{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:49:11Z","timestamp":1792190951280,"version":"4.4.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"S9","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1186\/s12864-016-3092-5","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T13:38:37Z","timestamp":1476711517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Vascular endothelial growth factor (VEGFA) gene variation in polycystic ovary syndrome in a Tunisian women population"],"prefix":"10.1186","volume":"17","author":[{"given":"Assila","family":"Ben Salem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Megdich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfa","family":"Kacem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Souayeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten","family":"Hachani Ben Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sondes","family":"Hizem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faouzi","family":"Janhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounir","family":"Ajina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Abu-Elmagd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourad","family":"Assidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed H.","family":"Al Qahtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Touhami","family":"Mahjoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,17]]},"reference":[{"issue":"12","key":"3092_CR1","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","volume":"352","author":"DA Ehrmann","year":"2005","unstructured":"Ehrmann DA. Polycystic Ovary Syndrome. N Engl J Med. 2005;352(12):1223\u201336.","journal-title":"N Engl J Med"},{"issue":"2","key":"3092_CR2","first-page":"326","volume":"26","author":"J Klein","year":"2015","unstructured":"Klein J, Craven M, Vuguin PM. Polycystic Ovarian Syndrome. Adolesc Med State Art Rev. 2015;26(2):326\u201342.","journal-title":"Adolesc Med State Art Rev"},{"issue":"1","key":"3092_CR3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/humrep\/17.1.201","volume":"17","author":"H-A Pan","year":"2002","unstructured":"Pan H-A, Wu M-H, Cheng Y-C, Li C-H, Chang F-M. Quantification of Doppler signal in polycystic ovary syndrome using three-dimensional power Doppler ultrasonography: a possible new marker for diagnosis. Human Raproduction. 2002;17(1):201\u20136.","journal-title":"Human Raproduction"},{"issue":"3","key":"3092_CR4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0015-0282(00)00670-1","volume":"74","author":"E Geva","year":"2000","unstructured":"Geva E, Jaffe RB. Role of vascular endothelial growth factor in ovarian physiology and pathology. Fertil Steril. 2000;74(3):429\u201338.","journal-title":"Fertil Steril"},{"issue":"12","key":"3092_CR5","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1177\/1947601911423031","volume":"2","author":"M Shibuya","year":"2011","unstructured":"Shibuya M. Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. Genes Cancer. 2011;2(12):1097\u2013105.","journal-title":"Genes Cancer"},{"issue":"6","key":"3092_CR6","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.fertnstert.2007.06.049","volume":"89","author":"EJ Lee","year":"2008","unstructured":"Lee EJ, Oh B, Lee JY, Kimm K, Park JM, Baek KH. Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome. Fertil Steril. 2008;89(6):1751\u20139.","journal-title":"Fertil Steril"},{"issue":"1","key":"3092_CR7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejogrb.2009.06.026","volume":"147","author":"P Vural","year":"2009","unstructured":"Vural P, Kusku-Kiraz Z, Dogru-Abbasoglu S, Cil E, Karadag B, Akgul C, Uysal M. Vascular endothelial growth factor \u22122578 A\/C, \u2212460 T\/C and +405 G\/C polymorphisms in polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2009;147(1):57\u201360.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"10","key":"3092_CR8","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s10815-014-0310-4","volume":"31","author":"P Guruvaiah","year":"2014","unstructured":"Guruvaiah P, Govatati S, Reddy TV, Lomada D, Deenadayal M, Shivaji S, Bhanoori M. The VEGF +405\u00a0G\u2009>\u2009C 5\u2032 untranslated region polymorphism and risk of PCOS: a study in the South Indian Women. J Assist Reprod Genet. 2014;31(10):1383\u20139.","journal-title":"J Assist Reprod Genet"},{"issue":"4","key":"3092_CR9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1744-313X.2010.00915.x","volume":"37","author":"P Vural","year":"2010","unstructured":"Vural P, Kusku-Kiraz Z, Dogru-Abbasoglu S, Cil E, Karadag B, Uysal M. Vascular endothelial growth factor +405G\/C,-460 T\/C and \u22122578 A\/C polymorphisms are not associated with insulin resistance in polycystic ovary syndrome. Int J Immunogenet. 2010;37(4):239\u201343.","journal-title":"Int J Immunogenet"},{"issue":"1\u20132","key":"3092_CR10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11010-015-2417-z","volume":"405","author":"S Choudhuri","year":"2015","unstructured":"Choudhuri S, Chowdhury IH, Das S, Dutta D, Saha A, Sarkar R, Mandal LK, Mukherjee S, Bhattacharya B. Role of NF-kappaB activation and VEGF gene polymorphisms in VEGF up regulation in non-proliferative and proliferative diabetic retinopathy. Mol Cell Biochem. 2015;405(1\u20132):265\u201379.","journal-title":"Mol Cell Biochem"},{"issue":"10","key":"3092_CR11","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1007\/s11033-014-3540-8","volume":"41","author":"A Ben Salem","year":"2014","unstructured":"Ben Salem A, Attaoua R, Mtiraoui N, Belkahla S, Ezzidi I, Ajina M, Souissi M, Poucheret P, Vintila M, Grigorescu F, et al. Common polymorphisms of calpain-10 and the risk of polycystic ovary syndrome in Tunisian population: a case\u2013control study. Mol Biol Rep. 2014;41(10):6569\u201374.","journal-title":"Mol Biol Rep"},{"issue":"2","key":"3092_CR12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.gene.2014.12.004","volume":"565","author":"A Ben Salem","year":"2015","unstructured":"Ben Salem A, Attaoua R, Mtiraoui N, Meddeb S, Kacem O, Ajina M, Souissi M, Poucheret P, Normand C, Mahjoub T, et al. Haplotyping strategy highlights the specificity of FTO gene association with polycystic ovary syndrome in Tunisian women population. Gene. 2015;565(2):166\u201370.","journal-title":"Gene"},{"key":"3092_CR13","doi-asserted-by":"crossref","unstructured":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertility and Sterility. 2004;81(1):19\u201325.","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"issue":"4","key":"3092_CR14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11154-016-9326-7","volume":"16","author":"E Palioura","year":"2015","unstructured":"Palioura E, Diamanti-Kandarakis E. Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs). Rev Endocr Metab Disord. 2015;16(4):365\u201371.","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"3092_CR15","first-page":"44","volume":"33","author":"N Davies","year":"2016","unstructured":"Davies N. PCOS: Polycystic Ovarian Syndrome. Diabetes Self Manag. 2016;33(1):44\u20137.","journal-title":"Diabetes Self Manag"},{"issue":"6","key":"3092_CR16","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S0015-0282(02)04242-5","volume":"78","author":"R Agrawal","year":"2002","unstructured":"Agrawal R, Jacobs H, Payne N, Conway G. Concentration of vascular endothelial growth factor released by cultured human luteinized granulosa cells is higher in women with polycystic ovaries than in women with normal ovaries. Fertil Steril. 2002;78(6):1164\u20139.","journal-title":"Fertil Steril"},{"issue":"2","key":"3092_CR17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejogrb.2004.07.024","volume":"118","author":"DE Abd El Aal","year":"2005","unstructured":"Abd El Aal DE, Mohamed SA, Amine AF, Meki AR. Vascular endothelial growth factor and insulin-like growth factor-1 in polycystic ovary syndrome and their relation to ovarian blood flow. Eur J Obstet Gynecol Reprod Biol. 2005;118(2):219\u201324.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"8","key":"3092_CR18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/09513590600906607","volume":"22","author":"PG Artini","year":"2006","unstructured":"Artini PG, Monti M, Matteucci C, Valentino V, Cristello F, Genazzani AR. Vascular endothelial growth factor and basic fibroblast growth factor in polycystic ovary syndrome during controlled ovarian hyperstimulation. Gynecol Endocrinol. 2006;22(8):465\u201370.","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"3092_CR19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/14647270802621358","volume":"12","author":"PG Artini","year":"2009","unstructured":"Artini PG, Ruggiero M, Parisen Toldin MR, Monteleone P, Monti M, Cela V, Genazzani AR. Vascular endothelial growth factor and its soluble receptor in patients with polycystic ovary syndrome undergoing IVF. Hum Fertil (Camb). 2009;12(1):40\u20134.","journal-title":"Hum Fertil (Camb)"},{"key":"3092_CR20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.domaniend.2015.09.003","volume":"54","author":"MK VanKlompenberg","year":"2016","unstructured":"VanKlompenberg MK, Manjarin R, Donovan CE, Trott JF, Hovey RC. Regulation and localization of vascular endothelial growth factor within the mammary glands during the transition from late gestation to lactation. Domest Anim Endocrinol. 2016;54:37\u201347.","journal-title":"Domest Anim Endocrinol"},{"key":"3092_CR21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1677\/joe.0.1730219","volume":"173","author":"AM Corbacho","year":"2002","unstructured":"Corbacho AM, Martinez de la Escalera G, Clapp C. Roles of prolactin and related members of the prolactin\/growth hormone\/placental lactogen family in angiogenesis. J Endocrinol. 2002;173:219\u201338.","journal-title":"J Endocrinol"},{"issue":"1\u20132","key":"3092_CR22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mce.2005.01.005","volume":"232","author":"AS Goldhar","year":"2005","unstructured":"Goldhar AS, Vonderhaar BK, Trott JF, Hovey RC. Prolactin-induced expression of vascular endothelial growth factor via Egr-1. Mol Cell Endocrinol. 2005;232(1\u20132):9\u201319.","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"3092_CR23","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jcb.20167","volume":"93","author":"L Malaguarnera","year":"2004","unstructured":"Malaguarnera L, Imbesi RM, Scuto A, D\u2019Amico F, Licata F, Messina A, Sanfilippo S. Prolactin increases HO-1 expression and induces VEGF production in human macrophages. J Cell Biochem. 2004;93(1):197\u2013206.","journal-title":"J Cell Biochem"},{"issue":"6","key":"3092_CR24","doi-asserted-by":"crossref","first-page":"788","DOI":"10.5713\/ajas.2009.80519","volume":"22","author":"K-I Nakajima","year":"2009","unstructured":"Nakajima K-I, Nakamura M, Ishisaki A, Kozakai T. Synergistic Effect of Dexamethasone and Prolactin on VEGF Expression in Bovine Mammary Epithelial Cells via p44\/p42 MAP Kinase. Asian-Aust J Anim Sci. 2009;22(6):788\u201395.","journal-title":"Asian-Aust J Anim Sci"},{"issue":"2","key":"3092_CR25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.tjog.2016.02.002","volume":"55","author":"KM Seow","year":"2016","unstructured":"Seow KM, Lee WL, Wang PH. A challenge in the management of women with polycystic ovary syndrome. Taiwan J Obstet Gynecol. 2016;55(2):157\u20138.","journal-title":"Taiwan J Obstet Gynecol"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-016-3092-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T01:20:28Z","timestamp":1498353628000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/s12864-016-3092-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":25,"journal-issue":{"issue":"S9","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["3092"],"URL":"https:\/\/doi.org\/10.1186\/s12864-016-3092-5","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]},"article-number":"748"}}