{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:13:48Z","timestamp":1788135228704,"version":"build-2803163510"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":74,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Nutr"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1186\/s12263-026-00809-9","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:21:52Z","timestamp":1781785312000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of synbiotic supplementation on oxidative stress biomarkers in adults: an updated GRADE-assessed systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-6547","authenticated-orcid":false,"given":"Mohammad Vesal","family":"Bideshki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maedeh","family":"Nojoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Behzadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasir","family":"Arefinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedyeh","family":"Askarpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Sohrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Esmailian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8212-9737","authenticated-orcid":false,"given":"Mohammad","family":"Ali-Hassanzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"issue":"10","key":"809_CR1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1089\/met.2015.0095","volume":"13","author":"P Manna","year":"2015","unstructured":"Manna P, Jain SK. Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies. Metab Syndr Relat Disord. 2015;13(10):423\u201344.","journal-title":"Metab Syndr Relat Disord"},{"key":"809_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.phrs.2018.11.011","volume":"139","author":"M Sepidarkish","year":"2019","unstructured":"Sepidarkish M, Farsi F, Akbari-Fakhrabadi M, et al. The effect of vitamin D supplementation on oxidative stress parameters: a systematic review and meta-analysis of clinical trials. Pharmacol Res. 2019;139:141\u201352.","journal-title":"Pharmacol Res"},{"issue":"5","key":"809_CR3","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.3390\/ijms12053117","volume":"12","author":"A Fern\u00e1ndez-S\u00e1nchez","year":"2011","unstructured":"Fern\u00e1ndez-S\u00e1nchez A, Madrigal-Santill\u00e1n E, Bautista M, et al. Inflammation, oxidative stress, and obesity. Int J Mol Sci. 2011;12(5):3117\u201332. https:\/\/doi.org\/10.3390\/ijms12053117.","journal-title":"Int J Mol Sci"},{"key":"809_CR4","doi-asserted-by":"publisher","unstructured":"Nobari H, Saedmocheshi S, Chung LH, et al. An overview on how exercise with green tea consumption can prevent the production of reactive oxygen species and improve sports performance. Int J Environ Res Public Health. 2021;19(1). https:\/\/doi.org\/10.3390\/ijerph19010218.","DOI":"10.3390\/ijerph19010218"},{"issue":"3","key":"809_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.mad.2004.08.012","volume":"126","author":"GN Landis","year":"2005","unstructured":"Landis GN, Tower J. Superoxide dismutase evolution and life span regulation. Mech Ageing Dev. 2005;126(3):365\u201379.","journal-title":"Mech Ageing Dev"},{"issue":"6","key":"809_CR6","doi-asserted-by":"publisher","first-page":"F1121","DOI":"10.1152\/ajprenal.00265.2002","volume":"284","author":"R Komers","year":"2003","unstructured":"Komers R, Anderson S. Paradoxes of nitric oxide in the diabetic kidney. Am J Physiology-Renal Physiol. 2003;284(6):F1121\u201337.","journal-title":"Am J Physiology-Renal Physiol"},{"issue":"14","key":"809_CR7","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.1021\/jf506326t","volume":"63","author":"V Mishra","year":"2015","unstructured":"Mishra V, Shah C, Mokashe N, et al. Probiotics as potential antioxidants: a systematic review. J Agric Food Chem. 2015;63(14):3615\u201326.","journal-title":"J Agric Food Chem"},{"issue":"4","key":"809_CR8","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","volume":"54","author":"O Ighodaro","year":"2018","unstructured":"Ighodaro O, Akinloye O. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria J Med. 2018;54(4):287\u201393.","journal-title":"Alexandria J Med"},{"key":"809_CR9","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.clnesp.2019.02.003","volume":"30","author":"H Roshan","year":"2019","unstructured":"Roshan H, Ghaedi E, Rahmani J, et al. Effects of probiotics and synbiotic supplementation on antioxidant status: A meta-analysis of randomized clinical trials. Clin Nutr ESPEN. 2019;30:81\u20138.","journal-title":"Clin Nutr ESPEN"},{"issue":"2","key":"809_CR10","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/antiox9020116","volume":"9","author":"M Goschorska","year":"2020","unstructured":"Goschorska M, Gutowska I, Baranowska-Bosiacka I, et al. The use of antioxidants in the treatment of migraine. Antioxidants. 2020;9(2):116.","journal-title":"Antioxidants"},{"issue":"11","key":"809_CR11","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/s41575-020-0344-2","volume":"17","author":"KS Swanson","year":"2020","unstructured":"Swanson KS, Gibson GR, Hutkins R, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat reviews Gastroenterol Hepatol. 2020;17(11):687\u2013701.","journal-title":"Nat reviews Gastroenterol Hepatol"},{"key":"809_CR12","doi-asserted-by":"publisher","first-page":"107539","DOI":"10.1016\/j.fbio.2025.107539","volume":"72","author":"Y Wang","year":"2025","unstructured":"Wang Y, Tian L, Fabi JP, et al. The potential of prebiotics, probiotics, and synbiotics for ameliorating intestinal barrier dysfunction and modulating inflammatory responses as dietary supplements in diabetes mellitus management. Food Bioscience. 2025;72:107539. https:\/\/doi.org\/10.1016\/j.fbio.2025.107539.","journal-title":"Food Bioscience"},{"issue":"5","key":"809_CR13","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1080\/87559129.2019.1710748","volume":"37","author":"A Kazemi","year":"2021","unstructured":"Kazemi A, Soltani S, Ghorabi S, et al. Is probiotic and synbiotic supplementation effective on immune cells? A systematic review and meta-analysis of clinical trials. Food Reviews Int. 2021;37(5):491\u2013537.","journal-title":"Food Reviews Int"},{"issue":"5","key":"809_CR14","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1016\/j.clnu.2019.06.004","volume":"39","author":"E Vaghef-Mehrabany","year":"2020","unstructured":"Vaghef-Mehrabany E, Maleki V, Behrooz M, et al. Can psychobiotics mood ify gut? An update systematic review of randomized controlled trials in healthy and clinical subjects, on anti-depressant effects of probiotics, prebiotics, and synbiotics. Clin Nutr. 2020;39(5):1395\u2013410.","journal-title":"Clin Nutr"},{"key":"809_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-026-41111-3","author":"MV Bideshki","year":"2026","unstructured":"Bideshki MV, Ali-Hasanzadeh M, Gargari BP. Synbiotic supplementation effects on muscle damage and inflammation in professional futsal players in a randomized clinical trial. Sci Rep. 2026. https:\/\/doi.org\/10.1038\/s41598-026-41111-3.","journal-title":"Sci Rep"},{"key":"809_CR16","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jff.2018.04.049","volume":"46","author":"J Heshmati","year":"2018","unstructured":"Heshmati J, Farsi F, Shokri F, et al. A systematic review and meta-analysis of the probiotics and synbiotics effects on oxidative stress. J Funct Foods. 2018;46:66\u201384.","journal-title":"J Funct Foods"},{"key":"809_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.phrs.2019.02.016","volume":"142","author":"HJ Zheng","year":"2019","unstructured":"Zheng HJ, Guo J, Jia Q, et al. The effect of probiotic and synbiotic supplementation on biomarkers of inflammation and oxidative stress in diabetic patients: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2019;142:303\u201313.","journal-title":"Pharmacol Res"},{"issue":"4","key":"809_CR18","doi-asserted-by":"publisher","first-page":"889","DOI":"10.4314\/tjpr.v18i4.29","volume":"18","author":"BS Sivamaruthi","year":"2019","unstructured":"Sivamaruthi BS, Prasanth MI, Kesika P, et al. Probiotics in human mental health and diseases-A minireview. Trop J Pharm Res. 2019;18(4):889\u201395.","journal-title":"Trop J Pharm Res"},{"issue":"8","key":"809_CR19","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.3390\/ijerph17082647","volume":"17","author":"BS Sivamaruthi","year":"2020","unstructured":"Sivamaruthi BS, Suganthy N, Kesika P, et al. The role of microbiome, dietary supplements, and probiotics in autism spectrum disorder. Int J Environ Res Public Health. 2020;17(8):2647.","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"809_CR20","doi-asserted-by":"publisher","first-page":"3535982","DOI":"10.1155\/2020\/3535982","volume":"2020","author":"BS Sivamaruthi","year":"2020","unstructured":"Sivamaruthi BS, Kesika P, Chaiyasut C. The role of probiotics in colorectal cancer management. Evidence-Based Complement Altern Med. 2020;2020(1):3535982.","journal-title":"Evidence-Based Complement Altern Med"},{"key":"809_CR21","doi-asserted-by":"publisher","first-page":"k2179","DOI":"10.1136\/bmj.k2179","volume":"361","author":"AM Valdes","year":"2018","unstructured":"Valdes AM, Walter J, Segal E, et al. Role of the gut microbiota in nutrition and health. BMJ. 2018;361:k2179. https:\/\/doi.org\/10.1136\/bmj.k2179.","journal-title":"BMJ"},{"key":"809_CR22","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.foodres.2017.09.031","volume":"104","author":"A Septembre-Malaterre","year":"2018","unstructured":"Septembre-Malaterre A, Remize F, Poucheret P. Fruits and vegetables, as a source of nutritional compounds and phytochemicals: Changes in bioactive compounds during lactic fermentation. Food Res Int. 2018;104:86\u201399.","journal-title":"Food Res Int"},{"issue":"4","key":"809_CR23","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1039\/d2fo03348h","volume":"14","author":"F Fallah","year":"2023","unstructured":"Fallah F, Mahdavi R. L-Carnitine and synbiotic co-supplementation: beneficial effects on metabolic-endotoxemia, meta-inflammation, and oxidative-stress biomarkers in obese patients: a double blind, randomized, controlled clinical trial. Food Funct. 2023;14(4):2172\u201387. https:\/\/doi.org\/10.1039\/d2fo03348h.","journal-title":"Food Funct"},{"issue":"10","key":"809_CR24","doi-asserted-by":"publisher","first-page":"858","DOI":"10.3390\/nu3100858","volume":"3","author":"MA Vinolo","year":"2011","unstructured":"Vinolo MA, Rodrigues HG, Nachbar RT, et al. Regulation of inflammation by short chain fatty acids. Nutrients. 2011;3(10):858\u201376.","journal-title":"Nutrients"},{"issue":"2","key":"809_CR25","first-page":"187","volume":"4","author":"A D\u2019Souza","year":"2012","unstructured":"D\u2019Souza A, Cai CL, Kumar D, et al. Cytokines and Toll-like receptor signaling pathways in the terminal ileum of hypoxic\/hyperoxic neonatal rats: benefits of probiotics supplementation. Am J Translational Res. 2012;4(2):187.","journal-title":"Am J Translational Res"},{"issue":"10","key":"809_CR26","first-page":"687","volume":"19","author":"M Jamilian","year":"2016","unstructured":"Jamilian M, Bahmani F, Vahedpoor Z, et al. Effects of Probiotic Supplementation on Metabolic Status in Pregnant Women: a Randomized, Double-blind, Placebo-Controlled Trial. Arch Iran Med. 2016;19(10):687\u20132.","journal-title":"Arch Iran Med"},{"issue":"1","key":"809_CR27","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2180-10-4","volume":"10","author":"B Vitali","year":"2010","unstructured":"Vitali B, Ndagijimana M, Cruciani F, et al. Impact of a synbiotic food on the gut microbial ecology and metabolic profiles. BMC Microbiol. 2010;10(1):4. https:\/\/doi.org\/10.1186\/1471-2180-10-4.","journal-title":"BMC Microbiol"},{"issue":"4","key":"809_CR28","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1080\/10408398.2020.1740645","volume":"61","author":"HJ Zheng","year":"2021","unstructured":"Zheng HJ, Guo J, Wang Q, et al. Probiotics, prebiotics, and synbiotics for the improvement of metabolic profiles in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2021;61(4):577\u201398.","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"19","key":"809_CR29","doi-asserted-by":"publisher","first-page":"4456","DOI":"10.3390\/jcm10194456","volume":"10","author":"TTU Nguyen","year":"2021","unstructured":"Nguyen TTU, Kim HW, Kim W. Effects of probiotics, prebiotics, and synbiotics on uremic toxins, inflammation, and oxidative stress in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials. J Clin Med. 2021;10(19):4456.","journal-title":"J Clin Med"},{"issue":"2","key":"809_CR30","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1080\/10408398.2020.1821166","volume":"62","author":"B Pourrajab","year":"2021","unstructured":"Pourrajab B, Fatahi S, Sohouli MH, et al. The effects of probiotic\/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2021;62(2):490\u2013507.","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"809_CR31","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s12602-018-9500-1","volume":"12","author":"B Zamani","year":"2020","unstructured":"Zamani B, Sheikhi A, Namazi N, et al. The Effects of Supplementation with Probiotic on Biomarkers of Oxidative Stress in Adult Subjects: a Systematic Review and Meta-analysis of Randomized Trials. Probiotics Antimicrob Proteins. 2020;12(1):102\u201311. https:\/\/doi.org\/10.1007\/s12602-018-9500-1.","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"2","key":"809_CR32","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1080\/10408398.2020.1821166","volume":"62","author":"B Pourrajab","year":"2022","unstructured":"Pourrajab B, Fatahi S, Sohouli MH, et al. The effects of probiotic\/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2022;62(2):490\u2013507. https:\/\/doi.org\/10.1080\/10408398.2020.1821166.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"809_CR33","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.clnesp.2019.02.003","volume":"30","author":"H Roshan","year":"2019","unstructured":"Roshan H, Ghaedi E, Rahmani J, et al. Effects of probiotics and synbiotic supplementation on antioxidant status: A meta-analysis of randomized clinical trials. Clin Nutr ESPEN. 2019;30:81\u20138. https:\/\/doi.org\/10.1016\/j.clnesp.2019.02.003.","journal-title":"Clin Nutr ESPEN"},{"key":"809_CR34","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.phrs.2019.02.016","volume":"142","author":"HJ Zheng","year":"2019","unstructured":"Zheng HJ, Guo J, Jia Q, et al. The effect of probiotic and synbiotic supplementation on biomarkers of inflammation and oxidative stress in diabetic patients: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2019;142:303\u201313. https:\/\/doi.org\/10.1016\/j.phrs.2019.02.016.","journal-title":"Pharmacol Res"},{"issue":"1","key":"809_CR35","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1159\/000365153","volume":"65","author":"M Tajadadi-Ebrahimi","year":"2014","unstructured":"Tajadadi-Ebrahimi M, Bahmani F, Shakeri H, et al. Expression of Concern - Effects of daily consumption of synbiotic bread on insulin metabolism and serum high-sensitivity C-reactive protein among diabetic patients: a double-blind, randomized, controlled clinical trial. Ann Nutr Metab. 2014;65(1):34\u201341. https:\/\/doi.org\/10.1159\/000365153.","journal-title":"Ann Nutr Metab"},{"issue":"8","key":"809_CR36","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1017\/s000711451700085x","volume":"117","author":"B Zamani","year":"2017","unstructured":"Zamani B, Farshbaf S, Golkar HR, et al. Expression of Concern - Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2017;117(8):1095\u2013102. https:\/\/doi.org\/10.1017\/s000711451700085x.","journal-title":"Br J Nutr"},{"issue":"3","key":"809_CR37","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1007\/s12602-017-9313-7","volume":"10","author":"M Karamali","year":"2018","unstructured":"Karamali M, Nasiri N, Taghavi Shavazi N, et al. Expression of concern - The Effects of Synbiotic Supplementation on Pregnancy Outcomes in Gestational Diabetes. Probiotics Antimicrob Proteins. 2018;10(3):496\u2013503. https:\/\/doi.org\/10.1007\/s12602-017-9313-7.","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"1","key":"809_CR38","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12902-018-0248-0","volume":"18","author":"K Nasri","year":"2018","unstructured":"Nasri K, Jamilian M, Rahmani E, et al. Expression of concern - The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. BMC Endocr Disord. 2018;18(1):21. https:\/\/doi.org\/10.1186\/s12902-018-0248-0.","journal-title":"BMC Endocr Disord"},{"issue":"1","key":"809_CR39","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s12602-017-9343-1","volume":"11","author":"A Farrokhian","year":"2019","unstructured":"Farrokhian A, Raygan F, Soltani A, et al. Expression of concern - The Effects of Synbiotic Supplementation on Carotid Intima-Media Thickness, Biomarkers of Inflammation, and Oxidative Stress in People with Overweight, Diabetes, and Coronary Heart Disease: a Randomized, Double-Blind, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2019;11(1):133\u201342. https:\/\/doi.org\/10.1007\/s12602-017-9343-1.","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"4","key":"809_CR40","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1007\/s12602-018-9405-z","volume":"11","author":"M Samimi","year":"2019","unstructured":"Samimi M, Dadkhah A, Haddad Kashani H, et al. Expression of Concern - The Effects of Synbiotic Supplementation on Metabolic Status in Women With Polycystic Ovary Syndrome: a Randomized Double-Blind Clinical Trial. Probiotics Antimicrob Proteins. 2019;11(4):1355\u201361. https:\/\/doi.org\/10.1007\/s12602-018-9405-z.","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"2","key":"809_CR41","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s11745-013-3867-2","volume":"49","author":"M Taghizadeh","year":"2014","unstructured":"Taghizadeh M, Hashemi T, Shakeri H, et al. Expression of Concern - Synbiotic food consumption reduces levels of triacylglycerols and VLDL, but not cholesterol, LDL, or HDL in plasma from pregnant women. Lipids. 2014;49(2):155\u201361. https:\/\/doi.org\/10.1007\/s11745-013-3867-2.","journal-title":"Lipids"},{"key":"809_CR42","doi-asserted-by":"publisher","unstructured":"Asemi Z, Khorrami-Rad A, Alizadeh SA, et al. Retraction notice to: Effects of synbiotic food consumption on metabolic status of diabetic patients: a double-blind randomized cross-over controlled clinical trial [Clin Nutr. 2014;33:198\u2013203]. Clin Nutr. 2025;53:284. https:\/\/doi.org\/10.1016\/j.clnu.2025.08.016.","DOI":"10.1016\/j.clnu.2025.08.016"},{"issue":"6","key":"809_CR43","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1080\/07315724.2015.1032443","volume":"35","author":"F Bahmani","year":"2016","unstructured":"Bahmani F, Tajadadi-Ebrahimi M, Kolahdooz F, et al. Retracted article - The Consumption of Synbiotic Bread Containing Lactobacillus sporogenes and Inulin Affects Nitric Oxide and Malondialdehyde in Patients with Type 2 Diabetes Mellitus: Randomized, Double-Blind, Placebo-Controlled Trial. J Am Coll Nutr. 2016;35(6):506\u201313. https:\/\/doi.org\/10.1080\/07315724.2015.1032443.","journal-title":"J Am Coll Nutr"},{"issue":"4","key":"809_CR44","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.clnu.2015.07.009","volume":"35","author":"Z Asemi","year":"2016","unstructured":"Asemi Z, Alizadeh SA, Ahmad K, et al. Expression of Concern - Effects of beta-carotene fortified synbiotic food on metabolic control of patients with type 2 diabetes mellitus: A double-blind randomized cross-over controlled clinical trial. Clin Nutr. 2016;35(4):819\u201325. https:\/\/doi.org\/10.1016\/j.clnu.2015.07.009.","journal-title":"Clin Nutr"},{"key":"809_CR45","doi-asserted-by":"publisher","first-page":"n160","DOI":"10.1136\/bmj.n160","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, Moher D, Bossuyt PM, et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;372:n160. https:\/\/doi.org\/10.1136\/bmj.n160.","journal-title":"BMJ"},{"issue":"7650","key":"809_CR46","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924\u20136. https:\/\/doi.org\/10.1136\/bmj.39489.470347.AD.","journal-title":"BMJ"},{"key":"809_CR47","doi-asserted-by":"crossref","unstructured":"Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions. Chichester, UK: John Wiley & Sons; 2008.","DOI":"10.1002\/9780470712184"},{"issue":"10","key":"809_CR48","doi-asserted-by":"publisher","first-page":"Ed000142","DOI":"10.1002\/14651858.Ed000142","volume":"10","author":"M Cumpston","year":"2019","unstructured":"Cumpston M, Li T, Page MJ, et al. Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database Syst Rev. 2019;10(10):Ed000142. https:\/\/doi.org\/10.1002\/14651858.Ed000142.","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"809_CR49","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/j.0006-341x.2000.00455.x","volume":"56","author":"S Duval","year":"2000","unstructured":"Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56(2):455\u201363. https:\/\/doi.org\/10.1111\/j.0006-341x.2000.00455.x.","journal-title":"Biometrics"},{"key":"809_CR50","doi-asserted-by":"publisher","unstructured":"Kuskunov T, Tilkiyan E, Zdravkova I, et al. The impact of a 10-month synbiotic intake on eGFR, uremic toxins, oxidative stress, and inflammatory markers in non-dialysis chronic kidney disease patients: a prospective, non-randomized, placebo-controlled study. Medicina (Kaunas). 2025;61(7). https:\/\/doi.org\/10.3390\/medicina61071199.","DOI":"10.3390\/medicina61071199"},{"key":"809_CR51","doi-asserted-by":"publisher","first-page":"2638703","DOI":"10.1155\/2020\/2638703","volume":"2020","author":"AMM Ton","year":"2020","unstructured":"Ton AMM, Campagnaro BP, Alves GA, et al. Oxidative Stress and Dementia in Alzheimer\u2019s Patients: Effects of Synbiotic Supplementation. Oxid Med Cell Longev. 2020;2020:2638703. https:\/\/doi.org\/10.1155\/2020\/2638703.","journal-title":"Oxid Med Cell Longev"},{"key":"809_CR52","doi-asserted-by":"publisher","unstructured":"Lalitsuradej E, Sirilun S, Sittiprapaporn P, et al. The effects of synbiotics administration on stress-related parameters in Thai subjects: a preliminary study. Foods. 2022;11(5). https:\/\/doi.org\/10.3390\/foods11050759.","DOI":"10.3390\/foods11050759"},{"key":"809_CR53","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.bbi.2024.06.012","volume":"120","author":"G Arteaga-Henr\u00edquez","year":"2024","unstructured":"Arteaga-Henr\u00edquez G, Ramos-Sayalero C, Iba\u00f1ez-Jimenez P, et al. Efficacy of a synbiotic in the management of adults with Attention-Deficit and Hyperactivity Disorder and\/or Borderline Personality Disorder and high levels of irritability: Results from a multicenter, randomized, placebo-controlled, basket trial. Brain Behav Immun. 2024;120:360\u201371. https:\/\/doi.org\/10.1016\/j.bbi.2024.06.012.","journal-title":"Brain Behav Immun"},{"issue":"6","key":"809_CR54","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1111\/j.1472-765X.2009.02607.x","volume":"48","author":"P H\u00fctt","year":"2009","unstructured":"H\u00fctt P, Andreson H, Kullisaar T, et al. Effects of a synbiotic product on blood antioxidative activity in subjects colonized with Helicobacter pylori. Lett Appl Microbiol. 2009;48(6):797\u2013800. https:\/\/doi.org\/10.1111\/j.1472-765X.2009.02607.x.","journal-title":"Lett Appl Microbiol"},{"key":"809_CR55","doi-asserted-by":"publisher","first-page":"105397","DOI":"10.1016\/j.jff.2022.105397","volume":"100","author":"S Mehrabani","year":"2023","unstructured":"Mehrabani S, Khorvash F, Heidari Z, et al. The effects of synbiotic supplementation on oxidative stress markers, mental status, and quality of life in patients with Parkinson\u2019s disease: A double-blind, placebo-controlled, randomized controlled trial. J Funct Foods. 2023;100:105397. https:\/\/doi.org\/10.1016\/j.jff.2022.105397.","journal-title":"J Funct Foods"},{"issue":"2","key":"809_CR56","doi-asserted-by":"publisher","first-page":"2247025","DOI":"10.1080\/19490976.2023.2247025","volume":"15","author":"X Li","year":"2023","unstructured":"Li X, Hu S, Yin J, et al. Effect of synbiotic supplementation on immune parameters and gut microbiota in healthy adults: a double-blind randomized controlled trial. Gut Microbes. 2023;15(2):2247025. https:\/\/doi.org\/10.1080\/19490976.2023.2247025.","journal-title":"Gut Microbes"},{"key":"809_CR57","doi-asserted-by":"publisher","first-page":"102216","DOI":"10.1016\/j.ctim.2019.102216","volume":"47","author":"A Hadi","year":"2019","unstructured":"Hadi A, Sepandi M, Marx W, et al. Clinical and psychological responses to synbiotic supplementation in obese or overweight adults: A randomized clinical trial. Complement Ther Med. 2019;47:102216. https:\/\/doi.org\/10.1016\/j.ctim.2019.102216.","journal-title":"Complement Ther Med"},{"key":"809_CR58","doi-asserted-by":"publisher","unstructured":"Quero CD, Manonelles P, Fern\u00e1ndez M, et al. Differential health effects on inflammatory, immunological and stress parameters in professional soccer players and sedentary individuals after consuming a synbiotic: a triple-blinded, randomized, placebo-controlled pilot study. Nutrients. 2021;13(4). https:\/\/doi.org\/10.3390\/nu13041321.","DOI":"10.3390\/nu13041321"},{"issue":"1","key":"809_CR59","doi-asserted-by":"publisher","first-page":"20333","DOI":"10.1038\/s41598-024-71264-y","volume":"14","author":"MA Zolghadrpour","year":"2024","unstructured":"Zolghadrpour MA, Jowshan MR, Seyedmahalleh MH, et al. Consumption of a new developed synbiotic yogurt improves oxidative stress status in adults with metabolic syndrome: a randomized controlled clinical trial. Sci Rep. 2024;14(1):20333. https:\/\/doi.org\/10.1038\/s41598-024-71264-y.","journal-title":"Sci Rep"},{"issue":"10","key":"809_CR60","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1007\/s00268-005-0653-1","volume":"30","author":"K Kotzampassi","year":"2006","unstructured":"Kotzampassi K, Giamarellos-Bourboulis EJ, Voudouris A, et al. Benefits of a synbiotic formula (Synbiotic 2000Forte) in critically Ill trauma patients: early results of a randomized controlled trial. World J Surg. 2006;30(10):1848\u201355. https:\/\/doi.org\/10.1007\/s00268-005-0653-1.","journal-title":"World J Surg"},{"issue":"2","key":"809_CR61","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s00394-020-02271-8","volume":"60","author":"AFG Cicero","year":"2021","unstructured":"Cicero AFG, Fogacci F, Bove M, et al. Impact of a short-term synbiotic supplementation on metabolic syndrome and systemic inflammation in elderly patients: a randomized placebo-controlled clinical trial. Eur J Nutr. 2021;60(2):655\u201363. https:\/\/doi.org\/10.1007\/s00394-020-02271-8.","journal-title":"Eur J Nutr"},{"key":"809_CR62","doi-asserted-by":"publisher","first-page":"607","DOI":"10.2147\/dmso.S238867","volume":"13","author":"A Zare Javid","year":"2020","unstructured":"Zare Javid A, Aminzadeh M, Haghighi-Zadeh MH, et al. The Effects of Synbiotic Supplementation on Glycemic Status, Lipid Profile, and Biomarkers of Oxidative Stress in Type 1 Diabetic Patients. A Placebo-Controlled, Double-Blind, Randomized Clinical Trial. Diabetes Metab Syndr Obes. 2020;13:607\u201317. https:\/\/doi.org\/10.2147\/dmso.S238867.","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"6","key":"809_CR63","doi-asserted-by":"publisher","first-page":"775","DOI":"10.3920\/bm2015.0011","volume":"6","author":"N Ipar","year":"2015","unstructured":"Ipar N, Aydogdu SD, Yildirim GK, et al. Effects of synbiotic on anthropometry, lipid profile and oxidative stress in obese children. Benef Microbes. 2015;6(6):775\u201382. https:\/\/doi.org\/10.3920\/bm2015.0011.","journal-title":"Benef Microbes"},{"key":"809_CR64","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1089\/bfm.2012.0078","volume":"8","author":"L Nikniaz","year":"2013","unstructured":"Nikniaz L, Mahdavi R, Ostadrahimi A, et al. Effects of synbiotic supplementation on total antioxidant capacity of human breastmilk. Breastfeed Med. 2013;8:217\u201322. https:\/\/doi.org\/10.1089\/bfm.2012.0078.","journal-title":"Breastfeed Med"},{"key":"809_CR65","doi-asserted-by":"publisher","first-page":"278","DOI":"10.17179\/excli2016-846","volume":"16","author":"G Ekhlasi","year":"2017","unstructured":"Ekhlasi G, Zarrati M, Agah S, et al. Effects of symbiotic and vitamin E supplementation on blood pressure, nitric oxide and inflammatory factors in non-alcoholic fatty liver disease. EXCLI J. 2017;16:278\u201390. https:\/\/doi.org\/10.17179\/excli2016-846.","journal-title":"EXCLI J"},{"key":"809_CR66","doi-asserted-by":"publisher","first-page":"9315375","DOI":"10.1155\/2017\/9315375","volume":"2017","author":"P Kleniewska","year":"2017","unstructured":"Kleniewska P, Pawliczak R. Influence of Synbiotics on Selected Oxidative Stress Parameters. Oxid Med Cell Longev. 2017;2017:9315375. https:\/\/doi.org\/10.1155\/2017\/9315375.","journal-title":"Oxid Med Cell Longev"},{"issue":"8","key":"809_CR67","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1093\/jn\/nxy088","volume":"148","author":"F Bakhshimoghaddam","year":"2018","unstructured":"Bakhshimoghaddam F, Shateri K, Sina M, et al. Daily Consumption of Synbiotic Yogurt Decreases Liver Steatosis in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial. J Nutr. 2018;148(8):1276\u201384. https:\/\/doi.org\/10.1093\/jn\/nxy088.","journal-title":"J Nutr"},{"key":"809_CR68","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.diabres.2018.02.008","volume":"138","author":"Z Nabhani","year":"2018","unstructured":"Nabhani Z, Hezaveh SJG, Razmpoosh E, et al. The effects of synbiotic supplementation on insulin resistance\/sensitivity, lipid profile and total antioxidant capacity in women with gestational diabetes mellitus: A randomized double blind placebo controlled clinical trial. Diabetes Res Clin Pract. 2018;138:149\u201357. https:\/\/doi.org\/10.1016\/j.diabres.2018.02.008.","journal-title":"Diabetes Res Clin Pract"},{"key":"809_CR69","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s13098-019-0496-9","volume":"11","author":"A Ghafouri","year":"2019","unstructured":"Ghafouri A, Zarrati M, Shidfar F, et al. Effect of synbiotic bread containing lactic acid on glycemic indicators, biomarkers of antioxidant status and inflammation in patients with type 2 diabetes: a randomized controlled trial. Diabetol Metab Syndr. 2019;11:103. https:\/\/doi.org\/10.1186\/s13098-019-0496-9.","journal-title":"Diabetol Metab Syndr"},{"issue":"1","key":"809_CR70","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1080\/01635581.2019.1616781","volume":"72","author":"M Navaei","year":"2020","unstructured":"Navaei M, Haghighat S, Janani L, et al. The Effects of Synbiotic Supplementation on Antioxidant Capacity and Arm Volumes in Survivors of Breast Cancer-Related Lymphedema. Nutr Cancer. 2020;72(1):62\u201373. https:\/\/doi.org\/10.1080\/01635581.2019.1616781.","journal-title":"Nutr Cancer"},{"issue":"4","key":"809_CR71","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1007\/s12602-018-9499-3","volume":"11","author":"A Soleimani","year":"2019","unstructured":"Soleimani A, Motamedzadeh A, Zarrati Mojarrad M, et al. The Effects of Synbiotic Supplementation on Metabolic Status in Diabetic Patients Undergoing Hemodialysis: a Randomized, Double-Blinded, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2019;11(4):1248\u201356. https:\/\/doi.org\/10.1007\/s12602-018-9499-3.","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"2","key":"809_CR72","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/hdi.12748","volume":"23","author":"A Kooshki","year":"2019","unstructured":"Kooshki A, Tofighiyan T, Miri M. A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients. Hemodial Int. 2019;23(2):254\u201360. https:\/\/doi.org\/10.1111\/hdi.12748.","journal-title":"Hemodial Int"},{"key":"809_CR73","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2147\/DMSO.S230060","volume":"13","author":"H Bazyar","year":"2020","unstructured":"Bazyar H, Maghsoumi-Norouzabad L, Yarahmadi M, et al. The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial. Diabetes Metab Syndr Obes. 2020;13:19\u201329. https:\/\/doi.org\/10.2147\/DMSO.S230060.","journal-title":"Diabetes Metab Syndr Obes"},{"key":"809_CR74","doi-asserted-by":"publisher","unstructured":"Chaiyasut C, Sivamaruthi BS, Kesika P, et al. Synbiotic supplementation improves obesity index and metabolic biomarkers in Thai obese adults: a randomized clinical trial. Foods. 2021;10(7). https:\/\/doi.org\/10.3390\/foods10071580.","DOI":"10.3390\/foods10071580"},{"key":"809_CR75","doi-asserted-by":"publisher","first-page":"105668","DOI":"10.1016\/j.phrs.2021.105668","volume":"169","author":"A Ghavami","year":"2021","unstructured":"Ghavami A, Khorvash F, Heidari Z, et al. Effect of synbiotic supplementation on migraine characteristics and inflammatory biomarkers in women with migraine: Results of a randomized controlled trial. Pharmacol Res. 2021;169:105668. https:\/\/doi.org\/10.1016\/j.phrs.2021.105668.","journal-title":"Pharmacol Res"},{"issue":"1","key":"809_CR76","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s13098-022-00858-1","volume":"14","author":"Z Nabhani","year":"2022","unstructured":"Nabhani Z, Clark CCT, Goudarzi N, et al. The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus: a secondary data-analysis of a randomized double-blind, placebo-controlled study. Diabetol Metab Syndr. 2022;14(1):87. https:\/\/doi.org\/10.1186\/s13098-022-00858-1.","journal-title":"Diabetol Metab Syndr"},{"key":"809_CR77","doi-asserted-by":"publisher","unstructured":"Oraphruek P, Chusak C, Ngamukote S, et al. Effect of a multispecies synbiotic supplementation on body composition, antioxidant status, and gut microbiomes in overweight and obese subjects: a randomized, double-blind, placebo-controlled study. Nutrients. 2023;15(8). https:\/\/doi.org\/10.3390\/nu15081863.","DOI":"10.3390\/nu15081863"},{"key":"809_CR78","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.clnu.2024.11.042","volume":"44","author":"C Zhang","year":"2025","unstructured":"Zhang C, Zhang Q, Zhang X, et al. Effects of synbiotics surpass probiotics alone in improving type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial. Clin Nutr. 2025;44:248\u201358. https:\/\/doi.org\/10.1016\/j.clnu.2024.11.042.","journal-title":"Clin Nutr"},{"issue":"7","key":"809_CR79","doi-asserted-by":"publisher","first-page":"3897","DOI":"10.1007\/s10787-025-01752-8","volume":"33","author":"ME Ramadan","year":"2025","unstructured":"Ramadan ME, Mostafa TM, Ghali AA, et al. Randomized controlled trial evaluating synbiotic supplementation as an adjuvant therapy in the treatment of Parkinson\u2019s disease. Inflammopharmacology. 2025;33(7):3897\u2013908. https:\/\/doi.org\/10.1007\/s10787-025-01752-8.","journal-title":"Inflammopharmacology"},{"issue":"2","key":"809_CR80","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00394-022-03012-9","volume":"62","author":"K Naseri","year":"2023","unstructured":"Naseri K, Saadati S, Ghaemi F, et al. The effects of probiotic and synbiotic supplementation on inflammation, oxidative stress, and circulating adiponectin and leptin concentration in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials. Eur J Nutr. 2023;62(2):543\u201361.","journal-title":"Eur J Nutr"},{"key":"809_CR81","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.clnesp.2023.01.016","volume":"54","author":"A St-Amant","year":"2023","unstructured":"St-Amant A, Bergdahl A. A systematic review and meta-analysis of randomized controlled trials investigating the effects of probiotics on oxidative stress in healthy adults. Clin Nutr ESPEN. 2023;54:180\u20136. https:\/\/doi.org\/10.1016\/j.clnesp.2023.01.016.","journal-title":"Clin Nutr ESPEN"},{"issue":"6","key":"809_CR82","doi-asserted-by":"publisher","first-page":"e20635","DOI":"10.1371\/journal.pone.0020635","volume":"6","author":"S Bharrhan","year":"2011","unstructured":"Bharrhan S, Koul A, Chopra K, et al. Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model. PLoS ONE. 2011;6(6):e20635.","journal-title":"PLoS ONE"},{"issue":"3","key":"809_CR83","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0168-1605(01)00674-2","volume":"72","author":"T Kullisaar","year":"2002","unstructured":"Kullisaar T, Zilmer M, Mikelsaar M, et al. Two antioxidative lactobacilli strains as promising probiotics. Int J Food Microbiol. 2002;72(3):215\u201324. https:\/\/doi.org\/10.1016\/S0168-1605(01)00674-2.","journal-title":"Int J Food Microbiol"},{"issue":"3","key":"809_CR84","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jbiotec.2010.11.008","volume":"151","author":"JG LeBlanc","year":"2011","unstructured":"LeBlanc JG, del Carmen S, Miyoshi A, et al. Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn\u2019s disease in mice. J Biotechnol. 2011;151(3):287\u201393.","journal-title":"J Biotechnol"},{"issue":"1","key":"809_CR85","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1159\/000335468","volume":"60","author":"Z Asemi","year":"2012","unstructured":"Asemi Z, Jazayeri S, Najafi M, et al. Effect of daily consumption of probiotic yogurt on oxidative stress in pregnant women: a randomized controlled clinical trial. Annals Nutr metabolism. 2012;60(1):62\u20138.","journal-title":"Annals Nutr metabolism"},{"issue":"4","key":"809_CR86","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1080\/07315724.2014.959208","volume":"35","author":"E Vaghef-Mehrabany","year":"2016","unstructured":"Vaghef-Mehrabany E, Homayouni-Rad A, Alipour B, et al. Effects of probiotic supplementation on oxidative stress indices in women with rheumatoid arthritis: a randomized double-blind clinical trial. J Am Coll Nutr. 2016;35(4):291\u20139.","journal-title":"J Am Coll Nutr"},{"key":"809_CR87","doi-asserted-by":"crossref","unstructured":"Lu Q, Yang M-F, Liang Y-J, et al. Immunology of inflammatory bowel disease: molecular mechanisms and therapeutics. Journal of Inflammation Research. 2022:1825\u20131844.","DOI":"10.2147\/JIR.S353038"},{"issue":"1","key":"809_CR88","first-page":"9621668","volume":"2022","author":"J Mishra","year":"2022","unstructured":"Mishra J, Stubbs M, Kuang L, et al. Inflammatory bowel disease therapeutics: A focus on probiotic engineering. Mediat Inflamm. 2022;2022(1):9621668.","journal-title":"Mediat Inflamm"},{"key":"809_CR89","doi-asserted-by":"publisher","first-page":"128910","DOI":"10.1016\/j.biortech.2023.128910","volume":"376","author":"S Hilaluddin, Mondal","year":"2023","unstructured":"Hilaluddin, Mondal S, Rakshit S, et al. Production of glutathione from probiotic Bacillus amyloliquefaciens KMH10 using banana peel extract. Bioresour Technol. 2023;376:128910. https:\/\/doi.org\/10.1016\/j.biortech.2023.128910.","journal-title":"Bioresour Technol"},{"key":"809_CR90","doi-asserted-by":"publisher","first-page":"111333","DOI":"10.1016\/j.foodres.2022.111333","volume":"156","author":"RL Binati","year":"2022","unstructured":"Binati RL, Larini I, Salvetti E, et al. Glutathione production by non-Saccharomyces yeasts and its impact on winemaking: A review. Food Res Int. 2022;156:111333. https:\/\/doi.org\/10.1016\/j.foodres.2022.111333.","journal-title":"Food Res Int"},{"issue":"7","key":"809_CR91","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3390\/antiox14070767","volume":"14","author":"MDM Viana","year":"2025","unstructured":"Viana MDM, Santos SS, Cruz ABO, et al. Probiotics as Antioxidant Strategy for Managing Diabetes Mellitus and Its Complications. Antioxidants. 2025;14(7):767.","journal-title":"Antioxidants"},{"issue":"1\u20132","key":"809_CR92","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.mam.2008.07.001","volume":"30","author":"SK Biswas","year":"2009","unstructured":"Biswas SK, Rahman I. Environmental toxicity, redox signaling and lung inflammation: the role of glutathione. Mol Aspects Med. 2009;30(1\u20132):60\u201376. https:\/\/doi.org\/10.1016\/j.mam.2008.07.001.","journal-title":"Mol Aspects Med"},{"key":"809_CR93","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2147\/ijgm.S15618","volume":"4","author":"P Ghezzi","year":"2011","unstructured":"Ghezzi P. Role of glutathione in immunity and inflammation in the lung. Int J Gen Med. 2011;4:105\u201313. https:\/\/doi.org\/10.2147\/ijgm.S15618.","journal-title":"Int J Gen Med"},{"issue":"3","key":"809_CR94","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/10253890400012685","volume":"7","author":"M Sivonov\u00e1","year":"2004","unstructured":"Sivonov\u00e1 M, Zitnanov\u00e1 I, Hlinc\u00edkov\u00e1 L, et al. Oxidative stress in university students during examinations. Stress. 2004;7(3):183\u20138. https:\/\/doi.org\/10.1080\/10253890400012685.","journal-title":"Stress"},{"issue":"1","key":"809_CR95","first-page":"29","volume":"13","author":"I Cernak","year":"2000","unstructured":"Cernak I, Savic V, Kotur J, et al. Alterations in magnesium and oxidative status during chronic emotional stress. Magnes Res. 2000;13(1):29\u201336.","journal-title":"Magnes Res"},{"issue":"5\u20136","key":"809_CR96","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/j.1440-1681.2007.04584.x","volume":"34","author":"E Sahin","year":"2007","unstructured":"Sahin E, G\u00fcm\u00fc\u015fl\u00fc S. Stress-dependent induction of protein oxidation, lipid peroxidation and anti-oxidants in peripheral tissues of rats: comparison of three stress models (immobilization, cold and immobilization-cold). Clin Exp Pharmacol Physiol. 2007;34(5\u20136):425\u201331. https:\/\/doi.org\/10.1111\/j.1440-1681.2007.04584.x.","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"Pt 4","key":"809_CR97","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1258\/0004563054255461","volume":"42","author":"V Mishra","year":"2005","unstructured":"Mishra V, Baines M, Wenstone R, et al. Markers of oxidative damage, antioxidant status and clinical outcome in critically ill patients. Ann Clin Biochem. 2005;42(Pt 4):269\u201376. https:\/\/doi.org\/10.1258\/0004563054255461.","journal-title":"Ann Clin Biochem"},{"key":"809_CR98","doi-asserted-by":"publisher","first-page":"578386","DOI":"10.3389\/fimmu.2021.578386","volume":"12","author":"F Cristofori","year":"2021","unstructured":"Cristofori F, Dargenio VN, Dargenio C, et al. Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body. Front Immunol. 2021;12:578386. https:\/\/doi.org\/10.3389\/fimmu.2021.578386.","journal-title":"Front Immunol"},{"issue":"5","key":"809_CR99","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.nut.2011.08.013","volume":"28","author":"HS Ejtahed","year":"2012","unstructured":"Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, et al. Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition. 2012;28(5):539\u201343. https:\/\/doi.org\/10.1016\/j.nut.2011.08.013.","journal-title":"Nutrition"},{"issue":"33","key":"809_CR100","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.3748\/wjg.v16.i33.4145","volume":"16","author":"SK Hegazy","year":"2010","unstructured":"Hegazy SK, El-Bedewy MM. Effect of probiotics on pro-inflammatory cytokines and NF-kappaB activation in ulcerative colitis. World J Gastroenterol. 2010;16(33):4145\u201351. https:\/\/doi.org\/10.3748\/wjg.v16.i33.4145.","journal-title":"World J Gastroenterol"},{"issue":"15","key":"809_CR101","doi-asserted-by":"publisher","first-page":"4481","DOI":"10.1128\/aem.01229-14","volume":"80","author":"E Karunasena","year":"2014","unstructured":"Karunasena E, McMahon KW, Chang D, et al. Host responses to the pathogen Mycobacterium avium subsp. paratuberculosis and beneficial microbes exhibit host sex specificity. Appl Environ Microbiol. 2014;80(15):4481\u201390. https:\/\/doi.org\/10.1128\/aem.01229-14.","journal-title":"Appl Environ Microbiol"},{"issue":"8","key":"809_CR102","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1002\/jcp.24340","volume":"228","author":"LR McCabe","year":"2013","unstructured":"McCabe LR, Irwin R, Schaefer L, et al. Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice. J Cell Physiol. 2013;228(8):1793\u20138. https:\/\/doi.org\/10.1002\/jcp.24340.","journal-title":"J Cell Physiol"},{"issue":"2","key":"809_CR103","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s12602-017-9299-1","volume":"10","author":"R Tabrizi","year":"2018","unstructured":"Tabrizi R, Moosazadeh M, Lankarani KB, et al. The Effects of Synbiotic Supplementation on Glucose Metabolism and Lipid Profiles in Patients with Diabetes: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Probiotics Antimicrob Proteins. 2018;10(2):329\u201342. https:\/\/doi.org\/10.1007\/s12602-017-9299-1.","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"6","key":"809_CR104","first-page":"8","volume":"23","author":"HS Ejtahed","year":"2017","unstructured":"Ejtahed HS, Hasani-Ranjbar S, Larijani B. Human Microbiome as an Approach to Personalized Medicine. Altern Ther Health Med. 2017;23(6):8\u20139.","journal-title":"Altern Ther Health Med"},{"issue":"2","key":"809_CR105","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1007\/s40200-020-00703-0","volume":"23","author":"HS Ejtahed","year":"2024","unstructured":"Ejtahed HS, Hasani-Ranjbar S, Soroush AR, et al. Microbiota research in Iran; current knowledge and future perspective. J Diabetes Metab Disord. 2024;23(2):1479\u201384. https:\/\/doi.org\/10.1007\/s40200-020-00703-0.","journal-title":"J Diabetes Metab Disord"}],"container-title":["Genes &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12263-026-00809-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12263-026-00809-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12263-026-00809-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T23:20:06Z","timestamp":1788132006000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12263-026-00809-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":105,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["809"],"URL":"https:\/\/doi.org\/10.1186\/s12263-026-00809-9","relation":{},"ISSN":["1555-8932","1865-3499"],"issn-type":[{"value":"1555-8932","type":"print"},{"value":"1865-3499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]},"assertion":[{"value":"14 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All of the included studies provided a statement on ethics approval and consent with a registration number. Considering that in this study we did not conduct experiments directly on humans and only extracted the information available in other studies, having a code of ethics was not necessary for this study. Also, according to the type of study, we registered our protocol in Prospero with this code (no. CRD420251103060), which is accessible.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"21"}}