{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:59:57Z","timestamp":1791298797266,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genet"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12863-015-0180-5","type":"journal-article","created":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T10:52:50Z","timestamp":1425120770000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population"],"prefix":"10.1186","volume":"16","author":[{"given":"Celia M","family":"Pereda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Lesueur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroulio","family":"Pertesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivonirina","family":"Robinot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J","family":"Lence-Anta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Turcios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros","family":"Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mae","family":"Chappe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idalmis","family":"Infante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Bustillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabel","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enora","family":"Clero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Xhaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Maillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Damiola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Rubino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirced","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regla","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"de Vathaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"180_CR1","volume-title":"Anuario estad\u00edstico de salud (Annual report of health statistics) 2012","author":"MINSAP-DNE","year":"2013","unstructured":"MINSAP-DNE. Anuario estad\u00edstico de salud (Annual report of health statistics) 2012. La Havana: direccion nacional de registros medicos y estadisticas de salud; 2013."},{"key":"180_CR2","volume-title":"Art and archaeology of pre-Columbian Cuba","author":"R Dacal","year":"1996","unstructured":"Dacal R, Rivero de la Calle M. Art and archaeology of pre-Columbian Cuba. Pittsburgh: University of Pittsburgh Press; 1996."},{"key":"180_CR3","volume-title":"Cancer incidence in five continents Vol. IX. IARC scientific publication no. 160","author":"P Curado","year":"2007","unstructured":"Curado P, Edwards B, Shin HR, Storm H, Ferlay J, Heanue M, et al. Cancer incidence in five continents Vol. IX. IARC scientific publication no. 160. Lyon: IARC Scientific Publications; 2007."},{"key":"180_CR4","first-page":"189","volume":"3","author":"JL Lence-Anta","year":"2014","unstructured":"Lence-Anta JL, Xhaard C, Ortiz RM, Kassim H, Pereda CM, Turcios S, et al. Environmental, lifestyle, and anthropometric risk factors for differentiated thyroid cancer in Cuba: a case-control study. Eur Thy J. 2014;3:189\u201396.","journal-title":"Eur Thy J"},{"key":"180_CR5","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1093\/emboj\/16.11.3185","volume":"16","author":"M Zannini","year":"1997","unstructured":"Zannini M, Avantaggiato V, Biffali E, Arnone MI, Sato K, Pischetola M, et al. TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J. 1997;16:3185\u201397.","journal-title":"EMBO J"},{"key":"180_CR6","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1440-1827.2006.01959.x","volume":"56","author":"P Zhang","year":"2006","unstructured":"Zhang P, Zuo H, Nakamura Y, Nakamura M, Wakasa T, Kakudo K. Immunohistochemical analysis of thyroid-specific transcription factors in thyroid tumours. Pathol Int. 2006;56:240\u20135.","journal-title":"Pathol Int"},{"key":"180_CR7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1089\/thy.1997.7.377","volume":"7","author":"MG Perna","year":"1997","unstructured":"Perna MG, Civitareale D, De Filippis V, Sacco M, Cisternino C, Tassi V. Absence of mutations in the gene encoding thyroid transcription factor-1 (TTF-1) in patients with thyroid dysgenesis. Thyroid. 1997;7:377\u201381.","journal-title":"Thyroid"},{"key":"180_CR8","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/ng.339","volume":"41","author":"J Gudmundsson","year":"2009","unstructured":"Gudmundsson J, Sulem P, Gudbjartsson DF, Jonasson JG, Sigurdsson A, Bergthorsson JT, et al. Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. Nat Genet. 2009;41:460\u20134.","journal-title":"Nat Genet"},{"key":"180_CR9","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1002\/ijc.28543","volume":"134","author":"E Bonora","year":"2014","unstructured":"Bonora E, Rizzato C, Diquigiovanni C, Oudot-Mellakh T, Campa D, Vargiolu M, et al. The FOXE1 locus is a major genetic determinant for familial nonmedullary thyroid carcinoma. Int J Cancer. 2014;134:2098\u2013107.","journal-title":"Int J Cancer"},{"key":"180_CR10","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s11684-014-0310-x","volume":"8","author":"L Ai","year":"2014","unstructured":"Ai L, Yu Y, Liu X, Wang C, Shi J, Sun H, et al. Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern China? Front Med. 2014;8:113\u20137.","journal-title":"Front Med"},{"key":"180_CR11","doi-asserted-by":"publisher","first-page":"7085","DOI":"10.1007\/s13277-014-1865-5","volume":"35","author":"J Kang","year":"2014","unstructured":"Kang J, Deng XZ, Fan YB, Wu B. Relationships of FOXE1 and ATM genetic polymorphisms with papillary thyroid carcinoma risk: a meta-analysis. Tumour Biol. 2014;35:7085\u201396.","journal-title":"Tumour Biol"},{"key":"180_CR12","doi-asserted-by":"publisher","first-page":"6159","DOI":"10.1007\/s13277-014-1896-y","volume":"35","author":"Y Zhuang","year":"2014","unstructured":"Zhuang Y, Wu W, Liu H, Shen W. Common genetic variants on FOXE1 contributes to thyroid cancer susceptibility: evidence based on 16 studies. Tumour Biol. 2014;35:6159\u201366.","journal-title":"Tumour Biol"},{"key":"180_CR13","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1136\/jmedgenet-2011-100586","volume":"49","author":"AM Jones","year":"2012","unstructured":"Jones AM, Howarth KM, Martin L, Gorman M, Mihai R, Moss L, et al. Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24. J Med Genet. 2012;49:158\u201363.","journal-title":"J Med Genet"},{"key":"180_CR14","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1093\/hmg\/ddq123","volume":"19","author":"M Takahashi","year":"2010","unstructured":"Takahashi M, Saenko VA, Rogounovitch TI, Kawaguchi T, Drozd VM, Takigawa-Imamura H, et al. The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. Hum Mol Genet. 2010;19:2516\u201323.","journal-title":"Hum Mol Genet"},{"key":"180_CR15","doi-asserted-by":"publisher","first-page":"e1000637","DOI":"10.1371\/journal.pgen.1000637","volume":"5","author":"I Landa","year":"2009","unstructured":"Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-P\u00e9rez L, Schiavi F, Leskel\u00e4 S, et al. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1\/USF2 transcription factors. PLoS Genet. 2009;5:e1000637.","journal-title":"PLoS Genet"},{"key":"180_CR16","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1002\/ijc.28483","volume":"134","author":"F Damiola","year":"2014","unstructured":"Damiola F, Byrnes G, Moissonnier M, Pertesi M, Deltour I, Fillon A, et al. Contribution of ATM and FOXE1 (TTF2) to risk of papillary thyroid carcinoma in Belarusian children exposed to radiation. Int J Cancer. 2014;134:1659\u201368.","journal-title":"Int J Cancer"},{"key":"180_CR17","doi-asserted-by":"publisher","first-page":"E1814","DOI":"10.1210\/jc.2012-1456","volume":"97","author":"M Bullock","year":"2012","unstructured":"Bullock M, Duncan EL, O\u2019Neill C, Tacon L, Sywak M, Sidhu S, et al. Association of FOXE1 polyalanine repeat region with papillary thyroid cancer. J Clin Endocrinol Metab. 2012;97:E1814\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"180_CR18","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s00439-007-0420-5","volume":"122","author":"A Carre","year":"2007","unstructured":"Carre A, Castanet M, Sura-Trueba S, Szinnai G, Van Vliet G, Trochet D, et al. Polymorphic length of FOXE1 alanine stretch: evidence for genetic susceptibility to thyroid dysgenesis. Hum Genet. 2007;122:467\u201376.","journal-title":"Hum Genet"},{"key":"180_CR19","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1080\/01621459.1961.10482090","volume":"56","author":"OJ Dunn","year":"1961","unstructured":"Dunn OJ. Multiple comparisons among means. JASA. 1961;56:52\u201364.","journal-title":"JASA"},{"key":"180_CR20","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.1038\/sj.onc.1202577","volume":"17","author":"CE Canman","year":"1998","unstructured":"Canman CE, Lim DS. The role of ATM in DNA damage responses and cancer. Oncogene. 1998;17:3301\u20138.","journal-title":"Oncogene"},{"key":"180_CR21","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1093\/aje\/kwm288","volume":"167","author":"P Brindel","year":"2008","unstructured":"Brindel P, Doyon F, Rach\u00e9di F, Boissin JL, Sebbag J, Shan L, et al. Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in native women in French Polynesia: a population-based case-control study. Am J Epidemiol. 2008;167:219\u201329.","journal-title":"Am J Epidemiol"},{"key":"180_CR22","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1677\/ERC-08-0336","volume":"16","author":"NM Akulevich","year":"2009","unstructured":"Akulevich NM, Saenko VA, Rogounovitch TI, Drozd VM, Lushnikov EF, Ivanov VK, et al. Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. Endocr Relat Cancer. 2009;16:491\u2013503.","journal-title":"Endocr Relat Cancer"},{"key":"180_CR23","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.ajhg.2009.08.018","volume":"85","author":"SV Tavtigian","year":"2009","unstructured":"Tavtigian SV, Oefner PJ, Babikyan D, Hartmann A, Healey S, Le Calvez-Kelm F, et al. Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. Am J Hum Genet. 2009;85:427\u201346.","journal-title":"Am J Hum Genet"},{"key":"180_CR24","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/gcc.22162","volume":"53","author":"A W\u00f3jcicka","year":"2014","unstructured":"W\u00f3jcicka A, Czetwerty\u0144ska M, \u015awierniak M, D\u0142ugosi\u0144ska J, Maci\u0105g M, Czajka A, et al. Variants in the ATM-CHEK2-BRCA1 axis determine genetic predisposition and clinical presentation of papillary thyroid carcinoma. Genes Chromosomes Cancer. 2014;53:516\u201323.","journal-title":"Genes Chromosomes Cancer"},{"key":"180_CR25","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrm3546","volume":"14","author":"Y Shiloh","year":"2013","unstructured":"Shiloh Y, Ziv Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol. 2013;14:197\u2013210.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"180_CR26","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3389\/fonc.2014.00106","volume":"4","author":"CE Caldon","year":"2014","unstructured":"Caldon CE. Estrogen Signaling and the DNA damage response in hormone dependent breast cancers. Front Oncol. 2014;4:106.","journal-title":"Front Oncol"},{"key":"180_CR27","doi-asserted-by":"publisher","first-page":"R99","DOI":"10.1186\/bcr3218","volume":"14","author":"J Lecarpentier","year":"2012","unstructured":"Lecarpentier J, Nogu\u00e8s C, Mouret-Fourme E, Gauthier-Villars M, Lasset C, Fricker JP, et al. Variation in breast cancer risk associated with factors related to pregnancies according to truncating mutation location, in the French National BRCA1 and BRCA2 mutations carrier cohort (GENEPSO). Breast Cancer Res. 2012;14:R99.","journal-title":"Breast Cancer Res"},{"key":"180_CR28","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1002\/humu.20949","volume":"30","author":"D Nguyen","year":"2009","unstructured":"Nguyen D, Calvez-Kelm FL, Forey N, McKay-Chopin S, Garritano S, Gioia-Patricola L, et al. Description and validation of high-throughput simultaneous genotyping and mutation scanning by high-resolution melting curve analysis. Hum Mutat. 2009;30:884\u201390.","journal-title":"Hum Mutat"},{"key":"180_CR29","volume-title":"The growth of the surface area of the human body","author":"E Boyd","year":"1935","unstructured":"Boyd E. The growth of the surface area of the human body. Minneapolis: University of Minnesota Press; 1935."},{"key":"180_CR30","volume-title":"Statistical methods in cancer research. Volume I - the analysis of case-control studies","author":"NE Breslow","year":"1980","unstructured":"Breslow NE, Day NE. Statistical methods in cancer research. Volume I - the analysis of case-control studies. Lyon: IARC Scientific Publication; 1980."},{"key":"180_CR31","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/bib\/3.2.146","volume":"3","author":"CM Lewis","year":"2002","unstructured":"Lewis CM. Genetic association studies: design, analysis and interpretation. Brief Bioinform. 2002;3:146\u201353.","journal-title":"Brief Bioinform"}],"container-title":["BMC Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12863-015-0180-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12863-015-0180-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12863-015-0180-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12863-015-0180-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T08:50:04Z","timestamp":1630572604000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenet.biomedcentral.com\/articles\/10.1186\/s12863-015-0180-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["180"],"URL":"https:\/\/doi.org\/10.1186\/s12863-015-0180-5","relation":{},"ISSN":["1471-2156"],"issn-type":[{"value":"1471-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,1]]},"assertion":[{"value":"6 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"22"}}