{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:21:44Z","timestamp":1794007304407,"version":"4.8.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ophthal Inflamm Infect"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Postpartum hemorrhage is a leading cause of maternal morbidity and mortality, with intrauterine tamponade techniques increasingly employed in its management. Chitosan-based products, such as Celox\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , have been introduced for their hemostatic properties. However, their potential systemic effects remain insufficiently understood. This case series describes six patients who developed acute bilateral intermediate uveitis shortly after receiving intrauterine Chitosan tamponade during obstetric care.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main body<\/jats:title>\n                    <jats:p>A retrospective review was conducted on six postpartum patients who developed acute bilateral intraocular inflammation following the use of intrauterine Chitosan tamponade. Clinical data, laboratory findings, and ophthalmological assessments were analyzed. All six women presented with bilateral anterior and posterior segment inflammation within 48 to 72\u00a0h after tamponade placement. Common ocular findings included limbal corneal infiltrates, anterior chamber cells, vitritis, and decreased visual acuity. Three patients also experienced non-ocular symptoms, including perichondritis and auditory disturbances. Comprehensive evaluations, including infectious and autoimmune workups, were unremarkable in all cases. None of the patients had a prior history of uveitis or known systemic inflammatory conditions. Prompt initiation of topical and systemic corticosteroids led to the resolution of inflammation and recovery of visual function in all individuals. The uniform timing, bilateral occurrence of inflammation, and lack of alternative explanations indicate a possible association with the use of the Chitosan-based tamponade. The underlying mechanism remains uncertain, but an immunologic or toxic reaction is suspected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case series highlights a possible association between intrauterine Chitosan tamponade and the onset of bilateral intermediate uveitis in postpartum patients. Although causality cannot be definitely established, the temporal clustering and consistent clinical presentation warrant caution and further investigation into the systemic immunogenic potential of Chitosan-based products.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12348-025-00548-9","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T16:03:09Z","timestamp":1766592189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bilateral acute intermediate uveitis following intrauterine Chitosan tamponade: a case series"],"prefix":"10.1186","volume":"16","author":[{"given":"David","family":"Beckers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Pleyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Beckers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Maul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mascha","family":"L\u00fcder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Schaudig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birthe","family":"Stemplewitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"548_CR1","unstructured":"WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage. 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The Ethics Committee of the Hamburg Medical Association determined that no consultation or formal approval was required for this project (reference 2025-300667-WF).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors have written informed consent by all patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Prof Uwe Pleyer is an Associate Editor for the Journal of Ophthalmic Inflammation and Infection. However, he was not involved in the editorial handling or decision-making process for this manuscript. The rest of the authors have no conflict of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5"}}