{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:01:20Z","timestamp":1740160880185,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ophthal Inflamm Infect"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Describe the proportion of patients with wide-field fluorescein angiographic (WFFA) findings in patients with active anterior scleritis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>An observational, descriptive, cross-sectional study of the WFFA findings of patients with active anterior scleritis including nodular, diffuse, or necrotizing involvement\u00a0was performed. Studies were performed with the Heidelberg Spectralis module (102\u00ba). Images were saved and assessed by two masked co-authors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Seventy-nine eyes from 39 patients, 31 (79%) females with a mean age of 50.5 years\u2009\u00b1\u200913.98. Mean best-corrected visual acuity (BCVA) of 0.1343 \u00b1\u20090.2475\u00a0logMar or 20\/27. WFFA findings were observed in 39.58% of eyes with active scleritis and in 16.66% of eyes without scleritis. Systemic association was present at 50%, with ANCA-associated vasculitis being the most prevalent. WFFA findings were more frequent in cases of anterior diffuse scleritis and correlated with scleritis severity when central and peripheral leakage (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.022) and cystoid macular edema (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.013) were present.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Almost 40% of eyes with anterior scleritis have WFFA findings of vascular leakage and 16% of eyes without scleritis. Retinal vascular leakage needs to be explored as a sign of local and\/or systemic activity in patients with anterior scleritis and may have implications for disease severity and management.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12348-024-00439-5","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T17:51:55Z","timestamp":1734544315000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wide-field fluorescein angiography findings in active anterior scleritis"],"prefix":"10.1186","volume":"14","author":[{"given":"Juan C.","family":"Romo-Aguas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Zavaleta-Mercado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashel","family":"Cheja-Kalb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Hubbe-Tena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0081-7745","authenticated-orcid":false,"given":"Luz Elena","family":"Concha-del-R\u00edo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"439_CR1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.rdc.2010.05.005","volume":"36","author":"AA Kubal","year":"2010","unstructured":"Kubal AA, Perez VL (2010) Ocular manifestations of ANCA-associated Vasculitis. 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This study was approved by the institutional ethics committee \u201cComit\u00e9 de Etica de la Asociaci\u00f3n Para Evitar la Ceguera en Mexico APEC\u201d with protocol number UV-18-03. Informed consent for participation in this study was obtained from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable (NA).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"67"}}