy. 2022;77(2):357\u201377. https:\/\/doi.org\/10.1111\/all.15032.","journal-title":"Allergy."},{"issue":"2","key":"718_CR19","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/pan.13303","volume":"28","author":"N Clark","year":"2018","unstructured":"Clark N, Morris S, Sargant N. Comment on Chiem J, Ivanova I, Jimenez N. Anaphylactic reaction to tranexamic acid in an adolescent undergoing posterior spinal fusion. Paediatr Anaesth. 2018;28(2):184\u20135. https:\/\/doi.org\/10.1111\/pan.13303.","journal-title":"Paediatr Anaesth."}],"container-title":["International Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12245-024-00718-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12245-024-00718-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12245-024-00718-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:06:18Z","timestamp":1727679978000},"score":1,"resource":{"primary":{"URL":"https:\/\/intjem.biomedcentral.com\/articles\/10.1186\/s12245-024-00718-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["718"],"URL":"https:\/\/doi.org\/10.1186\/s12245-024-00718-x","relation":{},"ISSN":["1865-1380"],"issn-type":[{"type":"electronic","value":"1865-1380"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"31 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case report has been approved by the ethics committee of Isfahan University of Medical Sciences (approval ID: IR.ARI.MUI.REC.1402.087) based on the ethical standards in the declaration of Helsinki. A written informed consent was obtained from the patient\u2019s legal guardian.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The legal guardian of the patient provided written informed consent for the publication of this report, in compliance with the journal\u2019s patient consent policy.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"129"}}