{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:48:15Z","timestamp":1791776895795,"version":"4.3.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":93,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Innovation Special Fund of Ruian Science and Technology Bureau","award":["MS2024001"],"award-info":[{"award-number":["MS2024001"]}]},{"name":"Innovation Special Fund of Ruian Science and Technology Bureau","award":["MS2024001"],"award-info":[{"award-number":["MS2024001"]}]},{"name":"Innovation Special Fund of Ruian Science and Technology Bureau","award":["MS2024001"],"award-info":[{"award-number":["MS2024001"]}]},{"name":"Innovation Special Fund of Ruian Science and Technology Bureau","award":["MS2024001"],"award-info":[{"award-number":["MS2024001"]}]},{"name":"Innovation Special Fund of Ruian Science and Technology Bureau","award":["MS2024001"],"award-info":[{"award-number":["MS2024001"]}]},{"name":"Innovation Special Fund of Ruian Science and Technology Bureau","award":["MS2024001"],"award-info":[{"award-number":["MS2024001"]}]},{"name":"Innovation Special Fund of Ruian Science and Technology Bureau","award":["MS2024001"],"award-info":[{"award-number":["MS2024001"]}]},{"name":"Innovation Special Fund of Ruian Science and Technology Bureau","award":["MS2024001"],"award-info":[{"award-number":["MS2024001"]}]},{"name":"Innovation Special Fund of Ruian Science and Technology Bureau","award":["MS2024001"],"award-info":[{"award-number":["MS2024001"]}]},{"name":"Medical and Health Science Program of Zhejiang Province","award":["2025HY1115"],"award-info":[{"award-number":["2025HY1115"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Proced Online"],"DOI":"10.1186\/s12575-026-00351-3","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:14:55Z","timestamp":1783757695000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Expression of SAMM50 Indicates Poor Clinical Prognosis in Hepatocellular Carcinoma and Represents a Potential Novel Biomarker"],"prefix":"10.1186","volume":"28","author":[{"given":"Huawei","family":"Zhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banglian","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenmiao","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-9760","authenticated-orcid":false,"given":"Jinhai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"key":"351_CR1","doi-asserted-by":"crossref","unstructured":"Rui T, Zhang X, Guo J, Xiang A, Tang N, Liu J et al. Serum-Exosome-Derived miRNAs Serve as Promising Biomarkers for HCC Diagnosis. Cancers (Basel). 2022;15(1):205.","DOI":"10.3390\/cancers15010205"},{"issue":"2","key":"351_CR2","doi-asserted-by":"publisher","first-page":"e307","DOI":"10.1002\/ctm2.307","volume":"11","author":"F Qian","year":"2021","unstructured":"Qian F, Wang J, Wang Y, Gao Q, Yan W, Lin Y, et al. MiR-378a-3p as a putative biomarker for hepatocellular carcinoma diagnosis and prognosis: Computational screening with experimental validation. Clin Transl Med. 2021;11(2):e307.","journal-title":"Clin Transl Med"},{"issue":"2","key":"351_CR3","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3350\/cmh.2023.0426","volume":"30","author":"M Sogbe","year":"2024","unstructured":"Sogbe M, Bilbao I, Marchese FP, Zazpe J, De Vito A, Pozuelo M, et al. Prognostic value of ultra-low-pass whole-genome sequencing of circulating tumor DNA in hepatocellular carcinoma under systemic treatment. Clin Mol Hepatol. 2024;30(2):177\u201390.","journal-title":"Clin Mol Hepatol"},{"issue":"29","key":"351_CR4","doi-asserted-by":"publisher","first-page":"48169","DOI":"10.18632\/oncotarget.18327","volume":"8","author":"W Guo","year":"2017","unstructured":"Guo W, Zhang J, Zhang D, Cao S, Li G, Zhang S, et al. Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma. Oncotarget. 2017;8(29):48169\u201377.","journal-title":"Oncotarget"},{"issue":"4","key":"351_CR5","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1136\/gutjnl-2020-322526","volume":"70","author":"X Wang","year":"2021","unstructured":"Wang X, He Y, Mackowiak B, Gao B. MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases. Gut. 2021;70(4):784\u201395.","journal-title":"Gut"},{"issue":"1","key":"351_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2174\/0113892029308243240709073945","volume":"26","author":"IP Gudivada","year":"2025","unstructured":"Gudivada IP, Amajala KC. Integrative Bioinformatics Analysis for Targeting Hub Genes in Hepatocellular Carcinoma Treatment. Curr Genomics. 2025;26(1):48\u201380.","journal-title":"Curr Genomics"},{"key":"351_CR7","doi-asserted-by":"publisher","first-page":"e18761429310703","DOI":"10.2174\/0118761429310703240823045808","volume":"17","author":"B Sensi","year":"2024","unstructured":"Sensi B, Angelico R, Toti L, Conte L, Coppola A, Tisone G, et al. Mechanism, Potential, and Concerns of Immunotherapy for Hepatocellular Carcinoma and Liver Transplantation. Curr Mol Pharmacol. 2024;17:e18761429310703.","journal-title":"Curr Mol Pharmacol"},{"key":"351_CR8","first-page":"e18761429358008","volume":"17","author":"W Xu","year":"2024","unstructured":"Xu W, Liao S, Hu Y, Huang Y, Zhou J. Upregulation of miR-3130-5p Enhances Hepatocellular Carcinoma Growth by Suppressing Ferredoxin 1: miR-3130-5p Enhances HCC Growth via Inhibiting FDX1. Curr Mol Pharmacol. 2024;17:e18761429358008.","journal-title":"Curr Mol Pharmacol"},{"key":"351_CR9","doi-asserted-by":"publisher","first-page":"e18761429260902","DOI":"10.2174\/0118761429260902230925044009","volume":"17","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Gu J, Yu H, Chen F, Long C, Maihemuti M, et al. Screening and Identification of ESR1 as a Target of Icaritin in Hepatocellular Carcinoma: Evidence from Bibliometrics and Bioinformatic Analysis. Curr Mol Pharmacol. 2024;17:e18761429260902.","journal-title":"Curr Mol Pharmacol"},{"key":"351_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1472-6807-14-17","volume":"14","author":"CN Leettola","year":"2014","unstructured":"Leettola CN, Knight MJ, Cascio D, Hoffman S, Bowie JU. Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3. BMC Struct Biol. 2014;14:17.","journal-title":"BMC Struct Biol"},{"issue":"3","key":"351_CR11","doi-asserted-by":"publisher","first-page":"450","DOI":"10.2174\/0929867325666181009114445","volume":"27","author":"M Vincenzi","year":"2020","unstructured":"Vincenzi M, Mercurio FA, Leone M. Sam Domains in Multiple Diseases. Curr Med Chem. 2020;27(3):450\u201376.","journal-title":"Curr Med Chem"},{"issue":"5","key":"351_CR12","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1002\/hep.32471","volume":"76","author":"L Chen","year":"2022","unstructured":"Chen L, Dong J, Liao S, Wang S, Wu Z, Zuo M, et al. Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury. Hepatology. 2022;76(5):1389\u2013408.","journal-title":"Hepatology"},{"key":"351_CR13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","volume":"152","author":"Z Chen","year":"2020","unstructured":"Chen Z, Tian R, She Z, Cai J, Li H. Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease. Free Radic Biol Med. 2020;152:116\u201341.","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"351_CR14","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/cdd.2017.3","volume":"24","author":"V Chiusolo","year":"2017","unstructured":"Chiusolo V, Jacquemin G, Yonca Bassoy E, Vinet L, Liguori L, Walch M, et al. Granzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis. Cell Death Differ. 2017;24(4):747\u201358.","journal-title":"Cell Death Differ"},{"issue":"2","key":"351_CR15","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/ki.2015.122","volume":"88","author":"Z Bakey","year":"2015","unstructured":"Bakey Z, Bihoreau MT, Piedagnel R, Delestr\u00e9 L, Arnould C, de Villiers A, et al. The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes. Kidney Int. 2015;88(2):299\u2013310.","journal-title":"Kidney Int"},{"issue":"5","key":"351_CR16","doi-asserted-by":"publisher","first-page":"E94","DOI":"10.1002\/hep.32529","volume":"76","author":"Z Rao","year":"2022","unstructured":"Rao Z, Li F, Guan Z, Zhou H. Letter to the editor: Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury. Hepatology. 2022;76(5):E94\u20135.","journal-title":"Hepatology"},{"issue":"7","key":"351_CR17","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00439-013-1294-3","volume":"132","author":"T Kitamoto","year":"2013","unstructured":"Kitamoto T, Kitamoto A, Yoneda M, Hyogo H, Ochi H, Nakamura T, et al. Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan. Hum Genet. 2013;132(7):783\u201392.","journal-title":"Hum Genet"},{"issue":"1","key":"351_CR18","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1091\/mbc.e07-08-0796","volume":"19","author":"NC Chan","year":"2008","unstructured":"Chan NC, Lithgow T. The peripheral membrane subunits of the SAM complex function codependently in mitochondrial outer membrane biogenesis. Mol Biol Cell. 2008;19(1):126\u201336.","journal-title":"Mol Biol Cell"},{"issue":"6561","key":"351_CR19","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1126\/science.abh0704","volume":"373","author":"Q Wang","year":"2021","unstructured":"Wang Q, Guan Z, Qi L, Zhuang J, Wang C, Hong S, et al. Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex. Science. 2021;373(6561):1377\u201381.","journal-title":"Science"},{"issue":"9","key":"351_CR20","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.7150\/ijms.80488","volume":"20","author":"VB Kumar","year":"2023","unstructured":"Kumar VB, Lee CH, Su TC, Lin CC, Mohammedsaleh ZM, Yeh CM, et al. Prognostic and Clinical Implications of UNC13C expression in Hepatocellular Carcinoma Patients. Int J Med Sci. 2023;20(9):1235\u20139.","journal-title":"Int J Med Sci"},{"issue":"1","key":"351_CR21","doi-asserted-by":"publisher","first-page":"60","DOI":"10.5114\/pjp.2021.115662","volume":"73","author":"M Ko\u0142odziej-Rzepa","year":"2022","unstructured":"Ko\u0142odziej-Rzepa M, Biesaga B, S\u0142onina D, Mucha-Ma\u0142ecka A. Nanog expression in patients with squamous cell carcinoma of oropharynx in relation to immunohistochemical score. Pol J Pathol. 2022;73(1):60\u201371.","journal-title":"Pol J Pathol"},{"issue":"2","key":"351_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41419-023-05578-6","volume":"14","author":"Z Dong","year":"2023","unstructured":"Dong Z, Li J, Dai W, Yu D, Zhao Y, Liu S, et al. RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated \u03b2-catenin suppression. Cell Death Dis. 2023;14(2):89.","journal-title":"Cell Death Dis"},{"key":"351_CR23","doi-asserted-by":"crossref","unstructured":"Lin H, Han Q, Wang J, Zhong Z, Luo H, Hao Y et al. Methylation-Mediated Silencing of RBP7 Promotes Breast Cancer Progression through PPAR and PI3K\/AKT Pathway. J Oncol. 2022;2022:9039110.","DOI":"10.1155\/2022\/9039110"},{"key":"351_CR24","doi-asserted-by":"publisher","first-page":"111243","DOI":"10.1016\/j.cellsig.2024.111243","volume":"120","author":"J Li","year":"2024","unstructured":"Li J, Qian L, Ge M, Zhao J, Yang Y. hsa_circ_0000518 stimulates the malignant progression of hepatocellular carcinoma via regulating ITGA5 to activate the Warburg effect. Cell Signal. 2024;120:111243.","journal-title":"Cell Signal"},{"issue":"1","key":"351_CR25","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/s41418-019-0345-2","volume":"27","author":"J Tang","year":"2020","unstructured":"Tang J, Zhang K, Dong J, Yan C, Hu C, Ji H, et al. Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact. Cell Death Differ. 2020;27(1):146\u201360.","journal-title":"Cell Death Differ"},{"issue":"1","key":"351_CR26","doi-asserted-by":"publisher","first-page":"102406","DOI":"10.1016\/j.jceh.2024.102406","volume":"15","author":"A Koshy","year":"2025","unstructured":"Koshy A. Evolving Global Etiology of Hepatocellular Carcinoma (HCC): Insights and Trends for 2024. J Clin Exp Hepatol. 2025;15(1):102406.","journal-title":"J Clin Exp Hepatol"},{"key":"351_CR27","doi-asserted-by":"crossref","unstructured":"Kocjan J, Rydel M, Adamek M. Hepatocellular Carcinoma (HCC) Metastasis to the Diaphragm Muscle: A Systematic Review and Meta-Analysis of Case Reports. Cancers (Basel). 2024;16(17):3076.","DOI":"10.3390\/cancers16173076"},{"issue":"5","key":"351_CR28","first-page":"295","volume":"162","author":"M Cohen-Naftaly","year":"2023","unstructured":"Cohen-Naftaly M, Simon R, Lubezky N, Braun M, Khalaileh A, Safadi R, et al. [HCC TRANSPLANT CANDIDATES\u2019 SURVIVAL ON THE WAITING LIST - CAN ORGAN UTILIZATION BE IMPROVED?]. Harefuah. 2023;162(5):295\u20138.","journal-title":"Harefuah"},{"key":"351_CR29","doi-asserted-by":"crossref","unstructured":"Lu F, Ott C, Bista P, Lu X. Three-Dimensional Structure of Novel Liver Cancer Biomarker Liver Cancer-Specific Serine Protease Inhibitor Kazal (LC-SPIK) and Its Performance in Clinical Diagnosis of Hepatocellular Carcinoma (HCC). Diagnostics (Basel). 2024;14(7):725.","DOI":"10.3390\/diagnostics14070725"},{"issue":"10","key":"351_CR30","first-page":"e46576","volume":"15","author":"R Kwei-Nsoro","year":"2023","unstructured":"Kwei-Nsoro R, Attar B, Ojemolon PE, Annor EN, Go B. A Curious Case of Vanishing Hepatocellular Carcinoma (HCC). Cureus. 2023;15(10):e46576.","journal-title":"Cureus"},{"issue":"7","key":"351_CR31","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s11864-023-01098-9","volume":"24","author":"B Alawyia","year":"2023","unstructured":"Alawyia B, Constantinou C. Hepatocellular Carcinoma: a Narrative Review on Current Knowledge and Future Prospects. Curr Treat Options Oncol. 2023;24(7):711\u201324.","journal-title":"Curr Treat Options Oncol"},{"key":"351_CR32","doi-asserted-by":"crossref","unstructured":"Temraz S, Nassar F, Kreidieh F, Mukherji D, Shamseddine A, Nasr R. Hepatocellular Carcinoma Immunotherapy and the Potential Influence of Gut Microbiome. Int J Mol Sci. 2021;22(15):7800.","DOI":"10.3390\/ijms22157800"},{"issue":"5","key":"351_CR33","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.jhep.2024.12.030","volume":"82","author":"N Ganne-Carri\u00e9","year":"2025","unstructured":"Ganne-Carri\u00e9 N, Nahon P. Differences between hepatocellular carcinoma caused by alcohol and other aetiologies. J Hepatol. 2025;82(5):909\u201317.","journal-title":"J Hepatol"},{"key":"351_CR34","doi-asserted-by":"crossref","unstructured":"Nischalke HD, Schmalz F, Buch S, Fischer J, M\u00f6ller C, Matz-Soja M et al. Genetic Variation of SAMM50 Is Not an Independent Risk Factor for Alcoholic Hepatocellular Carcinoma in Caucasian Patients. Int J Mol Sci. 2022;23(23):15353.","DOI":"10.3390\/ijms232315353"},{"key":"351_CR35","doi-asserted-by":"publisher","first-page":"1464852","DOI":"10.3389\/fphar.2024.1464852","volume":"15","author":"X Li","year":"2024","unstructured":"Li X, Chen S, Shi Y, Wang Y, Wang X, Lin Q, et al. Transcription factor MEF2D regulates aberrant expression of ACSL3 and enhances sorafenib resistance by inhibiting ferroptosis in HCC. Front Pharmacol. 2024;15:1464852.","journal-title":"Front Pharmacol"},{"key":"351_CR36","doi-asserted-by":"crossref","unstructured":"Brozzetti S, Tancredi M, Bini S, De Lucia C, Antimi J, D\u2019Alterio C et al. HCC in the Era of Direct-Acting Antiviral Agents (DAAs): Surgical and Other Curative or Palliative Strategies in the Elderly. Cancers (Basel). 2021;13(12):3025.","DOI":"10.3390\/cancers13123025"},{"key":"351_CR37","unstructured":"Lee PC, Wu CJ, Hung YW, Lee CJ, Mon HC, Chi CT et al. Distinct gut microbiota but common metabolomic signatures between viral and MASLD HCC contribute to outcomes of combination immunotherapy. Hepatology. 2025;12(7):12543."},{"issue":"1","key":"351_CR38","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ajg.2022.10.002","volume":"24","author":"B Moudi","year":"2023","unstructured":"Moudi B, Mohades MR, Mahmoudzadeh-Sagheb H, Heidari Z. Immunohistochemical expression of CB1 receptors in the liver of patients with HBV related-HCC. Arab J Gastroenterol. 2023;24(1):34\u20139.","journal-title":"Arab J Gastroenterol"},{"issue":"1","key":"351_CR39","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41698-024-00545-6","volume":"8","author":"Y Wang","year":"2024","unstructured":"Wang Y, Zhao Z, Guo T, Wu T, Zhang M, Luo D, et al. SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis. NPJ Precis Oncol. 2024;8(1):58.","journal-title":"NPJ Precis Oncol"},{"issue":"1","key":"351_CR40","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1038\/s41598-024-52884-w","volume":"14","author":"BJB Beudeker","year":"2024","unstructured":"Beudeker BJB, Guha R, Stoyanova K, JNM IJ, de Man RA, Sprengers D, et al. Cryptogenic non-cirrhotic HCC: Clinical, prognostic and immunologic aspects of an emerging HCC etiology. Sci Rep. 2024;14(1):4302.","journal-title":"Sci Rep"},{"issue":"1","key":"351_CR41","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12575-023-00199-x","volume":"25","author":"B Tang","year":"2023","unstructured":"Tang B, Wang Y, Zhu J, Song J, Fang S, Weng Q, et al. TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC. Biol Proced Online. 2023;25(1):13.","journal-title":"Biol Proced Online"},{"key":"351_CR42","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cytogfr.2024.08.006","volume":"79","author":"B Yu","year":"2024","unstructured":"Yu B, Ma W. Biomarker discovery in hepatocellular carcinoma (HCC) for personalized treatment and enhanced prognosis. Cytokine Growth Factor Rev. 2024;79:29\u201338.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"351_CR43","doi-asserted-by":"publisher","first-page":"6451","DOI":"10.1038\/s41467-025-61448-z","volume":"16","author":"Z Lin","year":"2025","unstructured":"Lin Z, Liu X, Wang H, Li S, Miao Z, Yang J, et al. Androgen receptor promotes arachidonic acid metabolism and angiogenic microenvironment in AFP-negative hepatocellular carcinoma. Nat Commun. 2025;16(1):6451.","journal-title":"Nat Commun"},{"issue":"2","key":"351_CR44","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.cgh.2022.01.047","volume":"21","author":"N Tayob","year":"2023","unstructured":"Tayob N, Kanwal F, Alsarraj A, Hernaez R, El-Serag HB. The Performance of AFP, AFP-3, DCP as Biomarkers for Detection of Hepatocellular Carcinoma (HCC): A Phase 3 Biomarker Study in the United States. Clin Gastroenterol Hepatol. 2023;21(2):415\u2013e423414.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"8","key":"351_CR45","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1007\/s00259-022-05723-x","volume":"49","author":"S An","year":"2022","unstructured":"An S, Zhang D, Zhang Y, Wang C, Shi L, Wei W, et al. GPC3-targeted immunoPET imaging of hepatocellular carcinomas. Eur J Nucl Med Mol Imaging. 2022;49(8):2682\u201392.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"6","key":"351_CR46","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.7150\/thno.92672","volume":"14","author":"SMP Vadevoo","year":"2024","unstructured":"Vadevoo SMP, Kang Y, Gunassekaran GR, Lee SM, Park MS, Jo DG, et al. IL4 receptor targeting enables nab-paclitaxel to enhance reprogramming of M2-type macrophages into M1-like phenotype via ROS-HMGB1-TLR4 axis and inhibition of tumor growth and metastasis. Theranostics. 2024;14(6):2605\u201321.","journal-title":"Theranostics"}],"container-title":["Biological Procedures Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12575-026-00351-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12575-026-00351-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12575-026-00351-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:38:02Z","timestamp":1791776282000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12575-026-00351-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,11]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["351"],"URL":"https:\/\/doi.org\/10.1186\/s12575-026-00351-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9536726\/v1","asserted-by":"object"}]},"ISSN":["1480-9222"],"issn-type":[{"value":"1480-9222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,11]]},"assertion":[{"value":"27 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All aspects of this study were approved by the Research Ethics Committee of the Third Affiliated Hospital of Wenzhou Medical University.","order":1,"name":"Ethics","label":"Ethics Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"38"}}