{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:55:36Z","timestamp":1777956936616,"version":"3.51.4"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ophthal Inflamm Infect"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eales\u2019 disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnosed with Eales\u2019 disease in both eyes with persistent intraocular inflammation. Enucleation of the pthisical right eye was subjected for histopathological examination immunohistochemistry and molecular biologic study for mycobacterial tuberculosis DNA. Our study showed that Eales disease is probably a T cell mediated disease which is triggered by mycobacterial TB DNA. Further studies are needed to confirm our findings.<\/jats:p>","DOI":"10.1186\/s12348-021-00259-x","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:05:57Z","timestamp":1630454757000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales\u2019 disease"],"prefix":"10.1186","volume":"11","author":[{"given":"Amravi","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha","family":"Giridhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gazal","family":"Patnaik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Mhatre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipankar","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K.","family":"Janani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Mahadevan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1214-5429","authenticated-orcid":false,"given":"Jyotirmay","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"key":"259_CR1","doi-asserted-by":"crossref","unstructured":"Biswas J, Sharma T, Gopal L, Madhavan HN, Sulochana KN, Ramakrishnan S (2002) Eales Disease \u2013 An update. Surv Ophthalmol 47(3):197\u2013214","DOI":"10.1016\/S0039-6257(02)00288-6"},{"issue":"1","key":"259_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1869-5760-3-11","volume":"3","author":"J Biswas","year":"2013","unstructured":"Biswas J, Ravi RK, Narayanasamy A, Kulandai LT, Madhavan HN (2013) Eales\u2019 disease- current concepts in diagnosis and management. J Ophthalmic Inflamm Infect 3(1):11. https:\/\/doi.org\/10.1186\/1869-5760-3-11","journal-title":"J Ophthalmic Inflamm Infect"},{"issue":"3","key":"259_CR3","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s10792-015-0144-9","volume":"36","author":"A Verma","year":"2016","unstructured":"Verma A, Biswas J, Dhanurekha L, Gayathiri R, Therese KL (2016) Detection of mycobacterium tuberculosis with nested polymerase chain reaction analysis in enucleated eye ball in Eales\u2019 disease. Int Ophthalmol 36(3):413\u2013417. https:\/\/doi.org\/10.1007\/s10792-015-0144-9","journal-title":"Int Ophthalmol"},{"issue":"3","key":"259_CR4","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3109\/08916939209148460","volume":"12","author":"DG Charteris","year":"1992","unstructured":"Charteris DG, Barton K, Mccartney ACE, Lightman SL (1992) CD4+ lymphocyte involvement in ocular Behcet\u2019s disease. Autoimmunity 12(3):201\u2013206. https:\/\/doi.org\/10.3109\/08916939209148460","journal-title":"Autoimmunity"},{"issue":"7","key":"259_CR5","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.4103\/ijo.IJO_1800_18","volume":"67","author":"D Das","year":"2019","unstructured":"Das D, Boddepalli A, Biswas J (2019) Clinicopathological and immunohistochemistry correlation in a case of Vogt-Koyanagi-Harada disease. Indian J Ophthalmol 67(7):1217\u20131219. https:\/\/doi.org\/10.4103\/ijo.IJO_1800_18","journal-title":"Indian J Ophthalmol"},{"issue":"8","key":"259_CR6","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1097\/IAE.000000000000000506","volume":"35","author":"HA Aziz","year":"2015","unstructured":"Aziz HA, Flynn HW, Young RC, Davis LJ, Dubovy RS (2015) Sympathetic Ophthalmia: Clinicopathologic Correlation in a Consecutive Case Series. Retina 35(8):1696\u20131703. https:\/\/doi.org\/10.1097\/IAE.000000000000000506","journal-title":"Retina"},{"issue":"8","key":"259_CR7","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1136\/bjo.83.8.994","volume":"83","author":"J Biswas","year":"1999","unstructured":"Biswas J, Therese L, Madhavan HN (1999) Use of polymerase chain reaction in detection of mycobacterium tuberculosis complex DNA from vitreous sample of Eales\u2019 disease. Br J Ophthalmol 83(8):994. https:\/\/doi.org\/10.1136\/bjo.83.8.994","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"259_CR8","first-page":"822","volume":"41","author":"HN Madhavan","year":"2000","unstructured":"Madhavan HN, Therese KL, Gunisha P, Jayanthi U, Biswas J (2000) Polymerase chain reaction for detection of mycobacterium tuberculosis in Epiretinal membrane in Eales\u2019 disease. Invest Ophthalmol Vis Sci 41(3):822\u2013825","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Journal of Ophthalmic Inflammation and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12348-021-00259-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12348-021-00259-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12348-021-00259-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:08:39Z","timestamp":1630454919000},"score":1,"resource":{"primary":{"URL":"https:\/\/joii-journal.springeropen.com\/articles\/10.1186\/s12348-021-00259-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["259"],"URL":"https:\/\/doi.org\/10.1186\/s12348-021-00259-x","relation":{},"ISSN":["1869-5760"],"issn-type":[{"value":"1869-5760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,1]]},"assertion":[{"value":"23 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval: Not applicable. Patient\u2019s\u00a0consent was duly obtained prior to any imaging. Consent for publication has been taken.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29"}}