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Demographic, clinical and imaging data were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Included were 29 children (50 eyes) with a mean age of 7.9\u2009\u00b1\u20092.9\u00a0years. Presenting OCT-RNFLT (28 eyes) was 209.6\u2009\u00b1\u2009179\u00a0\u03bcm. Twenty-two eyes (78.6%) had OCT-RNFLT\u2009\u2265\u2009130\u00a0\u03bcm and it was significantly associated with higher BIO score (2.02\u2009\u00b1\u20091.21 vs. 0.42\u2009\u00b1\u20090.80 in eyes with OCT-RNFLT\u2009&lt;\u2009130\u00a0\u03bcm), anterior uveitis, papillitis, conventional disease-modifying antirheumatic drugs and biologic therapy. Following the initiation of therapy, improvement in BIO score was observed promptly, preceding the improvement in OCT-RNFLT. In the univariate general linear model, BIO group classification demonstrated the strongest association with RNFLT (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u200916.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Papillitis was also significantly associated with higher RNFL values (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u20096.47,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). Anterior uveitis did not show a significant association with RNFLT (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u20090.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.883), suggesting that posterior segment findings could be more relevant indicators of RNFLT in this cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      To date, this is the first longitudinal study that investigated OCT-RNFLT in pediatric pars planitis patients. OCT-RNFLT strongly correlated with disease severity and eyes with OCT-RNFLT\u2009\n                      <jats:italic>\u2265<\/jats:italic>\n                      130\u00a0\u00b5m required at a higher rate the institution of intensive immunosuppressive regimen. The reduction in OCT-RNFLT with resolving inflammation highlights its potential role as a tool for monitoring therapeutic response over time.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12348-025-00564-9","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T01:55:26Z","timestamp":1765331726000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implications of peripapillary retinal nerve fiber layer thickening by optical coherence tomography in children with pars planitis"],"prefix":"10.1186","volume":"16","author":[{"given":"Diala","family":"Abu Al-Halawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-4254","authenticated-orcid":false,"given":"Radgonde","family":"Amer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"564_CR1","doi-asserted-by":"publisher","first-page":"469","DOI":"10.4103\/2008-322X.176897","volume":"10","author":"PC Ozdal","year":"2015","unstructured":"Ozdal PC, Berker N, Tugal-Tutkun I (2015) Pars planitis: epidemiology, clinical characteristics, management and visual prognosis. 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