{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:23:28Z","timestamp":1764073408272,"version":"3.45.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ophthal Inflamm Infect"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To describe the clinical features and management of three cases of bilateral endogenous fungal endophthalmitis following elective surgical abortion performed at the same outpatient surgical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Observations<\/jats:title>\n                    <jats:p>Three immunocompetent women presented with vision loss days to weeks following elective surgical abortions performed at a single outpatient clinic. Initial visual acuities ranged from 20\/20 to 20\/300. Fundoscopic examination revealed multiple white round chorioretinal lesions with vitreous infiltration bilaterally in all three patients. Vitreous tap samples were obtained for culture and broad-spectrum intravitreal antimicrobials were administered. Despite negative cultures and systemic workup, the clinical presentation was consistent with fungal endophthalmitis. All patients received systemic and intravitreal antifungal therapy, leading to gradual resolution of lesions and improvement of visual acuity to 20\/25 or better in all eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This cases series represents the first reported cluster of endogenous fungal endophthalmitis following surgical abortion. Prompt recognition and treatment with intravitreal and systemic antifungals can result in favorable outcomes. The findings highlight the importance of stringent sterilization protocols in outpatient surgical settings and the need for heighted clinical suspicion in similar presentations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12348-025-00547-w","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:20:10Z","timestamp":1764073210000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral endogenous fungal endophthalmitis following elective surgical abortion: a single center case series"],"prefix":"10.1186","volume":"15","author":[{"given":"Viet Q.","family":"Chau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse D.","family":"Sengillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavius A.","family":"Beca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia L.","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Albini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry W.","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"547_CR1","doi-asserted-by":"crossref","unstructured":"Wang H, Chang Y, Zhang Y, Yang R, Shi H, Zhang M (2023) Bilateral endogenous fungal endophthalmitis: A case report. Medicine. 102(16). https:\/\/journals.lww.com\/md-journal\/fulltext\/2023\/04210\/bilateral_endogenous_fungal_endophthalmitis__a.15.aspx","DOI":"10.1097\/MD.0000000000033585"},{"issue":"5","key":"547_CR2","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1080\/09273948.2018.1465100","volume":"27","author":"B Lei","year":"2019","unstructured":"Lei B, Jiang R, Gu R, Xu G, Song F, Zhou M (2019) Endogenous fungal endophthalmitis associated with genitourinary procedures. Ocul Immunol Inflamm 27(5):747\u2013755. https:\/\/doi.org\/10.1080\/09273948.2018.1465100","journal-title":"Ocul Immunol Inflamm"},{"issue":"1","key":"547_CR3","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1186\/s13104-018-3682-1","volume":"11","author":"S Zafar","year":"2018","unstructured":"Zafar S, Siddiqui MAR (2018) Sub-retinal abscess as presenting feature of endogenous Candida endophthalmitis. BMC Res Notes 11(1):598. https:\/\/doi.org\/10.1186\/s13104-018-3682-1","journal-title":"BMC Res Notes"},{"issue":"3","key":"547_CR4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1080\/09273940802689396","volume":"17","author":"X Shen","year":"2009","unstructured":"Shen X, Xu G (2009) Vitrectomy for endogenous fungal endophthalmitis. Ocul Immunol Inflamm 17(3):148\u2013152. https:\/\/doi.org\/10.1080\/09273940802689396","journal-title":"Ocul Immunol Inflamm"},{"key":"547_CR5","unstructured":"Chang TS, yen, Chen WC yen, Chen HSL, Lee HWH (2002) Endogenous Candida endophthalmitis after two consecutive procedures of suction dilatation and curettage. Chang Gung Med J. 25(11):778\u2013782"},{"issue":"6","key":"547_CR6","first-page":"676","volume":"42","author":"J Siki\u0107","year":"2001","unstructured":"Siki\u0107 J, Vukojevi\u0107 N, Katusi\u0107 D, Sari\u0107 B (2001) Bilateral endogenous Candida endophthalmitis after induced abortion. Croat Med J 42(6):676\u2013678","journal-title":"Croat Med J"},{"issue":"6","key":"547_CR7","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/s0002-9394(98)00052-x","volume":"125","author":"SJ Chen","year":"1998","unstructured":"Chen SJ, Chung YM, Liu JH (1998) Endogenous Candida endophthalmitis after induced abortion. Am J Ophthalmol 125(6):873\u2013875. https:\/\/doi.org\/10.1016\/s0002-9394(98)00052-x","journal-title":"Am J Ophthalmol"},{"key":"547_CR8","doi-asserted-by":"publisher","unstructured":"Kortsmit K, Nguyen AT, Mandel MG et al (2021) Abortion Surveillance - United States, MMWR Surveill Summ. 2023;72(9):1\u201329. https:\/\/doi.org\/10.15585\/mmwr.ss7209a1","DOI":"10.15585\/mmwr.ss7209a1"},{"key":"547_CR9","doi-asserted-by":"publisher","unstructured":"Sun Z, Ge X, Qiu B et al (2023) Vulvovaginal candidiasis and vaginal microflora interaction: microflora changes and probiotic therapy. Front Cell Infect Microbiol 13. https:\/\/www.frontiersin.org\/articles\/https:\/\/doi.org\/10.3389\/fcimb.2023.1123026","DOI":"10.3389\/fcimb.2023.1123026"},{"issue":"1","key":"547_CR10","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/clinids\/13.1.146","volume":"13","author":"I Potasman","year":"1991","unstructured":"Potasman I, Leibovitz Z, Sharf M (1991) Candida sepsis in pregnancy and the postpartum period. Rev Infect Dis 13(1):146\u2013149. https:\/\/doi.org\/10.1093\/clinids\/13.1.146","journal-title":"Rev Infect Dis"},{"issue":"6","key":"547_CR11","doi-asserted-by":"publisher","first-page":"747","DOI":"10.2165\/00003495-200161060-00004","volume":"61","author":"A Smith","year":"2001","unstructured":"Smith A, Pennefather PM, Kaye SB, Hart CA (2001) Fluoroquinolones: place in ocular therapy. Drugs 61(6):747\u2013761. https:\/\/doi.org\/10.2165\/00003495-200161060-00004","journal-title":"Drugs"},{"issue":"3","key":"547_CR12","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s40123-020-00270-w","volume":"9","author":"A Grzybowski","year":"2020","unstructured":"Grzybowski A, Turczynowska M, Schwartz SG, Relhan N, Flynn HWJ (2020) The role of systemic antimicrobials in the treatment of endophthalmitis: A review and an international perspective. Ophthalmol Ther 9(3):485\u2013498. https:\/\/doi.org\/10.1007\/s40123-020-00270-w","journal-title":"Ophthalmol Ther"},{"issue":"5","key":"547_CR13","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1093\/cid\/ciq204","volume":"52","author":"JIV Riddell","year":"2011","unstructured":"Riddell JIV, Comer GM, Kauffman CA (2011) Treatment of endogenous fungal endophthalmitis: focus on new antifungal agents. Clin Infect Dis 52(5):648\u2013653. https:\/\/doi.org\/10.1093\/cid\/ciq204","journal-title":"Clin Infect Dis"},{"key":"547_CR14","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.2147\/OPTH.S362888","volume":"16","author":"VK Govindaraju","year":"2022","unstructured":"Govindaraju VK, Chao JT, Duvall ER et al (2022) Incidence of endogenous fungal endophthalmitis in screening dilated exams in patients with elevated Beta-D-Glucan levels versus positive fungal blood cultures. Clin Ophthalmol 16:2743\u20132750. https:\/\/doi.org\/10.2147\/OPTH.S362888","journal-title":"Clin Ophthalmol"},{"issue":"11","key":"547_CR15","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1007\/s10096-011-1244-8","volume":"30","author":"O Albert","year":"2011","unstructured":"Albert O, Toubas D, Strady C et al (2011) Reactivity of (1\u21923)-\u03b2-d-glucan assay in bacterial bloodstream infections. Eur J Clin Microbiol Infect Dis 30(11):1453\u20131460. https:\/\/doi.org\/10.1007\/s10096-011-1244-8","journal-title":"Eur J Clin Microbiol Infect Dis"}],"container-title":["Journal of Ophthalmic Inflammation and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12348-025-00547-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12348-025-00547-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12348-025-00547-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:20:13Z","timestamp":1764073213000},"score":1,"resource":{"primary":{"URL":"https:\/\/joii-journal.springeropen.com\/articles\/10.1186\/s12348-025-00547-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["547"],"URL":"https:\/\/doi.org\/10.1186\/s12348-025-00547-w","relation":{},"ISSN":["1869-5760"],"issn-type":[{"value":"1869-5760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"30 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the tenets of the Declaration of Helsinki and the Health Insurance Portability and Accountability Act. It was deemed exempt from review by the University of Miami Institutional Review Board, given that it fulfilled criteria for a small case series (3 or fewer patients).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained for all patients included in this study","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"89"}}