{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:07:16Z","timestamp":1789067236464,"version":"build-2803163510"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Tianjin Health Research Project","award":["TJWJ2023QN012"],"award-info":[{"award-number":["TJWJ2023QN012"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82303718"],"award-info":[{"award-number":["82303718"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-009A"],"award-info":[{"award-number":["TJYXZDXK-009A"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Proced Online"],"DOI":"10.1186\/s12575-024-00254-1","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T08:02:12Z","timestamp":1727510532000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Metabolic and Immunological Implications of MME+CAF-Mediated Hypoxia Signaling in Pancreatic Cancer Progression: Therapeutic Insights and Translational Opportunities"],"prefix":"10.1186","volume":"26","author":[{"given":"Bin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuchen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yameng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"issue":"10242","key":"254_CR1","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","volume":"395","author":"JD Mizrahi","year":"2020","unstructured":"Mizrahi JD, et al. Pancreatic cancer. Lancet. 2020;395(10242):2008\u201320.","journal-title":"Lancet"},{"issue":"7","key":"254_CR2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41575-021-00457-x","volume":"18","author":"AP Klein","year":"2021","unstructured":"Klein AP. Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors. Nat Rev Gastroenterol Hepatol. 2021;18(7):493\u2013502.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"8","key":"254_CR3","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1016\/j.cell.2023.02.014","volume":"186","author":"CJ Halbrook","year":"2023","unstructured":"Halbrook CJ, et al. Pancreatic cancer: advances and challenges. Cell. 2023;186(8):1729\u201354.","journal-title":"Cell"},{"issue":"9","key":"254_CR4","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41571-020-0363-5","volume":"17","author":"WJ Ho","year":"2020","unstructured":"Ho WJ, et al. The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities. Nat Rev Clin Oncol. 2020;17(9):527\u201340.","journal-title":"Nat Rev Clin Oncol"},{"key":"254_CR5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-031621-024600","volume":"18","author":"MH Sherman","year":"2023","unstructured":"Sherman MH, et al. Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance. Annu Rev Pathol. 2023;18:123\u201348.","journal-title":"Annu Rev Pathol"},{"issue":"9","key":"254_CR6","first-page":"851","volume":"326","author":"W Park","year":"2021","unstructured":"Park W, et al. Pancreat Cancer: Rev Jama. 2021;326(9):851\u201362.","journal-title":"Pancreat Cancer: Rev Jama"},{"issue":"9791","key":"254_CR7","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/S0140-6736(10)62307-0","volume":"378","author":"A Vincent","year":"2011","unstructured":"Vincent A, et al. Pancreatic cancer. Lancet. 2011;378(9791):607\u201320.","journal-title":"Lancet"},{"issue":"1","key":"254_CR8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12943-023-01860-5","volume":"22","author":"H Zhang","year":"2023","unstructured":"Zhang H, et al. Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials. Mol Cancer. 2023;22(1):159.","journal-title":"Mol Cancer"},{"issue":"1","key":"254_CR9","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1152\/physrev.00048.2019","volume":"101","author":"G Biffi","year":"2021","unstructured":"Biffi G, et al. Diversity and Biology of Cancer-Associated fibroblasts. Physiol Rev. 2021;101(1):147\u201376.","journal-title":"Physiol Rev"},{"issue":"8","key":"254_CR10","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1158\/2159-8290.CD-19-0094","volume":"9","author":"E Elyada","year":"2019","unstructured":"Elyada E, et al. Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals Antigen-Presenting Cancer-Associated fibroblasts. Cancer Discov. 2019;9(8):1102\u201323.","journal-title":"Cancer Discov"},{"issue":"8","key":"254_CR11","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41575-020-0300-1","volume":"17","author":"AN Hosein","year":"2020","unstructured":"Hosein AN, et al. Pancreatic cancer stroma: an update on therapeutic targeting strategies. Nat Rev Gastroenterol Hepatol. 2020;17(8):487\u2013505.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"254_CR12","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.ccell.2022.04.011","volume":"40","author":"H Huang","year":"2022","unstructured":"Huang H, et al. Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer. Cancer Cell. 2022;40(6):656\u2013e737.","journal-title":"Cancer Cell"},{"issue":"2","key":"254_CR13","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1158\/2159-8290.CD-18-0710","volume":"9","author":"G Biffi","year":"2019","unstructured":"Biffi G, et al. IL1-Induced JAK\/STAT signaling is antagonized by TGF\u03b2 to shape CAF heterogeneity in pancreatic ductal adenocarcinoma. Cancer Discov. 2019;9(2):282\u2013301.","journal-title":"Cancer Discov"},{"issue":"1","key":"254_CR14","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ccell.2023.12.002","volume":"42","author":"G Mucciolo","year":"2024","unstructured":"Mucciolo G, et al. EGFR-activated myofibroblasts promote metastasis of pancreatic cancer. Cancer Cell. 2024;42(1):101\u2013e1811.","journal-title":"Cancer Cell"},{"issue":"11","key":"254_CR15","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1038\/s41418-021-00804-0","volume":"28","author":"Y Hou","year":"2021","unstructured":"Hou Y, et al. YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect. Cell Death Differ. 2021;28(11):3105\u201324.","journal-title":"Cell Death Differ"},{"key":"254_CR16","doi-asserted-by":"publisher","first-page":"216285","DOI":"10.1016\/j.canlet.2023.216285","volume":"567","author":"M Chen","year":"2023","unstructured":"Chen M, et al. NUSAP1-LDHA-Glycolysis-lactate feedforward loop promotes Warburg effect and metastasis in pancreatic ductal adenocarcinoma. Cancer Lett. 2023;567:216285.","journal-title":"Cancer Lett"},{"issue":"9","key":"254_CR17","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.cmet.2022.08.002","volume":"34","author":"D Guo","year":"2022","unstructured":"Guo D, et al. Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of I\u03baB\u03b1. Cell Metab. 2022;34(9):1312\u2013e246.","journal-title":"Cell Metab"},{"issue":"17","key":"254_CR18","doi-asserted-by":"publisher","first-page":"8322","DOI":"10.7150\/thno.62378","volume":"11","author":"Z Li","year":"2021","unstructured":"Li Z, et al. Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming. Theranostics. 2021;11(17):8322\u201336.","journal-title":"Theranostics"},{"key":"254_CR19","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.actbio.2022.05.045","volume":"148","author":"S Zang","year":"2022","unstructured":"Zang S, et al. Metabolic reprogramming by dual-targeting biomimetic nanoparticles for enhanced tumor chemo-immunotherapy. Acta Biomater. 2022;148:181\u201393.","journal-title":"Acta Biomater"},{"issue":"1","key":"254_CR20","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.cmet.2018.08.007","volume":"29","author":"M Curtis","year":"2019","unstructured":"Curtis M, et al. Fibroblasts mobilize Tumor Cell glycogen to promote proliferation and metastasis. Cell Metab. 2019;29(1):141\u2013e559.","journal-title":"Cell Metab"},{"key":"254_CR21","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.canlet.2019.03.024","volume":"452","author":"Q Hu","year":"2019","unstructured":"Hu Q, et al. UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer. Cancer Lett. 2019;452:226\u201336.","journal-title":"Cancer Lett"},{"issue":"9","key":"254_CR22","doi-asserted-by":"publisher","first-page":"107701","DOI":"10.1016\/j.celrep.2020.107701","volume":"31","author":"LM Becker","year":"2020","unstructured":"Becker LM, et al. Epigenetic reprogramming of Cancer-Associated fibroblasts deregulates glucose metabolism and facilitates progression of breast Cancer. Cell Rep. 2020;31(9):107701.","journal-title":"Cell Rep"},{"key":"254_CR23","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s13046-015-0221-y","volume":"34","author":"GJ Yoshida","year":"2015","unstructured":"Yoshida GJ. Metabolic reprogramming: the emerging concept and associated therapeutic strategies. J Experimental Clin cancer Research: CR. 2015;34:111.","journal-title":"J Experimental Clin cancer Research: CR"},{"key":"254_CR24","doi-asserted-by":"publisher","first-page":"155214","DOI":"10.1016\/j.phymed.2023.155214","volume":"123","author":"X Hu","year":"2024","unstructured":"Hu X, et al. Shikonin reverses cancer-associated fibroblast-induced gemcitabine resistance in pancreatic cancer cells by suppressing monocarboxylate transporter 4-mediated reverse Warburg effect. Phytomedicine. 2024;123:155214.","journal-title":"Phytomedicine"},{"key":"254_CR25","doi-asserted-by":"crossref","unstructured":"Kitamura F et al. Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer. JCI Insight. 2023;8(20).","DOI":"10.1172\/jci.insight.163022"},{"issue":"2","key":"254_CR26","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1158\/2159-8290.CD-22-0876","volume":"13","author":"C Falcomat\u00e0","year":"2023","unstructured":"Falcomat\u00e0 C, et al. Context-specific determinants of the immunosuppressive Tumor Microenvironment in Pancreatic Cancer. Cancer Discov. 2023;13(2):278\u201397.","journal-title":"Cancer Discov"},{"issue":"3","key":"254_CR27","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1158\/2159-8290.CD-19-0958","volume":"10","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, et al. Regulatory T-cell depletion alters the Tumor Microenvironment and accelerates pancreatic carcinogenesis. Cancer Discov. 2020;10(3):422\u201339.","journal-title":"Cancer Discov"},{"issue":"4","key":"254_CR28","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1158\/2159-8290.CD-17-1134","volume":"8","author":"S Pushalkar","year":"2018","unstructured":"Pushalkar S, et al. The pancreatic Cancer Microbiome promotes oncogenesis by induction of Innate and Adaptive Immune suppression. Cancer Discov. 2018;8(4):403\u201316.","journal-title":"Cancer Discov"},{"issue":"1","key":"254_CR29","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/hep.32099","volume":"75","author":"Y Lin","year":"2022","unstructured":"Lin Y, et al. CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5-lipoxygenase. Hepatology. 2022;75(1):28\u201342.","journal-title":"Hepatology"},{"issue":"5","key":"254_CR30","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.ccell.2023.04.001","volume":"41","author":"M Piper","year":"2023","unstructured":"Piper M, et al. Simultaneous targeting of PD-1 and IL-2R\u03b2\u03b3 with radiation therapy inhibits pancreatic cancer growth and metastasis. Cancer Cell. 2023;41(5):950\u2013e696.","journal-title":"Cancer Cell"},{"issue":"1","key":"254_CR31","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12943-021-01428-1","volume":"20","author":"X Mao","year":"2021","unstructured":"Mao X, et al. Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives. Mol Cancer. 2021;20(1):131.","journal-title":"Mol Cancer"},{"key":"254_CR32","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.cytogfr.2022.09.001","volume":"68","author":"T Luong","year":"2022","unstructured":"Luong T, et al. Fibroblast heterogeneity in pancreatic ductal adenocarcinoma: perspectives in immunotherapy. Cytokine Growth Factor Rev. 2022;68:107\u201315.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2","key":"254_CR33","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.ccell.2022.01.001","volume":"40","author":"S Kumagai","year":"2022","unstructured":"Kumagai S, et al. Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments. Cancer Cell. 2022;40(2):201\u2013. \u2013\u200918.e9.","journal-title":"Cancer Cell"},{"issue":"5","key":"254_CR34","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/j.jcmgh.2022.07.008","volume":"14","author":"S Wu","year":"2022","unstructured":"Wu S, et al. Hyperglycemia enhances immunosuppression and aerobic glycolysis of pancreatic Cancer through Upregulating Bmi1-UPF1-HK2 pathway. Cell Mol Gastroenterol Hepatol. 2022;14(5):1146\u201365.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"4","key":"254_CR35","doi-asserted-by":"publisher","first-page":"2002746","DOI":"10.1002\/advs.202002746","volume":"8","author":"F Sun","year":"2021","unstructured":"Sun F, et al. Regulating glucose metabolism with Prodrug nanoparticles for promoting photoimmunotherapy of pancreatic Cancer. Adv Sci (Weinh). 2021;8(4):2002746.","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"254_CR36","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41421-023-00529-z","volume":"9","author":"GQ Zhu","year":"2023","unstructured":"Zhu GQ, et al. CD36(+) cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor. Cell Discov. 2023;9(1):25.","journal-title":"Cell Discov"},{"issue":"1","key":"254_CR37","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/s41421-021-00271-4","volume":"7","author":"Y Wang","year":"2021","unstructured":"Wang Y, et al. Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response. Cell Discov. 2021;7(1):36.","journal-title":"Cell Discov"},{"issue":"1","key":"254_CR38","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1038\/s41467-024-46504-4","volume":"15","author":"MT Broz","year":"2024","unstructured":"Broz MT, et al. Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas. Nat Commun. 2024;15(1):2498.","journal-title":"Nat Commun"},{"issue":"7","key":"254_CR39","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1016\/j.ajpath.2019.04.007","volume":"189","author":"M Li","year":"2019","unstructured":"Li M, et al. Membrane metalloendopeptidase (MME) suppresses metastasis of esophageal squamous cell carcinoma (ESCC) by inhibiting FAK-RhoA Signaling Axis. Am J Pathol. 2019;189(7):1462\u201372.","journal-title":"Am J Pathol"},{"issue":"6","key":"254_CR40","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.jacc.2016.04.060","volume":"68","author":"A Bayes-Genis","year":"2016","unstructured":"Bayes-Genis A, et al. A test in Context: Neprilysin: function, inhibition, and Biomarker. J Am Coll Cardiol. 2016;68(6):639\u201353.","journal-title":"J Am Coll Cardiol"},{"issue":"22","key":"254_CR41","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1016\/j.neuron.2023.08.012","volume":"111","author":"E Kim","year":"2023","unstructured":"Kim E, et al. Irisin reduces amyloid-\u03b2 by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling. Neuron. 2023;111(22):3619\u2013e338.","journal-title":"Neuron"},{"issue":"6","key":"254_CR42","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1002\/ejhf.799","volume":"19","author":"E D\u2019Elia","year":"2017","unstructured":"D\u2019Elia E, et al. Neprilysin inhibition in heart failure: mechanisms and substrates beyond modulating natriuretic peptides. Eur J Heart Fail. 2017;19(6):710\u20137.","journal-title":"Eur J Heart Fail"},{"issue":"7","key":"254_CR43","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1007\/s00125-019-4889-y","volume":"62","author":"N Esser","year":"2019","unstructured":"Esser N, et al. Neprilysin inhibition: a new therapeutic option for type 2 diabetes? Diabetologia. 2019;62(7):1113\u201322.","journal-title":"Diabetologia"},{"issue":"1","key":"254_CR44","doi-asserted-by":"publisher","first-page":"4294","DOI":"10.1038\/s41467-023-39762-1","volume":"14","author":"L Cords","year":"2023","unstructured":"Cords L, et al. Cancer-associated fibroblast classification in single-cell and spatial proteomics data. Nat Commun. 2023;14(1):4294.","journal-title":"Nat Commun"},{"issue":"3","key":"254_CR45","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.ccell.2023.12.021","volume":"42","author":"L Cords","year":"2024","unstructured":"Cords L, et al. Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer. Cancer Cell. 2024;42(3):396\u2013e4125.","journal-title":"Cancer Cell"},{"issue":"11","key":"254_CR46","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1101\/gr.239244.118","volume":"28","author":"A Mayakonda","year":"2018","unstructured":"Mayakonda A, et al. Maftools: efficient and comprehensive analysis of somatic variants in cancer. Genome Res. 2018;28(11):1747\u201356.","journal-title":"Genome Res"},{"issue":"4","key":"254_CR47","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.cell.2018.01.009","volume":"172","author":"S Su","year":"2018","unstructured":"Su S, et al. CD10(+)GPR77(+) Cancer-Associated fibroblasts promote Cancer formation and chemoresistance by sustaining Cancer Stemness. Cell. 2018;172(4):841\u2013e5616.","journal-title":"Cell"},{"issue":"25","key":"254_CR48","doi-asserted-by":"publisher","first-page":"6119","DOI":"10.1016\/j.cell.2021.11.017","volume":"184","author":"S Raghavan","year":"2021","unstructured":"Raghavan S, et al. Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer. Cell. 2021;184(25):6119\u2013e3726.","journal-title":"Cell"},{"issue":"3","key":"254_CR49","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","volume":"20","author":"E Sahai","year":"2020","unstructured":"Sahai E, et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 2020;20(3):174\u201386.","journal-title":"Nat Rev Cancer"},{"key":"254_CR50","doi-asserted-by":"publisher","first-page":"100960","DOI":"10.1016\/j.drup.2023.100960","volume":"68","author":"R Qi","year":"2023","unstructured":"Qi R, et al. Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs. Drug Resist Updat. 2023;68:100960.","journal-title":"Drug Resist Updat"},{"issue":"3","key":"254_CR51","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1084\/jem.20162024","volume":"214","author":"D \u00d6hlund","year":"2017","unstructured":"\u00d6hlund D, et al. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med. 2017;214(3):579\u201396.","journal-title":"J Exp Med"},{"issue":"1","key":"254_CR52","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12943-022-01501-3","volume":"21","author":"C Hu","year":"2022","unstructured":"Hu C, et al. circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF\/STAT3 axis. Mol Cancer. 2022;21(1):24.","journal-title":"Mol Cancer"},{"issue":"1","key":"254_CR53","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12943-020-01168-8","volume":"19","author":"H Zhang","year":"2020","unstructured":"Zhang H, et al. CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer. Mol Cancer. 2020;19(1):43.","journal-title":"Mol Cancer"},{"issue":"14","key":"254_CR54","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.7150\/thno.25541","volume":"8","author":"J Ren","year":"2018","unstructured":"Ren J, et al. Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19. Theranostics. 2018;8(14):3932\u201348.","journal-title":"Theranostics"},{"issue":"5","key":"254_CR55","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.trecan.2023.01.007","volume":"9","author":"L Arpinati","year":"2023","unstructured":"Arpinati L, et al. From gatekeepers to providers: regulation of immune functions by cancer-associated fibroblasts. Trends Cancer. 2023;9(5):421\u201343.","journal-title":"Trends Cancer"},{"issue":"4","key":"254_CR56","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41568-023-00549-7","volume":"23","author":"M Tsoumakidou","year":"2023","unstructured":"Tsoumakidou M. The advent of immune stimulating CAFs in cancer. Nat Rev Cancer. 2023;23(4):258\u201369.","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"254_CR57","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1053\/j.gastro.2022.07.076","volume":"163","author":"J Datta","year":"2022","unstructured":"Datta J, et al. Combined MEK and STAT3 inhibition uncovers stromal plasticity by enriching for Cancer-Associated fibroblasts with mesenchymal stem cell-like features to overcome Immunotherapy Resistance in Pancreatic Cancer. Gastroenterology. 2022;163(6):1593\u2013612.","journal-title":"Gastroenterology"},{"issue":"4","key":"254_CR58","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1158\/1078-0432.CCR-11-0383","volume":"18","author":"C Desmedt","year":"2012","unstructured":"Desmedt C, et al. Characterization and clinical evaluation of CD10\u2009+\u2009stroma cells in the breast cancer microenvironment. Clin cancer Research: Official J Am Association Cancer Res. 2012;18(4):1004\u201314.","journal-title":"Clin cancer Research: Official J Am Association Cancer Res"},{"issue":"9","key":"254_CR59","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1245\/s10434-015-4374-x","volume":"22","author":"K Kadota","year":"2015","unstructured":"Kadota K, et al. Tumoral CD10 expression correlates with aggressive histology and prognosis in patients with malignant pleural mesothelioma. Ann Surg Oncol. 2015;22(9):3136\u201343.","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"254_CR60","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1158\/0008-5472.CAN-06-3292","volume":"67","author":"M Winner","year":"2007","unstructured":"Winner M, et al. Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization. Cancer Res. 2007;67(1):186\u201393.","journal-title":"Cancer Res"},{"key":"254_CR61","doi-asserted-by":"publisher","first-page":"1028070","DOI":"10.3389\/fonc.2022.1028070","volume":"12","author":"H Sun","year":"2022","unstructured":"Sun H, et al. MIF promotes cell invasion by the LRP1-uPAR interaction in pancreatic cancer cells. Front Oncol. 2022;12:1028070.","journal-title":"Front Oncol"},{"key":"254_CR62","doi-asserted-by":"publisher","first-page":"40524","DOI":"10.1038\/srep40524","volume":"7","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, et al. Adrenomedullin promotes angiogenesis in epithelial ovarian cancer through upregulating hypoxia-inducible factor-1\u03b1 and vascular endothelial growth factor. Sci Rep. 2017;7:40524.","journal-title":"Sci Rep"},{"issue":"1","key":"254_CR63","doi-asserted-by":"publisher","first-page":"11127","DOI":"10.1038\/s41598-017-11769-x","volume":"7","author":"K Baba","year":"2017","unstructured":"Baba K, et al. Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines. Sci Rep. 2017;7(1):11127.","journal-title":"Sci Rep"},{"issue":"1","key":"254_CR64","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.canlet.2005.03.010","volume":"233","author":"H Shi","year":"2006","unstructured":"Shi H, et al. Transfection of mouse macrophage metalloelastase gene into murine CT-26 colon cancer cells suppresses orthotopic tumor growth, angiogenesis and vascular endothelial growth factor expression. Cancer Lett. 2006;233(1):139\u201350.","journal-title":"Cancer Lett"},{"key":"254_CR65","doi-asserted-by":"crossref","unstructured":"Bhattacharyya S et al. Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer. J Exp Med. 2020;217(8).","DOI":"10.1084\/jem.20191805"},{"issue":"8","key":"254_CR66","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1038\/s43018-022-00426-6","volume":"3","author":"M Yuan","year":"2022","unstructured":"Yuan M, et al. Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth. Nat Cancer. 2022;3(8):945\u201360.","journal-title":"Nat Cancer"}],"container-title":["Biological Procedures Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12575-024-00254-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12575-024-00254-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12575-024-00254-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T09:01:47Z","timestamp":1727514107000},"score":1,"resource":{"primary":{"URL":"https:\/\/biologicalproceduresonline.biomedcentral.com\/articles\/10.1186\/s12575-024-00254-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,28]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["254"],"URL":"https:\/\/doi.org\/10.1186\/s12575-024-00254-1","relation":{},"ISSN":["1480-9222"],"issn-type":[{"value":"1480-9222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,28]]},"assertion":[{"value":"17 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Cancer Institute of Tianjin Medical University and the Hospital Ethics Committee (bc20240074) approved the use of all samples and participants\u2019 information. Animal procedures were performed in accordance with the Ethics Committee of the Tianjin Medical University Cancer Institute and Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors declare their agreement for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"29"}}