{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:10:45Z","timestamp":1772165445007,"version":"3.50.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82271098"],"award-info":[{"award-number":["No. 82271098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ophthal Inflamm Infect"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To report a case of Bilateral Purtscher-like retinopathy associated with DRESS syndrome managed with ocular and systemic treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 29-year-old healthy female developed multi-organ (cutaneous, hematologic, renal and hepatic) disfunction and profound vision loss 1 month after Human papillomavirus vaccine injection. At the first presentation, her visual acuity was counting fingers in both eyes. Fundus exam showed remarkable cotton-wool spots, retinal hemorrhages and macular edema. She was diagnosed DRESS syndrome and Purtscher-like retinopathy and treated with intravitreal injection of ranibizumab, systemic steroids anticoagulants, and plasma exchange. The patient finally recovered from this life-threatening condition but left with permanent visual damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Purtscher-like retinopathy could be complicated by DRESS syndrome which is usually considered a type IV hypersensitivity reaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12348-024-00433-x","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:01:58Z","timestamp":1727672518000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral purtscher-like retinopathy associated with DRESS syndrome: a case report"],"prefix":"10.1186","volume":"14","author":[{"given":"Langxuan","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yucen","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianyan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqin","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"issue":"25","key":"433_CR1","doi-asserted-by":"publisher","first-page":"p101301","DOI":"10.1016\/j.ajoc.2022.101301","volume":"2022","author":"C Pinto","year":"2022","unstructured":"Pinto C, Fernandes T, Gouveia P, Sousa K (2022) Purtscher-like retinopathy: ocular findings in a young woman with chronic kidney disease. Am J Ophthalmol Case Rep 2022(25):p101301","journal-title":"Am J Ophthalmol Case Rep"},{"key":"433_CR2","doi-asserted-by":"crossref","unstructured":"Hama N, Abe R, Gibson A, Phillips EJ (2022) Drug-Induced Hypersensitivity Syndrome (DIHS)\/Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): Clinical Features and Pathogenesis. J Allergy Clin Immunol Pract, 2022. 10(5): pp. 1155\u20131167 e5","DOI":"10.1016\/j.jaip.2022.02.004"},{"key":"433_CR3","doi-asserted-by":"crossref","unstructured":"Kardaun SH, Sekula P, Valeyrie-Allanore L, Liss Y, Chu CY, Creamer D, Sidoroff A, Naldi L, Mockenhaupt M, Roujeau JC, RegiSCAR study group (2013) & Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol, 2013. 169(5): pp. 1071-80","DOI":"10.1111\/bjd.12501"},{"key":"433_CR4","doi-asserted-by":"crossref","unstructured":"Thatcher MD, Wu LZ, Varma R (2023) Bilateral Purtscher-Like Retinopathy Associated With COVID-19 Infection. JAMA Ophthalmol, 2023. 141(3): pp. 291\u2013293","DOI":"10.1001\/jamaophthalmol.2022.6255"},{"key":"433_CR5","doi-asserted-by":"crossref","unstructured":"Agrawal A, McKibbin MA (2006) Purtscher\u2019s and Purtscher-like retinopathies: a review. Surv Ophthalmol, 2006. 51(2): pp. 129\u2009\u2013\u200936","DOI":"10.1016\/j.survophthal.2005.12.003"},{"key":"433_CR6","doi-asserted-by":"crossref","unstructured":"Wu C, Dai R, Dong F, Wang Q (2014) Purtscher-like retinopathy in systemic lupus erythematosus. Am J Ophthalmol, 2014. 158(6): pp. 1335\u20131341 e1","DOI":"10.1016\/j.ajo.2014.09.001"},{"key":"433_CR7","doi-asserted-by":"crossref","unstructured":"Bottini AR, Steinmetz S, Blinder KJ, Shah GK (2021) Purtscher-Like Retinopathy in a Patient with COVID-19. Case Rep Ophthalmol Med, 2021. 2021: p. 6661541","DOI":"10.1155\/2021\/6661541"},{"key":"433_CR8","doi-asserted-by":"crossref","unstructured":"Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA (2024) Drug-induced hypersensitivity syndrome\/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management. J Am Acad Dermatol, 2024. 90(5): pp. 911\u2013926","DOI":"10.1016\/j.jaad.2023.02.073"},{"key":"433_CR9","doi-asserted-by":"crossref","unstructured":"Chen CB, Hung WK, Wang CW, Lee CC, Hung SI, Chung WH (2023) Advances in understanding of the pathogenesis and therapeutic implications of drug reaction with eosinophilia and systemic symptoms: an updated review. Front Med (Lausanne), 2023. 10: p. 1187937","DOI":"10.3389\/fmed.2023.1187937"},{"key":"433_CR10","doi-asserted-by":"crossref","unstructured":"Liang LL, Zhou DD, Lu CW (2017) Purtscher-like Retinopathy. The American Journal of the Medical Sciences, 2017. 354(3)","DOI":"10.1016\/j.amjms.2017.02.009"}],"container-title":["Journal of Ophthalmic Inflammation and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12348-024-00433-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12348-024-00433-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12348-024-00433-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:02:30Z","timestamp":1727672550000},"score":1,"resource":{"primary":{"URL":"https:\/\/joii-journal.springeropen.com\/articles\/10.1186\/s12348-024-00433-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["433"],"URL":"https:\/\/doi.org\/10.1186\/s12348-024-00433-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4777309\/v1","asserted-by":"object"}]},"ISSN":["1869-5760"],"issn-type":[{"value":"1869-5760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"21 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case report was exempt from approval of the ethics committee of First affiliated hospital of Xi\u2019an Jiaotong University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The consent for publication was obtained from the study patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"46"}}