{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:48:50Z","timestamp":1792064930803,"version":"4.4.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":89,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Specialized Department Construction for Traditional Chinese Medicine Strengths of Yueyang Hospital","award":["YW(2025-2026)-01-04"],"award-info":[{"award-number":["YW(2025-2026)-01-04"]}]},{"name":"Zhu Junfeng Traditional Chinese Medicine Inheritance and Innovation Studio of Shanghai","award":["2025CXGZS-16"],"award-info":[{"award-number":["2025CXGZS-16"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Proced Online"],"DOI":"10.1186\/s12575-026-00354-0","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T18:54:08Z","timestamp":1784400848000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Mechanisms of Ruangan Huayu Formula in Liver Cirrhosis: Network Pharmacology, Molecular Docking and Experimental Validation"],"prefix":"10.1186","volume":"28","author":[{"given":"Haina","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luming","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"issue":"7","key":"354_CR1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s00535-021-01788-x","volume":"56","author":"H Yoshiji","year":"2021","unstructured":"Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, et al. Evidence-based clinical practice guidelines for Liver Cirrhosis 2020. J Gastroenterol. 2021;56(7):593\u2013619. https:\/\/doi.org\/10.1007\/s00535-021-01788-x. Epub 20210707.","journal-title":"J Gastroenterol"},{"issue":"5","key":"354_CR2","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1515\/jtim-2025-0044","volume":"13","author":"M Ruan","year":"2025","unstructured":"Ruan M, Yin Y, Ning W, Zhang B, Lin H, Yu H, et al. Effect of bone marrow mononuclear cells therapy on long-term survival of patients with liver cirrhosis: A 10-year retrospective cohort study using propensity score matching. J Transl Int Med. 2025;13(5):424\u201335. https:\/\/doi.org\/10.1515\/jtim-2025-0044. Epub 2025\/10\/31.","journal-title":"J Transl Int Med"},{"issue":"6","key":"354_CR3","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/s41575-023-00759-2","volume":"20","author":"DQ Huang","year":"2023","unstructured":"Huang DQ, Terrault NA, Tacke F, Gluud LL, Arrese M, Bugianesi E, et al. Global epidemiology of cirrhosis - aetiology, trends and predictions. Nat reviews Gastroenterol Hepatol. 2023;20(6):388\u201398. https:\/\/doi.org\/10.1038\/s41575-023-00759-2. Epub 20230328.","journal-title":"Nat reviews Gastroenterol Hepatol"},{"key":"354_CR4","doi-asserted-by":"publisher","unstructured":"Gin\u00e8s P, Krag A, Abraldes JG, Sol\u00e0 E, Fabrellas N, Kamath PS. Liver cirrhosis. Lancet (London, England). 2021;398(10308):1359-76. Epub 20210917. https:\/\/doi.org\/10.1016\/s0140-6736(21)01374-x. PubMed PMID: 34543610.","DOI":"10.1016\/s0140-6736(21)01374-x"},{"key":"354_CR5","doi-asserted-by":"publisher","first-page":"115550","DOI":"10.1016\/j.jep.2022.115550","volume":"297","author":"C Wei","year":"2022","unstructured":"Wei C, Qiu J, Wu Y, Chen Z, Yu Z, Huang Z, et al. Promising traditional Chinese medicine for the treatment of cholestatic liver disease process (cholestasis, hepatitis, liver fibrosis, liver cirrhosis). J Ethnopharmacol. 2022;297:115550. https:\/\/doi.org\/10.1016\/j.jep.2022.115550. Epub 2022\/07\/22.","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"354_CR6","doi-asserted-by":"publisher","first-page":"e0211525","DOI":"10.1128\/spectrum.02115-25","volume":"14","author":"Y Ma","year":"2026","unstructured":"Ma Y, Zhao H, Liu Y, Meng M, Chen J, Sun Y, et al. Compound Biejia-Ruangan tablets activate the STING-TBK1 pathway to alleviate hepatic fibrosis in alveolar echinococcosis. Microbiol Spectr. 2026;14(6):e0211525. https:\/\/doi.org\/10.1128\/spectrum.02115-25. Epub 2026\/04\/21.","journal-title":"Microbiol Spectr"},{"issue":"2","key":"354_CR7","doi-asserted-by":"publisher","first-page":"e70366","DOI":"10.1002\/jssc.70366","volume":"49","author":"H Li","year":"2026","unstructured":"Li H, Ma T, Jin G, Guan S, Li J, Huang P, et al. An Integrated UHPLC-Q-Orbitrap-MS\/MS and In Vitro Gastrointestinal Simulation Strategy for Characterizing the Chemical Constituents and Metabolites of Shaoyao RuanGan Decoction. J Sep Sci. 2026;49(2):e70366. https:\/\/doi.org\/10.1002\/jssc.70366. Epub 2026\/02\/12.","journal-title":"J Sep Sci"},{"key":"354_CR8","doi-asserted-by":"publisher","first-page":"157434","DOI":"10.1016\/j.phymed.2025.157434","volume":"148","author":"X Zhu","year":"2025","unstructured":"Zhu X, Zhang J, Zhou Z, Liangpunsakul S, Wang J, Ge G, et al. Huangjia Ruangan granules with entecavir for fibrosis regression in Chroinc Hepatitis B: A multicenter, randomized, double-blind, phase II trial. Phytomedicine. 2025;148:157434. https:\/\/doi.org\/10.1016\/j.phymed.2025.157434. Epub 2025\/10\/26.","journal-title":"Phytomedicine"},{"key":"354_CR9","doi-asserted-by":"publisher","first-page":"754807","DOI":"10.3389\/fphar.2021.754807","volume":"12","author":"X Shang","year":"2021","unstructured":"Shang X, Yuan H, Dai L, Liu Y, He J, Chen H, et al. Anti-Liver Fibrosis Activity and the Potential Mode of Action of Ruangan Granules: Integrated Network Pharmacology and Metabolomics. Front Pharmacol. 2021;12:754807. PubMed PMID: 35115923; PubMed Central PMCID: PMCPMC8805709.","journal-title":"Front Pharmacol"},{"key":"354_CR10","doi-asserted-by":"publisher","first-page":"121791","DOI":"10.1016\/j.jep.2026.121791","volume":"368","author":"Y Hu","year":"2026","unstructured":"Hu Y, Zhang Z, Liang Y, Tang E, Wang B, Liu W, et al. Fuzheng Huayu formula attenuates ductular reaction and liver fibrosis potentially through suppressing Gli1 pathway. J Ethnopharmacol. 2026;368:121791. https:\/\/doi.org\/10.1016\/j.jep.2026.121791. Epub 2026\/05\/14.","journal-title":"J Ethnopharmacol"},{"key":"354_CR11","doi-asserted-by":"publisher","first-page":"157586","DOI":"10.1016\/j.phymed.2025.157586","volume":"150","author":"F Ge","year":"2026","unstructured":"Ge F, Wang X, Li Z, Su G, Li L, Yu J, et al. Study on the anti-liver cirrhosis of Fuzheng Huayu tablet: Targeting macrophage PPAR\u03b1 axis-fatty acid metabolic. Phytomedicine. 2026;150:157586. https:\/\/doi.org\/10.1016\/j.phymed.2025.157586. Epub 2025\/12\/12.","journal-title":"Phytomedicine"},{"issue":"1","key":"354_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-026-01368-2","volume":"21","author":"Z Zhang","year":"2026","unstructured":"Zhang Z, Tang EQ, Li CH, Wang BB, Liang Y, Lv JX et al. Fuzheng Huayu formula ameliorates chronic cholestatic liver injury by upregulating PPARa in mice. Chin Med. 2026;21(1):93. Epub 2026\/03\/18. PubMed PMID: 41845391; PubMed Central PMCID: PMCPMC12998289. https:\/\/doi.org\/10.1186\/s13020-026-01368-2.","journal-title":"Chin Med"},{"key":"354_CR13","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9719872","volume":"2020","author":"P Xia","year":"2020","unstructured":"Xia P, Gao K, Xie J, Sun W, Shi M, Li W et al. Data Mining-Based Analysis of Chinese Medicinal Herb Formulae in Chronic Kidney Disease Treatment. Evid Based Complement Alternat Med. 2020;22020:9719872. Epub 2020\/02\/13. https:\/\/doi.org\/10.1155\/2020\/9719872.","journal-title":"Evid Based Complement Alternat Med"},{"key":"354_CR14","doi-asserted-by":"publisher","first-page":"9079","DOI":"10.2147\/dddt.S533551","volume":"19","author":"L Jin","year":"2025","unstructured":"Jin L, Chen M, Lou J, Fu J, Bai N, Liu X, et al. FAK-Induced Time Dependent Cell Response Profiling: Prediction, Identification, and Analysis of Anti-Tumor Immune Natural Products. Drug Des Devel Ther. 2025;19:9079\u201397. https:\/\/doi.org\/10.2147\/dddt.S533551. Epub 2025\/10\/13.","journal-title":"Drug Des Devel Ther"},{"key":"354_CR15","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5489215","author":"GK Feng","year":"2018","unstructured":"Feng GK, Ma XJ, Chen YY, Bian GR, Yang C, Gu BD. Effects of Chailong Jieyu Pill on Behavior, Monoamine Neurotransmitters, and Corticosteroid Receptors in a Rat Model of Anxiety Disorder. Evid Based Complement Alternat Med. 2018. https:\/\/doi.org\/10.1155\/2018\/5489215. 2018:5489215. Epub 2018\/06\/30.","journal-title":"Evid Based Complement Alternat Med"},{"key":"354_CR16","doi-asserted-by":"publisher","first-page":"103590","DOI":"10.1016\/j.fochx.2026.103590","volume":"34","author":"X Cai","year":"2026","unstructured":"Cai X, Chen L, Li W, Wang H, Sun Y, Xue X, et al. Effects of steam processing conditions on the aroma and dryness-like effect of Citri Sarcodactylis fructus(FoShou tea). Food Chem X. 2026;34:103590. PubMed PMID: 41674693; PubMed Central PMCID: PMCPMC12887779.","journal-title":"Food Chem X"},{"key":"354_CR17","doi-asserted-by":"publisher","first-page":"155915","DOI":"10.1016\/j.phymed.2024.155915","volume":"135","author":"C Jia","year":"2024","unstructured":"Jia C, Wu H, Yang A, Chen A, Wang X, Ding S, et al. Mechanism Research of QingReJieDu Formula for Treating Hepatitis B Virus Based on Network Pharmacology. Phytomedicine. 2024;135:155915. https:\/\/doi.org\/10.1016\/j.phymed.2024.155915. Epub 20240810.","journal-title":"Phytomedicine"},{"issue":"1","key":"354_CR18","doi-asserted-by":"publisher","first-page":"bbad518","DOI":"10.1093\/bib\/bbad518","volume":"25","author":"P Zhang","year":"2023","unstructured":"Zhang P, Zhang D, Zhou W, Wang L, Wang B, Zhang T, et al. Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine. Brief Bioinform. 2023;25(1):bbad518. PubMed PMID: 38197310; PubMed Central PMCID: PMCPMC10777171 https:\/\/doi.org\/10.1093\/bib\/bbad518","journal-title":"Brief Bioinform"},{"key":"354_CR19","doi-asserted-by":"publisher","unstructured":"Mu D, Chen B, Liu X, Zheng S, Zhang Y, Ni H, et al. Exploring the potential mechanisms of Da ChaiHu decoction against pancreatic cancer based on network pharmacology prediction and molecular docking approach. Naunyn Schmiedebergs Arch Pharmacol. 2025;398(10):14099-114. Epub 20250423. PubMed PMID: 40266298. https:\/\/doi.org\/10.1007\/s00210-025-04107-w","DOI":"10.1007\/s00210-025-04107-w"},{"issue":"2","key":"354_CR20","first-page":"99","volume":"33","author":"C Cao","year":"2023","unstructured":"Cao C, Li L, Zi M, Fu J, Ren J, Li L, et al. Methods for determining animal sample sizes in medical experimental studies. Chin J Comp Med. 2023;33(2):99\u2013105.","journal-title":"Chin J Comp Med"},{"issue":"11","key":"354_CR21","doi-asserted-by":"publisher","first-page":"905","DOI":"10.14218\/jcth.2025.00237","volume":"13","author":"Y Ding","year":"2025","unstructured":"Ding Y, Huang C, Yang G, Liu E, Wang Z, Su Y, et al. Inflammation and Mitochondrial Dysfunction in Cirrhotic Cardiomyopathy: Therapeutic Implications. J Clin Transl Hepatol. 2025;13(11):905\u201317. https:\/\/doi.org\/10.14218\/jcth.2025.00237. Epub 20251020.","journal-title":"J Clin Transl Hepatol"},{"key":"354_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6280265","volume":"2022","author":"Y Han","year":"2022","unstructured":"Han Y, Zhou Y, Shan T, Li W, Liu H. Immunomodulatory Effect of Lycium barbarum Polysaccharides against Liver Fibrosis Based on the Intelligent Medical Internet of Things. J Healthc Eng. 2022;2022:6280265. Epub 20220125. 10.1155\/2022\/6280265 PubMed PMID: 35126934; PubMed Central PMCID: PMCPMC8808186. https:\/\/doi.org\/10.1155\/2022\/6280265","journal-title":"J Healthc Eng"},{"issue":"1","key":"354_CR23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s10020-022-00460-1","volume":"28","author":"S Liu","year":"2022","unstructured":"Liu S, Han D, Xu C, Yang F, Li Y, Zhang K, et al. Antibody-drug conjugates targeting CD248 inhibits liver fibrosis through specific killing on myofibroblasts. Mol Med. 2022;28(1):37. https:\/\/doi.org\/10.1186\/s10020-022-00460-1. Epub 20220322.","journal-title":"Mol Med"},{"key":"354_CR24","doi-asserted-by":"publisher","first-page":"856484","DOI":"10.3389\/fnut.2022.856484","volume":"9","author":"T Shoko","year":"2022","unstructured":"Shoko T, Manhivi VE, Mtlhako M, Sivakumar D. Changes in Functional Compounds, Volatiles, and Antioxidant Properties of Culinary Herb Coriander Leaves (Coriandrum sativum) Stored Under Red and Blue LED Light for Different Storage Times. Front Nutr. 2022;9:856484. PubMed PMID: 35634386; PubMed Central PMCID: PMCPMC9134111.","journal-title":"Front Nutr"},{"key":"354_CR25","doi-asserted-by":"publisher","first-page":"115682","DOI":"10.1016\/j.foodres.2025.115682","volume":"203","author":"H Wei","year":"2025","unstructured":"Wei H, Rui J, Yan X, Xu R, Chen S, Zhang B, et al. Plant polyphenols as natural bioactives for alleviating lipid metabolism disorder: Mechanisms and application challenges. Food Res Int. 2025;203:115682. https:\/\/doi.org\/10.1016\/j.foodres.2025.115682.","journal-title":"Food Res Int"},{"issue":"10","key":"354_CR26","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1002\/ptr.4897","volume":"27","author":"NG Sahib","year":"2013","unstructured":"Sahib NG, Anwar F, Gilani AH, Hamid AA, Saari N, Alkharfy KM. Coriander (Coriandrum sativum L.): a potential source of high-value components for functional foods and nutraceuticals\u2013a review. Phytother Res. 2013;27(10):1439\u201356. https:\/\/doi.org\/10.1002\/ptr.4897. Epub 20121219.","journal-title":"Phytother Res"},{"key":"354_CR27","doi-asserted-by":"publisher","first-page":"154622","DOI":"10.1016\/j.phymed.2022.154622","volume":"110","author":"F Yang","year":"2023","unstructured":"Yang F, Hou R, Liu X, Tian Y, Bai Y, Li J, et al. Yangqing Chenfei formula attenuates silica-induced pulmonary fibrosis by suppressing activation of fibroblast via regulating PI3K\/AKT, JAK\/STAT, and Wnt signaling pathway. Phytomedicine. 2023;110:154622. https:\/\/doi.org\/10.1016\/j.phymed.2022.154622. Epub 2022\/12\/29.","journal-title":"Phytomedicine"},{"issue":"1","key":"354_CR28","doi-asserted-by":"publisher","first-page":"23496","DOI":"10.1038\/s41598-025-09206-5","volume":"15","author":"J Pan","year":"2025","unstructured":"Pan J. Integrated analyses to explore the mechanism of Gancao Renshen Zhixue Decoction in treating liver cirrhosis. Sci Rep. 2025;15(1):23496. https:\/\/doi.org\/10.1038\/s41598-025-09206-5. Epub 2025\/07\/03.","journal-title":"Sci Rep"},{"key":"354_CR29","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3389\/fphar.2018.00525","volume":"9","author":"X Xing","year":"2018","unstructured":"Xing X, Chen S, Li L, Cao Y, Chen L, Wang X, et al. The Active Components of Fuzheng Huayu Formula and Their Potential Mechanism of Action in Inhibiting the Hepatic Stellate Cells Viability - A Network Pharmacology and Transcriptomics Approach. Front Pharmacol. 2018;9:525. PubMed PMID: 29881350; PubMed Central PMCID: PMCPMC5976863.","journal-title":"Front Pharmacol"},{"issue":"1","key":"354_CR30","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13020-025-01220-z","volume":"20","author":"C Jin","year":"2025","unstructured":"Jin C, Ma T, Zhang Y, Gu X, Zhu T, Wu X, et al. Integration of network pharmacology, transcriptomics and single-cell sequencing to explore the effect of Rougan Keli in alleviating liver cirrhosis. Chin Med. 2025;20(1):153. https:\/\/doi.org\/10.1186\/s13020-025-01220-z. Epub 2025\/10\/03.","journal-title":"Chin Med"},{"key":"354_CR31","doi-asserted-by":"publisher","first-page":"119937","DOI":"10.1016\/j.jep.2025.119937","volume":"349","author":"H Xu","year":"2025","unstructured":"Xu H, Jiang N, Chen GF, He Y, Xiong JF, Chen DY, et al. Gan-tang-yi decoction improves hepatic insulin resistance through activation of IRS2\/PI3K\/Akt pathway and inhibition of AGEs\/RAGE pathway in cirrhotic rats. J Ethnopharmacol. 2025;349:119937. https:\/\/doi.org\/10.1016\/j.jep.2025.119937. Epub 2025\/05\/10.","journal-title":"J Ethnopharmacol"},{"key":"354_CR32","doi-asserted-by":"publisher","first-page":"125126","DOI":"10.1016\/j.jchromb.2026.125126","volume":"1280","author":"MC Wen","year":"2026","unstructured":"Wen MC, Li JY, Sun Q, Hu C, Ju S, Tian F, et al. Rougan Granules ameliorates liver fibrosis through autophagy regulation: Insights from HPLC-Q-TOF-MS\/MS, network pharmacology, and experimental validation. J Chromatogr B Analyt Technol Biomed Life Sci. 2026;1280:125126. https:\/\/doi.org\/10.1016\/j.jchromb.2026.125126. Epub 2026\/05\/18.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"354_CR33","doi-asserted-by":"publisher","unstructured":"Cheng X, Han ZX, Su ZJ, Zhang FL, Li BP, Jiang ZR et al. Network Pharmacology-Based Exploration on the Intervention of Qinghao Biejia Decoction on the Inflammation-Carcinoma Transformation Process of Chronic Liver Disease via MAPK and PI3k\/AKT Pathway. Biomed Res Int. 2022;2022:9202128. Epub 2022\/10\/25. https:\/\/doi.org\/10.1155\/2022\/9202128. PubMed PMID: 36277879; PubMed Central PMCID: PMCPMC9586778.","DOI":"10.1155\/2022\/9202128"},{"key":"354_CR34","doi-asserted-by":"publisher","first-page":"117886","DOI":"10.1016\/j.taap.2026.117886","volume":"513","author":"D Karabulut","year":"2026","unstructured":"Karabulut D, \u00c7etin A, Sayan M, \u00d6nal E, De\u011fer N, Karag\u00f6z H, et al. Thymoquinone is effective in thioacetamide-induced liver damage via the RIP1\/RIP3\/MLKL axis. Toxicol Appl Pharmacol. 2026;513:117886. https:\/\/doi.org\/10.1016\/j.taap.2026.117886. Epub 2026\/05\/26.","journal-title":"Toxicol Appl Pharmacol"},{"key":"354_CR35","doi-asserted-by":"publisher","unstructured":"Akk\u0131z H, Gieseler RK, Canbay A. Liver Fibrosis: From Basic Science towards Clinical Progress, Focusing on the Central Role of Hepatic Stellate Cells. Int J Mol Sci. 2024;25(14). https:\/\/doi.org\/10.3390\/ijms25147873. Epub 2024\/07\/27.","DOI":"10.3390\/ijms25147873"},{"key":"354_CR36","doi-asserted-by":"publisher","unstructured":"Zheng S, Chen A. Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro. Biochem J. 2004;384(Pt 1):149\u2009\u2013\u200957. https:\/\/doi.org\/10.1042\/bj20040928. PubMed PMID: 15320868; PubMed Central PMCID: PMCPMC1134098.","DOI":"10.1042\/bj20040928"},{"issue":"4","key":"354_CR37","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/s0002-9440\/10\/62324-3","volume":"166","author":"K Yoshida","year":"2005","unstructured":"Yoshida K, Matsuzaki K, Mori S, Tahashi Y, Yamagata H, Furukawa F, et al. Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2\/3 phosphorylation in rat hepatic stellate cells after acute liver injury. Am J Pathol. 2005;166(4):1029\u201339. https:\/\/doi.org\/10.1016\/s0002-9440\/10\/62324-3 . PubMed PMID: 15793284; PubMed Central PMCID: PMCPMC1602385.","journal-title":"Am J Pathol"},{"issue":"5","key":"354_CR38","doi-asserted-by":"publisher","first-page":"8863","DOI":"10.3390\/ijms15058863","volume":"15","author":"DS Lee","year":"2014","unstructured":"Lee DS, Kim KS, Ko W, Li B, Jeong GS, Jang JH, et al. The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2\/ARE and JNK\/ERK MAPK-mediated heme oxygenase-1 expression. Int J Mol Sci. 2014;15(5):8863\u201377. https:\/\/doi.org\/10.3390\/ijms15058863. Epub 20140519.","journal-title":"Int J Mol Sci"},{"key":"354_CR39","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.neuint.2014.04.016","volume":"74","author":"SH Kwon","year":"2014","unstructured":"Kwon SH, Ma SX, Lee SY, Jang CG. Sulfuretin inhibits 6-hydroxydopamine-induced neuronal cell death via reactive oxygen species-dependent mechanisms in human neuroblastoma SH-SY5Y cells. Neurochem Int. 2014;74:53\u201364. https:\/\/doi.org\/10.1016\/j.neuint.2014.04.016. Epub 2014\/05\/08.","journal-title":"Neurochem Int"},{"issue":"1","key":"354_CR40","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s13205-025-04641-7","volume":"16","author":"L Singh","year":"2026","unstructured":"Singh L, Kalia R, Sharma S, Singh A, Dalal D. Apigenin as a multifunctional flavone against liver fibrosis: mechanistic insights into its modulation of key fibrogenic signalling pathways. 3 Biotech. 2026;16(1):32. https:\/\/doi.org\/10.1007\/s13205-025-04641-7. Epub 2025\/12\/23.","journal-title":"3 Biotech"},{"key":"354_CR41","doi-asserted-by":"publisher","unstructured":"Wang X, Cao Y, Chen S, Yang X, Bian J, Huang D. Antioxidant and Anti-Inflammatory Effects of 6,3\u2019,4\u00b4- and 7,3\u00b4,4\u00b4-Trihydroxyflavone on 2D and 3D RAW264.7 Models. Antioxid (Basel). 2023;12(1). https:\/\/doi.org\/10.3390\/antiox12010204 . PubMed PMID: 36671068; PubMed Central PMCID: PMCPMC9855077. Epub 2023\/01\/22.","DOI":"10.3390\/antiox12010204"}],"container-title":["Biological Procedures Online"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12575-026-00354-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12575-026-00354-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12575-026-00354-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:57:50Z","timestamp":1792061870000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12575-026-00354-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["354"],"URL":"https:\/\/doi.org\/10.1186\/s12575-026-00354-0","relation":{},"ISSN":["1480-9222"],"issn-type":[{"value":"1480-9222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]},"assertion":[{"value":"14 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experimental protocols were approved by the Medical Ethics Committee of the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine (Approval Number: PZSHUTCM2409290005) and adhered to the ARRIVE guidelines 2.0.","order":1,"name":"Ethics","label":"Ethics Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"39"}}