{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T04:47:58Z","timestamp":1648529278233},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"science and technology project of honghuagang district, zunyi cit","award":["NO. Industrial Class (2016) 14"],"award-info":[{"award-number":["NO. Industrial Class (2016) 14"]}]},{"name":"bijzonder onderzoeksfonds","award":["NO. 51010106"],"award-info":[{"award-number":["NO. 51010106"]}]},{"DOI":"10.13039\/501100010580","name":"department of science and technology, hubei provincial people's government","doi-asserted-by":"crossref","award":["NO. C-662"],"award-info":[{"award-number":["NO. C-662"]}],"id":[{"id":"10.13039\/501100010580","id-type":"DOI","asserted-by":"crossref"}]},{"name":"guizhou provincial health department fund","award":["No. 20120424"],"award-info":[{"award-number":["No. 20120424"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Clin. Androl."],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The ischiocavernosus muscle (ICM) encompasses a pair of short pinnate muscles attached to the pelvic ring. The ICM begins at the ischial tuberosity and ends at the crus of the penis while covering the surface of the crus. According to the traditional view, the contraction of the ICM plays an auxiliary role in penile erection. However, we have previously shown that the ICM plays an important role in penile erection through an indirect method of diagnosing erectile dysfunction (ED) caused by ICM injury by observing the infertility of paired female rats. Since intracavernosal pressure (ICP) is the current gold standard for diagnosing ED, this study aimed to amputate unilaterally\/bilaterally the ICM to establish an ED model by detecting the ICP, recording the infertility of matching female rats, and comparing the two methods.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Forty sexually mature adult male rats were selected and randomly divided into the following groups: the control group (<jats:italic>n<\/jats:italic> = 10), sham operation group (<jats:italic>n<\/jats:italic> = 10), unilateral ischiocavernosus muscle (Uni-ICM) amputation group (<jats:italic>n<\/jats:italic> = 10), and bilateral ischiocavernosus muscle (Bi-ICM) amputation group (<jats:italic>n<\/jats:italic> = 10). Eighty female reproductive rats were randomly assigned to the above groups at a ratio of 2:1. We evaluated the time to conception for the paired female rats and the effects of unilateral\/bilateral severing of the ICM on erectile function. The results showed that the baseline and maximum intracavernosal pressure (ICP) in the control group, sham operation group, Uni-ICM amputation group, and Bi-ICM amputation group were 17.44\u00b12.50 mmHg and 93.51\u00b110.78 mmHg, 17.81\u00b12.81 mmHg and 95.07\u00b110.40 mmHg, 16.73\u00b12.11 mmHg and 83.49\u00b112.38 mmHg, and 14.78\u00b12.78 mmHg and 33.57\u00b16.72 mmHg, respectively, immediately postsurgery. The max ICP in the Bi-ICM amputation group was lower than that in the remaining three groups (all <jats:italic>P<\/jats:italic>&lt;0.05). The pregnancy rates were 100, 100, 90, and 0% in the control group, sham operation group, Uni-ICM amputation group, and the Bi-ICM amputation group, respectively. The pregnancy rate in the Bi-ICM amputation group was significantly lower than that in the remaining groups (all <jats:italic>P<\/jats:italic>&lt;0.05). The time to conception was approximately 7\u201310 days later in the Uni-ICM amputation group than in the control and sham groups (all <jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Male rats undergoing Bi-ICM amputation may develop permanent ED, which affects their fertility. In contrast, rats undergoing Uni-ICM amputation may experience transient ED.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12610-021-00151-7","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:10:47Z","timestamp":1641341447000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of unilateral\/bilateral amputation of the ischiocavernosus muscle in male rats on erectile function and conception"],"prefix":"10.1186","volume":"32","author":[{"given":"Chengren","family":"Gou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zidong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyi","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congcong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"151_CR1","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/j.1939-4640.2004.tb02810.x","volume":"25","author":"GL Hsu","year":"2004","unstructured":"Hsu GL, Hsieh CH, Wen HS, et al. 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The Animal Management Committee of Zunyi Medical University approved the present study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable for that section.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1"}}