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When left untreated, syphilis has a mortality rate of 8\u201358%, with a higher death rate in males. Eye manifestations occur both in secondary and tertiary stages of syphilis, although ocular involvement may occur at any stage of the disease.<\/jats:p>\n                    <jats:p>Syphilis has been always recognized as \u201cthe great mimicker\u201d since it can have multiple clinical patterns of presentation.<\/jats:p>\n                    <jats:p>However, Acute Syphilitic Posterior Placoid Chorioretinitis (ASPPC) represents the typical pattern of the disease and can be easily distinguished.<\/jats:p>\n                    <jats:p>In addition, the advent of modern technologies and the progress made in multimodal imaging have provided more details on its identikit: the pattern of pre-retinal, retinal, retinochoroidal and optic nerve involvement can be identified before going through the laboratory work-up for a correct and appropriate investigation of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review highlights the peculiar pattern of ASPPC, by reporting the diagnostic process made by all the imaging techniques used for a correct multimodal imaging assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12348-022-00286-2","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T06:03:19Z","timestamp":1645509799000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Acute syphilitic posterior placoid chorioretinitis: when the great mimicker cannot pretend any more; new insight of an old acquaintance"],"prefix":"10.1186","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7673-4276","authenticated-orcid":false,"given":"Piergiorgio","family":"Neri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"issue":"10","key":"286_CR1","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1086\/429626","volume":"40","author":"BM Rothschild","year":"2005","unstructured":"Rothschild BM (2005) History of syphilis. 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