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During the infection process, <jats:italic>M. oryzae<\/jats:italic> secretes effector proteins that help in hijacking the host's immune responses to establish infection. However, little is known about the interaction between the effector protein AvrPik-D and the host protein Pikh, and how AvrPik-D increases disease severity to promote infection. In this study, we show that the <jats:italic>M. oryzae<\/jats:italic> effector AvrPik-D interacts with the zinc finger-type transcription factor WG7 in the nucleus and promotes its transcriptional activity. Genetic removal (knockout) of the gene <jats:italic>WG7<\/jats:italic> in transgenic rice enhances resistance to <jats:italic>M. oryzae<\/jats:italic> and also results in an increased burst of reactive oxygen species after treatments with chitin. In addition, the hormone level of SA and JA, is increased and decreased respectively in <jats:italic>WG7<\/jats:italic> KO plants, indicating that WG7 may negatively mediate resistance through salicylic acid pathway. Conversely, <jats:italic>WG7<\/jats:italic> overexpression lines reduce resistance to <jats:italic>M. oryzae.<\/jats:italic> However, WG7 is not required for the Pikh-mediated resistance against rice blast. In conclusion, our results revealed that the <jats:italic>M. oryzae<\/jats:italic> effector AvrPik-D targets and promotes transcriptional activity of WG7 to suppress rice innate immunity to facilitate infection.<\/jats:p>","DOI":"10.1186\/s12284-024-00693-0","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T17:03:23Z","timestamp":1707843803000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Magnaporthe oryzae effector AvrPik-D targets a transcription factor WG7 to suppress rice immunity"],"prefix":"10.1186","volume":"17","author":[{"given":"Tao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luao","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-dong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"693_CR1","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1534\/genetics.108.095034","volume":"180","author":"I Ashikawa","year":"2008","unstructured":"Ashikawa I, Hayashi N, Yamane H, Kanamori H, Wu J, Matsumoto T, Ono K, Yano M (2008) Two adjacent nucleotide-binding site-leucine-rich repeat class genes are required to confer Pikm-specific rice blast resistance. 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