{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:49:11Z","timestamp":1783010951306,"version":"3.54.6"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Manipal Academy of Higher Education, Manipal"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ophthal Inflamm Infect"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>\n              <jats:italic>Pseudallescheria boydii<\/jats:italic> with its asexual form, <jats:italic>Scedosporium apiospermum<\/jats:italic>, is now recognized as an important emerging opportunistic pheoid-hypomycosis. Usually results in invasive infections in immunocompromised patients but rarely can infect the eyes. Herein, we report a challenging case of <jats:italic>Pseudallescheria boydii<\/jats:italic> keratitis in a lady with traumatic injury.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case Report<\/jats:title>\n            <jats:p>A 38-year-old female presented with alleged history of penetrating injury to right eye with stick by her spouse for which she was started on antibiotic eye drops from nearby local hospital and became symptomatically better. Later she had alleged history of ashes thrown to her right eye 2 weeks ago. She was referred here from a nearby hospital, with complaints of pain, itching, watering of eye and blurring of vision. On examination, Limbal -limbal ulcer with peripherally thinned out cornea and mucoid discharge was present. Corneal scrapings revealed <jats:italic>P boydii<\/jats:italic>. She was managed with antibiotics such as moxifloxacin, tobramycin and antifungals such as Natamycin, fluconazole. She did not improve symptomatically. She was referred to a higher center for keratoplasty and the patient was thus discharged for the same.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>\u00a0<jats:italic>Pseudallescheria boydii<\/jats:italic> is a soil saprophytic, uncommon fungi entering body via respiratory or penetrating injury. It is often mistaken as Aspergillosis, This fungi shows resistance to amphotericin B, flucytosine and susceptible to triazoles. Surgical resection of lesion shows better outcome. The response of disseminated infection to combination therapy with interferon gamma and antifungal agents is encouraging.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12348-025-00533-2","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:41:47Z","timestamp":1758883307000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Scedosporium-induced keratitis: insights from a case study"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4248-5664","authenticated-orcid":false,"given":"Liya","family":"Fathima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9341-1852","authenticated-orcid":false,"given":"L.","family":"Annapurneswari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0717-783X","authenticated-orcid":false,"given":"Pooja","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-386X","authenticated-orcid":false,"given":"Teena","family":"Mendonca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"533_CR1","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s11046-015-9952-8","volume":"181","author":"T Lahmer","year":"2016","unstructured":"Lahmer T, Messer M, Ehmer U et al (2016) Pseudallescheria Boydii with Aspergillus fumigatus and Aspergillus terreus in a critically ill hematopoietic stem cell recipient with ARDS. Mycopathologia 181:267\u2013271. https:\/\/doi.org\/10.1007\/s11046-015-9952-8","journal-title":"Mycopathologia"},{"key":"533_CR2","volume-title":"Medically important fungi: A guide to identification","author":"TJ Larone","year":"2018","unstructured":"Larone TJ (2018) Medically important fungi: A guide to identification, 6th edn. ASM, Washington, DC","edition":"6"},{"key":"533_CR3","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12941-024-00754-8","volume":"23","author":"Y Xiao","year":"2024","unstructured":"Xiao Y, Li X, Hu L et al (2024) Clinical features and antifungal treatment of invasive Scedosporium Boydii infection: report of a case and literature overview. Ann Clin Microbiol Antimicrob 23:94. https:\/\/doi.org\/10.1186\/s12941-024-00754-8","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"533_CR4","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1089\/jop.2010.0069","volume":"26","author":"ACM Wong","year":"2010","unstructured":"Wong ACM, Mak ST, Luk S et al (2010) Successful treatment of Pseudallescheria Boydii keratitis with topical Natamycin as monotherapy. J Ocul Pharmacol Ther 26:519\u2013521","journal-title":"J Ocul Pharmacol Ther"},{"issue":"5","key":"533_CR5","first-page":"519","volume":"21","author":"MD Wu, Ziqiang","year":"2022","unstructured":"Wu, Ziqiang MD, Ying HMD, Yiu PD, Irvine SMDPD, Smith JMD, Ronald MD (2022) Fungal Keratitis Caused by Scedosporium Apiospermum: Report of Two Cases and Review of Treatment. 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