{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:01:56Z","timestamp":1762376516043,"version":"3.37.3"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T00:00:00Z","timestamp":1552003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009329","name":"Scientific Research and Technology Development Program of Guangxi","doi-asserted-by":"crossref","award":["2016YFE0206600"],"award-info":[{"award-number":["2016YFE0206600"]}],"id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"crossref"}]},{"name":"13th Five-year Informatization Plan of Chinese Academy of Sciences","award":["XXH13505-05"],"award-info":[{"award-number":["XXH13505-05"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Evol Biol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12862-019-1400-9","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T13:03:09Z","timestamp":1552050189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene"],"prefix":"10.1186","volume":"19","author":[{"given":"Suman","family":"Seemab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nashaiman","family":"Pervaiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabail","family":"Zehra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saneela","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Ali","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,8]]},"reference":[{"issue":"7436","key":"1400_CR1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature11896","volume":"494","author":"A Venkatakrishnan","year":"2013","unstructured":"Venkatakrishnan A, Deupi X, Lebon G, Tate CG, Schertler GF, Babu MM. Molecular signatures of G-protein-coupled receptors. Nature. 2013;494(7436):185.","journal-title":"Nature"},{"issue":"1","key":"1400_CR2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1210\/me.2009-0473","volume":"24","author":"RP Millar","year":"2010","unstructured":"Millar RP, Newton CL. The year in G protein-coupled receptor research. Mol Endocrinol. 2010;24(1):261\u201374.","journal-title":"Mol Endocrinol"},{"issue":"1","key":"1400_CR3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/sj.embor.7400052","volume":"5","author":"S Terrillon","year":"2004","unstructured":"Terrillon S, Bouvier M. Roles of G-protein-coupled receptor dimerization: from ontogeny to signalling regulation. EMBO Rep. 2004;5(1):30\u20134.","journal-title":"EMBO Rep"},{"issue":"6","key":"1400_CR4","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1124\/mol.63.6.1256","volume":"63","author":"R Fredriksson","year":"2003","unstructured":"Fredriksson R, Lagerstr\u00f6m MC, Lundin L-G, Schi\u00f6th HB. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol. 2003;63(6):1256\u201372.","journal-title":"Mol Pharmacol"},{"key":"1400_CR5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.pharmtox.48.113006.094830","volume":"48","author":"AC Hanyaloglu","year":"2008","unstructured":"Hanyaloglu AC, Zastrow M. Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu Rev Pharmacol Toxicol. 2008;48:537\u201368.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"1400_CR6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev-pharmtox-032112-135923","volume":"53","author":"V Katritch","year":"2013","unstructured":"Katritch V, Cherezov V, Stevens RC. Structure-function of the G protein\u2013coupled receptor superfamily. Annu Rev Pharmacol Toxicol. 2013;53:531\u201356.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"6741","key":"1400_CR7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/22214","volume":"400","author":"M Peifer","year":"1999","unstructured":"Peifer M. Signal transduction: neither straight nor narrow. Nature. 1999;400(6741):213.","journal-title":"Nature"},{"issue":"3","key":"1400_CR8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.devcel.2006.02.010","volume":"10","author":"C-L Pan","year":"2006","unstructured":"Pan C-L, Howell JE, Clark SG, Hilliard M, Cordes S, Bargmann CI, Garriga G. Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans. Dev Cell. 2006;10(3):367\u201377.","journal-title":"Dev Cell"},{"issue":"7","key":"1400_CR9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/gb-2004-5-7-234","volume":"5","author":"H-C Huang","year":"2004","unstructured":"Huang H-C, Klein PS. The Frizzled family: receptors for multiple signal transduction pathways. Genome Biol. 2004;5(7):234.","journal-title":"Genome Biol"},{"key":"1400_CR10","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1136\/bjo.2010.190116","volume":"95","author":"JM Robitaille","year":"2010","unstructured":"Robitaille JM, Zheng B, Wallace K, Beis MJ, Tatlidil C, Yang J, Sheidow TG, Siebert L, Levin AV, Lam W-C. The role of Frizzled-4 mutations in familial exudative vitreoretinopathy and Coats disease. Br J Ophthalmol. 2010;95:574\u20139.","journal-title":"Br J Ophthalmol."},{"issue":"7","key":"1400_CR11","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1167\/iovs.03-1044","volume":"45","author":"C Toomes","year":"2004","unstructured":"Toomes C, Bottomley HM, Scott S, Mackey DA, Craig JE, Appukuttan B, Stout JT, Flaxel CJ, Zhang K, Black GC. Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2004;45(7):2083\u201390.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"1400_CR12","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1167\/iovs.14-13885","volume":"55","author":"RM Milhem","year":"2014","unstructured":"Milhem RM, Ben-Salem S, Al-Gazali L, Ali BR. Identification of the cellular mechanisms that modulate trafficking of frizzled family receptor 4 (FZD4) missense mutants associated with familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2014;55(6):3423\u201331.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1400_CR13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/bs.ctdb.2015.11.028","volume":"117","author":"Y Wang","year":"2016","unstructured":"Wang Y, Chang H, Rattner A, Nathans J. Frizzled receptors in development and disease. Curr Top Dev Biol. 2016;117:113\u20139.","journal-title":"Curr Top Dev Biol."},{"issue":"4","key":"1400_CR14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1586\/eop.12.40","volume":"7","author":"BS Shastry","year":"2012","unstructured":"Shastry BS. Genetics of familial exudative vitreoretinopathy and its implications for management. Expert Rev Ophthalmol. 2012;7(4):377\u201386.","journal-title":"Expert Rev Ophthalmol"},{"issue":"12","key":"1400_CR15","doi-asserted-by":"crossref","first-page":"a007880","DOI":"10.1101\/cshperspect.a007880","volume":"4","author":"BT MacDonald","year":"2012","unstructured":"MacDonald BT, He X. Frizzled and LRP5\/6 receptors for Wnt\/\u03b2-catenin signaling. Cold Spring Harb Perspect Biol. 2012;4(12):a007880.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"8","key":"1400_CR16","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/pro.2105","volume":"21","author":"J Pei","year":"2012","unstructured":"Pei J, Grishin NV. Cysteine-rich domains related to Frizzled receptors and Hedgehog-interacting proteins. Protein Sci. 2012;21(8):1172\u201384.","journal-title":"Protein Sci"},{"issue":"1","key":"1400_CR17","first-page":"20","volume":"33","author":"T Ramasarma","year":"1996","unstructured":"Ramasarma T. Transmembrane domains participate in functions of integral membrane proteins. Indian J Biochem Biophys. 1996;33(1):20\u20139.","journal-title":"Indian J Biochem Biophys"},{"issue":"7","key":"1400_CR18","doi-asserted-by":"crossref","first-page":"8579","DOI":"10.3390\/molecules18078579","volume":"18","author":"S Gayen","year":"2013","unstructured":"Gayen S, Li Q, Kim YM, Kang C. Structure of the C-terminal region of the Frizzled receptor 1 in detergent micelles. Molecules. 2013;18(7):8579\u201390.","journal-title":"Molecules"},{"issue":"14","key":"1400_CR19","doi-asserted-by":"crossref","first-page":"9359","DOI":"10.1074\/jbc.M707108200","volume":"283","author":"MH Magdesian","year":"2008","unstructured":"Magdesian MH, Carvalho MM, Mendes FA, Saraiva LM, Juliano MA, Juliano L, Garcia-Abreu J, Ferreira ST. Amyloid-\u03b2 binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt\/\u03b2-catenin signaling. J Biol Chem. 2008;283(14):9359\u201368.","journal-title":"J Biol Chem"},{"issue":"11","key":"1400_CR20","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0968-0004(98)01290-0","volume":"23","author":"M Rehn","year":"1998","unstructured":"Rehn M, Pihlajaniemi T, Hofmann K, Bucher P. The frizzled motif: in how many different protein families does it occur? Trends Biochem Sci. 1998;23(11):415\u20137.","journal-title":"Trends Biochem Sci"},{"issue":"5","key":"1400_CR21","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S1097-2765(03)00427-1","volume":"12","author":"H-C Wong","year":"2003","unstructured":"Wong H-C, Bourdelas A, Krauss A, Lee H-J, Shao Y, Wu D, Mlodzik M, Shi D-L, Zheng J. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell. 2003;12(5):1251\u201360.","journal-title":"Mol Cell"},{"issue":"1","key":"1400_CR22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2105-9-40","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang Y. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics. 2008;9(1):40.","journal-title":"BMC Bioinformatics"},{"issue":"9","key":"1400_CR23","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","volume":"2","author":"C Colovos","year":"1993","unstructured":"Colovos C, Yeates TO. Verification of protein structures: patterns of nonbonded atomic interactions. Protein Sci. 1993;2(9):1511\u20139.","journal-title":"Protein Sci"},{"issue":"13","key":"1400_CR24","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"EF Pettersen","year":"2004","unstructured":"Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. UCSF Chimera\u2014a visualization system for exploratory research and analysis. J Comput Chem. 2004;25(13):1605\u201312.","journal-title":"J Comput Chem"},{"key":"1400_CR25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/srep00032","volume":"1","author":"AA Abbasi","year":"2011","unstructured":"Abbasi AA. Molecular evolution of HR, a gene that regulates the postnatal cycle of the hair follicle. Sci Rep. 2011;1:32.","journal-title":"Sci Rep"},{"issue":"23","key":"1400_CR26","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1242\/dev.083352","volume":"139","author":"H Yu","year":"2012","unstructured":"Yu H, Ye X, Guo N, Nathans J. Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Development. 2012;139(23):4383\u201394.","journal-title":"Development"},{"key":"1400_CR27","doi-asserted-by":"publisher","unstructured":"Zhang R, Fang Y, Wu B, Chemban M, Laakhey N, Cai C, Shi O. Gene-gene interaction between VANGL1, FZD3, and FZD6 correlated with neural tube defects in Han population of Northern China. Genet Mol Res. 2016;15(3). https:\/\/doi.org\/10.4238\/gmr.15039010 .","DOI":"10.4238\/gmr.15039010"},{"issue":"1","key":"1400_CR28","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/dvdy.22127","volume":"239","author":"S Stuebner","year":"2010","unstructured":"Stuebner S, Faus-Kessler T, Fischer T, Wurst W, Prakash N. Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect. Dev Dyn. 2010;239(1):246\u201360.","journal-title":"Dev Dyn"},{"key":"1400_CR29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/B978-0-12-385952-5.00003-8","volume":"62","author":"G Romero","year":"2011","unstructured":"Romero G, von Zastrow M, Friedman PA. Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity. Adv Pharmacol. 2011;62:279.","journal-title":"Adv Pharmacol"},{"issue":"12","key":"1400_CR30","doi-asserted-by":"crossref","first-page":"10210","DOI":"10.1074\/jbc.M110.194399","volume":"286","author":"K Zhang","year":"2011","unstructured":"Zhang K, Harada Y, Wei X, Shukla D, Rajendran A, Tawansy K, Bedell M, Lim S, Shaw PX, He X. An essential role of the cysteine-rich domain of FZD4 in Norrin\/Wnt signaling and familial exudative vitreoretinopathy. J Biol Chem. 2011;286(12):10210\u20135.","journal-title":"J Biol Chem"},{"key":"1400_CR31","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1038\/srep02659","volume":"3","author":"V Lemma","year":"2013","unstructured":"Lemma V, D\u2019agostino M, Caporaso MG, Mallardo M, Oliviero G, Stornaiuolo M, Bonatti S. A disorder-to-order structural transition in the COOH-tail of Fz4 determines misfolding of the L501fsX533-Fz4 mutant. Sci Rep. 2013;3:2659.","journal-title":"Sci Rep"},{"issue":"6","key":"1400_CR32","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.sbi.2008.10.002","volume":"18","author":"AK Dunker","year":"2008","unstructured":"Dunker AK, Silman I, Uversky VN, Sussman JL. Function and structure of inherently disordered proteins. Curr Opin Struct Biol. 2008;18(6):756\u201364.","journal-title":"Curr Opin Struct Biol"},{"issue":"5844","key":"1400_CR33","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1126\/science.1142819","volume":"317","author":"EA Ortlund","year":"2007","unstructured":"Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW. Crystal structure of an ancient protein: evolution by conformational epistasis. Science. 2007;317(5844):1544\u20138.","journal-title":"Science"},{"issue":"5638","key":"1400_CR34","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1126\/science.1082808","volume":"301","author":"W Chen","year":"2003","unstructured":"Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ. Dishevelled 2 recruits \u00df-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science. 2003;301(5638):1391\u20134.","journal-title":"Science"},{"issue":"8","key":"1400_CR35","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/dneu.22250","volume":"75","author":"WJ Bian","year":"2015","unstructured":"Bian WJ, Miao WY, He SJ, Wan ZF, Luo ZG, Yu X. A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of frizzled 4. Dev Neurobiol. 2015;75(8):805\u201322.","journal-title":"Dev Neurobiol"},{"issue":"2","key":"1400_CR36","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/07391102.2003.10506918","volume":"21","author":"VN Uversky","year":"2003","unstructured":"Uversky VN. A protein-chameleon: conformational plasticity of \u03b1-synuclein, a disordered protein involved in neurodegenerative disorders. J Biomol Struct Dyn. 2003;21(2):211\u201334.","journal-title":"J Biomol Struct Dyn"},{"key":"1400_CR37","doi-asserted-by":"crossref","unstructured":"Pau MS, Gao S, Malbon CC, Wang H-y, Bertalovitz AC. The intracellular loop 2 F328S Frizzled-4 mutation implicated in familial exudative vitreoretinopathy impairs Dishevelled recruitment. J Mol Signal. 2015;10:5.","DOI":"10.5334\/1750-2187-10-6"},{"issue":"6","key":"1400_CR38","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1074\/jbc.M609618200","volume":"282","author":"PM Smallwood","year":"2007","unstructured":"Smallwood PM, Williams J, Xu Q, Leahy DJ, Nathans J. Mutational analysis of Norrin-Frizzled4 recognition. J Biol Chem. 2007;282(6):4057\u201368.","journal-title":"J Biol Chem"},{"key":"1400_CR39","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez XM, Birney E. Ensembl Genome Browser. In: Vogel and Motulsky's Human Genetics. Berlin Heidelberg: Springer; 2010. p. 923\u2013939.","DOI":"10.1007\/978-3-540-37654-5_45"},{"issue":"3","key":"1400_CR40","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol. 1990;215(3):403\u201310.","journal-title":"J Mol Biol"},{"issue":"suppl_1","key":"1400_CR41","doi-asserted-by":"crossref","first-page":"D13","DOI":"10.1093\/nar\/gkm1000","volume":"36","author":"DL Wheeler","year":"2007","unstructured":"Wheeler DL, Barrett T, Benson DA, Bryant SH, Canese K, Chetvernin V, Church DM, DiCuccio M, Edgar R, Federhen S. Database resources of the national center for biotechnology information. Nucleic Acids Res. 2007;36(suppl_1):D13\u201321.","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"1400_CR42","first-page":"406","volume":"4","author":"N Saitou","year":"1987","unstructured":"Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol. 1987;4(4):406\u201325.","journal-title":"Mol Biol Evol"},{"issue":"30","key":"1400_CR43","doi-asserted-by":"crossref","first-page":"11030","DOI":"10.1073\/pnas.0404206101","volume":"101","author":"K Tamura","year":"2004","unstructured":"Tamura K, Nei M, Kumar S. Prospects for inferring very large phylogenies by using the neighbor-joining method. Proc Natl Acad Sci U S A. 2004;101(30):11030\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"1400_CR44","first-page":"725","volume":"11","author":"N Goldman","year":"1994","unstructured":"Goldman N, Yang Z. A codon-based model of nucleotide substitution for protein-coding DNA sequences. Mol Biol Evol. 1994;11(5):725\u201336.","journal-title":"Mol Biol Evol"},{"issue":"5","key":"1400_CR45","first-page":"514","volume":"6","author":"N Saitou","year":"1989","unstructured":"Saitou N, Imanishi T. Relative efficiencies of the Fitch-Margoliash, maximum-parsimony, maximum-likelihood, minimum-evolution, and neighbor-joining methods of phylogenetic tree construction in obtaining the correct tree. Mol Biol Evol. 1989;6(5):514\u201325.","journal-title":"Mol Biol Evol"},{"issue":"4","key":"1400_CR46","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1558-5646.1985.tb00420.x","volume":"39","author":"J Felsenstein","year":"1985","unstructured":"Felsenstein J. Confidence limits on phylogenies: an approach using the bootstrap. Evolution. 1985;39(4):783\u201391.","journal-title":"Evolution"},{"issue":"1\u20133","key":"1400_CR47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0014-5793(02)02831-4","volume":"521","author":"H Hering","year":"2002","unstructured":"Hering H, Sheng M. Direct interaction of Frizzled-1,-2,-4, and-7 with PDZ domains of PSD-95. FEBS Lett. 2002;521(1\u20133):185\u20139.","journal-title":"FEBS Lett"},{"issue":"1","key":"1400_CR48","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/onc.2010.389","volume":"30","author":"DS Wheeler","year":"2011","unstructured":"Wheeler DS, Barrick SR, Grubisha MJ, Brufsky AM, Friedman PA, Romero G. Direct interaction between NHERF1 and frizzled regulates \u03b2-catenin signaling. Oncogene. 2011;30(1):32\u201342.","journal-title":"Oncogene"},{"issue":"1","key":"1400_CR49","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","volume":"7","author":"F Sievers","year":"2011","unstructured":"Sievers F, Wilm A, Dineen D, Gibson TJ, Karplus K, Li W, Lopez R, McWilliam H, Remmert M, S\u00f6ding J. Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol. 2011;7(1):539.","journal-title":"Mol Syst Biol"},{"issue":"10","key":"1400_CR50","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1136\/bjo.87.10.1291","volume":"87","author":"H Kondo","year":"2003","unstructured":"Kondo H, Hayashi H, Oshima K, Tahira T, Hayashi K. Frizzled 4 gene (FZD4) mutations in patients with familial exudative vitreoretinopathy with variable expressivity. Br J Ophthalmol. 2003;87(10):1291\u20135.","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"1400_CR51","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/13816810802464312","volume":"30","author":"JM Robitaille","year":"2009","unstructured":"Robitaille JM, Wallace K, Zheng B, Beis MJ, Samuels M, Hoskin-Mott A, Guernsey DL. Phenotypic overlap of familial exudative vitreoretinopathy (FEVR) with persistent fetal vasculature (PFV) caused by FZD4 mutations in two distinct pedigrees. Ophthalmic Genet. 2009;30(1):23\u201330.","journal-title":"Ophthalmic Genet"},{"issue":"2","key":"1400_CR52","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tjo.2015.04.002","volume":"5","author":"H Kondo","year":"2015","unstructured":"Kondo H. Complex genetics of familial exudative vitreoretinopathy and related pediatric retinal detachments. Taiwan J Ophthalmol. 2015;5(2):56\u201362.","journal-title":"Taiwan J Ophthalmol"},{"key":"1400_CR53","doi-asserted-by":"crossref","unstructured":"Webb B, Sali A. Protein structure modeling with MODELLER. In: Kihara D, editor. Protein struct prediction. Methods in molecular biology (methods and protocols), vol. 1137. New York: Humana Press; 2014. p. 1\u201315.","DOI":"10.1007\/978-1-4939-0366-5_1"},{"issue":"2","key":"1400_CR54","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1006\/jmbi.1994.1017","volume":"235","author":"VN Maiorov","year":"1994","unstructured":"Maiorov VN, Crippen GM. Significance of root-mean-square deviation in comparing three-dimensional structures of globular proteins. J Mol Biol. 1994;235(2):625\u201334.","journal-title":"J Mol Biol"},{"issue":"4","key":"1400_CR55","first-page":"1125","volume":"62","author":"J Cheng","year":"2006","unstructured":"Cheng J, Randall A, Baldi P. Prediction of protein stability changes for single-site mutations using support vector machines. Proteins: structure, function. Bioinformatics. 2006;62(4):1125\u201332.","journal-title":"Bioinformatics"},{"issue":"4","key":"1400_CR56","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/bioinformatics\/13.4.425","volume":"13","author":"RW Hooft","year":"1997","unstructured":"Hooft RW, Sander C, Vriend G. Objectively judging the quality of a protein structure from a Ramachandran plot. Bioinformatics. 1997;13(4):425\u201330.","journal-title":"Bioinformatics"}],"container-title":["BMC Evolutionary Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12862-019-1400-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12862-019-1400-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12862-019-1400-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:29:38Z","timestamp":1694683778000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcevolbiol.biomedcentral.com\/articles\/10.1186\/s12862-019-1400-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,8]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1400"],"URL":"https:\/\/doi.org\/10.1186\/s12862-019-1400-9","relation":{},"ISSN":["1471-2148"],"issn-type":[{"type":"electronic","value":"1471-2148"}],"subject":[],"published":{"date-parts":[[2019,3,8]]},"assertion":[{"value":"30 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"72"}}